Orgasm Research
Center established in 1997, starting from LinPlaza.com.
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hyperactivity disorder
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& Masturbation/Orgasm
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& Orgasm
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& no Orgasm
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Orgasm
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Orgasm
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or Ejaculation
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& Orgasm
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Orgasm
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Disorder (OCD)& Excessive Sex
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& Orgasm
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erection)
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Welcome to Orgasm Research Center
In GOD we trust; all others provide evidences - data and cases! Yes, we got
them all! Since 1997, we have collected human and animal sexual and drug
experiences
and experiments, classical, empirical and academic, from 5000 years ago to
today, to share with you!
Suffering is Believing,
Seeing
is Believing, Hearing
is Believing, Forgetting
is Believing, Shaking
is Believing; Dizzying
is Believing; Head-aching
is Believing; Peeing
is Believing; Vibrating
is Believing; Tiring
is Believing; Depressing
is Believing; Feeling
is Believing; Stressing
is Believing; ReTooling
is Believeing; Pleasing
is Believing;
or get Benefits
from Optimal Orgasms (This is what you love to hear about) or More! Warning,
Warning: Finally,
some conscious researchers want to tell you that high-frequency
sexual activity (intercourse, masturbation, overall) may increase risk of
prostate cancer as given in http://www3.interscience.wiley.com/journal/121510647/abstract.
It
is not a joke! But, do you believe in them this time since the last time you
were told that masturbation can reduce prostate cancer risk (yes, and you got
excited by the "good" news which becomes your nightmare now!)?
Dr Lin has collected the ill effects (sexual exhaustion symptoms) from
Over-masturbation/Over-ejaculation/Excessive Orgasm since 1997 to prove what the
5000-year old Chinese medical text said. Dr. Lin has concluded sex/psychological-
induced excessive prolactin,
norepinephrine,
epinephrine
and prostaglandin
E2 can cause autoimmune
disorders (more
reference?), brain overheating with fever/flu-like symptoms ( http://ajpregu.physiology.org/cgi/content/full/294/4/R1294
) vasoconstriction ( although prostaglandin E2 is an inflammator
as well as a dilator), fear, anxiety, restlessness, pounding headaches,
dizziness, tremors, weakness, respiratory difficulty, palpitations, cardiac arrhythmias, skin
cancers, skin
disorders (including acne
), allergy, asthma,
hair
loss( more
reference, and more;
on hair
cycling), neuroplasticity ( http://www.la-press.com/redirect_file.php?fileId=829&filename=GRSB-1-Akenaya&fileType=pdf
)and cancerous/tumorous
cellular development and locomotion, and ignite negative neuro-immuro-reaction,
arterial
constriction (via the alpha-adrenergic receptors) / inflammatory
narrowness and venous
constriction for blood-cutoff castration of the
hypothalamus-pituitary-testicular axis and
heart diseases, and inflammatory
responses. Interrupting the stimulation of
nuerohormones norepinephrine and epinephrine on the beta-adrenergic receptors
via the sympathetic nerves (T10-L2) results in the prostate atrophy for spinal-injured
men- http://www.nature.com/sc/journal/v44/n1/abs/3101804a.html
while sympathetic nervous over-excitation of the neurohormones on the prostate
causes prostate enlargement and pains. For more information on Cancer, Sex
and Stress, please click here - Stress
Increases Prostate (and Ovarian) Cancer Risk. Yes, ovarian
cancer too (yes,
more reference); actually, any
types of cancers or tumors, (for examples: skin
cancers, colon
cancer, liver
cancer, et. al.) as well; and neuroplastic
Post-Stress-Trauma brain/nervous damage. No doubt, current researches
have tied breast
and prostate cancers to excessive prolactin release and stress
hormones norepinephrine
(more?)and epinephrine By the way, if you have
been misled to over-masturbation, over-ejaculation (high-frequency ejaculation),
or excessive sex, our products can help you get recovery from Sexual
Exhaustion Symptoms unless your testicular function was fully castrated by
excessive sex. When sex stresses your Hypothalamus-Pituitary-Adrenal (HPA)
axis out, you get neuroplastic Post-Sex Stress Trauma Disorders (PSSTD), that is
Dr. Lin's Sexual
Exhaustion Symptoms, but no health benefit at all: you die for sex like
insects! Are you on the way to selfdestruction? By the way, you may would
like to know what
are effects of semen and sperms on you can your partner (please click
here)!
Why?
Consider the Sexual
Arousal Neuroimmune Pathway: The dopamine nervous system stimulates the
hypothalamus-pituitary axis, with orchestral effects of androgen hormones
DHEA/testosterone/DHT ( http://csbn.concordia.ca/Faculty/Pfaus/docs/Damsma,Pfaus,Wenkstern,Phillips,Fibiger%20(1992)%20Behav%20Neurosci.pdf,
http://www.jneurosci.org/cgi/reprint/17/12/4849
, http://www.koreamed.org/SearchBasic.php?RID=198197&DT=1
, http://www.nature.com/ijir/journal/v13/n3s/pdf/3900719a.pdf
),
to activate the norepinephrine/sympathetic nervous action and the oxytocin, NOergic (NO
= Nitric Oxide - released from the parasympathetic nervous endings) and
prostaglandin E2 stimulation on sex organs (prostate, seminal vesicles, penis and testicles,
clitoris, uterus, vagina and ovaries), leading to the induction of swelling/congestive/inflammatory
pressure,
arterial dilation and nervous sensitivity. The swelling/congestive/inflammatory
pressure won't give you pain, but nervous sensitivity if the tissues release
sufficient prostaglandins E1 and E3 to relax the nerves and blood vessels and to
enhance their elasticity and flexibility. This is how sexual desire
initiates and how people experience the persistent sexual arousal symptom.
Noticeably, the highly stretched penile nerves may be desensitized when a penis
is ballooned into the 2nd stage erection where the erecting penis becomes about
120% bigger than the initial erection. This exception can be achieved by the
penile ballooning enlargement where prostaglandins E1/E2/E3, androgen
hormones, oxytocin, histamine, sympathetic and parasympathetic nervous erectile
mechanism are synchronically working together. Before sexual exhaustion, prostaglandin
E2, with oxytocin and histamine, acts as a vasodepressor/vasodilator; after sexual exhaustion, it,
with a high level of prolactin and a lack of oxytocin and NO release, becomes
vasopressor/vasoconstrictor and arterial/venous narrowing imflammator,
even with a high level of histamine. The tricky roles of
prostaglandin E2 are also described in http://hyper.ahajournals.org/cgi/reprint/35/5/1129
. Men or women can get a lot of erection, sex-organ swelling, and sexual desire from
the stimulation of prostaglandin
E2 (in conjunction with a high level of histamine release) with a high price - inflammatory
body pains, congestive headaches, dizziness, or/and excessive, unwanted
leakage/discharge out of the penis/vagina, if the cholinergic/vagal/serotonin/GABA
nervous function, in conjunction with action of androgen hormones and
prostaglandins E1 and E3, are too weak to modulate the local inflammatory
response induced by noradrenergic (norepinephrine)/sympathetic nervous fires (pyrogens)
and prostaglandin E2 in the sympathetic adrenergic receptors. In the
brain, the hypothalamic dopamine-norepinephrine conversion during sexual arousal
triggers endogenous pyrogens to act on the Organum Vasculation of the Lamina
Terminalis of the third ventricle to promote prostaglandin E2 release to open
the blood-brain barriers for more androgen hormones (stress hormones and toxins
too!) to enter the brain and central nervous system, and to elevate the core
temperature for sex heat. That is why you feel heat and warm when you become
sexual arousal. You may feel dizziness in your first encounter with a new
partner. In the body, prostaglandin E2 promotes bradykinin-induced pains,
spinal/back pains, the coagulation of platelets, bone resorption and formation
(good!), immune disabling (for
infection, but good for making babies: 1. de-activating the urethral, vaginal
and uterine immune to help sperms survive through male ejaculation duct, female
vagina, cervix, and uterus; 2. disabling the egg immune to help a sperm
fertilize the egg; 3. disabling the uterine immune to allow the fertilized egg
to be implanted or transplanted; 4. inducing labor (orgasms too)),
cancer and carcinogenesis, hypertension, muscle protein degradation
(muscular weakness and shrinkage), cardiovascular disorders, and synaptic
neuroplasticity for alternation and reprogramming of brain/nervous functions
(for better or worse), short-and long-term memory (including sexual pleasures!),
addiction (of drug and sex!), alzheimer's disease, psychological disorders, and promotion of chronic
noradrenergic/sympathetic fight or flight responses. You see, prostaglandin E2
plays the role of the good, the bad and the ugly in your life from the beginning
to the end (death.)
Thus, sex is a neuro-immune and hypothalamus-pituitary-adrenal and
-testicular (-ovarian) challenge, good (constructive) or bad (destructive)
depending on how you manipulate and perform it. Sexual
arousal or orgasm triggers the neuro-immuno-endocrine function for better or worse, depending on
the immunoreaction of the noradrenergic (norepinephrine)/sympathetic nervous
system to its resulted stress and on the balance of its induced
pro-inflammatory and anti-inflammatory responses. If you ignore
the neuro-immune responses to sex-induced stressors norepinephrine and
epinephrine, sex will destroy your health for no more orgasm, but pains and
psychological disorders like drug abuse. The neuro-immune-endocrine responses to sex-induced
stress are driven by the sympathetic nervous alpha- and beta-adrenergic receptors of the
immune cells which release immunotransitters cytockines and protein kinases for
pro-inflammation or/and anti-inflammation. The classic Taoism teaching considers
sex as a powerful drug for better or worse, up to individual practices. Don't
become a LOOSER!
Over-masturbation/over-ejaculation/excessive-orgasm can
castrate the hypothalamus-pituitary-testicular(ovarian) axis by arterial constriction and
inflammatory narrowness in your brain and pelvic organs (testicles, prostate,
seminal vesicles, penis, ovaries, uterus, vagina and clitoris) due to excessive
release of prolactin, norepinephrine, and epinephrine, excessive binding of
norepinephrine/epinephrine on the alpha-adrenergic receptors, the
norepinephrine/epinephrine induced excessive prostaglandin E2, and the post-sex
deficiency of nitric oxide and prostaglandins E1/E3 production. As a result
of arterial constriction and inflammatory narrowness (leading to arterial
thrombosis and atherothrombosis! http://jem.rupress.org/cgi/content/full/204/2/311;
http://jpet.aspetjournals.org/cgi/content/full/300/2/393;
http://jem.rupress.org/cgi/content/full/204/2/311
), your brain,
testicles, penis, (clitoris, vulva, G-spot, vagina, uterus and ovaries for
women) feet and hands get low blood supplies and less androgen
hormones and nuerochemicals, but more inflammatory hormone production and stress
hormones. And, it will take a long time for you to get recovery from
sexual exhaustion and post-sex inflammation. You may also wonder why your
penis or clitoris go limps and your vagina become dry in the middle of
sex. When your adrenal and testicular
(or ovarian) function are disabled, you will have to rely on the skin
neruoendocrine function to elevate your androgen hormones. Please also
note that prostaglandin E2 also inflame veins too - http://atvb.ahajournals.org/cgi/content/full/18/10/1655,
http://ajpcell.physiology.org/cgi/content/full/281/3/C1038,
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=199422,
and http://atvb.ahajournals.org/cgi/content/full/17/9/1644
. When you get inflamed arteries and veins, your blood circulation won't
reach the inflamed areas and you will experience pain, numbness or cramp .
As for sex, you don't want inflamed arteries and veins in your penis and
testicles (clitoris, labia, G-spot, vagina. uterus (and its support
ligaments and tissues) and ovaries for women), do you? In
addition, excessively accumulation of prolactin as a result of
high-frequency ejaculation or orgasm disables the activin release from the
testicles, epididymis, prostate,and seminal vesicles (or ovaries for women),
leading to a low pituitary FSH release, followed by a low pituitary LH release,
resulting in deficiency of androgen hormonal production from the testicles and
ovaries. On the other hand, activin is a negative regulator of prolactin and
cell growth ( http://mend.endojournals.org/cgi/content/full/18/6/1558
). Without sufficient activin, the excessive release prolactin becomes
persistent, and thus the androgen hormones (testosterone and DHT) level
remains too low to help the exhausted hypothalamus-pituitary-adrenal and
testicular (ovarian) axis to recover from sexual exhaustion or post-sex illness
or to suppress the inflammatory pains. No wonder, you will experience
persistent sexual exhaustion, fatigue, tiredness and inflammatory pains.
Recent studies show that sexual exhaustion also reduces the androgen
receptor density and expression, but upregulates estrogen receptor alpha
expression, particularly in in the medial preoptic area (MPOA),
ventromedial hypothalamic nucleus (VMH), medial amygdala (MeA), and
lateral septum, ventral part (LSV) - http://www.ncbi.nlm.nih.gov/pubmed/12914589
, http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000099250,
http://www.ncbi.nlm.nih.gov/pubmed/17239879?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/19073212?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed
These researches basically re-verify the effectiveness of our products which
were in the markets for solve sexual exhaustion symptoms long before these
studies were done. However, the studies doesn't address catastrophic (permanent)
castration of the pituitary-testicular and ovarian axis due to excessive
prolactin and norepinephrine induced arterial and venous constriction and
inflammatory narrowness in the brain, testicles, penis, ovaries, clitoris and
other pelvic organs. We have found there are about 5-10% of sexual exhausted
patients unable to get recovery. Why are sexual exhaustion symptoms
complicated by the exhaustion of the
hypothalamus-pituitary-adrenal and -testicular (-ovarian) axis and the
destruction of the dopamine, cholinergic/vegal/parasympathetic, serotonin and
GABA nervous function with inflammatory responses?
Orgasm-stress induced inflammatory hormone prostaglandin
E2 can over-excite mast cells to release histamine to activates the central
histaminergic nerves and other numerous vasoactive, neurosensitizing and
inflammatory molecules. Histamine and its receptors are very
dense in the hypothalamus, heart, lungs and arteries; Psychological or physiological stress, including
sex-induced stress, can induce significant alterations in both
histamine synthesis and its concentration in several brain regions.
During stress reactions, histamine may act as a neurotransmitter
within the hypothalamus. A high density of brain mast cells in
regions situated at the boundary between the central nervous system
(CNS) and its surroundings such as in the circumventricular organs
and median eminence can induce immediate hypersensitivity either in
the CNS or in the periphery. This gives you orgasmic headaches, allergic responses,
asthma, sneezing, sinus, itchiness, scalping burning sensation, hair
loss and premature ejaculation. Histamine, in turn, may also trigger the
release of various stress hormones to prolong your sex-induced stress for
several days. Psychological or physiological stress, including
orgasm/sex-induced stress also induces cardiac mast cell activation and
histamine release into the bloodstream. Chronic excessive norepinephrine and its
induced excessive histamine and prostaglandin E2 promote the development of
atherosclerosis, coronary inflammation and cardiac ischemia, besides
environmental toxins such as smoking (nicotine, pot, etc.). In myocardial
ischemia, excessive norepinephrine release causes severe arrhythmias and sudden
cardiac death. Recent studies shows histamine H3-receptors can
provide a negative feedback control for the release of norepinephrine from the
sympathetic nervous endings, and for a number of other neurotransmitters such as
histamine itself, dopamine, GABA, acetylcholine, and serotonin. But, this negative feed control can be easily
breakdown by excessive stress. On the other hands, histamine H1 and H2
receptors promote cardiac disorders. Reduction of endogenous histamine
release or/and blockade of histamine H1 and H2 receptors can protects against
ischemia. This is why there are a lot of reports about sudden death
or cardiac arrest during intercourse or masturbation when histamine stimulates
H1 and H2 receptors more than H3. And, severe allergy can cause cardiac
arrest. However, what happens when histamine over-stimulates H3 but
understimulate H1 and H2? In this regard, you will likely experience the
sexual exhaustion symptoms resulted from post-sex deficiency of dopamine,
acetylcholine, norepinephrine, serotonin and GABA. Unfortunately, in the
most of sexual exhaustion symptoms we have collected, it seems H3 fails to
negatively feedback control the norepinephrine and histamine release since
sexual arousal, orgasm or ejaculation always triggers the hypothalamic and
adrenal dopamine-norepinephrine conversion and histamine release when you are in
the exhaustion state of the hypothalamus-pituitary-adrenal axis. For those with
premature ejaculation, precum flooding, or premature orgasm, the sex organs
start to release excessive histamine when norepinephrine and its induced
prostaglandin E2 start to heat up the brain, sex organs and noradrenergic/adrenergic/sympathetic
nervous systems. Our readers' urinary analyses always showed an excess of
norepinephrine and a severe deficiency of serotonin. This indicates that under
the stimulation of excessive inflammatory hormone prostaglandin E2 and prolactin
in sexual exhaustion conditions, H3 fails to suppress the histamine
and norepinephrine release, but it positively and successfully block the
dopamine, acetylcholine, serotonin, and GABA release in the nervous
terminals. You may wonder why sexual exhaustion symptoms are complicated by
the exhaustion of the hypothalamus-pituitary-adrenal and -testicular axis as
well as the destruction of the dopamine, cholinergic(acetylcholine)/vegal/parasympathetic,
serotonin and GABA nervous functions, but with the excessive noradrenergic,
adrenergic, sympathetic, histaminergic or/and glutamate nervous function.
Ref:
http://www.ingentaconnect.com/content/mksg/all/2006/00000061/00000004/art00016
http://www.ingentaconnect.com/content/bsc/pse/1999/00000220/00000002/art09913
http://clincancerres.aacrjournals.org/cgi/reprint/11/19/6807
http://www.jimmunol.org/cgi/content/full/165/11/6545
http://www.ncbi.nlm.nih.gov/pubmed/9274980?dopt=Abstract
http://ps.fass.org/cgi/reprint/86/5/843
http://www.jneurosci.org/cgi/content/abstract/23/14/5975
http://www.faqs.org/abstracts/Health/Production-of-prostaglandin-E2-induced-by-histamine-by-cloned-rheumatoid-synovial-cells.html
http://ajpgi.physiology.org/cgi/content/abstract/242/1/G21
http://www.jci.org/articles/view/107307/pdf
http://www.jleukbio.org/cgi/content/abstract/74/3/420
http://ajrccm.atsjournals.org/cgi/content/full/161/2/S1/S62
http://ajrccm.atsjournals.org/cgi/content/full/169/1/15
http://www.jci.org/articles/view/13930
http://ajpheart.physiology.org/cgi/content/full/273/6/H2726
http://gut.bmj.com/cgi/content/abstract/18/6/429
http://ard.bmj.com/cgi/content/abstract/49/7/504
http://www.ingentaconnect.com/content/klu/428/2004/00000445/00000005/art00008
In
addition, excessive histamine stimulates excessive α-MSH
release in the tissues around the eyes (dark eye circles), scrotum, labia majors or
minors, perineum, inner thighs and even nipples, leading to skin darkness known
as Hyperpigmentation. Thus,
darkness of these skins indicate excessive histamine release locally. Beside
excessive sex, other factors such as genetic factors, allergy, sleeping
depletion (melatonin deficiency), sickness, and psychological
stress, can also cause excessive α-MSH
release. However, high-frequency sex will darken eye circles and labia minors
very fast due to its induced poor local blood circulation and overall blood
color change as result of excessive norepinephrine, epinephrine, prolactin and α-MSH
in the bloodstream. For more information, please go to Excessive sex for darker eye cycles,
nips, labia minors, pelvic area, perineum,
clitoral and penile foreskin.
By the way, excessive norepinephrine and prostaglandin E2 in the brain causes Homosynaptic
and Heterosynaptic plasticity ( http://www.la-press.com/redirect_file.php?fileId=829&filename=GRSB-1-Akenaya&fileType=pdf
), that is nervous damage or alternation. Homosynaptic plasticity
alternates synaptic strength that results from the history of activity at a
particular synapse. For examples, norepinephrine increases the noradrenergic and
sympathetic nervous fires; epinephrine increases the adrenergic and sympathetic
nervous fires. Serotonin Reuptaking Inhibitors outgrow the serotonin
neurons and post-synapses and produces long-term inhibitory effects on the
presynaptic terminals of the dopaminergic neurons. On the other hands,
heterotropic plasticity
changes synaptic strength that results for the activity of other neurons. For
example, chronic norepinephrine stimulation under the noradrenergic/sympathetic
nervous systems produces long-term inhibitory effects on the presynaptic
terminals of neurons of the cholinergic/vegal/parasympathetic/serotonin/GABA
neurons. This is why Drug and excessive Sex are so destructive to the
brain, in particular, when alcohol opens the brain-blood barriers to allow more
excitatory toxins and neurohormones (such as norepinephrine, epinephrine,
glutamate, histamine and prostaglandin E2) to screw up the brain and nervous
systems.
Excessive sweating and Frequent Urination vs. the hypothalamic overheating
and the pituitary AVP (Arginine
vasopressin):
Noradrenergic, adrenergic and sympathetic nervous fires overheat the body for sweating. Sweating is to expel the internal body heat from the skin
surface, and serves as a means of thermoregulation.
External heat (hot weather), muscular or joint heat, nervousness and
nausea, panic responses, physical or psychological stress can cause excessive
sweating. Exhaustion of the hypothalamus-pituitary-adrenal axis can cause excessive
noradrenergic, adrenergic and sympathetic nervous fires and/or deficiency of AVP.
Frequent urination is a result of the excessive sympathetic nervous action on
the adrenergic alpha receptors in the bladder and urethra (and prostate for men)
while the vagal, serotonin and GABA nervous control are very weak.
When the AVP level is low, the fluid passes through the digestive tract, kidney
and the bladder very fast by its dehydration effect. This will increase
urination frequency upon fluid intake. A abrupt drop of AVP during the
hypothalamic-pituitary overheating can may also trigger sudden sweating in
conjunction with urinary urgency. This is likely to occur for the drug
abusers with sexual exhaustion, who serotonin and GABA nervous control on the
hypothalamic dopamine-norepinephrine conversion and the core temperature
regulation is out of order..
OK, we provide the following topics
for you, so that you can understand why sex is not for entertainment:
1. Destruction of Excessive Orgasms(for
men and women) -
About 5-10% of over-masturbators get permanently damaged!
Over-masturbation/over-ejaculation/excessive-orgasm can castrate your
hypothalamus-pituitary-testicular(ovarian) axis by arterial constriction and
inflammatory narrowness in your brain and pelvic organs (testicles, prostate,
seminal vesicles, penis, ovaries, uterus, vagina and clitoris) due to excessive
release of prolactin, norepinephrine, and epinephrine, excessive binding of
norepinephrine/epinephrine on the alpha-adrenergic receptors, the
norepinephrine/epinephrine induced excessive prostaglandin E2, and the post-sex
deficiency of nitric oxide and prostaglandins E1/E3 production. God
punishes the self-destructors! Don't become one of them! Or you have to pay a
high price for the consequence.
2. Male Ejaculatory
Frequency and Seasonal Change vs Semen Quality
3. Male Ejaculation
Frequency vs. Testosterone Level -
Psychological (Sexual) Stress locks up
the hypothalamus-pituitary-adrenal and testicular axis via cortisol, prolactin
and inflammatory hormone prostaglandin E2
4. Semen contains human growth hormone, Insulin-like growth factor-I,
alpha2-macroglobulin, testosterone, other therapeutic and pharmaceutical
proteins
and a lot of prostaglandins for better (Prostaglandin E1 and E3 for
healing) or worse (prostaglandin E2 causes cancers and tumors in the
prostate and cervix) 5. Sex as an Addictive Drug
(but, can we
retrain old dogs with new tricks to reverse addiction?)- the
neuroplasticity of the hypothalamus by norepinephrine and its induced
prostaglandin E2(for men and women)
6. Excessive sex for darker eye cycles,
nips, labia minors, pelvic area, perineum,
clitoral and penile foreskin
7. Excessive sex and Light Over-Sensitivity in Retina
8 Benefits
from Optimal Orgasms(for men and women)
9. Brain-Skin/Brain-Hair connection - the effect of excessive sex-induced
stress on skin (acne) and hair (hair loss)
(for men and women)
10. Sex-stress
(Norepinephrine/ Epinephrine) induced Inflammatory
Pains, Headaches and Hangover (for men and women)- Norepinephrine-induced prostaglandin E2 release sets the brain and body
on fire for sexual arousal/orgasm and pains
11. Persistently Sexual Arousal (breeding)
or Over-ejaculation (Frequent Orgasm) Reducing/Suppressing Male Immune Function via Norepinephrine Induced Prostaglandin E2 Release
12. Liver/organs malfunction and inflammation
and Hypothalamus-Pituitary-Adrenal
impairement -
ageing - induced by sex stress with chronic elevation
of immunotransmitter cytokines and inflammatory hormone prostaglandin E2 (for
men and women)
13. Stress hormones norepinephrine and epinephrine induced apoptosis in blood
vessels.
14. Orgasm Brain Sex Pain examples
(for men and women)
Destruction
of Excessive Orgasms
After you enjoyed too many sexual orgasms and/or too much pleasure, you have likely
blown your brain/nervous bioelectric circuit breaker, and may have started to deal with
the
Sexual Exhaustion Symptoms - the exhaustion of the
hypothalamus-pituitary-adrenal/-testicular (-ovarian) axis (cases are listed in Over.htm,
Over2.htm,
Over3.htm, and
GirlOverSex.htm)
very possibly or likely
including the hypothalamus-pituitary-thyroid dysfunction, and
deducing/downgrading or desensitization of the androgen hormonal receptors in
the hypothalamus, hippocampus and pituitary, resulting from the Nervous Excitotoxicity and Inflammation induced by
excessive norepinephrine, epinephrine and glutamate (& other excitory
neurohormones, for a short-term
pleasure reward and the long-term dopamine depletion), long-term excessive
elevation of prolactin ( to inhibit GnRH release from the hypothalamus and
therefore LH and FSH secretion from the pituitary and to directly desensitize
pituitary gonadotropic cells and the Leydig cells of the testes) , and Prostaglandin E2 (the brain heater for the core
temperature rise!) At the sexual exhaustion state, the constant
elevation of excessive prolactin (mimics Hyperprolactinaemia) suppress
sensitivity of prolactin-negative feedback on hypothalamic
tuberoinfundibular dopaminergic (TIDA) neurons for persistently low
dopamine synthesis, blocks the beta-adrenergic receptors and nitric oxide
nervous mechanisms and promotes norepinphrine and epinpehrine binding to the
alpha-adrenergic receptors for vasoconstriction and restriction of blood flow to
the brain and genitals, and destroys or desensitizes the hypothalamic androgen
receptors, as described in
http://jp.physoc.org/cgi/content/abstract/576/2/585
http://cancerres.aacrjournals.org/cgi/content/abstract/65/17/7984
http://endo.endojournals.org/cgi/content/abstract/145/12/5714
http://endo.endojournals.org/cgi/content/abstract/148/8/4080
http://www3.interscience.wiley.com/journal/118874269/abstract?CRETRY=1&SRETRY=0
http://www.psy.fsu.edu/faculty/hull/D&H_review.pdf
http://ep.physoc.org/cgi/content/abstract/91/3/603
http://jp.physoc.org/cgi/content/abstract/557/1/307
http://endo.endojournals.org/cgi/content/full/147/3/1195
Cutting down the brain and genital blood circulation naturally alternates the
neurotransmitters and hormonal syntheses, the major brain nervous function
including the dopamine, acetylcholine, serotonin, GABA, noradrenergic,
adrenergic, glutamate, oxytocin, nitric-oxide(NO), vagal and autonomic nerves
functions, and the hypothalamus-pituitary-adrenal and
-testicular(-ovarian) function.
The Traditional Chinese Medicine has termed the hypothalamus-pituitary-adrenal (HPA)
exhaustion as "Kidney Deficiency", since the classic Chinese anatomy
text assumed the tiny adrenal gland, sitting on the top of the kidney, is
a part of the kidney about 2000 years ago. The HPA exhaustion results in the erratic
release of CRH (corticotropin releasing hormone), POMC (proopinomelanocortin),
ACTH (adrenocorticotropc hormone), ß-lipotropic hormone, ß-endorphin,
α-melanocyte-stimulating
hormone (α-MSH),
ß-MSH, CA (catecholamines) and TSH (thyroid
stimulation hormone), in response to stress, sex and environmental/dyshomeostatic
stimuli. Since skin and hair follicles also display a functional equivalent
of the HPA axis, sexual exhaustion will also extensively affect your skin (for
examples: darkening skins in certain areas such as eye cycles, nips, labia
minors, foreskin, perineum and groins, due to excessive release or trapping of
the POMC peptide α-MSH
which is also an anti-inflammatory and immunomodulating hormone - anti-tissue
abrasion!) and the hair (for examples: hair loss in the scalp and gray
hair, but it won't grow hair in your palms although it will destroy your HPA
axis.) The explanation of the HPA,
skin and hair connection are given in the following links:
http://edrv.endojournals.org/cgi/reprint/21/5/457, http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1839836&blobtype=pdf ,
http://www.fasebj.org/cgi/reprint/04-1968fjev1.pdf, http://www.tufts.edu/sackler/pharmacology/faculty/theoharides/documents/TiI-brain-skin.pdf ,
http://physrev.physiology.org/cgi/reprint/80/3/979 ,
http://ard.bmj.com/cgi/content/abstract/66/suppl_3/iii52 , http://www.ncbi.nlm.nih.gov/pubmed/12576179 ,
http://www.fasebj.org/cgi/reprint/19/10/1332.pdf,
http://www.annalsnyas.org/cgi/content/abstract/885/1/350 , and http://www.jci.org/articles/view/33508/pdf
As a result, sex is like a good investment with a bad
return. When you reach the neuro-endocrine breaking point, it is like the stoke
market cash leading to the great depression!! Yes, excessive sex induces
psychological and physiological disorders.
For example:
His ER (Emergence Room) doctors puzzled about his UFO
sexual exhaustion symptoms: dizziness, headaches, ear buzzing (inner ear
or cochlea inflammation), neck stiffness, shoulders tightness and pains,
sleeping disorders, fatigue, short breathing racing heart, involuntary leg jerks
and hand shaking (hyperactive sympathetic nerves L1 and L2 for Parkinson
symptoms with dopamine, cholinergic serotonin and GABA nervous control
disorders), and water retention (too much vasopressin), as a result of
chronic over-masturbation and over-ejaculation.
==> http://www.actionlove.com/cases/case16084.htm
Destructive over-masturbation practices at 3-5 times a day
resulted in brain fires and hydraulic shock waves, unconsciousness,
panics, rapid heart beat, hypertension, short breathing, chest weird feeling
urination difficulty, and frequent urination.
==> http://www.actionlove.com/cases/case15882.htm
After sexually exhausting his the brain's and internal
Hypothalamus-Pituitary-Adrenal (HPA) axis, he has gotten headache and felt death
and exhaustion from wet dream, even once a weak. Why he felt worse on the 2nd
day after ejaculation? He may have to rely on the Cutaneous Hypothalamus-Pituitary-Adrenal (CHPA) function
to assist post-ejaculation or post-orgasm recovery.
http://www.actionlove.com/cases/case15761.htm
Excessive dopamine-norepinephrine/epinephrine induced excessive prostaglandin E2
production to elevate core temperature for over-heating brain, skin and hair
follicles' neuro-endocrine function, leading to dark eyes, enlarged
eye pupils, low testosterone, hot flushes, low libido, cognitive disorders,
and speed disorders.
==> http://www.actionlove.com/cases/case15821.htm
Why psychological stress (excessive norepinephrine/epinephrine) induced
excessive prostaglandin E2 production to elevate core temperature for
over-heating brain, skin and hair follicles' neuro-endocrine function,leading to no erection, dark eyes, enlarged eye pupils, low testosterone,
low libido, erectile dysfunction, cognitive disorders and testicular disorders for no sexual orgasm - solution
==> http://www.actionlove.com/cases/case15822.htm
Chronic over-stress in war zone results in Posttraumatic
Stress Disorder (PTSD), traumatic brain injury (TBI), depression, panic and
erectile disorders due to serotonin/GABA neuroplasticity in hypothalamus,
hippocampus and adrenal glands - Dr. Lin's proposed solution for neuroplasticity reversal.
http://www.actionlove.com/cases/case15877.htm
After our 10-year case collection
and research, we now understand why excessive sex and drug abuses are so
destructive. We are able to zoom into the main causes:
(1). Sex-induced excessive excitory neurohormones
norepinephrine/epinephrine/glutamate/histamine production for nervous toxicity: According to a American Scientists's report - http://www.americanscientist.org/template/AssetDetailNoFrame;jsessionid=aaaaBjcbX4%0D%0AuGmh?assetId=49707),
epinephrine can easily penetrate the mouse's blood-brain barrier into the
limbic system, and allow lupus-like
autoantibodies to reach the amygdala,
where " the antibodies bind to and overactivate certain cell receptors,
eventually killing the cells through excitotoxicity." Excessive
dopamine-norepinephrine-epinephrine conversion during sexual
arousal/orgasm/ejaculation will drop the dopamine level (yes, for dopamine
excitotoxicity prevention and rewarding pleasure if your
dopamine level is too high!) , leading to excessive pituitary
prolactin release to cause testicular and ovarian disorders, and keep the stress
neurohormone norepinephrine or/and epinephrine in the
excitotoxicity level. Our readers also reported chronic excessive
orgasm/ejaculation induced seizure, headache, migraine, blackout, allergy, asthma,
eye floaters and ear ringing (tinnitus), as a result of nervous excitotoxicity
induced by excessive norepinephrine, epinephrine (particularly this one), glutamate or/and histamine.
Prolonged and repeated assaults on the hippocampus nerve cell structure may
permanently fry your brain. (Here are the other recent
research examples:
http://jcem.endojournals.org/cgi/reprint/87/9/4245
http://www.biomedcentral.com/1471-2172/5/22
http://circ.ahajournals.org/cgi/content/full/102/1/96
http://www.algonot.com/pdf/mastcellsinflammation.pdf
http://www.ionchannels.org/showabstract.php?pmid=15970488
http://www.pnas.org/cgi/reprint/103/3/678
http://www.sciencemag.org/cgi/content/abstract/174/4008/512,
http://www.pnas.org/cgi/content/full/96/12/7093
http://ajpheart.physiology.org/cgi/content/full/289/4/H1577
http://jcem.endojournals.org/cgi/content/full/89/5/2000
http://www.anesthesia-analgesia.org/cgi/content/full/100/2/520
http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6793231, as
addressed in this link- How
to kick the pornography addiction: Reduction of the inflammatory hormone
prostaglandin E2 production, Excessive epinephrine and norepinephrine induces
inflammatory responses, persistent sexual arousal, and brain/nervous
excitotocixity, and enhancement of the serotonin and GABA nervous modulation and
control
==> http://www.actionlove.com/cases/case15570.htm).
Dopamine and glutamate are essential for sex. For healthy person, sexual stimulation elevates the dopamine and glutamate synthesis.
Excessive dopamine triggers the stress hormone production and promotes the liver
P450 enzymes and Monoamine oxidases (MAO) to deamination of dopamine and
stress hormones. In addition to elevating the stress hormones norepinephrine and
epinephrine, chronic excessive sexual stimulation, excessive orgasm, over-masturbation/over ejaculation,
or drug abuse will result in excessive glutamate release or
accumulation due to a shortage of the enzyme
L-glutamic
acid decarboxylase and pyridoxal
phosphate in efficiently converting elevating glutamate into GABA during
sex, or/and due to a shortage of the enzymes gamma-glutamylcysteine
synthetase and glutathione
synthetase or/and a shortage of amino acids L-cysteine
and glycine,
in converting elevating glutamate into the liver detoxification promoter
Glutathione.
Elevation of GABA with serotonin, norepinephrine and prolactin after sex or
orgasm will trigger the
pineal gland to release melatonin for sleeping and restoration; Elevating
of glutathione can reduce the formation of oxidative toxins, such as Hydrogen
peroxide (H2O2), associated with oxidative
injury and cellular/nervous damage.
Hair graying is a typical
example of the hydrogen peroxide (H2O2)
damage. According to the recent study (http://www.fasebj.org/cgi/content/abstract/fj.08-125435v1
), accumulation of hydrogen peroxide (H2O2)
bleaches human
gray/white scalp hair shafts for graying when methionine sulfoxide (Met-S=O)
is insufficient to repair in the
entire gray hair follicle. It also indicates that hydrogen peroxide (H2O2)
damages hair
follicle melanocyte apoptosis and DNA. That is, H2O2-mediated
oxidative stress alternate human hair color by blunting methionine
sulfoxide repair. Excessive psychological and physiological stress can
interrupt the Methionine-Glutathione
Transsulfuration pathway with a lack of the choline-phosphatidylethanolamin
synthesis, the phosphatidylcholine synthesis- ( http://www.ajcn.org/content/vol85/issue3/images/large/znu0030743980001.jpeg
& http://www.ajcn.org/cgi/content/full/85/3/702
). These research results seem to support the folk medicine approach
of using eggs to shampoo the scalp for reversing gray hairs. Stress
also attack the Hair Follicle Pigmentary unit, and disable or reduce hair
pigmentation while hydrogen peroxide (H2O2)
bleaches hair shafts or damages the follicles. Note that a pigment
is any colored
material of plant or animal cells. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1201498&blobtype=pdf and
http://www3.interscience.wiley.com/cgi-bin/fulltext/120756708/PDFSTART
Of course, you will benefit from optimal sex and
orgasm if you get a resulted elevation of both GABA and glutathione.
However, when the liver are stressed out
by orgasm, over-ejaculation, drugs, and aged/toxified by the monoamine oxidization
toxins, the liver can not efficiently provide the enzyme L-glutamic
acid decarboxylase and pyridoxal
phosphate for glutamate-GABA conversion, leading to accumulation of
glutamate in the brain/nervous systems and cerebrospinal fluid for ultimate
nervous and brain destruction. ( Note that increasing the conversion of L-arginine
to the inhibitory neurotransmitter agmatine can help block the action of
glutamate on the NMDA receptor and acts as a neuromodulator. This is an
important mechanism in preventing the harmful effects of excess glutamate.
Agmatine is decarboxylated argenine. Studies shows agmatine can reverse pain
induced by inflammation, neuropathy, and spinal cord injury - http://www.pnas.org/cgi/content/abstract/97/19/10584
).
Furthermore, chronically excessive sexual arousal, over-ejaculation (overmaturbation),
excessive orgasms or/and drug abuse can hyperativate the enzyme Monoamine oxidases (MAO) for
dopamine-DOPAL conversion , where DOPAL stands for
3,4-dihydroxyphenylacetaldehyde. DOPAL is a potent neurotoxin to cause
Parkinson's-like brain lesions, and its resulted cognitive impairment is very
similar to autism. In addition to DOPAL, norepinephine and epinephrine can be
converted to 3,4-dihydroxyphenylglycoaldehyde (DOPEGAL) by MAO too. DOPEGAL has
been found to trigger apoptosis and cause the loss of CNS neurons. Therefore,
the synergic destructive effects of both DOPAL and DOPEGAL accelerates death of
nerve cells, as seen in SIDS (sudden infant death syndrome), Alzheimer’s, Parkinson’s disease, and
dysfunctional disorders of development and aging.
Overmasturbation resulted in Parkinson's symptom - restless or shivering legs
and hands - due to abrupt drop of dopamine for excessive dopamine-neorepinephrine-epinephrine-DOPEGAL
(3,4-dihydroxyphenylacetaldehyde) and dopamine-DOPAL(3,4-dihydroxyphenylacetic
acid) conversion, leading to neurotoxicity and nervous death for no more sexual
orgasm
==> http://www.actionlove.com/cases/case15611.htm
http://www.jneurosci.org/cgi/reprint/19/1/456
http://www.jneurosci.org/cgi/content/full/17/12/4849
http://psycnet.apa.org/index.cfm?fa=main.showContent&id=1992-18831-001&view=fulltext&format=pdf
MAO, the brain/nervous and liver enzyme, exists virtually in all mammalian cell types, with the
notable exception of the erythrocyte. Excessive monoamines such as dopamine,
norepinephrine and epinephrine induced by chronic stress, excessive sexual
stimulation and orgasm and/or drugs will activate the liver Cytochrome P450 and
MAO for oxidization (deamination) and detoxification, as described above, in
order to maintain the homeostasis of the brain and nervous function. But,
unfortunately, the resulting toxins destroy or damage the local neurons or
synapses. In humans, there are two types of MAO: MAO-A
and MAO-B. Both
are found in neurons,
hypothalamus, cerebral cortex (conscious control center), cerebellar cortex,
pons, medulla oblongata, substantia nigra, caudate, astroglia,
skins, and skeletal muscles. Outside the brain and central nervous system,
the liver, gastrointestinal
tract , adrenal glands, kidnes, heart, lungs, and placenta
have about 60-90% MAO-A and 10-40% MAO-B, but, MAO-B is mostly found in blood
platelets.
MAO's are enzymes
that catalyze
the oxidation
of monoamines.
They are found bound to the outer membrane of mitochondria
in most cell types in the body. After placenta, liver contains the highest level
of MAO, followed by kidneys, adrenal glands, heart, hypothalamus, substania
nigra, lungs, intestine, caudate, medulla oblongata, pons, cerebral cortex and
cerebellar cortex. That is, the liver, kidneys, adrenal glands,
heart, hypothalamus and substania nigra are likely aged or damaged by the
MAO-deaminated
or oxidized toxins DOPAL, DOPEGAL, hydrogen peroxide
(H2O2) and 5-Hydroxyindoleacetic
acid (5-HIAA, as discussed below) faster than the other organs, and the
liver will be damaged first.
The main substrates of MAO-A include dopamine, serotonin, norepinephrine, epinephrine,
octopamine, tyramine and tryptamine; the main
subtstrates of MAO-B include dopamine, phenylethylamine, -phenylethylamine
(PEA), benzylamine, MPTP
(1-methyl 4-phenyl
1,2,3,6-tetrahydropyridine),
tyramine, and tryptamine.
MAO plays the key roles in the development of
neurodegenerative disease, including not only its putative role in
converting an exogenous protoxin to a toxin, as mentioned above, but also its role in the formation
of peroxides generated from the oxidative metabolism of dopamine. MAO
catalyzed deamination of dopamine to DOPAL and production of hydrogen peroxide
(H2O2) and ammonia NH3 depend on concentrations of dopamine within the
cytoplasm. Hydrogen peroxide, if not detoxified by glutathione peroxidase, can
be converted by iron-mediated Fenton reactions to toxic hydroxyl radicals ( -OH)
that induce lipid peroxidation and cell death. In addition, excessive
ammonia accumulation in the bloodstream, termed as hyperammonemia, can
cause the confusion and coma
of hepatic
encephalopathy as well as the neurologic disease.
On the other hand, MAO-A breaks down serotonin
into 5-Hydroxyindoleacetic
acid (5-HIAA) and steals serotonin from arylalklamine N-acetyltransferase (AANAT),
resulting in depleting the melatonin synthesis. Melatonin plays the key role
for the mechanisms of circadian rhythm for healing the damaged cells while
5-HIAA is responsible for the developments of certain tumors
or cancers.
Graveyard workers are at risk due to hyperactivities of MAO. Our product
DeToxiA, MoodMax, ViaGrowth-IV, PinealTonin and ArgiNOx have been
formulated to help you reduce the MAO gene expression
(or weaken the MAO activities in the dopamine, serotonin, norepinephrine and
epinephrine nervous terminals) and hydrogen peroxide
(H2O2) formation, and enhance the liver urea cycle
to remove ammonia NH3 from the blood stream (that is,
detoxification of the nervous system, liver and blood!)
Most recent studies also indicate there is significant positive correlations between platelet MAO activity and cortisol
measures. In normal sexual activities, orgasm or ejaculation is supposed to drop the cortisol
level and to elevate norepinephrine and
epinephrine level. If MAO turns serotonin into 5-HIAA and depletes serotonin
production during or after sex, the post-sex elevation of norepinephrine and
epinephrine will activate the MAO action on the adrenal cortex for excessive
cortisol elevation several hours after the cortisol drop induced by ejaculation
or orgasm. Cortisol overshooting suppresses the adrenal DHEA production
and testicular function, resulting depletion of androgen hormones in the
brain, and then causes post-sex hangover, memory loss and
depression in the next few days. Maintaining a high level of cortisol
will suppress immune function, promote atherosclerosis, and damage and kill
brain cells eventually. Excessive sex, orgasm or ejaculation, or/and drug
abuse for pleasure rewarding or/and sexual enhancements can let you experience
both hypocortisolism and hypercortisolism in your daily life when the cortisol
diurnal rhythm is disturbed or the cortisol level is too low in the
certain time of a day, but becomes over-shooting in the other time. The
complicated symptoms induced by sexual practices was named as Sexual Exhaustion
Symptoms by Dr. Lin, as given in http://www.actionlove.com/cases/case9848.htm.
- Hypocortisolism:
an abrupt drop of cortisol with symptoms of Addison's
disease symptoms and others,
including: fatigue, muscle weakness, weight
loss, vomiting, diarrhea or digestive panic responses, headache, sweating, bipolar, mood swing, OCD, and joint and muscle pains; goiter; vitiligo; dark eye circles; darkening (hyperpigmentation) of the skin, including areas not exposed to the
sun, such as groins nipples, penis, testicles, labia majors and minors, and the
inside of the cheek (buccal mucosa); orthostatic hypotension; cravings for
salt or salty foods due to the urinary losses of sodium.
- Hypercortisolism: an
excessive level of cortisol in the bloodstream resulting in the so-called Cushing's
syndrome and others,
including: rapid weight
gain or central
obesity; moon
face; excess sympathetic nervous sweating,
telangiectasia
(dilation of capillaries); thinning of the skin for easy bruising or
inflaming, particularly in the penis, testicles, face, breasts, hands, legs
and other mucous membranes; purple or red striae
;hirsutism;
insomnia; reduced libido;
impotence;
amenorrhoea;infertility;
euphoria; psychosis;
depression; anxiety;
persistent hypertension
(due to cortisol's enhancement of epinephrine's
vasoconstrictive effect and binding into the adrenergic alpha-2 receptors); insulin
resistance (especially common in ectopic
ACTH production), leading to hyperglycemia
(high blood
sugars) which can lead to diabetes
mellitus; heart
disease; hyperpigmentation, resulting from Melanocyte-Stimulating Hormone
production as a byproduct of ACTH synthesis from Proopiomelanocortin (POMC);
abnormal mineralcorticoid
to worsen the hypertension and to hypokalemia; gastrointestinal
disturbances; immune disorders; impairment of wound healing; osteoporosis
since the cortisol suppresses adrenal, testicular and ovarian function.
With an exhausting hypothalamus-pituitary-adrenal axis, patients may experience
some of hypocortisolism symptoms during sex or in couple hours after sex,
followed by some of hypercortisolism symptoms several hours or in next
days after sex. This will puzzle your medical doctors.
(2). Sex-induced excessive inflammatory hormone prostaglandin E2
production, due to the excessive excitory neurohormones and the deficiency of
androgen hormones (due to the disabling of the testicular and ovarian function
by an excessive, persistent prolactin elevation at about 2-4
hours after orgasm/ejaculation):
In this regard, prostaglandin E2 induced body pain or inflammation originally
serves as a warning sign of excessive sex. If you ignore the warning
signal, prostaglandin E2 will eventually give you more, including inflammation responses, cellular multiplication, nervous excitation (for
androgen hormone production and memory neuroplasticity (the good),
inflammatory orgasm (the bad) and
persistent sexual arousal and synaptic damage (the ugly)), nervous
exitotoxcity and immune suppression. Prostaglandin E2 induces
enhancement of synaptic transmission is mediated via a cAMP/PKA(Protein Kinase
A) pathway. Prostaglandin E2 plays an important role in
fever, pain, inflammation, sleep disorders, regulation of membrane excitability,
sexual behavior, synaptic transmission, integration, neurotoxicity
neuroplasticity, and neurologic disorders such as epilepsy and
Alzheimer's disease. Excessive prostaglandin E2 can also degrade the short time memory and
spatial navigation by enhancing membrane excitability (burning the synapse out) and then
causing long-term damaged synaptic neuroplasticity in hippocampal perforant path-dentate gyrus synapses.
Sexual pleasure and images will be imprinted in your hippocampus by
synaptic neuroplasticity resulted from the orgasm-induced prostaglandin E2 with
a help of calcium channel of the synapse, like remembering what you
learn, hear, or see in daily life. Neuroplasticity is essential to learning and
memory, like burning data
into EEPROM. In eleccronic
circuit, EEPROM can be eased and re-written. I think our hippocampus can
be reprogrammed by neuroplasticity (reversing sex and drug addition), with long-term
potentiation (LTP) and long-term memory (LTM) formation, like training
old dogs new tricks. However, if you
apply a voltage to a memory cell higher than the upper limit of the EEPROM
biased voltage, you will burn the memory cell out. This condition also
happens to your hippocampus. Prostaglandin E-2 amplifies the excitatory post
synaptic potentials (EPSPs) and heats the neuron and its synapse. Repeating the stimulation
of the neuron and its synapse over time with accumulation of prostaglandin E2 will
increase the action potential (accumulatively) in the neuron and synapse to
cause the permanent deformation (forever memory) or damage (electrical
overloading or thermal overheating ) of the synapse and neuron. It can happen in the short
time when prostaglandin E2 is excessive under a high-stress. extreme or/and
shock condition. For this reason, you always remember your first-time
masturbation and sexual intercourse. In addition, persistent action of prostaglandin E2
on a cell will eventually alternate the cellular gene for potential cancerous or
tumor development. For examples, excessive prostaglandin E2 causes
inflammation, enlargement, tumor and even cancers in the prostate, breasts,
uterus and cervix. Ref: http://jnnp.bmj.com/cgi/content/abstract/77/1/85
http://bmc.ub.uni-potsdam.de/1471-2202-6-14/
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=356994
http://ajpgi.physiology.org/cgi/content/full/274/3/G493
http://jn.physiology.org/cgi/reprint/93/2/929?ijkey=a9024b9ce74ad6d9ccd2311f9f39ee084760b417,
http://jpet.aspetjournals.org/cgi/reprint/293/2/417?ijkey=3badb86cdf65c4b7c1d53623aea092cf7279b9b2
, http://jn.physiology.org/cgi/content/abstract/87/6/2851?ijkey=5cee184dd3946b4945f9cc00585dec35e2d51349&keytype2=tf_ipsecsha
http://cancerres.aacrjournals.org/cgi/content/abstract/65/12/5211
http://www.jbc.org/cgi/content/abstract/263/11/5380
http://www.annalssurgicaloncology.org/cgi/content/full/10/4/469
http://cancerres.aacrjournals.org/cgi/content/abstract/63/17/5218
http://cancerres.aacrjournals.org/cgi/content/abstract/65/2/657
http://www.spacedu.com/ereprints/prostatecfos.pdf
http://www.ncbi.nlm.nih.gov/pubmed/16293724
http://www.pnas.org/cgi/content/short/101/2/415
http://www.jneurosci.org/cgi/content/full/25/43/9858#REF41
http://pharmrev.aspetjournals.org/cgi/reprint/58/1/115.pdf
http://www.nature.com/mp/journal/v5/n6/full/4000811a.html
http://www.cellscience.com/Reviews5/Ca2+_stimulated_Adenylyl_Cyclases_Hippocampal_Neuroplasticity.html
In addition, excessive sex or/and drug abuse also alternate the
functions of the hypothalamus-pituitary-adrenal axis (HPA) and the sympathetic
adrenomedullary system. In addition to body pains and inflammation, our
readers have also reported sex-or drug-induced memory
loss, absent mindedness, no concentration, less focusing, hangover,
or pseudo-Alzheimer's symptoms.
These problems can be associated with an overshooting of cortisol. In the normal
condition, the sexual activities should not increase the cortisol level unless
sexual arousal or orgasm induces inflammation; instead, normal
sex tends to slightly reduce the cortisol level for activation of the pituitary-adrenal
and -testicular function during and after sex. In some case, the cortisol level drops too low,
low enough to activate the inflammatory factors, leading to sex-induced pains ,
cramps or
headaches while the norepinephrine and epinephrine level shoot up or remain too
high. During sexual arousal, if the cortisol level shoots up (Note:
prolonged exercises overshoot cortisol, epinephrine, norepinephrine, Glucagon
and growth hormones at the same time for a hyper-sympathetic nervous Fight), the prolactin
level will follow; the man will go limp and the women will becomes dry; the
lovemaking couples will experience sympathetic nervous Flight responses and the
sexual arousal will be terminated. The release of cortisol, from
the adrenal cortex, is supposed to suppress the activities of the
pro-inflammatory factors induced by an elevation of epinephrine, norepinephrine
or/and histamine when the hypothalamus-pituitary-adrenal axis (HPA) responds to sexual
arousal, orgasm, masturbation, ejaculation, stress or drugs.
Under chronic loading of sexual arousal, orgasm, masturbation,
ejaculation, stress or drugs, the HPA can respond in 2 ways: either
abruptly dropping cortisol or excessively releasing cortisol. If the
adrenal cortex released insufficient cortisol, the patients will
experience immediate shape pain or mood change when the epinephrine,
norepinephrine or/and histamine level overshoot out of the normal range. Under
adrenal fatigue or deficiency conditions, the patient can experience the deficiency of both
cortisol and androgen hormones (DHEA, testosterone or DHT), leading to
persistent and severe body pains or inflammatory responses. On the other
hand, if the adrenal cortex persistently shoot up the cortisol level and
keep it high, the patient will experience foggy brain,
memory/contraction/focusing loss, sleeping disorder, and hangover in next few days. If either
prolactin or cortisol level maintains too high, high enough to slow or shut down
the adrenal and testicular function, leading to deficiency of DHEA,
androstenedione, testosterone or/and DHT, the patient will also experience
post-sex inflammatory body pains, cramps or muscular rigidity due to excessive
prostaglandin E2 production as a warning sign. The inflammatory responses
usually occurs in few hours and the next day when the DHEA, androstenedione,
testosterone or/and DHT are used up and drop down to deficient levels, too low
to suppress the pro-inflammatory responses induced by excessive epinephrine
and/or, norepinephrine.
A chronic elevation of cortisol in the cerebrospinal fluid will cause depression
and memory loss since cortisol can shrink or atrophy the hippocampus, associated
with many kinds of memory and learning. Unfortunately, under the
conditions of chronically excessive sex/orgasm or
over-masturbation/over-ejaculation, prolonged stress or drug abuse, excessive
release of epinephrine, norepinephrine or/and histamine will open the
brain-blood barrier (BBB) for more cortisol and other toxins to cross the BBB to
pollute the cerebrospinal fluid and then to shrink the hippocampus, like
the elderly people experience. Memory, brain and nervous functions can be also
associated with Phosphorylcholine, a molecule mainly secreted by the seminal
vesicle. But, Dawson also reported that phosphorylcholine can also be found in
the rat liver, testicles, spleen, intestines, kidney and brain, but there is
only trace amounts in muscles, heart and blood, as given in http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1215699
and http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1215984.
More recently, it was found that the phosphorylcholine synthesis also occurs in the photoreceptors
in supporting the eye visual sensing system (for example, http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=348559&blobtype=pdf
). Phosphorylcholine combines with ceramide
through a phosphodiester bond to create sphingomyelin,
an important compound in the formation of the myelin
sheath. Stroke victims and Alzheimer patients have shown improvement by
increasing the phosphorylcholine level. In rat studies, tissue examination
showed that phosphorylcholine was able to help repair damaged neurons.
Phosphorylcholine was also found to help prevent a drug-induced drop in
acetylcholine levels and improve memory and cognitive function ( http://www.fasebj.org/cgi/content/full/14/14/2198
). Over-ejaculation or excessive orgasm burns out, interrupts or
discharges excessive phosphorylcholine and may let you experience
poor memory or concentration and visual disorders. I suspect that the
depletion of phosphorylcholine synthesis induced by excessive ejaculation or orgasm, in
conjunction with neuroexcitotocity of glutamate/norepinephrine/epinephrine and monoamine oxidization
toxins (3,4-dihydroxyphenylacetaldehyde(DOPAL), 3,4-dihydroxyphenylglycoaldehyde
(DOPEGAL), hydrogen peroxide (H2O2) and 5-Hydroxyindoleacetic
acid (5-HIAA)), its resulted excessive release of prolactin/cortisol
and prostaglandin E2, and its resulted deficiency of androgen hormones, leads to premature onset of Alzheimer's
and Parkinson's disease, brain/nervous damage,
liver/spleen/digestive/testicular disorders, cardiovascular disorders, and poor vision.
Note:
Semen has high concentrations of potassium, zinc, calcium, magnesium,
citric acid, fructose, phosphorylcholine, spermine, prostatic acid phosphatase,
free amino acids, prostaglandins and enzymes, which nourish and protect the
sperm. Due to the high concentration of Phosphorylcholine in semen, the
old Taoists theorized that men can return semen (actually phosphorylcholine) to
revert the brain. Generally speaking, the concept is correct; however,
when the brain's dopamine or testosterone level is too high for excessive semen
production, you still have to ejaculate to burn the dopamine and testosterone
and to induce the prolactin release in the pituitary and retina for some
protective and anti-inflammatory hormone 16K-prolactin to cool down the nervous
systems, so that you can avoid the side effects of excessive dopamine or
testosterone. In this way, you can benefit from sex. Note that
testosterone and acetylcholine can excite the dopamine-hypothalamus-pituitary
axis and oxytocin release for sex.
Futhermore, Semen contains a lot of GABA ( http://www.andrologyjournal.org/cgi/content/full/25/1/140
, http://www.ncbi.nlm.nih.gov/pubmed/6237538?ordinalpos=1&itool=
EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1
) and beta-endorphin http://www.ncbi.nlm.nih.gov/pubmed/6291653?ordinalpos=1&itool=
EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1
, http://www.ncbi.nlm.nih.gov/pubmed/2216060?ordinalpos=8&itool=
EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum), both of
which are the calm/inhibitory neurochemicals. For a healthy man,
ejaculation triggers glutamate-GABA conversion with the liver enzyme glutamate
decarbozylase while glutamine is converted to glutamate by the liver enzymes
glutamate synthase and synthelase. In a male rates model, the
cerebrospinal fluid(CSF)'s GABA and Asparagine/glutamate
concentration increases 1000% and 200%, respectively, and there is a small
decrements in amino accids such as serine, arginine, Alanine
and leucine
( http://www.ncbi.nlm.nih.gov/pubmed/2877423?ordinalpos=4&itool=
EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum.
). If there is a lack of the liver enzyme glutamate decarbozylase,
glutamate in CSF becomes too high and GABA becomes too low. This is why
ejaculation causes deficiency of GABA and excessive glutmamte for the brain and
nervous instability and sympathetic nervous Fight or Flight responses. Semen's
GABA and beta-endorphin in the vaginal and cervix can block the female
dopamine, oxytcoin and glutamate nervous excitation in the brain via the
pituitary-uterus/cervix vagal nervous pathway, Both GABA and beta-endorphin
also increase the female cerebrospinal fluid's GABA and beta-endocrine
concentration right after male ejaculation, leading to calming the female
central nervous system and reducing the oxytocin release. That is why premature
ejaculation will disable libido immediately, unless the semen's prostaglandin
E2 and glutamate can continue exciting the clitoral, G-spot, cervix and uterus
vagal nerves. However, semen/CSF's GABA and beta-endorphin can help male and
female post-orgasm pains in the urethra, prostate, bladder, clitoris,
vagina, uterus, and tailbone http://endo.endojournals.org/cgi/reprint/145/3/1331.
Note: Beta-endorphin is mainly produced by the hypothalamus-pituitary-adrenal
and -testicular/Ovarian axis in response to stress. A sexual exhaustion
person will fail to release sufficient beta-endorphin in help suppress pains.
A persistent sexual arousal person lacks of GABA and beta endorphin, but has a
high level of glutamate, dopamine, norepinephrine, epinephrine and/or
histamine. Obviously, a person with a lack of serotonin, GABA and
beta-endorphin will experience severe anxiety, depression, mood swing,
de-realization, irrational thinking, irritation, panic responses, premature
ejaculation, penile or clitoral over-sensitivity, and pains.
Therefore, excessive sex or/and drug abuse
result in multiple, sexual exhaustion symptoms which become UFO for western
doctors and medical societies, although the Chinese Sex Bible and medicine
documented them 5000 years ago.
==> http://www.actionlove.com/cases/case15448.htm
Why great sex life can result in divorce and end his sex life with low libido and headaches.
==> http://www.actionlove.com/cases/case15717.htm
On the effect of ejaculation on
the testosterone production and aggressiveness or mode swing. Why it will take
about 7 days to release the post-ejaculation or post-orgasm sexual exhaustion
symptoms
http://www.actionlove.com/cases/case15719.htm
Warning: Pornography is a dirty bomb that can blast
your mind, body and soul away, that is, kills your brain by excitotoxicity!
And, SEX is a
most strange, addictive drug without ingredients, in the name of love. Sex overdosing is
an extremely destructive self-destruction, but unfortunately you will die for
it (you become addictive
to sex, due to the brain/dopamine nervous plasticity or the prostaglandin E2
induced persistent sexual arousal)!!!!! When you have sex overdosed, your
brain's acetylcholine, dopamine, serotonin and GABA nervous systems are burned
out (ok, Dr. Lin called it the nervous excitotoxicity), your hypothalamus-pituitary-adrenal and testicular (ovarian) axis are
partially or fully disabled, your blood and cerebrospinal fluid
chemistries are changed with a
chronic elevation of epinephrine, cortisol, prolactin and prostaglandin E-2 for sexual
exhaustion symptoms and sympathetic
nervous fires (anxiety, stress, mood swing,
hangover, sleeping
disorders,
Obsessive Compulsive Disorder (OCD), inflammatory pains (in the upper
back, neck, rear brain, joints,
pelvis,
perineum, low back, vulva,
clitoris,
vagina,
penis,
testicles,
urethra,
prostate
and stomach),
parkinsonism, memory
loss, vision
disorders, ear
ringing, chronic
fatigue, brain disorders,
headaches, dizziness,
migraines,
vertigo, inflammatorily
persistent sexual arousal symptoms, ejaculation
or post-orgasm pains or cramps, and so on) with a
lack of healing and restoration forces, even
if you are female, and your
excessive "love" becomes a poison to your health!
Realistically, your organs are bathed in the "bad" blood and your
brain and spinal nerves work under chemically- and hormonally-unbalanced cerebrospinal
fluid very
day!!! It is expected that the cellular DNA/genes in the organs will be
gradually changed for worse, accordingly. Your 20-year old body then become 60
years old!!!! And your
doctorS can not help you out even if prescribing drugs to shut down your
sexual function won't help. Your doctors may tell you that you have psychological
or psychiatric disorders. Please don't consider suicidal. We can help
you out.
Ejaculatory Frequency and Seasonal Change vs Semen Quality: according to
http://www.ncbi.nlm.nih.gov/pubmed/15302284?dopt=Abstract
, Increasing your ejaculatory frequency will drop your sperm concentration, but
there is no seasonal variations in sperm concentration, motility, or morphology.
Compared with one ejaculation per week, sperm concentration fell 29% with two
ejaculations per week, and by 41% with three ejaculations per week.
Noticeable, the spring ejaculatory frequency is significantly higher in spring
months than the winter's. Note: the pituitary-testicular axis and
the skin endocrine function respond to the seasonal temperature change, and more
active in warm weather.
Ejaculation Frequency vs. Testosterone
Level:
1. http://www.ncbi.nlm.nih.gov/pubmed/12659241?dopt=Abstract
- "The purpose of this study is to gain understanding of the relationship
between ejaculation and serum testosterone level in men. The serum testosterone
concentrations of 28 volunteers were investigated daily during abstinence
periods after ejaculation for two phases. The authors found that the
fluctuations of testosterone levels from the 2nd to 5th day of abstinence were
minimal. On the 7th day of abstinence, however, a clear peak of serum
testosterone appeared, reaching 145.7% of the baseline ( P < 0.01). No
regular fluctuation was observed following continuous abstinence after the
peak. Ejaculation is the precondition and beginning of the special periodic
serum testosterone level variations, which would not occur without ejaculation.
The results showed that ejaculation-caused variations were characterized by a
peak on the 7th day of abstinence; and that the effective time of an
ejaculation is 7 days minimum. These data are the first to document the
phenomenon of the periodic change in serum testosterone level; the correlation
between ejaculation and periodic change in the serum testosterone level, and
the pattern and characteristics of the periodic change." also in
http://www.ncbi.nlm.nih.gov/pubmed/12506329?ordinalpos=2&itool=EntrezSystem2.PEntrez .Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
or http://www.zju.edu.cn/jzus/2003/0302/030219.pdf
Please note that average testosterone in this study is 378 nd/dl (for the
ejaculation group) and 387 ng/dl (for the semen retention group), respectively.
Men with a testosterone level below 500 nd/gl can not sexually perform well will
likely experience post-orgasm andropause (male menopause) symptoms, such as
anxiety, stress, hot flushing, cognitive disorders, exhaustion, fatigue,
tremors, visual disorders, inflammatory pains, and so on. For those
with a testosterone level between 400-500 ng/dl , their erection will go limp
very quickly in the middle of intercourse and likely to experience sexual
exhaustion after ejaculating or sexual arousal; for those with a
testosterone level below 400 ng/dl, they will experience impotency from the
beginning of sexual encounter. Based upon our definition of sexual age, the participating men
in this study have a sexual age
of about 70 years old with a refraction time of 6-7 days as defined
below, despite of
the calendar ages from 28 years old to 45 years old, where the refraction time
is considered the sexual recovery time for another run of ejaculation. They are
premature-aged men! (as a result of chronic over-masturbation??? I
wonder). Our optimal
testosterone level for sexual performance is from 500 nd/dl to 1000 ng/dl.
This study also indicates that practicing sperm retention, like vasectomized men do,
will gradually disable the testicular function as described and explained in the
following links-
Non-orgasmic semen retention is as bad as over-ejaculation; both are for no more
sexual orgasm ,but for sympathetic nervous pains and burning. What is different
between both cases in term of the dopamine-norepinephrine-epinephrine
conversion?
==> http://www.actionlove.com/cases/case13176.htm
On seminal retention and prostate-cancer protection, and of course, on
Over-masturbation and sexual orgasm
==> http://www.actionlove.com/cases/case11407.htm
or
http://actionlove.com/extra/vascectomy.htm
You may also wonder why Buddhism monks practice sperm retention for
disabling their testicular function and forming semen stones from minerals
collected in semen at the same time.
2. http://www.ncbi.nlm.nih.gov/pubmed/11760788?dopt=Abstract
- "This current study examined the effect of a 3-week period of sexual
abstinence on the neuroendocrine response to masturbation-induced orgasm.
Hormonal and cardiovascular parameters were examined in ten healthy adult men
during sexual arousal and masturbation-induced orgasm. Blood was drawn
continuously and cardiovascular parameters were constantly monitored. This
procedure was conducted for each participant twice, both before and after a
3-week period of sexual abstinence. Plasma was subsequently analysed for
concentrations of adrenaline, noradrenaline, cortisol, prolactin, luteinizing
hormone and testosterone concentrations. Orgasm increased blood pressure, heart
rate, plasma catecholamines and prolactin. These effects were observed both
before and after sexual abstinence. In contrast, although plasma testosterone
was unaltered by orgasm, higher testosterone concentrations were observed
following the period of abstinence. These data demonstrate that acute abstinence
does not change the neuroendocrine response to orgasm but does produce elevated
levels of testosterone in males."
3. American population testosterone level dropped about 50 ng/dl
for men at around age 64-65 between 2 groups of men born in 1920-1924 and
1930-1934, according to in http://jcem.endojournals.org/cgi/reprint/92/1/196.
When the 1920-1924 group reached the median age 65, their mean testosterone
level was 500 ng/dl; when the 1930-1934 group reached the median age 56 and 64, their
mean testosterone was 529 ng/dl and 444 ng/dl, respectively. The 1930-1934 group
has a testosterone drop rate at about 10.65 ng/dl per year during ages 56-64.
This report also shows that the testosterone drop rate generally becomes faster
for the men from 55 to 65. If we use the same annual drop rate of the 1930-1934
group, the extrapolated, averaged testosterone level of of 20 year old men born
during 1930-1934 should be about 911 ng/dl. Assuming that the mean 20-year old testosterone
level for both groups are the same is about 911 ng/dl, the
overall-averaged testosterone drop for the 1920-1924
group is about 9.13 ng/dl/year, while the overall-averaged testosterone drop for the
1930-1934 group is about 10.61 ng/dl/year I suspect the higher
masturbation/ejaculation frequency in the younger generation after the 60's
sexual revolution resulted in a higher cortisol/ prolactin level (or faster
ageing of the hypothalamus-pituitary-adrenal and -testicular axis) accelerates the
testosterone drop, since some high-frequency over-masturbation young men
experience male menopause (andropause) between ages 20-30.
4. Our observations for healthy ejaculation frequency (or refraction times) vs age, in order to maximize the testosterone level, are:
1. 4-7 times per week for teenagers of age 16-19.
2. 3-6 times per week for young men of age 20-25.
3. 3-5 times per week for young men of age 25-30.
4. 2-4 times per week for men of age 30-45,
5. 1-3 times per week for men of age 45-60,
6. 1-2 times every 10 days for men of age 60-70.
7. No more than once a week days after age 70
Lovemaking orgasms stimulate the pituitary to release
oxytocin for a faster recovery; while masturbation may not help the pituitary to
release enough oxytocin. Therefore, the masturbation ejaculation frequency
should be limited to the low limit as possible as you can. If your ejaculation
orgasm produces sexual
exhaustion symptoms, your ejaculation frequency should be lower than
the listed above. The actual ejaculation frequency is associated the
refraction (recovery time) of the hypothalamus-pituitary-adrenal, -thyroid and
-testicular axis. The energetic time (full recovery with powering up) for a man
having a morning (8 AM) testosterone level at 350-400 nd/gl is about 7
days when his testosterone level reach its peak, over 500 ng/dl. If he keeps
this ejaculation frequency, he will likely maintain his testosterone level
around 450-550 ng/dl, thereafter. A man with a high testosterone level of 700 ng/dl
or higher can re-erect the penis in a few minutes after ejaculating if his
pituitary doesn't overshoot his prolactin level, but it doesn't mean he can
ejaculate again. This is because the ability of penile re-erection can be
associated with the dopamine nervous action on the pituitary oxytocin and
prolactin release and the stimulation of testosterone, nitric oxide,
prostaglandin E1 and prostaglandin E2 stimulation on the prostate and
penile erectile nerves. Prostaglandin E2 can re-erect the post-ejaculating
penis again when the oxytocin level is high and the prolactin level is not
overshooting out of the range. The prostaglandin E2 induced erection usually
accompanies a little pains in the prostate, urethra and penis. Even if you can
re-erect your penis for sex again, the post-ejaculation elevating cortisol
and prolactin will start to lock up the adrenal and testicular function to drop
your DHEA and testosterone production few hours after the first
ejaculation.
Like psychological stress or exercise-induced stress, sex-induced stress
induces excessive cortisol, prolactin and norepinephrine/epinpehrine release to
lock up the hypothalamus-pituitary-adrenal and -testicular axis during sex or
few hours later after orgasm or ejaculation. The neuro-immune-endocrine
responses to sex-induced stress can be delayed until cortisol starts to exert its effects on the adrenal cortex,
prolactin on the pituitary-testicular axis, and norepinephrine/epinephrine and
its induced prolstaglandin E2 overheat the hypothalamus, pituitary, adrenal glands, testicles (ovaries), prostate,
liver, lungs, heart and pancreases (for a high glucogan release) via the alpha-
and beta -andrenergic receptors. For the same reason, people with chronic stress, no matter from which
sources, generally have a lower testosterone level. Over-trained athletes and
soldiers and psychologically stressed-out persons are not exceptional.
Testosterone and norepinephrine can positively or negatively interact each other
through their receptors. Initially, testosterone induces norepinephrine release
to give your arousal and heat, and then excessive norepinephrine with a high
level of proactin and cortisol reduces testosterone release; on the other hand,
without the inhibition effects of excessive prolactin and cortisol, norepinpehrine stimulates testosterone release via action on both alpha-
and beta-andrenergic receptors in the adrenal and testicles (ovaries) when the testosterone level is
too low. To avoid the inhibition effects of excessive prolactin and cortisol,
you need a normal dopamine-hypothlamaus-pituitary-adrenal function. Any way, there
are a lot of researches backing up the claim about the interaction among the
nervous, immune and endocrine system:
Ref: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T99-42MFD98-12&_user=10&_rdoc=1&_fmt=&_orig=search
&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2ddd3a7402479afca7ce03f4b59238f9
http://hyper.ahajournals.org/cgi/content/abstract/32/5/880
http://cat.inist.fr/?aModele=afficheN&cpsidt=2480820
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600009&lng=e&nrm=iso&tlng=e
http://www.biolreprod.org/cgi/content/abstract/40/3/541
http://www.popline.org/docs/0198/751348.html
http://hyper.ahajournals.org/cgi/reprint/17/6/1104.pdf
http://cat.inist.fr/?aModele=afficheN&cpsidt=15071810
http://www.ncbi.nlm.nih.gov/pubmed/1337237
http://endo.endojournals.org/cgi/content/full/144/11/4923
The following research suggests the inflammatory cytokine IL-1beta and its induced prostaglandin E2 can
stimulate the hypothalamus to induce release of norepinephrine, dopamine, and
serotonin as a feedback control.
http://www.jneurosci.org/cgi/reprint/13/8/3574
This article suggest norepinephrine control the feedback of LH secretion
in the hypothalamus-pituitary-testicular axis - http://www.popline.org/docs/0188/761130.html You
will get more explanation in the following about the role of norepinephrine and
epinephrine in the sexual arousal, orgasm responses, sexual exhaustion
symptoms, and neuro-immune function.
Semen contains human growth hormone, Insulin-like growth factor-I,
alpha2-macroglobulin, testosterone, other therapeutic and pharmaceutical
proteins and prostaglandins for better or worse:
Pre-puberty overmasturbation may limit the body and penile growth. Chronic
over-masturbation/over-ejaculation or excessive sex exhausts the
hypothalamus-pituitary axis. don't expect the exhausted pituitary gland to
properly release hGH, oxytocin, prolactin and arginine vasopressin (AVP.) Vasectomy can significantly drops hGH and testosterone at about 30-60% and 25-53%, respectively, in seminal plasma. Also
sperm retention in Seminiferous tubules causes inflammatory hormone
production inside the testicles (leading to the blue ball effect at an extreme)
and forces the sperm antigen to leak through
the testicle-blood barriers to activate inflammatory hormone prostaglandin E2
production in the other areas, particularly in the prostate and seminal
vesicles. Elavation of prostaglandin E2 will also trigger excessive adrenal and
hypothalamic dopamine-norepinephrine conversion for sympathetic nervous Fight
and Flight responses, where Fight = " Premature Ejaculation" and
Flight = "Going Limp" during sex. A low dopamine nervous function
will also drop the hypothalamus-pituitary-testicular function, leading to Hypogandism.
http://humrep.oxfordjournals.org/cgi/reprint/11/11/2454
http://humrep.oxfordjournals.org/cgi/reprint/14/6/1534
http://www.biolreprod.org/cgi/reprint/67/2/648
http://ps.fass.org/cgi/content/full/86/1/112
The serum IGF-I concentration can be correlates to the IGF-I concentration in reproductive traits.
http://jas.fass.org/cgi/reprint/82/8/2285
It is also shown the seminal vesicles can produce HGH and other therapeutic and pharmaceutical
proteins -
http://www.bioteach.ubc.ca/TeachingResources/Genetics/MouseGeneticsQsAnsB.pdf
Semen contains a lot of proimflammatory factors such as cytokines,
prostaglandin E2 and 19-hydroxy prostaglandin E2, polyamines, and histamine.
Although it also have anti-inflammatory cytokines and prostaglandin E1/E3, the
pro-inflammatory factors usually overpower the anti-inflammatory factors since
the pro-inflammatory factors are essential to the immune suppression so that the
sperms can safely pass the male ejaculation tract in the prostate and urethra,
survive in the vagina and uterus, fertilize eggs, swell endometrium,
and eventually implant the fertilized eggs in the endometrium. For men,
chronically blasting the tissues and nerves of the ejaculation tract with
seminal fluids result in inflammation, immune suppression, and hypersensitivity.
The inflammatory mediators may also exert toxic effects on sperms, leading to
infertility too. Refs:
http://www.andrologyjournal.org/cgi/content/full/28/2/325
Prostaglandin E1and E3 are the good guys for healing and restoration, but prostaglandin E2 is
the good , the bad and the ugly. Prostaglandin E2 also stimulates the cells to grow and perform
multiplication, and induces orgasm and labors. Recent study suggest prostaglandin
E2 in seminal plasma promote cervical cancers -
http://jcem.endojournals.org/cgi/content/full/86/5/2243
http://endo.endojournals.org/cgi/content/full/147/7/3356
http://humrep.oxfordjournals.org/cgi/reprint/22/1/36.pdf
In addition to induction of inflammations, pains, tumors and cancers,
prostaglandin E2 causes premature ejaculation and anxiety by stimulating the
sympathetic nerves in the seminal vesicles and prostate for more hypothalamic
and adrenal norepinephrine and epinephrine production. After sexual
intercourse, the prostaglandin E2 release in the prostate, urethra,
vagina, cervix and uterine will shot up for 24-48 hours. The elevation of
prostaglandin E2 will skew the physical examination of the sex organs and their
secretion. If you want to have a precious physical examination in your pelvic
organs, you should avoid sex at least 48 hours before going to see your doctor.
Semen fluid disables neuroimmune responses of the female reproductive tract,
essential to establish pregnancy. Semen's cytokines and prostaglandins bind into
receptors on target cells in the cervix and uterus for activating changes in
gene expression for pro-inflammatory response with induction of proinflammatory
cytokines and COX-2 , and sperms also modulate neutrophil influx
into the uterine lumen to enhance the local leukocyte population and cytokines
synthesis originally elicited by semen plasma. As a result, semen fluid
signals the ovarian function to increase progesterone by stimulating the cervix
and uterus. Elevation of progesterone in the cervix receptors will shrink/harden
the cervical tissues and close the cervical orifice up in order to retain semen and
sperms. In some animals, such as dogs and pigs, which have a
long cervix to interlock the penis, semen fluid can trigger the long cervix to lock
up the penis, known as mating or copulatory tie. The mating or copulatory
tie also
happens to human. As a result of mating tie, some male insects die from mating due to a full drain of
semen and sperms. During the ovulation or heat, the cervix is very flexible and its orifice
is open to welcome the penis. After ovulating or heat, the cervix become less
flexible and its office closes. Since the human vagina is long and the cervix
orifice orients to about 30-45 degrees to the vaginal axis, the chance for the
penis to penetrate into the cervical office is very small, and therefore, the chance
of human copulatory tie is very small. But, for some
women with a titled cervix/uterus and uterus prolapsed, it is possible to have
copulatory tie. (examples: http://www.actionlove.com/cases/case15659.htm
and http://www.actionlove.com/cases/case16375.htm
) Semen fluid can also
stimulate vaginal/cervical/uterine master cells for histamine and prostaglandin
D2 release to trigger allergic and hypersensitive responses, which occurs for
some women. Although semen also contains anti-inflammatory cytokines and
prostaglandin E1/E3 to balance the inflammatory responses, but it produces more
effective proinflammatory responses than anti-inflammatory one. Thus, the chance of
post-copulatory inflammatory reaction
becomes high. With
a rough sex, vaginal or cervical abrasion can cause vaginal, vulva and cervical
inflammation, pains and even infection by mechanically stimulating enzyme COX-2
expression for extra prostaglandin E2 release. Therefore, the tissue abrasion
must be avoided during sexual intercourse.
For the sake of your girlfriends (girlfriend) and/or wives (wife) and
your prostate , you
should reduce the prostaglandin E2 level and increase hGH and other
therapeutic and pharmaceutical
proteins in your seminal plasma. You can last longer during
intercourse and also renourish your girlfriends and wives with your semen via the vaginal/cervical/uterine absorption. To improve your seminal quality,
you should take out ViaPal-hGH formulas. Don't let your poor semen cause
the vaginal yeast infection, urethral tract infection, Vaginosis or Vulvodynia, or even allergy
By the way, don't empty your seminal vesicles by multiple ejaculation in one
love session. You should leave about 1/3 of semen in seminal vesicles, so that
the residual semen can help you restore your nervous functions and your brain
and testicular blood circulation for recovery.
More about the seminal plasma and sperms induced anti-inflammatory and
pro-inflammatory immunogenic effects on the tissues (vaginal, cervix, uterine,
urethra and even male prostate), please read
http://jas.fass.org/cgi/reprint/85/13_suppl/E36
http://molehr.oxfordjournals.org/cgi/content/full/13/7/491
http://molehr.oxfordjournals.org/cgi/content/full/5/3/220
http://endo.endojournals.org/cgi/content/short/en.2005-1429v1
http://molehr.oxfordjournals.org/cgi/reprint/13/7/491
http://molehr.oxfordjournals.org/cgi/content/full/5/3/220#THOMPSON-ETAL-1992
http://molehr.oxfordjournals.org/cgi/reprint/13/7/491
http://humrep.oxfordjournals.org/cgi/reprint/12/3/586.pdf
http://humupd.oxfordjournals.org/cgi/reprint/12/1/23.pdf
http://www.biolreprod.org/cgi/content/full/66/2/445
http://www.andrologyjournal.org/cgi/content/full/24/5/704
http://www.reproduction-online.org/cgi/reprint/131/3/613
http://www.andrologyjournal.org/cgi/reprint/24/3/448
http://www.jbc.org/cgi/content/full/277/36/32562
http://www.jbc.org/cgi/reprint/275/29/21844
http://humrep.oxfordjournals.org/cgi/reprint/22/11/2928
http://www.andrologyjournal.org/cgi/content/full/28/2/325
http://humupd.oxfordjournals.org/cgi/reprint/13/3/225
http://www.ncbi.nlm.nih.gov/pubmed/16129942
http://www.jimmunol.org/cgi/content/abstract/136/8/2862
http://www.biolreprod.org/cgi/content/full/59/1/202
http://www.reproduction-online.org/cgi/reprint/132/1/147
http://www.reproduction-online.org/cgi/reprint/131/3/613
http://www.reproduction-online.org/cgi/reprint/128/2/237
http://www.jrijournal.org/article/S0165-0378(02)00042-6/abstract
http://www.ncbi.nlm.nih.gov/pubmed/7932389?dopt=Abstract
http://www.ncbi.nlm.nih.gov/pubmed/11839394?dopt=Abstract
http://humupd.oxfordjournals.org/cgi/content/full/12/1/23
http://www.reproduction-online.org/cgi/reprint/94/1/213?ijkey=3a5b7bcceb881f062ee51828c033c6aeaaffe200
http://www.reproduction-online.org/cgi/reprint/107/2/265?ijkey=a0d200ea06db70a2aec626c4916b5b199b9c6615
http://www.reproduction-online.org/cgi/reprint/66/1/157?ijkey=a9067f9685e5a013abf5cf7e4ae335d09afde778
Sex as an Addictive Drug (but, can we retrain old
dogs with new tricks to reverse addiction?) : Stimulation of a neuron will
promote release of neurotrophins from the neuron terminal. Neurotrophins, also
known as the -nerve
growth factor (NGF), brain-derived
neurotrophic factor (BDNF), belongs to a class of secreted proteins, responsible
for the growth and survival of developing neurons and the maintenance and
differentiation of mature neurons. Neurotrophic factors also are capable
of regrowing damaged neurons. BDNF can mediate neuronal plasticity
(neuroplasticity) and influences learning, memory and cognitive behavior. Neuroplasticity
is an alternation of a nervous system to adapt
the short- or long-term biochemical, physiological and morphological changes in
response to intrinsic or extrinsic inputs. Neuroplasticity
in the central nervous system is essential to learning and memory.
Therfoere, chronic nervous over-stimulation induces over-release of the
central BDNF, with drug or sex, can result in alternation of brain and synaptic
plasticity, leading to addiction behaviors. The central neuronal plasticity
promotes the noradenergic, adrenergic and sympathetic nervous function and weakens the
parasympathetic, vegal, serotonin and
GABA nervous synaptic modulation and control on the noradrenergic, andrenergic and
sympathetic nervous function. That is, chronic nervous over-stimulation
on certain nervous systems, for examples, such as dopaminergic, glutaminergic,
norandrenergic nervous systems, can modify the brain function for
psychological disorders and addiction. In addition, hormone such as hGH,
DHEA, oxytocin, prolactin, LH, FSH, testosterone, DHT, progesterone and
estrogen, can modify (enhance) BDNF release and nervous growth, differentiation
and maintenance. Therefore, we should separate neuroplasticity into the
positive or negative one. Reversal of a negative (destructive) neuroplasticity
into a positive one is very difficulty. You can consider the reversing process
is brainwash. A positive neuroplasticity allows a person to partially or fully
recover their brain function from stroke or brain injuries or illness. A
negative neuroplasicity will let people experience drug addiction, drug
withdrawal symptoms, mood swing, depression, stress, anxiety or
obsessive-compulsive disorder, due to synaptic rewiring , neuronal
outgrowth or neuronal death. For example, SSRIs antidepressants can outgrow
certain neurons in the brain, but drug withdrawal, without help the nervous
terminals to produce sufficient serotonin, will result in brain shock,
nervous sparking, agitation, more depression, more anxiety, akathisia,
panic attacks, irritability, aggressiveness, worsening of mood, dysphoria,
crying spells, mood/emotional lability, overactivity,
hyperactivity, depersonalization, decreased concentration, slowed thinking,
confusion, memory/concentration difficulties, nausea, drowsiness,
sleeping disorder, headache, migraines, dizziness, mania biopolar or
unipolar, premature ejaculation, persistent sexual arousal or orgasm, liver or
renal impairment, high photosensitivity, digestive panic response, overactive
bladder, and even suicidal tendency
Ref: http://content.karger.com/produktedb/produkte.asp?doi=103570
, http://www.ncbi.nlm.nih.gov/pubmed/16824691
, http://brain.oxfordjournals.org/cgi/content/full/129/7/1659
, http://www.springerlink.com/content/h1127g504q2h1060/,
http://www.pnas.org/cgi/content/abstract/80/11/3517,
http://www.sciencemag.org/cgi/content/abstract/227/4694/1544?ck=nck
, http://www.acnr.co.uk/JA07/ACNR_JA07_review_plasticity.pdf,
http://thomasland.metapress.com/content/a422g91uq4hb86xc/,
http://endo.endojournals.org/cgi/content/full/145/1/161
and http://humrep.oxfordjournals.org/cgi/reprint/22/4/995
A positive neuroplasticity should improve your life and productivity.Neuroplasticity also occurs when changes in electrical excitability and
changes in gene expression can long outlast the initial causal
stimulus. For example, airway inflammation in baby monkeys repeated
ozone exposures results to persistent increase in the excitability
of nucleus tractus solitarius neurons in the brain stem as described
in Plasticity in Respiratory Motor Control
Selected Contribution: Vagal neuroplasticity in nucleus tractus solitarius neurons
after episodic ozone exposure in infant primates
(http://jap.physiology.org/cgi/content/abstract/94/2/819?ijkey=0b358ac59f303cf9c8922f1afdf2b9d4a5889946&keytype2=tf_ipsecsha).
This is an adaptation of the respiratory motor responses, a part of
biological evolution. Vago-vagal reflex circuits controlling and
modulating digestive functions from the oral cavity to the transverse colon can
be activity-dependently plastic in controlling stomach behavioral and
physiological homeostasis.( http://ajpgi.physiology.org/cgi/content/full/284/2/G180
). Nerves can regrow in a failure transplant heart.
you can remodel the sympathetic nervous system with Neuroplasticity for better
or worse ( http://hyper.ahajournals.org/cgi/content/full/47/2/143). Biofeedback can train your cardiovascular
function for better output. http://www.psychosomaticmedicine.org/cgi/reprint/65/5/796.pdf .
Meditation may induce short-term and long-term neural changes as
described in http://www.pnas.org/cgi/content/full/101/46/16369
and http://www.pnas.org/content/101/46/16369.full#abstract-1
.
Meditation generally produces vagal or parasympathetic nervous plasticity, but
can be highly dopaminergic and noradrenergic , depending on what types of
parctices.. Some
people who do it in a wrong way get sympathetic neuroplasticity for headaches
or other sympathetic nervous Fight and Flight responses. This also indicates the sensory and motor nerves in the
central and peripheral
nervous system can be plastic. ( http://www.jneurosci.org/cgi/content/full/25/44/10167
and http://www.research.va.gov/programs/JRRD/45_2/Forrester.pdf
) This also tell you that you can reduce sexual urgency and may help you unhook yourself
from sex addiction with Dr.
Lin's ChiKong and anal breathing practices. You can improve your focusing
and cognitive function with a focusing effect of acetylcholine (ACh)
on neuroplasticity of cortical networks. ACh not only increased
selectively the efficacy of synapse-specific excitability-enhancing
neuroplasticity, but also prolonged the excitability
diminution in case of asynchronous synapse-specific inputs and
suppressed global excitability enhancements. ( http://www.jneurosci.org/cgi/content/full/27/52/14442
). That is why our pro-acetylcholine products ,such as Moodmax and
ViaGrowth-IV , can improve your congestive function.
Sexual or orgasm addiction is due to the nervous plasticity of the hypothalamic paraventricular nucleus (PVN) where the
dopamine, acetylcholine, oxytocinergic,
noradrenergic (norepinephrine), adrenergic(epinephrine), autonomic (sympathetic
and parasympathetic) vagal, glutamate, NOergic, GABAergic and serotonin nervous system innervate. The nervous
plastic remodeling occurs under a frequent oxytocin, prostaglandin E2 (http://ajpregu.physiology.org/cgi/content/full/294/4/R1294 )
and norepinephrine
stimulation during sex when the GABAergic and serotonin nervous function are
too weak to modulate the dopamine-norepinephrine conversion and the
noradrenergic nervous firing. The main source of noradrenergic
innervations of higher brain sites, including the hypothalamus and PVN, is the
locus ceruleus (LC) where norepinephrine activates pro-inflammatory
pyrogenic cytokins and protein kinases in LC for prostaglandin E2
which, in conjunction with action of oxytocin, let you feel high,
arousing and exciting. Sex can increase the density of PVN dopamine beta-hydroxylase
immunoreactivity (DBHir), so that the enzyme dopamine beta-hydroxylase
can constantly convert dopamine to norepinephrine to keep on sexual fire,
leading to addiction. Prostaglandin E2 is involved in the regulation of
synaptic activity, transmission and plasticity, and in brain evolution.
Prostaglandin E2 accelerates neuroplasticity. You need
prostaglandin E2 for neuroplasticity - learning, memory and addiction. Thus,
you have to study hard (for more norepinephrine and prostaglandin E2) to
memorize contents of the books you read in a short time. However, you
use them (norepinephrine and prostaglandin E2) for sex addiction, you will love sex more than your life.
Prostaglandin E2 can also degrade the short time memory and spatial navigation
by enhancing membrane excitability and then inducing long-term synaptic
plasticity in hippocampal perforant path-dentate gyrus synapses.
Ref: http://www.jneurosci.org/cgi/content/full/25/43/9858
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2292143&blobtype=pdf
http://www.nature.com/nm/journal/v7/n4/full/nm0401_414.html
http://ajpgi.physiology.org/cgi/content/full/277/1/G79
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1430829
http://jn.physiology.org/cgi/content/full/88/1/49
http://ajpheart.physiology.org/cgi/content/full/291/6/H2847
http://ajpheart.physiology.org/cgi/content/full/274/4/H1284
http://ep.physoc.org/cgi/content/full/90/2/169
http://www.jneurosci.org/cgi/content/full/24/35/7604/
http://physiologyonline.physiology.org/cgi/content/full/14/3/100
http://ajpregu.physiology.org/cgi/content/full/292/4/R1717
http://endo.endojournals.org/cgi/content/full/145/11/4917
http://joe.endocrinology-journals.org/cgi/content/full/190/3/593
http://www.acnp.org/g4/GN401000155/Default.htm
and http://jn.physiology.org/cgi/content/abstract/87/6/2851?ijkey=5cee184dd3946b4945f9cc00585dec35e2d51349&keytype2=tf_ipsecsha
Excessive sex also cause memory loss and learning inhibition, as reported in
http://www.actionlove.com/extra/alzheimer.htm
What happens inside your brain memory center - the hippocampus when you have
excessive sex? Does it make you become stupid? Yes, it can produce
destructive neuroplasticity. Here, neuroplasticity is referred to the
brain rewiring in response to changes in environment, experience or brain
chemistry. The brain areas related to memory formation and learning, such as
the hippocampus
and dentate
gyrus, were highly plastic. Neurons continue to be produced,
synoptically deformed, and destroyed into adulthood. You can alternate your
brain function in positive or negative way. The Ying-Type stress hormone
cortisol is responsible for alternating structure and function of the
hippocampus. Excessive cortisol inhibits adult neurogenesis in the dentate
gyrus, and impairs hippocampus-dependent learning and memory, as described in.
http://www.kzoo.edu/psych/Karten%20et%20al.2005.pdf
Note: Cortisol is one of corticosteroid hormones and biologically active while
cortisone is the biologically inert one. Cortisol is metabolized by the 11-beta
hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes:
11-beta HSD1 and 11-beta HSD2.
11-beta HSD1 utilizes the cofactor NADPH to convert biologically inert
cortisone to biologically active cortisol.
11-beta HSD2 utilizes the cofactor NAD+ to convert cortisol to
cortisone.
Case example:
Chronic
over-masturbation at 3 times a day since age 6 and 1-year marijuana smoking
results in memory loss, terrible eye floaters, dizziness, severe depression,
frequent urination, anxiety, insomnia, neck tremors, severe leg tremors, and
restless leg syndrome (Parkison's disease or symptoms) for no more sexual
orgasm
http://www.actionlove.com/cases/case15916.htm
Serotonin and GABA nervous deficiency and noradrenergic/sympathetic nervous
excess can be caused by pregnant mother's caffeine or drug abuse or/and by
individual chronic over-masturbation and drug abuse (marijuana,
methamphetamine, cocaine, heroin or other nervous toxins), leading to severe
eye floaters, dizziness, memory loss, depression, anxiety, tachycardia, penile
numbness, and psychological disorders (including suicidal tendency) for
no more sexual orgasm
http://www.actionlove.com/cases/case15914.htm
Chronic Over-masturbation results in premature ejaculation, erectile
dysfunction (going limp), precum leakage, urethral itching/sensation,
penile/groin/leg/prostate inflammatory pains, hair loss, irritation, anxiety,
mood swing, loss concentration and absent mindedness for no more sexual orgasm
http://www.actionlove.com/cases/case15904.htm
Over-Masturbation at 20-25 times a day since age 7,
masturbation addiction, masturbation withdrawal symptoms, and brain damage
turned a gifted kid into a stupid junkie
http://www.actionlove.com/cases/case15605.ht
Pornography triggers dopamine-norepinephrine conversion for psychological
stress; then, norepinephrine induces prostaglandin E2 production in your
hypothalamic preoptic area, adrenal glands, testicles, prostate, seminal
vesicles, bulbourethral glands and urethra for psychologically
stress-induce fever (brain overheating), body aches and pains, precum/semen
leakage and premature ejaculation/orgasm. Addiction on the norepinephrine and
prostaglandin E2 stimulation from pornography will produce withdrawal symptoms.
==> http://www.actionlove.com/cases/case15815.htm
The destructive testing results of over-masturbation from a 17-yearo-old boy - sexual exhaustion symptoms for no
more life and sexual orgasm, including, body pains, arthritis, testicular pain,
penile pain, prostate pain, back pain, face pain, gum pain, tinnitus (excessive
glutamate and inflammatory hormone prostaglandin E2), headcahes, fatigue,
anxiety, nightmare, chilliness and shivering attacks, hot flashing/fever
(premature male menopause), cracking joints, fibromyalgia, impotence, Restless
Leg Syndromes (pre-parkinson's disease) and so on.
==> http://www.actionlove.com/cases/case15655.htm
FDA Warnings:
News Upadated (July 8, 2005): All
the erectile PDE5 inhibiting drugs can cause sudden decreases or loss of
eyesight (even blindness, under a very fancy name "Nonarteritic Anterior
Ischemic Optic Neuropathy (NAION)", as warned by the US FDA in in -
http://www.fda.gov/cder/drug/InfoSheets/patient/sildenafilPIS.htm
http://www.fda.gov/cder/drug/infopage/cialis/default.htm
or http://www.fda.gov/cder/consumerinfo/viagra/default.htm
http://www.fda.gov/cder/drug/InfoSheets/HCP/sildenafilHCP.htm
or http://www.pbm.va.gov/alerts/PDE5.pdf
News Upadated (Oct. 18, 2007): All the erectile PDE5 inhibiting drugs can cause
sudden decreases or loss of hearing, tinnitus and dizziness as warned by the US
FDA in http://www.fda.gov/medwatch/safety/2007/safety07.htm#PDE5.
In fact, Dr. Lin has documented the sex-induced nervous
disorders since 1997 in our websites, although these problems were
well-addressed in the Chinese Sexual Bible "Suu-Nu Ching" and Medical
Textbook "Yellow Emperor's Classic of Internal Medicine" around 2600
B.C.. Realizing the sexual exhaustion systems, Dr. Lin has developed the
ViaPal-hGH formulas and other products to help you rejuvenate your exhausted
brain/nervous and endocrine functions for health and then sex. Dr. Lin has also
addressed the optimal, safe sexual/orgasm frequency for the different age groups
of people without damaging the brain and neuro-endocrine system.
Health Canada Warning - http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/2005/2005_83_e.html. So, you should read this link about sex and vision too
before taking erectile drugs -
http://www.actionlove.com/extra/eyefloater.htm,
but don't have to die for SEX!
The Root of Over-Masturbation/Excessive Sex:
Male/Female
Persistent Sexual Arousal Syndrome - http://www.actionlove.com/extra/psas.htm
Penile Enlargement Updated:
The role of DHT, prostaglandins E-1/E-2/E-3, and Nitric Oxide in the penile enlargement for more sexual orgasm
(Here is the fact: A balance action of prostaglandin E-1
and E-2 on the nerves and blood vessels allow the tissue to expand and stretch
without pains. For example: pregnant women stretch and grow the uterus and
abdomen without pains under a simultaneous, balanced action of prostaglandin E-1 and E-2,
but start labor contraction pains when prostaglandin E-2 overpower prostaglandin
E-1, in conjunction with the action of oxytocin, cotisol and epinephrine!)
http://www.actionlove.com/cases/case13917.htm
Natural Vaginal Rejuvenation and Tightness Updated:
ballooning of the
vaginal spongy tissues, G-spot erectile tissues, corpus cavernosum clitoridis,
and vestibular bulbs will tighten up you vaginal orifice and canal. For detail
please go to http://www.actionlove.com/extra/vsize.htm
The basic principle of the penile and clitoral/G-spot ballooning is to turn
the local skin into an endocrine organs for more DHEA, DHT, testosterone,
and prostaglandins production to feed the erectile tissues and nerves, as described in
http://www.fasebj.org/cgi/reprint/04-1968fjev1
and
http://edrv.endojournals.org/cgi/reprint/21/5/457
Excessive
Sex for dark eye cycles, nips, labia minors, pelvic area, perineum clitoral/penile
forskin: Skin is a neuroendocrine organ. Chronic stimulation
of sex organs can lead to over-production of α-MSH
and Trapping excessive α-MSH in certain
areas of skin results in extra skin darkness, particularly in eye cycles, nips, labia
minors, penile and clitoral foreskin, and perineum if the local skin
neuroendocrine function was working, but the local blood circulation becomes
poor due to excessive noepinephrine or epinpehrine binding in the sympathetic
andrenergic-α2 receptors of the blood
vessels or a lack of nitric oxide and prostaglandins E1/E3 in the local tissues.
Over-ejaculation, high-frequency sex or/and excessive orgasm causes excessive
histamine release; histamine, in turn, stimulates α-MSH
release from the pituitary in an attempt to counterbalance the histamine level and counteract the
histamine-induced inflammatory and allergic responses. Thus, excessive sex
results in excessive histamine, prostaglandin E2 and α-MSH release.
α-MSH stimulates excessive production of melanin, a brown pigment
manufactured by certain cells in the skin called melanocytes, from tyrosine. Excessive melanin
is responsible for dark skin color. This is called Hyperpigmentation. The dark
skin as a result of chronically excessive sex-stress norepinephrine induced
inflammatory hormone prostaglandin E2 stimulation is considered as
Post-inflammatory hyperpigmentation. In this regard, the excess melanin is
produced in the upper layer of skin (epidermis). The cells that normally produce
brown pigment evenly across your skin go into overdrive and produce too much
melanin. Then, the pigmentation color is a darker shade of brown.
http://www.fasebj.org/cgi/content/full/21/4/976
http://physrev.physiology.org/cgi/content/full/80/3/979
http://edrv.endojournals.org/cgi/content/full/21/5/457
The tissues
also around the eyes contain a
high level of COX enzyme receptors, histamine receptors, and master cells
. You will feel itchiness and allergy-like responses in your eyes. Due to the constriction of the arteries and veins, melanin is trapped
around the eye cycles leading to darkening of eye cycles. This also
happens in your groins area too. Generally, the skin in a poor blood
circulation area, even if there is no UV exposure, becomes darker than
the other areas.
Although melanin is a skin and hair protector, over-production of melanin
signals sexual exhaustion and reduces dopamine and oxytocin synthesis as a
self regulation of libido, thus, to slow down libido. However, in
the brain, overloading of neuro melanin (also known as neuromelanin) in
in the substantia nigra pars compacta is an increased contribution to
oxidative stress and intraneuronal damage in patients with Parkinson's disease,
resulting in degeneration of dopaminergic neurones. http://www.ingentaconnect.com/content/bsc/jnc/2003/00000086/00000005/art00009,
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1187132&blobtype=pdf
Does this concludes that the excessive sex, besides ageing and drug
uses, leads to restless leg syndromes or
parkinson's disease?
Genetic factors also play the important role in α-MSH and melanin release
and the distribution of melanin in cells over the body.The epidermis is avascular,
nourished by diffusion
from the dermis,
and composed of four cell types: keratinocytes,
melanocytes,
Langerhans
cells, and the Merkels
cell. Melanocytes
is responsible for pigmentation. Similar to paint or ink, skin
color is a result of mixing four biochromes: oxyhemoglobin (red), reduced
hemoglobin (blue), carotenoids (yellow) and, melatonin (brown). The
amounts and types of melanins produced and their distribution vary in the skin,
responding to α-MSH, blood circulation, and internal or external stimulus
including VU, drugs and mechanic/abrasive stimulation .
Different body parts have melanocyte density. For example, the palms and soles
contain less melanocytes while nipples have higher. For some people, the eye
circle tissues and groins also contain a high density of melanocyte than the
other areas do. Melanocytes are cells
located in the bottom layer (the stratum
basale) of the skin's epidermis,
hair follicles, the middle layer of the eye (the uvea,
the pigmented middle of the three concentric layers that make up an eye),
the inner ear, meninges, bones and heart. In the skin,
melanocytes comprise from 5% to 10% of the cells in the basal layer of
epidermis while keratinocytes is the major constituent of the epidermis,
constituting 90% to 95% of the cells in epidermis. Melanin is synthesized
and stored in membrane-bound organelles (termed melanosomes) where melanosomes
form a critical barrier, a protection layer, to shield DNA from external
stimulus such as ultraviolet radiation or external drug and mechanical
stimulation As melanosome grows to neighboring keratinocytes,
the protection layer expands as proliferating keratinocytes in the suprabasal
epidermal layers. As a result, the local skin becomes darker.
Recent studies shows glutathione, glycine, L-alanine, L-isoleucine
and L-leucine can inhibit melanin synthesis in the reaction of trysinase and
L-dopa. OurViaGrowth-IV contains glutathione, glycine and L-alanine, as
well as L-tyrosine
Ref: http://www.ncbi.nlm.nih.gov/pubmed/18670186
http://www.jstage.jst.go.jp/article/bpb/30/4/677/_pdf
http://www.jstage.jst.go.jp/article/bpb/30/11/2031/_pdf
http://endo.endojournals.org/cgi/reprint/146/2/532
and http://www.fasebj.org/cgi/content/full/20/7/882
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2678743&blobtype=pdf
Garland CF, et al. Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates.
Ann Epidemiol. 2003; 13(6):395–404.
http://www.ncbi.nlm.nih.gov/pubmed/12875796
Wolf P, et al. Effect of sunscreens on UV radiation-induced enhancement
of melanoma growth in mice. J. Natl Cancer Inst. 1994; 86 (2):99–105.
http://www.ncbi.nlm.nih.gov/pubmed/8271307
Tadokoro T, et al. UV-induced DNA damage and melanin content in human
skin differing in racial/ethnic origin. Faseb
J. 2003;17(9):1177–1179. http://www.fasebj.org/cgi/reprint/02-0865fjev1
Yamaguchi Y, et al. Mesenchymal-epithelial interactions in the skin:
increased expression of dickkopf1 by palmoplantar fibroblasts inhibits
melanocyte growth and differentiation. J. Cell Biol. 2004; 165 (2):275–285.
http://jcb.rupress.org/cgi/content/full/165/2/275
Montagna W, Carlisle K. The architecture of black and white facial skin.
J Am Acad Dermatol. 1991;24(6Pt 1):929–937.
http://www.ncbi.nlm.nih.gov/pubmed/1714469
Galus R, Zandecki Ł,Sajjad E, Jóźwiak J, Włodarski K. Factors affecting melanogenesis and methods used for identification of pigmentation disorders, Pol
Merkur Lekarski. 2008 Aug;25(146):188-91
http://www.ncbi.nlm.nih.gov/pubmed/18942345?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed
Special Note:
from http://en.wikipedia.org/wiki/Melanin:
The photochemical properties of melanin make it an excellent photoprotectant.
It absorbs harmful UV-radiation and transforms the energy into harmless
amounts of heat through a process called "ultrafast internal
conversion". This property enables melanin to dissipate more than
99.9% of the absorbed UV radiation as heat[3]
and it keeps the generation of free radicals at a minimum (see photoprotection).
This prevents the indirect
DNA damage which is responsible for the formation of malignant melanoma.
Excessive
sex and Light Over-Sensitivity in Retina: Beside
inflammation of eyeballs due to excessive prostaglandinE2 and histamine
induced by excessive norepinephrine and prolactin, melatonin, melanin,
dopamine and glutamate are responsible for visual perception and multilevel
regulation of visual sensitivity in response to the intensity of ambient
lighting, while the pupil, a circular opening located in the center of
the iris
of the eye controls the amount of light that enters the eye. Excessive
norepinephrine-induced prostaglandin E2 and histamine in the retina, with a
lack of prostaglandin E1, GABA, serotonin and glycine and agmatine nervous
modulation, can over-excite the visual receiving sensors.
Melanin in the eyes, in the iris
and choroid,
is supposed to adjust and darken the their color to filter out ultraviolet
and high-frequency
visible light. There are two layers in the iris: the front pigmented
fibrovascular
tissue, also known as stroma,
and, behind the stroma, pigmented epithelial cells. The stroma connects
to the iris sphincter muscle responsible for adjustment of the pupil
in response to light intensity. Strong light constrict the pupil for
limiting the rays.A wide pupil results in an image that is sharp around what
the iris is focusing on and blurred otherwise The back surface of the
stroma is covered by a heavily pigmented epithelial
layer, the iris pigment epithelium which release melanin in response to light.
The higher the pigment content is, the more light from passing through the
iris to the pupil is attenuated. This light filtration mechanism relies
on the release of melanin. Since L-Ddopa is the immediate
precursor of melanin, If there is a deficiency of L-dopa, this optical
filtration will be malfunctioning. If sexual arousal or orgasm turns too much
L-Dopa into dopamine and then norepinephrine and
epinephrine, the L-Dopa will drop too low to support the iris and
choroid pigmentation in response to light. As a result, your visual receiving
sensors will become hypersensitive to light, in addition to experiencing
UV damage
Melatonin is the main regulator of light sensitivity by many ways.
Melatonin is responsible for photomechanical movement, cone photoreceptor
elongation and rod photoreceptor contraction, as the adaptation to
decreasing light intensity which increases melatonin release. The
photosensitivity of the receiving circuits increases in the weak light to
compensate the weak visibility, so that the visual perception can become
clearer. The opposite photomechanical adjustment occurs in response to
increasing light intensity and the resulted increase of dopamine in the
central nervous system and retina. The dopamine release in the retina
increases after light exposure and decreases in darkness. Melatonin suppresses
the light-elicited dopamine release from retina, as photoreceptor adaptation
to darkness. That is, we can say: melatonin is the darkness
hormone while dopamine is the light hormone. The photosensitivity of the
receiving circuit decreases as dopamine increases, as a feedback control of
the visual circuit , so that there is no truncation of visual signals entering
the visual cortex. When the dopamine level is too low, the retinal receiving
circuit become too sensitive to light. In particular, the eye pupils are
dilated by the norepinephrine/sympathetic nervous function. Excessive
hypothalamic and adrenal dopamine-norepinephrine conversion can cause this
problem.
Melatonin, synthesized in the retina also modulates the retinal pigment
epithelium (RPE) function by aggregating pigmented cells in the RPE and
choroid of the eye. Thus, the another way for melatonin to regulate the
amount of light entering the photoreceptor is to control the movement of
melanosome granules within the RPE where melanosome granules stores melanin.
Eye pigmentation of releasing melanin in response to light attenuates the
light intense before entering the retina. Melatonin can also alter the
electrical activity of the RPE of the mammalian eye. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=286629&blobtype=pdf
Glutamate, the darkness neurotransmitter, in the retinal receiving
circuit modulate the visual response to the light by decreasing its
concentration. When the eyes abruptly expose to the light, it will take a
while to turn on the color receiving circuit by removing glutamate.
Unfortunately, dopamine
and glutamate are essential to sexual arousal and orgasm. During orgasm and in
the pos-orgasm state, excessive glutamate is supposed to turned into GABA,
5-HTP to serotonin, and dopamine to norepinephrine, resulting in elevation of melatonin to suppress dopamine synthesis. In some
cases, glutamate won't turn to GABA or/and dopamine drops too low, leading to
eye floaters, light-oversensitivity in retina, and of course, depression and
brain fog
MCCORMACK, C. A.,
AND B. BURNSIDE. A role for
endogenous dopamine in circadian regulation of retinal cone movement. Exp.
Eye Res. 55: 511-520, 1992, http://www.ncbi.nlm.nih.gov/pubmed/1426081?dopt=Abstract
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J. C. BESHARSE. Circadian
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STENKAMP, D. L., P.
M. IUVONE, AND R.
ADLER. Photomechanical movements of cultured embryonic photoreceptors:
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endogenous dopamine. J. Neurosci. 14: 3083-3096, 1994
,
http://www.jneurosci.org/cgi/reprint/14/5/3083?ijkey=5c1cba68d6e6d7db8ff1f6eb91514ceedcf544fd
THALER, C. D., AND
L. T. HAIMO. Regulation of
organelle transport in melanophores by calcineurin. J. Cell Biol. 111:
1939-1948, 1990, http://jcb.rupress.org/cgi/reprint/111/5/1939?ijkey=0c6f309ff96292b90ee0f74dd0d48ff9168e08de
PANG, S. F., AND D. T. YEW. Pigment
aggregation by melatonin in the retinal pigment epithelium and choroid of
guinea-pigs, Cavia porcellus. Experientia 35: 231-232, 1979.
KEMALI, M., N. MILICI, AND
D. KEMALI. Melatonin and LSD induce similar retinal
changes in the frog. Biol. Psychiatry 21: 981-985, 1986
NAO, I.. N, S. E. NILSSON, R. P. GALLEMORE,
AND R. H. STEINBERG. Effects of melatonin on
the chick retinal pigment epithelium: membrane potentials and light-evoked
responses. Exp. Eye Res. 49: 573-589, 1989, http://www.ncbi.nlm.nih.gov/pubmed/2806426?dopt=Abstract
WITKOVSKY, P., S. STONE, AND
J. C. BESHARSE. Dopamine
modifies the balance of rod and cone inputs to horizontal cells of the Xenopus
retina. Brain Res. 449: 332-336, 1988, http://www.ncbi.nlm.nih.gov/pubmed/3293703?dopt=Abstract
WIECHMANN, A. F., X.
L. YANG, S. M.
WU, AND J. G.
HOLLYFIELD. Melatonin enhances horizontal cell sensitivity in salamander
retina. Brain Res. 453: 377-380, 1988, http://physrev.physiology.org/cgi/external_ref?access_num=3401776&link_type=MED
BESHARSE, J. C., AND P. M. IUVONE. Is
dopamine a light-adaptive or a dark-adaptive modulator in retina? Neurochem.
Int. 20: 193-199, 1992.
BESHARSE, J. C., AND
D. A. DUNIS. Methoxyindoles and
photoreceptor metabolism: activation of rod shedding. Science 219:
1341-1343, 1983, http://physrev.physiology.org/cgi/ijlink?linkType=ABST&journalCode=sci&resid=219/4590/1341
TEXTORIUS, O., AND S.
E. NILSSON. Effects of intraocular irrigation
with melatonin on the c-wave of the direct current electroretinogram and on
the standing potential of the eye in albino rabbits. Doc. Ophthalmol.
65: 97-111, 1987, http://www.ncbi.nlm.nih.gov/pubmed/2444402?dopt=Abstract
DUBOCOVICH, M. L.. Melatonin is
a potent modulator of dopamine release in the retina. Nature 306:
782-784, 1983
http://www.ncbi.nlm.nih.gov/pubmed/6656879?dopt=Abstract
KAZULA, A., J. Z.
NOWAK, AND P. M.
IUVONE. Regulation of melatonin and dopamine biosynthesis in chick retina: the
role of GABA. Vis. Neurosci. 10: 621-629, 1993, http://www.ncbi.nlm.nih.gov/pubmed/8101728?dopt=Abstract
BOATRIGHT, J. H., M.
J. HOEL, AND P.
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release and metabolism in amphibian retina by light- and K+-evoked
depolarization. Brain Res. 482: 164-168, 1989
,http://www.ncbi.nlm.nih.gov/pubmed/2706474?dopt=Abstract
Benefits
from Optimal Orgasms (the Tao of Sexual Orgasms): Orgasm
triggers the pituitary to release prolactin. Although
chronically excessive
prolactin can disable the sexual function, induce cancerous development, screw
up the reproduction system and cause depression, an optimal prolactin
release from your pituitary and eyes, as a result of an orgasm, is good for hGH production, cancer and
tumor prevention and for healthy eyes, brain, heart, liver, kidneys, uterus and
prostate. Particularly, if
chondrocytes (bone marrow
stromal stem cells) can release the enzyme matrix metalloproteinases to convert
prolactin into 16K-prolactin (16 kDa N-terminal fragment of the
hormone prolactin), you will benefit from the antiangiogenic effects from
16K-prolactin. 16K-prolactin can block the blood vessel invasion or new
blood vessel growth, associated with the endochondral bone formation (blocking
mitogen-induced vascular endothelial cell proliferation, involved
activation of programmed cell death) and tissue repair after injury
and inflammation (by prostaglandin E2!), which is an important mechanism underlying
human diseases such as cancer, diabetic retinopathy, rheumatoid
arthritis, and heart diseases. It is antiangiogenic, but
excessive 16K-prolactin inhibits the penile or clitoral growth, or other normal
cellular or nervous repair and
regeneration/rejuvenation. Therefore, you need an optimal orgasm frequency to
prevent cancers (including prostate
cancers), tumors and
retinopathy
(non-inflammatory damage to the retina
of the eye, due to lack of of the blood supply, damaged or constricted blood
vessels.)
However, you should not have an excessive sex or orgasm since it will produce
excessive stress hormones to inhibit the
release of the enzyme matrix metalloproteinases,
to suppress the neuro-immune system,
and to activate the inflammatory factors
triggering
your health alarm
system, as a result of
the excessive prostaglandin E2 production.
The inflammatory factors actually damage the bone marrow cells. Due
to the fact that semen contains high concentration of Phosphorylcholine
essential to the brain and nervous function and repair, the old Taoists
theorized that men can return semen (actually phosphorylcholine) to revert the
brain. Generally speaking, the concept is correct; however, when the
brain's dopamine or testosterone level is too high for excessive semen
production, your pituitary will be over-exited, leading to excessive oxytocin
release and prolactin deficiency, in addition to neuroexcitotocity from
dopamine-induced excessive glutamate and histamine production, the deamination
of dopamine to DOPAL and the oxidative stress from the demination byproduct Hydrogen
Peroxide. Therefore, Optimal orgasm and ejaculation can help you burn
some dopamine and testosterone out, and then induce the prolactin release
from the pituitary and retina tissues for some protective and anti-inflammatory
hormone 16K-prolactin in cooling down the nervous systems. In this way, you can
avoid the side effects of excessive dopamine or testosterone, and benefit from
sex. That
is, an optimal orgasm or sex can improve your health.
Remember this:
Bone Morrow and Sperms: Reuters (April 13, 2007) said Dr. Karim Nayernia at the University of
Gottingen, discovered stem cells taken from the bone marrow of men may be able to transdifferentiate to sperm cells in 3-5
years - http://search.yahoo.com/search?p=Karim+Nayernia+sperm+marrow&ei=UTF-8&fr=moz2
The Traditional Chinese Medicine considered bone marrow is Essence (Jing) for semen production. What is a coincidence! This means that
over-ejaculation or excessive orgasm will cost your bone marrow and weaken your bone. Other stem cells researches have done similar work in female mice and turned bone marrow cells into egg cells. What does this mean to women's body pains or arthritis?
This means excessive orgasm/sex/ejaculation, job-related stress, substance abuse
or toxins can inhibit the enzyme matrix metalloproteinases
from the bone marrow
stromal stem cells. This is why our readers kept reporting inflammatory
pains and arthritis induced by orgasm/ejaculation, job-related stress,
substance abuse or toxins.
As of today, a high level of prolactin has been realized as a promoter
or co-initiator of breast and prostate cancers, in addition to disable the
sexual function. It appears to play a key role in the development and
progression of breast and prostate cancer and tumors. So, keep your
prolactin level in the normal range and avoid the synergistically biological effects of the
prolactin on the estrogen or/and DHT receptors.
You will get another benefit from sex and orgasm if you get a resulted
elevation of both GABA and glutathione which are converted from excitototoxicity
glutamate. GABA is synthesized from glutamate
using the enzyme
L-glutamic
acid decarboxylase and pyridoxal
phosphate as a cofactor,
and glutathione from the amino acids L-cysteine,
L-glutamate and glycine
in two adenosine
triphosphate-dependent steps: by combining L-glutamate and
cysteine via the enzyme gamma-glutamylcysteine
synthetase to form gamma-glutamylcysteine, and then adding glycine to gamma-glutamylcysteine
via the enzyme glutathione
synthetase to produce glutathione. Elevation of GABA with serotonin,
norepinephrine and prolactin after sex or orgasm will trigger the pineal gland
and retina to release melatonin for better sleeping, hGH production, nervous
regrowth, neuro-endocrine restoration, cellular repair, and shaper vision;
Elevating of glutathione can reduce the formation of oxidative toxins,
such as Hydrogen peroxide (H2O2), associated
with oxidative injury and cellular/nervous damage. However, if you lack of
these liver enzymes ( L-glutamic
acid decarboxylase, pyridoxal
phosphate , gamma-glutamylcysteine
synthetase and glutathione
synthetase) and amino acids L-cysteine
and glycine,
you will get excitotoxicity and brain/nervous damage from your orgasm sponsoring
neurotransmitters glutamate, dopamine, norepinephrine, epinephrine and histamine
which stimulate the gene over-expression of monoamine oxidase in your brain,
liver, kidneys, adrenal glands, heart and other organs for premature ageing,
brain and nervous damage, and sexual exhaustion symptoms (as listed in http://www.actionlove.com/cases/case9848.htm).
Sexual arousal, ejaculation or orgasm
induces a burst of norepinephrine and epinephrine release. For a health
person, the norepinephrine and epinephrine release is supposed to stop in few
minutes after sex and drops in maintaining the homeostasis. Overall, the norepinephrine and
epinephrine level will stay higher for few hours. Norepinephrine and
epinephrine can trigger both proinflammatory and anti-inflammatory cytokines and
kinases in the immune system via the stimulation of the alpha- and beta-adrenergic receptors. Moderate increase in norepinephrne and
epinephrine during and fater sex results in increase in the concentration of
lymphocytes in the bloodstream for immune enhancemen; t and the
anti-inflammatory cytokins overpowers the side effects produced by
proinflammatory cyrockins. That is why optimal sex, like moderate
exercises, can improve your health and neuroimmune function. However, excessive norepinephrine induces more
proinflammatory effects than anti-inflammatory ones, leading to excessive
prostaglandin E2 production to set your brain and body on fire - over-heating,
immune disorder and inflammatory responses. This is what you have to concern
about.
Brain-Skin/Brain-Hair connection - the effect of excessive sex-induced
stress on skin (acne) and hair (hair loss) !
My case collection since 1997 is given in
http://www.actionlove.com/extra/acne.htm
and
http://www.actionlove.com/extra/hailoss.htm
My intention is to have a statistical data (cases) to support the
traditional Taoism's and Chinese Medical claims about the side effects of
over-sex on the acne outbreak and hair loss. In the past, there have been a lot
of disputes on this issue (for example, please read http://answers.yahoo.com/search/search_result;_ylt=AlClvcr4x7agkfBvF65HS6Hpy6IX;_ylv=3?p=over+masturbation
). Luckily, I also have found the
scientific research support on these claims. Scientifically, it is called the
skin's and hair-follicle's hypothalamus-pituitary-adrenal axis or the skin/hair stress
response axis - the response of the body to acute and chronic stress induced by
temporarily or chronic over-sex activities. Under acute or chronic stress,
neurohormones, neurotransmitters, neuropeptides and neurotrophins
will stimulate a series of adaptation responses, leading to behavioral, cardiovascular, metabolic, endocrine and immunological changes.
The most critical one is the immunological changes ranging from immune
suppression to imflammation. Acne, skin allergy, and hair loss can be
considered as a result of inflammatory diseases. In fact, psychological
stress causes more inflammatory and autoimmune diseases than what you think. I
have termed the resuted diseases as
the
Sexual Exhaustion Symptoms if they are directly or indirectly induced by
sex-induced stress - chronic or acute! If you still don't understand why excessive stress induces acne and hair
loss, you should read the following links-
http://edrv.endojournals.org/cgi/reprint/21/5/457 ,
http://www.fasebj.org/cgi/reprint/04-1968fjev1,
http://edrv.endojournals.org/cgi/reprint/21/5/457,
http://www.psychosomaticmedicine.org/cgi/reprint/63/3/412,
http://www.tufts.edu/sackler/pharmacology/faculty/theoharides/documents/TiI-brain-skin.pdf,
http://edrv.endojournals.org/cgi/reprint/22/4/502,
http://www.fasebj.org/cgi/reprint/19/10/1332,
http://ajp.amjpathol.org/cgi/reprint/165/1/259,
http://www.nature.com/jid/journal/v122/n1/pdf/5602146a.pdf,
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1868107&blobtype=pdf
and http://www.nature.com/jid/journal/v117/n2/pdf/5601158a.pdf
Excessive sex,
drug/alcohol abuse, work overloads, Over-eating
(high-protein overdosing and high-tyramine foods), excessive caffeine intake, and
excessive exercises can induce excessive stress hormone production for hair
loss (actually, stopping hair regrowth after losing hair) and acne outbreak - the sympathetic nervous fires in your skin and hair
follicles. Sleeping disorders indicate excessive stress with insufficient
serotonin and GABA nervous modulation on the pineal and retinal function.
Your acne and hair loss can also be associated with sleeping disorders.
Sex-Stress
induced Inflammatory Pains (including your joints, muscles, brain, eyes,
ears and internal organs), Headaches and Hangover - Sexually norepinephrine-induced inflammatory hormone prostaglandin E2 release
for brain-overheating (fever, headaches, migraine and body pains), and
sexually epinephrine-induced hyperalgesia with a lack of parasympathetic/vagal/serotonin/GABA/endorphin
nervous modulation.
Sexual thought, arousal, activities or orgasm trigger the dopamine-norepinephrine/epinephrine conversion in the hypothalamus and adrenal medulla, and most of normal situations, maybe also induce the prolactin release from the pituitary.
http://joe.endocrinology-journals.org/cgi/reprint/177/1/57.pdf
http://journals.endocrinology.org/joe/177/joe1770057.htm
http://www.ncbi.nlm.nih.gov/pubmed/11760788?dopt=Abstract
http://www.psychosomaticmedicine.org/cgi/reprint/61/3/280
http://www.uni-essen.de/forensik/assets/applets/EJN_Paper_-_Kr%FCger_Schiffer_et_al_-_2006.pdf
http://www.psychosomaticmedicine.org/cgi/reprint/61/3/280.pdf
http://www.nature.com/ijir/journal/v14/n2/pdf/3900823a.pdf
http://pharmrev.aspetjournals.org/cgi/reprint/52/4/595
Norepinephrine is the neurohormonal fuel that triggers the neuro-immune
reaction for the generation of pyrogenic cytokins and protein kinase for
pro-inflammation and anti-inflammatory responses, where cytokines, acting as Immunotransmitters,
are small proteins secreted in response to an immune stimulus to mediate and regulate immunity, inflammation,
and hematopoiesis. The initially acute
release of norepinephrine induced by sexual arousal is pro-inflammatory to bring
you in the "heat" or "sexual rush" state with a surge of
prostaglandin E2 production in the brain, adrenal, testicles (or ovaries),
prostate, uterus, G-spot (vagina) penis and clitoris for sexual desire and
erectile function. This is how the sexual desire is initiated from the
brain down to the sex organs. Prostaglandin E2 elevates the temperature of
these organs and dilate the arteries to pump the blood into these organs and
help you get ready for mating if your cortisol and prolactin level won't rise
high enough to cause the arterial constriction. At the same time,
norepinephrine, in conjunction
with the acetylcholine, parasympathetic, serotonin, GABA, and endorphrin nervous
modulation, also triggers the anti-inflammatory process to balance the
excitatory effects induced by the inflammatory hormone prostaglandin E2.
For the normal neuro-immune and hypothalamus-pituitary-adrenal function
function, the anti-inflammatory process also promote the release of
prostaglandins E1/E3, endorphrin, and alpa-MSH in the brain, heart, liver,
adrenal glands, testicles, ovaries, prostate, uterus, vagina, seminal
vesicles, penis and skin to overcome the excitatory effects. The effect of
prostaglandin E2 on the brain, adrenal glands, testicles, ovaries, penis and
clitoris will be mediated by the follow-up prostaglandin E1/E3, oxytocin, Nitric
Oxide, DHEA, androstenedione, testosterone and DHT release for a
healthy persons when the dopamine-hypothalamus-pituitary-adrenal and
-testicular/ovarian axis is stimulated by prostaglandin E2 and when the cortisol
level slightly decreases or remains constant (that is, production =
consumption during sex); under this condition, the prostaglandin E2 release doesn't
trigger inflammatory pains and disorders yet, but induces sexual arousal and
orgasmic responses since the anti-inflammatory process is working properly. However, in the exhausted hypothalamus-pituitary-adrenal function,
the pituitary will release prolactin and the adrenal cortex will shoot up
cortisol to shut down sexual desire and erectile function immediately to protect
the neuro-immune system. If the neuro-immune system fails to exert an anti-inflammatory action, the adrenal cortisol release
mechanism will go wild; then the inflammatory alarm goes off, resulting in
body pains, cramps, headaches, migraine, hangeover,
premature orgasm/ejaculation, precum (or excessive wetness) in response to
sexual thought, sexual
stimulation, arousal, and orgasm, or in the post-orgasm state for several hours
or days.
Ok. let's consider how sexual thought/fantasy, romantic novels and movies, pornography, and visual,
auditory or physical stimulation heat up our brain and sexual organs and shorten
our orgasm responses (premature ejaculation for men too!). Sexual stimulation, arousal or orgasm
ignites the dopamine-norepinephrine conversion in the hypothalamus
and adrenal
medulla,
and, then, activates the norepinephrine (NE)
neurons of the locus coeruleus
(LC); the neural signals are relayed
to the preoptic area
(POA) of the hypothalamus via the ventral norepinephrine
noradrenergic bundle, where noepinephrine is released; then,
norepinephrine stimulates the synthesis of prostaglandin E2 in local
neurons and/or astrocytes, by activating a group of proinflammatory cytokines such as
IL-1 , IL-1ß,
IL-6, TNF- ,
IFN- , and
MIP-1
in the the immune system. These cytokines, acting as the endogenous pyrogen of
desire fires, turn on the brain by the following steps:
(1) performing active transport of cytokines into the brain,
(2) generating a blood cytokines-to-brain signal transduction at the circumventricular organs
which have an incomplete blood-brain
barrier and where neurons can directly sense and utilize various compounds
such as neurohormones, hormones, neuropetides, cytokines and
protein
kinase,
(3) producing the brain-permeable paracrine substance prostaglandin
E2 at endothelial cells in the cerebral
microvessels and
(4) stimulating somatic and visceral (including vagal) afferent nerves.
Ref: http://www.jbc.org/cgi/reprint/272/41/25693
http://jp.physoc.org/cgi/content/abstract/443/1/421?ck=nck
http://www.psychosomaticmedicine.org/cgi/content/abstract/63/3/476
http://jn.physiology.org/cgi/reprint/93/2/929?ijkey=a9024b9ce74ad6d9ccd2311f9f39ee084760b417
http://www.csbmb.princeton.edu/ncc/PDFs/Locus%20Coeruleus/Aston-Jones%20&%20Cohen%20(ARN%2005).pdf
and http://physrev.physiology.org/cgi/reprint/63/3/844?ijkey=f678964b1c98ed1891648bba0c8432d5f2385bc3&keytype2=tf_ipsecsha
That is, the cytokine-to-brain communication can result in alterations of brain function
and behavior. Finally, a combining action of prostaglandin E2 and dopamine-induced oxytocin release
turns on
sexual arousal/heat and orgasmic responses. In fact, prostaglandin E2
amplifies or enhance the excitatory postsynaptic potentials (EPSPs)
of neurons and synapses in all the nervous systems. It can be considered
as an initiator of sexual responses, which neurochemically initiates the
nervous transduction and communication between the brain and sex organs.
However, when excessive prostaglandin E2
over-stimulates the hypothalamus, it produces centrally-mediated "illness"
responses such as headaches, migraine, brain overheating, fever, hot flushes,
sweating, brain-stem inflammatory pains, eye inflammatory pain, blurry
vision, eye over-light sensitivity to light, sinus, flu-like symptoms, ear
ringing and inflammatory pressure, regardless of the dopamine level.
Example: Excessive norepinephrine and its induced prostaglandin E2
production in the hypothalamic locus coeruleus (LC) and preoptic area (POA) elevate the core temperature for excessive sweating during sex.
http://www.actionlove.com/cases/case15878.htm
At the same time, the adrenal medulla also release norepinephrine and epinephrine into the
bloodstream in response to sexual stimulation and orgasm. Norepinephrine reach all the alpha and beta adrenergic receptors everywhere in the body, where the
local tissues, under the norepinephrine stimulation, release postaglandin E2 into the bloodstream
or for exciting the local sensory nerves. When a local
tissue won't produce enough prostaglandin E1 and endorphin or have a weak serotonin and
GABA nervous modulation and control on the nervous
stimulation by prostaglandin E2, the local nerves will be inflammatory with
tingling, pains, cramps, allergy, or other nervous reaction symptoms,
such as frequent
urination, incontinence, peeing urgency without a full bladder, and premature
ejaculation. Similarly, sex organ under the norepinephrine action on
sympathetic nervous beta-and alpha-andrenergic receptors can release excessive
prostaglandin E2 release too. Please note: the binding of norepinephrine
in the alpha-adrenergic receptors will give your erectile dysfunction or let
your penis or clitoris and G-spot go limp while the excessive norepinephrine-induced
prostaglandin E2 produces premature orgasm, premature ejaculation, precum
or semen leakage, excessive vaginal wetness, inflammatory headaches or
migraines, inflammation-induced vision and hearing disorders (inflammatory
eyeballs and inner ears), and pains in your
sex organs, stomach, neck, joints or/and muscles. (special
ref: http://www.iovs.org/cgi/reprint/22/6/757
for the inflammatory iris-ciliary body of eyes, and http://www.iovs.org/cgi/reprint/15/2/102
)
Mechanical stimulation on sex organs (actually, any skin tissues) can also
trigger the cutaneous neuro-immino-endocrine function and induce norpeinephrine
and prostaglandin E2 release from the local cells without the central
hypothalamus-adrenal action, so that the stimulation signal can be amplified as
EPSPs and then coupled into the postsynaptic neurons for the sensory relay to
the brain and central nervous system. Once stimulation signal reaches the
brain, it can turn on the central neuro-immno-endocrine action from the
hypothalamus-pituitary-adrenal and -testicular axis.
It should be noted that sexual arousal and orgasm requires testosterone and
dopamine to sensitize the LC and POA nervous sensitivity, to promote the
dopamine-norepinephrine conversion for induction of the sympathetic nervous
fires and prostaglandin E2 release, and to stimulate the oxytocin release from
the pituitary. Testosterone is the fuel of sex, dopamine is the lighter,
and norepinephrine is the fire. However, we can not ignore the effect of the
5-alpha testosterone metabolite, DHT, on sexual function. Blocking
testosterone-DHT conversion will also reduce courtiship, sex organ erectile
function and size, and male semen production and quality. DHT acts to increase
survival of penile musculature followed by survival of spinal nucleus of the
bulbocavernosus (SNB), whose motoneurons innervate perineal muscles involved in
copulatory reflexes. In the adult, DHT also affects the morphology of SNB
neurons, the growth of cell bodies and dendrities, and the
penile/clitoral/G-spot size during erection when binding of DHT into its
receptors. The motoneurons innervate the bulbocavernosus (BC) and levator ani (LA),
in striated skeletal muscles that attach to the base of the penis (and maybe,
clitoris too.) The motoneurons also innervate the external anal sphincter
for both sexes. Deficiency of DHT will induce inflammatory pains, with
prostaglamndin E2 release, in the pelvic
floor (perineum), penis, testicles, vagina, vulva, and anus, and cause Interstitial Cystitis (IC).
Excessive DHT will over-expand the local tissues for pains too.
Ref: https://www.msu.edu/~breedsm/pdf/JCN2004ARinMuscle.pdf,
http://www.ingentaconnect.com/content/bsc/jneur/2007/00000019/00000010/art00010,
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=91005
http://content.karger.com/ProdukteDB/produkte.asp?Doi=48115
http://jcem.endojournals.org/cgi/content/abstract/79/2/409
http://endo.endojournals.org/cgi/reprint/136/4/1495
http://cat.inist.fr/?aModele=afficheN&cpsidt=14669477
http://www.andrologyjournal.org/cgi/reprint/26/2/242.pdf
http://www.mindfully.org/Pesticide/Alligator-Penis-Apopka-Guillette.htm
http://www.reproduction-online.org/cgi/content/full/133/2/331
http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1008-862X.2005.00003.x
http://www.ncbi.nlm.nih.gov/pubmed/11845321?dopt=Abstract
http://humupd.oxfordjournals.org/cgi/content/abstract/7/3/314?ijkey=99f7484e2eaccb186ea17615366f70e2a7798679&keytype2=tf_ipsecsha
http://www.ncbi.nlm.nih.gov/pubmed/2177574?dopt=Abstract
http://www.bch.msu.edu/~zacharet/publications/pdf/Rosen-JNeuroEndo14(1)19-28,2002.pdf,
http://www.medscape.com/medline/abstract/9212065
and http://endo.endojournals.org/cgi/content/full/147/5/2392
Excessive Prostaglandin E2 also suppresses the the neuroimmune and inflame
your internal organs and joints for functional disorders, and let you get
infection, allergy and sinus, and catch cold easily, and experience
arthritis and Chronic Fatigue Immune Deficiency Syndrome (CFIDS.) When your core
temperature rises due to the action of prostaglandin E2 on the brain, you only
feel over-heating and sweating for unknown reasons (even in a cool or cold
condition), but also are very easy to get sick or catch cold. Particularly, you
may become very hot and sweating due to the brain overheating, and then if you
feel chilly after sex, you can be in trouble.
Note that rheumatoid arthritis (RA) is an inflammatory disorder with characterization
of systemic and local inflammation resulting in cartilage and bone
destruction. Prostaglandin E2 can be linked to the edema and the erosion
of cartilage and juxta-articular bone. Reducing the stress-induced
prostaglandin E2 production and increasing the prostaglandin E1 and endorphin
production by improving the hypothalamus-pituitary-adrenal and
-testicular/ovarian function can resolve both the signs and levels
of inflammation. Therefore, reduction excessively sex-induced and other psychological
stress is the way to prevent the decay of the joints. Ref: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=151107&blobtype=pdf
The other problems associated with excessively norepinephrine-induced prostaglandin E2
are ejaculation/orgasm induced sleeping disorder and persistent sexual
arousal. It is like your
body on fire. The persistent sexual arousal and orgasm/ejaculation urgency
are due to excessive prostaglandin E2 stimulation on the seminal
vesicles, prostate, bulbourethral glands, penis, kidneys and bladder for
men, and the uterus, G-spot, vagina and clitoris for women.
This means the norepinephrine-induced prostaglandin E2 over-excited
your pineal gland and retinal and cut down your melatonin production,
inflamed your eye balls and sex organs, and over-dilated your eye pupils,
prostate, penis, G-spot and clitoris.
It is also found out-of-bounded hormones, such as DHEA (that may produce a
high level of testosterone, although an extremely high DHEA won't directly
cause inflammatory responses, according to this report- http://jcem.endojournals.org/cgi/reprint/83/6/2012.pdf
), testosterone, DHT,
LH, FSH, estrogen, and progesterone will also induce prostaglandin E2
production. The menopause symptoms, hot flushes, overheated brain and
spine, body pains, sweating, insomnia, are the typical examples. This is a
result of excessive LH-induced prostaglandin E2 release. It can happen to young men
and women who have excessive sex or the exhausted
hypothalamus-pituitary-adrenal/-testicular(-ovarian) function although it is
common for middle-age men and women, even without having sex. The
overshooting of the pituitary LH hormone responds to deficiency of testosterone (and
DHT) and estrogen/progesterone, for men and women,
respectively, several hours or days after sex, when the serotonin and GABA nervous modulation are too weak.
After ejaculation or orgasm, norepinephrine and its induced prostaglandin E2
remain very high in keeping your brain and sex organs in heat, while the
orgasm-induced cortisol and prolactin release will continue for several
hours or days and will become high enough to block the testosterone or estrogen/progesterone
production from the testicles and ovaries, respectively. In this case, the
pituitary gland will continue to fire up LH in an attempt to increase
testosterone and estrogen production to cool down the negative
dopamine-hypothalamus-pituitary-testicular/ovarian hormonal control loop.
Excessive LH release, in turn, elevates the prostaglandin E2 in the brain
and spinal fluid for hot flashes and core temperature rise- the menopause
symptoms for men and women. This results in sleep disorders, sweating,
pains, losing memory or concentration, even headaches or hangover. In this
regard, you will need ViaPal-hGH-M or ViaPa-hGH-E to turn off the negative
dopamine-hypothalamus-pituitary-testicular/ovarian hormonal control loop for a
good sleep.
Although norepinephrine is the main contributor to both inflammatory and
neuropathic pains. These pain states can be sensitized with increase
in the norepinephrine-epinephrine conversion in the adrenal medulla and
the sympathetic nervous neuromuscular endings via the stimulation of epinephrine
on the adrenergic beta receptors. Sexual arousal and orgasm/ejaculation
ultimately elevate the plasma concentrations of epinephrine as a final stage of
the catecholamines metabolism from dopamine. With oxytocin and
prostaglandin E2 stimulation, epinephrine produces a -adrenergic
receptor-mediated mechanical hyperalgesia for a swelling,
hypersensitive penis, clitoris and G-spot upon orgasm or ejaculation. The sex
organs can become too sensitive to touch or couple minutes after orgasm or
ejaculation. At some extreme
swellings cases, orgasm-induce excessive norepinephrine-epinephrine
conversion result in shooting pain in the brain, stomach, low back, low abdomen,
tailbone, testicles, prostate, uterus, penis, and vagina. In some cases,
the brain arteries are inflamed and restricted so much that the brain
blood flow is nearly cut off, resulting in blackout or seizure orgasm
responses or little death.
Researches have found that epinephrine induces cutaneous
mechanical hyperalgesia and sensitizes the dorsal root ganglion neurons via its
action at a -adrenergic
receptor and the effects of epinephrine are enhanced by both the
inflammatory protein kinases A and C second-messenger pathways.
Ref: http://jn.physiology.org/cgi/content/full/81/3/1104
Researches also found that epinephrine contributes to the mechanism of the
sensitizing effect of ethanol on the liver and the initiation and
progression of alcoholic liver disease. http://intl-ajpgi.physiology.org/cgi/content/abstract/00050.2008v1 .
Actually, alcohol can promote norepinephrine and epinephrine synthesis.
Prostaglandin E2 plays a key role in mediating liver inflammation and damage - http://ajpgi.physiology.org/cgi/content/full/275/4/G605
Therefore, drunk sex is very destructive to the liver and brain.People
with a sexually exhausted or genetically weak
hypothalamus-pituitary-adrenal axis, the hypothalamus and adrenal glands
constantly produces excessive dopamine-norepinephrine-epinephrine conversion and
keep a high prostaglandin E2 level in the local tissues and bloodstream. With a
high level of prostaglandin E2 in the brain and pelvic and sex organs, the
person, man or woman, will experience persistent sexual arousal, swelling
sex organs, and male pre-ejaculation fluid leakage or vaginal excessive wetness.
Besides psychological stresses, mechanical or heat stimulation on the skin can activate
the skin's neuroimmunoendocrine circuitry for release of prostaglandin E2 and
histamine. Prostaglandin E2 sensitizes local nerves, stimulates the
hypothalamus-pituitary-adrenal and -testicular (ovarian) axis, induces more
norepinephrine and epinephrine release, and alternates behaviors and brain
chemistry. Excessive dopamine-norepinephrine-epinephrine conversion can result
in deficiency of dopamine and oxytocin, but excess of cortisol and
prolactin in the bloodstream, leading to sexual exhaustion systems or delay of
post-ejaculation or post-orgasm recovery. However, for whose dopamine
level remains sufficient, they are likely to experience persistently
sexual arousal with sexual exhaustion symptoms. If there is a high level of androgen hormones, histamine and oxytocin to orchestrate
the stimulation of prostaglandin E2 on the brain and sympathetic nervous system,
the patient will suffer from constant orgasm or ejaculation urgency or persistent
sexual orgasm syndromes. Mechanical stimulation of sex organs by excessive
over-masturbation or rough sex (including vibrator abuse) results in
the skin's neuroimmunoendocrine responses, promotes the
hypothalamus-pituitary-adrenal's norepinephrine and epinpehrine release, and ignites the release
proinflammatory cytokines and other
mediators (enzymes and kinases) to signal the brain, and alternates behavior and
body reactions and responses.
Finally, Prostaglandin E2 is important in maintaining tumor and cancer integrity and growth, it prevent the timorous
or cancerous cells from committing
suicide, and Its mediated modulation of [Ca2+]
and the proliferative effects may be involved in tumorigenesis. http://cancerres.aacrjournals.org/cgi/content/full/62/2/403
Persistently Sexual Arousal (breeding)
or Over-ejaculation (Frequent Orgasm) Reducing/Suppressing Male Immune Function via Norepinephrine Induced Prostaglandin E2
Release: Ref - http://www.actionlove.com/extra/psas.htm
and http://www.actionlove.com/extra/over.htm
The effect of sex hormones on neuro-immune function is a very controversial topics. First, in the last few decades,
epicdemiological, clinical and laboratory data have suggested women generally have a higher serum immunoglobulin level and
stronger antibody response to infection or vaccination than do males. This
misleads a conclusion that testosterone is the main cause of male immune
disorders and an increase in testosterone will decrease male neuro-immune
function. In castrated animal models, it is shown the sex steroid hormones
enhance immunity in both male and female animals by rebalancing sex hormones
with injection. In fact, studies on hypertension show that testosterone
enhance renal norepinephrine release in animals with the chromosome
raising renal norepinephrine and release. This can explain what men hace a
greater incidence of hypertension than women, as given in
http://hyper.ahajournals.org/cgi/reprint/32/5/880 .
Thus, a high dose of testosterone replacement therapy or testosterone
injection can result in anxiety, stress and shot temper, or even irregular
cardiovascular output. The research result can also explain why testosterone is the fuel of sex
heat and norepinephrine is the fire for everything. Testosterone tends to
elevate the dopamine level and promote dopamine-norepinephrine conversion for
excessive norepinephrine to
activate the pro-inflammatory cytokines for COX-2 expression and prostaglandin E2
production during breeding or reproductive state where the oxytocin level is
high. This makes testosterone become a bad boy as a strong immunosuppressant.
However, bird breeding studies show that in the breeding state males have a lower immune
responses than both molting and nonbreeding birds, after a immune challenger
mitogen phystohmagglutinin(PHA) is injected into the patagium for swelling the wing web. Testosterone implant with PHA injection for nonbreading birds shows
there is a slight higher swelling (about 2% higher) in 24 hours, but after 30
hours, testosterone-implanted birds have much less swelling responses (about 30%
less) as shown in http://www.princeton.edu/~hau/ReprintLinks/Greenman%20et%20al%202005.pdf
(A medical castration study about the effect of testosterone in
http://ajpendo.physiology.org/cgi/reprint/290/5/E856
shows the similar result. Personally, I consider the testosterone replacement is likely to increase DHEA and DHT in the immune cells
due to the fact that the brain, adrenal glands and other tissues (including skin) metabolize DHEA to testosterone and then
DHT. Testosterone replacement is likely to reduce DHEA-testosterone
conversion and to increase testosterone-DHT conversion, leading to elevation of
DHEA and DHT as well. Both DHEA and DHT are anti-inflammatory in nature as
given in the following discussion if they are within their normal ranges.
Chemically or mechanically castrated animals or men likely have a lower DHEA
level and out-of-bounded low testosterone and DHT due to the null
testicular function. )
The bird study also suggests the transient testosterone burst will induce some
degrees of proinflammatory responses to immune challenger, but the immune
adaptive responses and anti-inflammatory cytokines release seems to in favor of
testosterone increase if there is no sexual arousal or excessive norepinephrine release.
Please note that the testosterone implant in that study is to bring the male
testosterone level back to the normal level after castrating. This may imply
testosterone can be proinflammatory and anti-inflammatory, depending on the
stress hormone level. A high level of norepinephrine and testosterone makes people become very aggressive and anxious (Ref:
http://cat.inist.fr/?aModele=afficheN&cpsidt=2480820).
Another study on castrated rats shows castration
significantly drop blood pressures but testosterone replacement restore the
blood pressure back - http://www.informaworld.com/smpp/content?content=10.3109/10641969409067965
Castration can increase norepinephrine release via stimulation of excessive pituitary LH release induced testosterone (or estrogen) deficiency
, similar to the responses of hypothalamus and adrenal function to andropause or menopause.
However, testosterone replacement on castrated rats do increase the
norepinephrine release by increase in dopamine-beta-hydroxylase activity for
dopamine-norepinephrine conversion. It also happens in rat vas deferens under androgenic control,
as shown in http://www.biolreprod.org/cgi/content/abstract/40/3/541
Endocrine feedback of testosterone in regulation of the hypothalamus-pituitary-testicular axis is via the effects of
testosterone on the noradrenergic (norepinephrine) system where the dopamine-norepinephrine conversion occurs in the brain.
One cellular culture study suggests that "DHT acts as an antiinflammatory agent and depresses
both nitric oxide and TNF-alpha production in a dose-dependent fashion, but testosterone treatment of microglia and peritoneal
macrophages increased supernatant nitrite levels, indicative
of a proinflammatory effect, as given in
http://endo.endojournals.org/cgi/content/short/148/7/3383
The similar arguments are given in
http://ajpcell.physiology.org/cgi/reprint/277/1/C35
, http://ajpcell.physiology.org/cgi/content/abstract/274/6/C1530
http://archsurg.ama-assn.org/cgi/reprint/139/2/157.pdf
, and http://jap.physiology.org/cgi/content/full/95/1/104
DHT therapy has been patented for treating prostate cancer in http://www.freepatentsonline.com/5648350.html.
Therefore, DHT is not a bad guy at all in term of immune responses, unless you have too much
DHT and too stress hormone norepinephrine together.
Please also note that in the Trauma or Hemorrhage state, the stress hormones norepinephrine and
epinephrine level are very high.
It is the stress hormones or testosterone, or both weakening the immune. Based upon the bird study, it seems testosterone enhanced stress-induced immune disorders.
Another study suggest that only constantly elevated DHT could decrease the cell immune
response but not at significantly. But, in realty, the androgenic metabolism
remains altered in the presence of exogenous androgens unless your tissues trap
a high level of DHT due to blood vessel constriction (poor blood circulation)
induced by the binding of stress hormones norepinephrine and epinephrine in the
alpha-adrenergic receptors. Therefore, we can not fully blame DHT for prostate
cancers and hair loss at all. In fact, "ecrease in DHT can cause autoimmune disorder
while "a DHT increase could protect the gland from immune aggression and/or its consequences in regard to
prostatic androgenic metabolism, as described in
Ref: http://linkinghub.elsevier.com/retrieve/pii/S0022534705628923
As for autoimmune, DHT seems a good guy -
http://www.jem.org/cgi/reprint/175/5/1409.pdf
These results suggest testosterone is a double-edge sword. You need it for DHT production but can not store too much.
On the other hand, DHEA always seems a good guy for the immune function.
DHEA significantly inhibits IL-6 secretion at serum concentrations of 5x10-9mol/L (or 1.4 ng/ml) to
5x10-8 (or 14 ng/ml), as described in
http://jcem.endojournals.org/cgi/reprint/83/6/2012.pdf,
which also shows a higher DHEA is harmless, and http://biomed.gerontologyjournals.org/cgi/content/abstract/52/1/M1
Castrated men or animals have fully relied on DHEA for their immune function. It can even help HIV patients to improve immunity.
http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102192754.html
DHEA can help overcame the age-related defect in the immunity of old mice against influenza.
http://cat.inist.fr/?aModele=afficheN&cpsidt=3022765
In following article, DHEA is portraited as pro-immune and antiageing, but cortisol is negatively (we know cortisol can
increase the stress hormones norepinephrine and epinephrine release!)
http://www.ingentaconnect.com/content/nrc/apnm/2008/00000033/00000003/art00001
and http://jp.physoc.org/cgi/content/abstract/557/1/307
For immune enhancement use, please this patent - http://www.freepatentsonline.com/5407684.html
In conclusion, you need an optimal range of androgen hormones to balance your pro-inflammatory and anti-inflammatory immune function responses.
In particular, the pro-inflammatory effects of testosterone (during sexual
arousal or breeding) should be balanced
by the anti-inflammatory effects of DHEA and testosterone, while the dopamine-norepinephrine
conversion in the hypothalamus and adrenal medulla should be properly modulated
by the serotonin and GABA nervous function and the liver enzyme dopamine beta-hydroxylase
with Vitamin C in order to avoid excessively- norepinephrine-induced persistent
sexual arousal and inflammatory responses.
Liver/organs
malfunction and inflammation
and Hypothalamus-Pituitary-Adrenal impairement induced by sex stress with chronic elevation
of immunotransmitter cytokines and inflammatory hormone prostaglandin E2:
Prostaglandin E2 promotes inflammation and scarring (organ fibrogenesis, or
tissue reconnection/growth (good for bad/ injured tissues) or inflammatory
enlargement (bad for good tissues)!).
http://pharmrev.aspetjournals.org/cgi/content/full/56/3/387#E._Immune_System
Cytokines are the immunotransmitters that regulates homeostatic nueroimmune
responses among multiple tissues. One role of cytokines is to modulate
inflammatory responses to anti-inflammatory healing cascades for the first line
of body defense. For people with a history of sexual exhaustion and drug
abuse, they seems to lose their healing power and have a weak nueorimmune
function with persistent inflammatory responses. The natural neuroimmune
generators from the acetylcholine/parasympathetic (vagal) nervous system and the
liver system can no longer support anti-inflammatory efforts, the vagal,
serotonin, and GABA nervous system and the liver system are too weak to
control the adrenal norepinephrine and epinephrine release. Instead, the liver
system dumps excessive dopamine beta-hydroxyalse to fuel the dopamine-norepeinphrine
conversion, but fails to supply the enzymes that help the synthesis of androgen
hormones and neurotransmitters, such as DHEA, DHT, serotonin, GABA,
endorphrin, alpha-MSH, glycine and agmatine, and optimization of testosterone,
to mediate proinflammatory responses. Therefore, we have to specially consider
the effects of prostaglandin E2 on the liver, visceral organs and brain.
Studies have demonstrated that norepinephrine induces calcium spikes for
portal hypertension, promotes liver stress, and activate its contraction proinflammatory
effects in the human hepatic stellate cells via the action of immflammatory cytokines RANETes and Interleukin-8
on the alpha1-andrenergic receptors, as described in
http://ajpgi.physiology.org/cgi/reprint/00537.2005v1.pdf
http://gut.bmj.com/cgi/content/abstract/50/4/571
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=546435&blobtype=pdf
http://jpet.aspetjournals.org/cgi/content/abstract/244/1/283
http://archsurg.ama-assn.org/cgi/content/full/140/8/801
http://ajpgi.physiology.org/cgi/content/full/290/1/G66
http://jpet.aspetjournals.org/cgi/reprint/jpet.107.121277v1.pdf
http://ajpregu.physiology.org/cgi/content/full/290/5/R1262
http://www.ncbi.nlm.nih.gov/pubmed/12901866?dopt=Abstract
In the liver, both norepinephrine and its induced prostaglandin E2 work
together to heighten the effects of calcium on the body bioelectric wave
functions such as nerve stimulation, hormonal regulation of liver
metabolism, or bile secretion, in both normal and pathogenic
conditions. The proimflammatory effect also induces proliferation and collagen gene expression
for liver hardening - hepatic fibrogensis. Actually, norepinephrine promote
inflammation in any tissues, and then, inflammation induces collagen release to harden
the local tissues. This is a bad news for the heart
and arteries, in addition to the direct induction of hypertension by the
norepinephrine-driven sympathetic nervous action on the cardiosvacular function.
The arteries inflammation and hardening can result in clogging the coronary
artery even if you have a good cholesterol makeup. It is medically termed as
coronary atherosclerosis. It is the major cause of heart attack. That is,
excessive sex-induced stress can cause heart attack. Scarring or hardening of
heart smooth muscles will let you heart over-work, but still cannot pump enough
blood flow to your brain and penis (or clitoris and G-spot). More references? please read
http://hyper.ahajournals.org/cgi/content/abstract/40/2/148
http://cardiovascres.oxfordjournals.org/cgi/content/full/55/2/329
and http://ajpheart.physiology.org/cgi/content/full/279/3/H1147
No wonder, it can give you poor blood circulation, dizziness, vertigo, headache, heart attack, and
strokes too.
When any tissues release excessive Inflammatory hormone prostaglandin E2 into the
bloodstream due to psychological or physical stresses,
internal organs will be on fire and damaged. The liver is not exceptional. Here is
one of examples, for the side effect of urinary retention on the liver -
http://ajprenal.physiology.org/cgi/content/full/288/5/F1005 .
Similar to urinary retention, semen retention, sperm retention
(due to vasectomy), or egg retention (tubaligation) can induce excessive
prostaglandin E2 production in the sex organs and elevate prostaglandin E2 into the
bloodstream for liver damage, sex organ pains, abdominal/pelvic pains, muscular
and joints pains, headaches and other psychological and physical disorders
- http://www.actionlove.com/extra/vascectomy.htm
http://www.actionlove.com/extra/tubaligation.htm
http://www.actionlove.com/cases/case13176.htm
Sex can induce prostaglandin E2 in two ways - by the internal neuro-immune-endocrine
stress responses and by the mechanical sex-organ stimulation, erection, and contraction
stress ( the engineering material stress). Masturbation or foreplay (vibrator, dildo, hand or oral stimulation) can
directly induced the local skin or tissue to release prostaglandin E2 to heat up
the brain, nervous systems, internal organs and local tissues/nerves and to
induce sexual arousal and orgasm. Prostaglandin E2, in turn, stimulate the
hypothalamus and adrenal glands for the norepinephrine release. On the other
hand, as we discussed before, sex-or drug- induced stressors norepinephrine and
epinephrine release, mediated by the hypothalamus-pituitary-adrenal axis, triggers the neuro-immune
reaction for the generation of pyrogenic cytokins and protein kinase for
pro-inflammation and anti-inflammatory response for excessive prostaglandin E2
release. That is, excessive sexual practice (over-masturbation, over-ejaculation
or/and excessive orgasm) keeps the stressors level in the bloodstream and brain
constantly high , leading to persistent sympathetic nervous Fight and Flight
responses with inflammation in the brain, organs and tissues. The
excessive norpeinephrine-induced prostaglandin E2, resulting from
excessive dopamine-norepinephrine conversion at the depletion of dopamine, also
stimulates the hypothalamus-pituitary-adrenal axis to release excessive cortisol
and prolactin which, in turn, block the adrenal DHEA, pituitary
oxytocin and testicular testosterone release, leading to few-days post-orgasm
physical illness and psychological disorders.
Excessive norepinephrine or/and epinephrine also kills cells and neurons, as mentioned before, and their induced persistent inflammation
stimulates collagen release in the damaged tissues for scarring and hardening
the internal organs such as the liver, heart, lungs, pancreases, blood vessels,
adrenal glands, kidneys, and sex organs (of course, you worry about the ovaries,
testicles, prostate, penis, G-spot and clitoris). This is what persistent
inflammation is so destructive. For example, inflammation and scarring of blood
vessels causes poor blood circulation (arterial and venous blockage) and
reduces the blood flow to the brain, any organs, joints, muscles, feet and toes.
Inflammation of the hypothalamus-pituitary-adrenal/-testicular axis or the liver
results in deficiency of androgen hormones ( DHEA, testosterone, DHT) and
oxytocin. Cool feet or toes, even if your brain is overheating), are the
sign of poor blood circulation or androgen deficiency.
The other liver inflammation factors beside psychological stress are given in
http://gut.bmj.com/cgi/content/full/54/2/303
http://content.nejm.org/cgi/content/extract/343/20/1467
http://jgld.ro/42006/42006_6.pdf
http://care.diabetesjournals.org/cgi/content/full/27/8/2057
http://pubs.niaaa.nih.gov/publications/arh27-4/307-316.pdf
http://www.hepatitis-central.com/hcv/info/2003/aug/hepcinfo413.pdf
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9122234
http://www2.niddk.nih.gov/NR/rdonlyres/7DDAC2D5-9096-4EAF-AC19-DCF781CFE390/0/ldrb_chapter7.pdf
Noticeably, over-eating/over-drinking
and alcohol abuse can be avoided by change of your life style.
Studies show that persistent stimulation of cytokine Interleukin 1beta (IL
1beta) on the hypothalamus-pituitary-adrenal axis results in an overall
inhibitory effect. Ref:
http://www.ncbi.nlm.nih.gov/pubmed/9050749?ordinalpos=40&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_
RVDocSum
http://endo.endojournals.org/cgi/reprint/145/1/104
http://www.ncbi.nlm.nih.gov/pubmed/8903845?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_
DiscoveryPanel.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/11155801?ordinalpos=25&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
An acute over-sex (multiple session of sexual activities, multiple
ejaculation, or multiple orgasms) even in one day, like over-eating,
can be very destructive. It stresses our the hypothalamus-pituitary-adrenal
axis, internal organs and sex organs for a global release of
cytokines. The resulted acute increases in serum cytokines can induce long
lasting increases in brain proinflammatory cytokines, result in persistent
alterations of cytokines, and significantly amplify the magnitude and duration
of central and peripheral proinflammatory cytokines and microglial
activation. This implies that one excessive sex session with
over-ejaculation or multiple orgasms, which causes an acute elevation of
norepinephrine from the adrenal medulla for an acute increase in serum
cytokines, will produce catastrophic damage. of the
hypothalamus-pituitary-adrenal and testicular/ovarian axis, as described
in
http://www.actionlove.com/cases/case15800.htm,
http://www.actionlove.com/cases/case15750.htm,
and more in
http://www.actionlove.com/extra/over.htm
http://www.actionlove.com/extra/over2.htm and
http://actionlove.com/extra/girloversex.htm.
Also, the inflammation
induced differential anti-inflammatory cytokine IL-10 responses in liver and
brain could cause long lasting disruption of cytokine cascades for autoimmune
disorders.
Ref:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18348728
http://www.ncbi.nlm.nih.gov/pubmed/12946286?ordinalpos=10&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
http://www.actabiomedica.it/data/2007/supp_1_2007/hopkins.pdf
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=333413&blobtype=pdf In
summary, norepinephrine and prostaglandin E2 causes nervous plasticity and
remodeling of your hypothalamus and internal organs (particularly, GABA nervous
control on PVN and LC, the liver, heart, lungs, adrenal glands, kidneys
and so on) for chronic physiological and psychological disorders. Even if
you don't have over-sex or other psychological stress , your brain and organ
will be deteriorated with natural ageing. The liver and heart always goes
before any organs or brain in the natural ageing process.
http://ajpregu.physiology.org/cgi/reprint/282/3/R909
http://ajpheart.physiology.org/cgi/content/full/287/5/H1895
http://www.brain.psu.edu/pdf/2006lullen_genes_brain_behav.pdf
A study shows "healthy, natural ageing" significantly increases the
sympathetic nervous system and brain norepinephrine turnover. In a group
of healthy men aged 60-75 years, the norepinephrine turnover in
suprabulbar subcortical brain regions is about 317 ng/min in average, while it
is about 107 ng/min in average for young men aged 20-30 years.
http://ajpregu.physiology.org/cgi/content/full/282/3/R909
http://diabetes.diabetesjournals.org/cgi/content/full/53/2/276
Reducing the norepinpehrine turnover can prevent age-related disease.
http://circ.ahajournals.org/cgi/content/full/circulationaha;91/2/351
http://ajpheart.physiology.org/cgi/content/full/287/5/H1895
http://www.brain.psu.edu/pdf/2006lullen_genes_brain_behav.pdf
For some ideas about "Neuroendocrinology of ageing" - http://ageing.oxfordjournals.org/cgi/reprint/30/4/279.pdf
Serotonin and GABA nervous modulation on the stress response axis - the hypothalamus-pituitary-adrenal
axis for better sex.
1. Serotonin regulates upstream corticotropin-releasing hormone (CRH) signaling systems via activation of serotonin 2C receptors (5-HT2CRs)in the
hypothalamic paraventricular nucleus (PVN).
http://www.jneurosci.org/cgi/content/full/27/26/6956
2. In the hypothalamus, here is a convergence of critical synaptic input including GABA and serotonin on proopiomelanocortin
(POMC)neurons to regulate the output of hypothalamic neurons.
http://molpharm.aspetjournals.org/cgi/content/abstract/72/4/885
Hypoththalamic proopiomelanocortin (POMC) neurons release GABA and respond to opioids
http://www.jneurosci.org/cgi/content/full/24/7/1578
3. Serotonergic nerve fibers and receptors have been found in both the
hypothalamic supraoptic nucleus (SON) and the paraventricular nucleus (PVN), where they play key role in regulating the release of adrenal and neurohypophysical hormones
(Sawchenko et al. 1983, Chaouloff 2000, Kang et al. 2004).
Accordingly, serotonin may play as a mediator/control of hormone secretion.
http://joe.endocrinology-journals.org/cgi/content/full/190/3/581
4. GABAergic and serotoninergic systems regulate gonadotrophin secretion and modify hypothalamic concentration of dopamine, norpeinpehrine and
epinpehrine.
5. Serotonin is very concentarted in hypothalamus and the raphe nuclei
in the mid-brain, and its neurons project in a diffuse way form raphe
nuclei to the cerebral cortex, hippocampus, limbic system, and hypothalamus as
well as down the spinal cord. But, the cortex and cerebellum contain low
concentrations. Serotoninergic nervous systems reduces the release of
norepinephrine from sympathetic nerves, by acting on 5HT1 receptors on the nerve terminals
in the adrenal medulla.
6. Serotonin inhibits offensive aggression
facilitated by the arginine vasopressin (AVP) system in the anterior
hypothalamic region. http://www.jneurosci.org/cgi/content/full/17/11/4331
. Chronic inhibition of GABA synthesis and consequently enhanced
glutamatergic excitation in the dorsomedial hypothalamus(DMH)
produce panic attack -
http://www.jneurosci.org/cgi/content/full/26/26/7093
.
7. Serotonin and GABA, in conjunction with dopamine, acetylcholine,
norepinephrine, melatonin and insulin, regulates the pituitary LH, FSH,
prolactin, oxytocin , hGH, adrenocorticotropin
(ACTH) and alpha-melanotropin. http://www.ihop-net.org/UniPub/iHOP/pm/541411.html?pmid=8625616
8. GABA acts as a paracrine or autocrine signaling molecule in
endocrine tissues such as the pancreatic islets, adrenal glands, vas deferens, prostate, epididymis, seminal vesicle,
ovaries (with activation of Calcium channel)s, and
testis (yes, sperm cells contain GABA receptors, important to male fertility). GABA is locally synthesized and stored by steroid-producing cells of
the adrenal cortex, possibly forming an auto- or paracrine GABAergic system,
and may influence these cells in cortisol and DHEA synthesis.
In addition to hormonal control by the circulating hormones ACTH and
angiotensin II, a wide variety of other hormones, neuropeptides, neurotransmitters,
and cytokines participate in the control of adrenal function. These
substances originate from the adrenal medulla, neurons, vascular
cells, and immune cells. GABA and functional GABAB receptors have
been detected in peripheral tissues such as adrenal medulla, islets
of Langerhans, placenta, and smooth muscle cells of the airway, urinary
bladder and uterus, responsible for control of norepinephrine and
epinpephrine release from adrenal medulla, relaxation of smooth muscles, and mitigation of
blood vessel constrictive and
inflammatory effects via the alpha-adrenergic receptors.
http://www.ncbi.nlm.nih.gov/pubmed/6237538?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_RVAbstractPlusDrugs1
http://ajplung.physiology.org/cgi/content/abstract/291/5/L923
http://ajplung.physiology.org/cgi/content/abstract/294/6/L1206
http://pats.atsjournals.org/cgi/content/abstract/5/1/47
http://ajplung.physiology.org/cgi/content/full/291/5/L923
http://www.ncbi.nlm.nih.gov/pubmed/16343781?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedarticles&logdbfrom=pubmed
and
http://endo.endojournals.org/cgi/content/abstract/145/5/2402
9. Both GABAergic and Serotoninergic neurons modulate the cleavage of Pro-OpioMelanoCortin
(POMC) into ACTH and β-lipotropin (β-LPH) in the anterior
pituitary gland; Corticotropin-like intermediate peptide (CLIP), γ-LPH,
α-MSH
, γ-MSH,
β-MSH
and β-endorphin
in the intermediate lobe; MSH, by POMC neurons in the arcuate
nucleus of the hypothalamus. α-MSH
released into the brain by these neurons has effects on feeding behavior, energy
expenditure, and sexual arousal; α-MSH released into the blood stream or
synthesized by skin cells or hair folliclesm, under action of UV or genes, will
darken the skin and hair color respectively. α-MSH stimulates
oxytocin (OT) release from dendrites of the magnocellular neurons in conjunction
with action of dopaminergic neurons on D2 receptors while blocking
"normal" OT release at the axonal release sites. This helps the brain
turn on the sexual libido and erectile circuits. Serotoninergic and GABAnergic(
with Chloride-dependent
Calcium Channel Activation) nervous system modulate the entire hypothalamus-pituitary-adrenal axis and
reduce the ACTH release or action while increasing endorphin, MSH and
lipotropin.
http://www.uco.es/investiga/grupos/endocelular/papers-pdf/Peptides-Regulation%20of%20alpha-MSH%20release%20by%
20GABA%20via%20a%20Cl-dependent%20Ca2+%20increase%20in%20frog%20melanotropes.pdf http://ajpregu.physiology.org/cgi/content/full/290/3/R577
http://www.jneurosci.org/cgi/content/full/23/32/10351
http://content.karger.com/ProdukteDB/produkte.asp?Doi=126582
http://jeb.biologists.org/cgi/content/abstract/203/11/1711
http://www.annalsnyas.org/cgi/content/abstract/994/1/90
http://jpet.aspetjournals.org/cgi/content/abstract/271/2/1000
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.7108414
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.17003261
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.466509
http://www.ncbi.nlm.nih.gov/pubmed/1003058?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.
Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed
http://sciencelinks.jp/j-east/article/200001/000020000199A0753468.php
http://joe.endocrinology-journals.org/cgi/content/abstract/90/1/53
http://www.ncbi.nlm.nih.gov/pubmed/7291039
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=237945
http://ajpendo.physiology.org/cgi/content/full/284/6/E1181
http://edrv.endojournals.org/cgi/content/full/27/7/736
http://www.jneurosci.org/cgi/content/abstract/12/3/864
http://www.patentstorm.us/patents/6051555/fulltext.html
10. GABAergic neurons in the peri-LC dendritic zone may provide
interneuronal integration for hypothalamic locus ceruleus (LC) noradrenergic
neurons, where GABA controls the dopamine-norepinpehrine conversion and
adrenergic/sympathetic nervous function. http://www.jneurosci.org/cgi/content/full/24/9/2313
http://www.jneurosci.org/cgi/content/abstract/28/22/5806
Stress hormones norepinephrine and epinephrine induced
apoptosis in blood vessels.
Norepinephrine and epinephrine induce apoptosis of
endothelial cells (Ref: Fu YC, Yin SC, Chi CS, Hwang B, Hsu SL, Norepinephrine
induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK
activation pathway. Apoptosis, 2006 Nov;11(11):2053-63; Yun-Ching Fu,
Ching-Shiang Chi, Sui-Chu Yin, Betau Hwang, Yung-Tsung Chiu and Shih-Lan Hsu,
Norepinephrine induces apoptosis in neonatal rat endothelial cells via
down-regulation of Bcl-2 and activation of β-adrenergic and caspase-2
pathways, Cardiovascular Research 2004 61(1):143-151 - http://cardiovascres.oxfordjournals.org/cgi/content/full/61/1/143;
Romeo F., Li D., Shi M., Mehta J.L. Carvedilol prevents epinephrine-induced
apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas
ligand and caspase-3 pathway. Cardiovasc. Res. (2000) 45:788–794, http://cardiovascres.oxfordjournals.org/cgi/reprint/45/3/788?ijkey=
bca9f5122205d5f9dd39125a4ede820f97d2e833;
Stefanec T. Endothelial apoptosis: could it have a role in the pathogenesis
and treatment of disease? Chest (2000) 117:841–854, http://www.chestjournal.org/content/117/3/841.full.pdf+html
, Communal C., Singh K., Pimentel D.R., Colucci W.S. Norepinephrine stimulates
apoptosis in adult rat ventricular myocytes by activation of the
beta-adrenergic pathway. Circulation (1998) 98:1329–1334, http://circ.ahajournals.org/cgi/reprint/98/13/1329?ijkey=f6a585d88fef2136ced80d0d9be63425f1870dd1
). Thus, chronic elevation of norepinephrine and epinephrine by
excessive sex can result in thinning blood vessels and ultimate breakage for
bleeding in the brain, prostate, urethra, colon and rectum too. Our empirical
data shows the excessive stress hormones elicit the prostate, stomach, colon and rectum
bleeding.
Generally, sex-induced excessive stress hormones, inflammatory hormone
Prostaglandin E2, and over-excitation of histamine H1 receptors cause the
stomach problems too. It is one of the sympathetic nervous Fight and Flight
responses.
Orgasm Brain Sex Pain?!! - Oops! Click the links in the left-handed
side if you need our case collection since 1997.
Or read some interested cases below:
On Taoist's ejaculation frequency vs testosterone level and sperm concentration.; 5000-years Sexual
exhaustion symptoms were also mentioned by the Seventh-day Adventist church; what is a consistence of old culture wisdoms!
==> http://www.actionlove.com/cases/case15675.htm
causes and solutions for sexual exhaustion symptoms - body pains, eye
floaters, blurry vision, ear buzzing, headaches, chronic non-bacterial
prostatitis and poor semen quality and quantity for no sexual orgasm. Why his
doctors could not found his UFO symptoms induced by sexual exhaustion!? And
Antibiotics won't work but can cause excessive histamine release in certain
cells for allergic responses
==> http://www.actionlove.com/cases/case16082.htm
Why sexual arousal gives him tiredness, and sexual orgasm worsens his tiredness?
http://www.actionlove.com/cases/case15955.htm
Excessive dopamine-norepinephrine/epinephrine conversion, resulting from
parasympathetic/vagal, GABA and serotonin nervous control disorder, induces
organ inflammation, brain fog, depression, autoimmune disorder, chronic
infection, inflammatory pain, digestive disorder and panic responses, low
libido, premature ejaculation, adrenal fatigue and lyme disease.
==> http://www.actionlove.com/cases/case15858.htm
On Sexual Energy Exchange during intercourse for the Tao of Love -
He said 'I will continue to use your products for time to time and hang on to your
words of wisdom.' on sexual energy exchange during intercourse for more sexual orgasm
==> http://www.actionlove.com/cases/case15578.htm
why ejaculation or sexual orgasm induced awful depression, anxiety, body pains
(dull throbbing gallbladder and liver pain) for a few day - Solution
==> http://www.actionlove.com/cases/case15444.htm
Pot smoking and alcohol result in memory loss, eye floaters, upper
abdominal/stomach pains (went to ER twice for MRI, scans, colonoscopy..),
vaginal dryness, uterine cramp and pain, post-sex low abdominal (uterine) pain,
allergies. sinus, puffy eyes, headaches, forehead tenderness and no more sexual orgasm
==> http://www.actionlove.com/cases/case15747.htm
What cause the post-ejaculation and post-orgasm pains, cramps, tightness,
joint rigidity and muscle weakness for no more sexual orgasm
==> http://www.actionlove.com/cases/case15079.htm
Sexual Hangover - Sex or orgasm induced
headache, poor mentality, mood swings, dizziness and vertigo - solution for the
severe side effects of sexual orgasm
==> http://www.actionlove.com/cases/case15010.htm
The similarity of between the penile jelq-induced damage and
heart failure as a result of increased collagen synthesis for no more sexual
orgasm - A special Penile Enlargement advice
http://www.actionlove.com/cases/case14906.htm
He said ' I am so incredibly grateful for everything you have done for me so far! My erection is back for good now, and what your miracle products did for my health remains truly without precedence. ViaPal-HgH-J helped me to rejuvenate my penile erectile nerves and revive my dead penis after a very severe penile injury, after I ruptured both of my spongy tissues with one of the
jelqing/stretching exercises I had found on the internet.' Re-grow Corpora Cavernosa
and penile nerves, heal penile varicose veins, improve penile curvature, solve
penile pains, stop precum, and restore libido and sexual orgasm.
==> http://www.actionlove.com/cases/case14677.htm
2-week Finasteride (5-alpha reductase inhibitor for Hair ReGrowth and
shrinking the enlarged prostate ) disabled his liver 5-alpha
reducatse release in blocking the testosterone-DHT conversion for a high
testosterone level, but
administration of aromatase inhibitor supplements, in conjunction with the side
effect of Finasteride, further kept his testosterone level too high, high enough
to stimulate the excessive liver SHBG protein release in binding testosterone in
the bloodstream for penile shrinkage, no more libido and sexual orgasm
==> http://www.actionlove.com/cases/case14664.htm
Why drug abuse and antidepression drugs result in excessive prostaglandin E-2
and epinephrine release to induce psychological disorders ( mood swing, anger,
and aggression), extremely headaches, shooting pains low stomach swelling, body
pains, body heat, light headedness confusion, uncontrollable
over-masturbation (persistent sexual arousal), particularly during ovulation,
for no more sexual orgasm
==>http://www.actionlove.com/cases/case14644.htm
Chronically over-masturbating for 2.5 years resulted in
low back pain, testicular pains, groins pains, urethral/penile pains, erectile
dysfunction, painful erection, chronic constipation and elevation of the liver enzymes LST and AST (liver damaged index enzymes) for no more sexual
orgasm, but pains.
==> http://www.actionlove.com/cases/case14451.htm
Why a hard core body builder or athletic person
experiences penile and testicular shrinkage even if he is taking a lot of Nitric
Oxide enhancements; on the role of the sympathetic nervous beta receptors in the
penile erection, testicular function and sexual orgasm (the same conditions
apply to women's clitoral/G-spot erectile dysfunction, vaginal looseness, and
ovarian functional disorder too)
==> http://www.actionlove.com/cases/case14402.htm
His and her post-orgasm sexual exhaustion symptoms -
sympathetic nervous panic and inflammatory responses, low back pains, low
abdomen pains/cramps, perineum inflammatory pains, and so on, for no sexual orgasm - solution
http://www.actionlove.com/cases/case13819.htm
Why ejaculation/orgasm causes his mood swing, anger, aggression,
anxiety, stress, fatigue, tiredness.... for no more sexual orgasm - On the
brain and body chemistry change in response to ejaculation or orgasm.
==> http://www.actionlove.com/cases/case13755.htm
He said ' I want to thank you because your products worked as you say they will and the value I got from them went beyond what I expected.'
with ViaPal-hGH-J, DeToxiA and PinealTonin in detoxification of anti-psychotic
and bipolar medication drugs for restoration of normal erection and sexual orgasm.
http://www.actionlove.com/cases/case13900.htm
She said ' a couple months ago I wrote to you about my problem with
vestibulitis. your prescribed that i take vial pal hgh j along with borage oil, fish oil, and 5-htp.
... my doctor, who is one of the few vulvodynia and vestibulitis specialists in the country, is amazed by my rapid progress.'
for solving vestibulitis, quitting pot smoking and restoring sexual orgasm.
==> http://www.actionlove.com/cases/case13584.htm
Solution for Persistent Sexual Arousal Syndrome and interstitial cystitis
induced by COX-2 over-expression and inflammatory hormone prostaglandin E-2 in
the pelvic cavity tissue and for control of unwanted, spontaneous sexual orgasm
http://www.actionlove.com/cases/case13532.htm
Non-orgasmic semen retention is as bad as over-ejaculation; both are for no more sexual orgasm
,but for sympathetic nervous pains and burning. What is different between both
cases in term of the dopamine-norepinephrine-epinephrine conversion?
==> http://www.actionlove.com/cases/case13176.htm
He said 'I want to thank you for your products. I cannot begin to tell you how great it was for us to be able to have her squirt, and boy did she. I had no idea of the quantity of fluid that would come out or how forceful the ejaculation would be, I know for a fact that the movies that I have seen are indeed real!!!'
with Heat Tea and L-Arginine! A realistic experiment for a healthy female ejaculation pumped out by an
extremely powerful sexual orgasm!
http://www.actionlove.com/cases/case13138.htm
Why his doctors and drugs can not solve his non-organic prostate and testicle
pains as a result of sexual exhaustion and prostate abrasion for no more sexual orgasm
http://www.actionlove.com/cases/case13121.htm
He said 'The chikong breathing worked! I thought your site was just after my
money, but when I tried your advice my control over ejaculation was exactly like
you said. The ballooning trick also worked and I was able to control (for the
first time in my life) as long as I wanted' for more sexual orgasm
http://www.actionlove.com/cases/case13080.htm
He said 'Your medium dosage of (MoodMax, 5HTP + Dopa Fibra, Dopa Fibra,
MoodMax) has been great.' for more sexual orgasm. How to shut down and
boost your oxytocinergic nervous action for control of libido, erection
and sexual orgasm.
http://www.actionlove.com/cases/case13040.htm
Chronic over-masturbating from age 14-31 results in all of the sexual
exhaustion symptoms, some fatigue, graying of hair, hair thinning, eye floaters,
sinus, ear aches, and sleeping disorder for no more sexual orgasm. On the
arylalklamine N-acetyltransferase gene expression disorder in the pineal gland
and retina for circadian rhythm and visual nervous disorders. Why can a good sex
improve your health?
http://www.actionlove.com/cases/case12909.htm
She said ' i am glad to notify you that it's unbeleavable how i have managed
to get almost all my problems eliminated.as of now', no more depression,
hypertension, painful periods due to fibroids, migraine headache, vaginal muscle
weakness, urinary sensation reaction, nausea, chronic sinuses, painful nipples,
and low libido, but for sexual orgasm; on the pineal gland gene expression
disorder.
==> http://www.actionlove.com/cases/case12813.htm
Over-ejaculating several times in 20-50 minutes have abraded his prostate and elevated a high
PSA release for many days - for self destruction and no more sexual orgasm!
http://www.actionlove.com/cases/case12785.htm
ViaPal-hGH-M and DeToxiA have helped her resolve her
chronic bladder disorder/ incontinence, vulva pain (Vulvodynia & vestibulitis
) & throat infection (tonsils), restore her menstrual cycle, and smooth out
her PMS Pains/Cramps, for restoration of sexual orgasm
==> http://www.actionlove.com/cases/case12703.htm
Chronic over-masturbation/over-ejaculation or excessive orgasm alternates the
Dopamine D1 and D2 gene expression for sympathetic nervous fires - no sexual orgasm
- the brainwash solution..
http://www.actionlove.com/cases/case12612.htm
The cellular biochemistry of premature ejaculation for no more sexual orgasm.
==> http://www.actionlove.com/cases/case12610.htm
How to treat pot smokers' common problems for restoration of sexual orgasm
==>http://www.actionlove.com/cases/case12583.htm
Why his penile stretching enlargement exercise for 2 days results in
youth (teenager's) impotence, glans shrinkage, premature ejaculation and low libido for no sexual orgasm
==> http://www.actionlove.com/cases/case12560.htm
A senior medical student said ' I have already been taking ViaPal-M for around 2 1/2 weeks and I must say that the results have been
significant improving my symptoms of anxiety, poor memorization, acne, depression, etc. ' for sexual orgasm, and questioned on medication drugs for
psychological and physiological disorders.
http://www.actionlove.com/cases/case12529.htm
Why this 20-year old man experiences orgasmic dysfunction
and withdrawal for no sexual orgasm. On the role of prolactin and
oxytocin in the sexual and orgasmic functions and in the switching of
sympathetic nervous beta and alpha receptors for orgasmic contraction for men and women.
==> http://www.actionlove.com/cases/case12488.htm
Chronically masturbating twice a day lets her feel sexually unfulfilled,
crave for more sex, and experience cramps in the low abdomen and back for sexual
exhaustion symptoms, but no sexual orgasm. On the physiology and psychology of orgasm
==> http://www.actionlove.com/cases/case12487.htm
Dr. Lin's advices to a porn actor: Avoid multiple ejaculation in one day; Knock out all your partners with one and only one ejaculation for
the most violent sexual orgasm by rhythmically stimulating the clitoris and blending the G-spot and Epicenter/cervix at the same time; Drink your own first
morning pee - the Natural Spectrum Hormone Therapy.
==> http://www.actionlove.com/cases/case12460.htm
Chronic Over-masturbation causes a chronic elevation of prolactin for seminal /
sperm production disorder, low libido, orgasmic disorder for infertility and no
more sexual orgasm! Why? http://www.actionlove.com/cases/case12388.htm
Over-masturbation/over-ejaculation and drugs abuse killed his
brain and nervous functions for chronic headaches, blurred vision, ear ringing
and no more sexual orgasm. Here is Dr. Lin's Brainwash Engineering treatment.
http://www.actionlove.com/cases/case12366.htm
Over-masturbation has alternated and exhausted this 19-years old boy's
brain/nervous functions for pains in the testicles/penile/groins/low abdomen/low
back/everywhere, eye floaters and suicidal thought for no more sexual orgasm,
beyond ability of his psychologist and urologist and SSRIs antidepression drugs.
The brain/nervous function destructed by over-masturbation or over-ejaculation can not be healed naturally!
Here is Dr.Lin's cheap 'Brainwash' solution.
http://www.actionlove.com/cases/case12364.htm
After he spent all his money, why all his doctorS and all the prescription drugS can have never solved his non-bacterial prostatitis and
prostate swelling with frequent urination, perineum heat/pains, and hair loss, leading to no more sexual orgasm - Here is Dr. Lin's cheap solution - The
Natural Prostaglandin E-1 therapy.
==> http://www.actionlove.com/cases/case12346.htm
He said ' I have purchased your ViaPal-hGH-J pack and have been very happy with the results with an improvement after only 2 weeks.'
how to balloon your penis and her clitoris/G-spot/vaginal/urethral erectile tissues for more sexual orgasm!
==> http://www.actionlove.com/cases/case12339.htm
Why his optometrist can not see his eye floaters resulting from over-masturbation/over-ejaculation or excessive sexual orgasm
==> http://www.actionlove.com/cases/case12334.htm
He said ' I have sexual functioning again.' with ViaPal-hGH-P; Re-Grow his
circumcised foreskin, enlarge his penis, restore his orgasm and penis
sensitivity after jelqing damage, and shrink his enlarged prostate back to
normal for peeing, and solve his urinary tract infection (UTI) for more erection
and sexual orgasm.
==> http://www.actionlove.com/cases/case12265.htm
Finally, a 21-year old heavy-duty pot-smoking, post-hernia-operation over-masturbator said ' my urinary incontinence is absolutely GONE AWAY... Thanks for your great product Dr.Lin !!'
Restoring his sexual orgasm in only 1 month!
http://www.actionlove.com/cases/case12201.htm
[Warning:
This article may be very offensive to you, but you can learn about the relationship between the penile/vaginal temperature and orgasmic response, and the relationship among the urogenital blood circulation, urinary continence, androgen hormones and prostaglandin E-1. For a better sex, keep your penis/clitoris/vagina hot, but your brain cool; that is, pump your blood down to your sex organs, but not to your brain during lovemaking!
Their sexual adventures in helping us cross-verify our long-term hypotheses should be highly appreciated! OK, Here we go for it:
After her husband failed to maintain his erection for her, she is interested in dog sex for sexual orgasm. Can she have a dog tie? Dr. Lin's
saddest advice! Updated (3/17/2004): She had experienced powerful multiple orgasms with the high-temperature dog
penis and semen (3 degrees F higher than the human's). The result of the Dog Sex experiments can lead to a new powerful therapeutic concept for urinary incontinence! Why?
==> http://www.actionlove.com/cases/case12137.htm]
Dr. Lin's penile growth theory and permanently penile enlargement for you to go all the way to heaven and to have more sexual orgasm after you die.
http://www.actionlove.com/cases/case12121.htm
How urethral female ejaculation occurs and produces pelvic/bladder/urethral/vagina/uterus spasms and legs shaking (a
temporary Parkison's phenomenon by sexual stimulation) , but no sexual orgasm; on the formation of the sensory-sympathetic L1/L2 nervous reflex arc.
==>http://www.actionlove.com/cases/case12082.htm
He said ' i have been purchasing your products for about 4 months now for my wife. and they have helped a great deal!' for
her Interstitial Cystitis (IC), fibromyalgia, migraine headaches, sleeping disorder, vaginismus (penetration/intercourse pains) and restoration of sexual
orgasm - This serious case has been abandoned by the medical societies.
==> http://www.actionlove.com/cases/case12046.htm
Ear ringing (Tinitus) - the ear stresses out for no sexual orgasm
==> http://www.actionlove.com/cases/case12026.htm
He said 'we all should recommend you for a noble prize in your field of study.' after experiencing the powerful Dr. Lin's Natural Prostaglandin
E-1 therapy for prolonging his erection and sexual orgasm, increasing his semen production, darkening his hair, dropping his bad cholesterol level and blood
pressure (with a high dose of Yohimbe in DopaFibra!?), eliminating his body pains ...
==> http://www.actionlove.com/cases/case11983.htm
Solution for the post-ejaculation or post-orgasmic brain/nervous disorder, trauma and fatigue - for sexual orgasm
==> http://www.actionlove.com/cases/case11980.htm
She said ' I ordered your products Moodmax, Viagrowth-IV and 5htp for vaginal looseness right before Christmas....
I can say Your products really work. Thank! You have a customer' for Vaginal Tightness and more sexual orgasm!
Again, the Dr. Lin's Natural Prostaglandin E-1 Therapy
==>http://www.actionlove.com/cases/case11964.htm
Dr. Lin's Prostatitis solutions - the restoration of sexual orgasm with Natural Prostaglandin E-1 therapy.
==> http://www.actionlove.com/cases/case11924.htm
An endocrinology doctor's experience with over-masturbation or over-ejaculation, resulting in prostatitis, urethritis, erectile dysfunction, low libido, and pains in penis, low
back, perineum and anus for no more sexual orgasm -Solution
==> http://www.actionlove.com/cases/case11918.htm
He said ' dear dr lin WOW it worked!!!! i took borage oil 1 capsule a day,3 capsules fish oil and 6 capsules of flaxseed per
day.....RESULT- longer sexual intercourse didnt cum as quick and a much harder penis that increased in length by 1 inch and a fatter girth
my girl loved my 8inch cannon. i notice also after doing your breathing method i can shoot my big cannon for another round i also take your moodmax and viagrowth4 great stuff'
for more sexual orgasm and having Merrier X'mas and happier holidays!
==> http://www.actionlove.com/cases/case11904.htm
He said ' Thank you for a wonderful set of products and information! I have enjoyed them and I believe they have assisted me and my wife to enjoy sex more and conceive a child on our first try!'
for a life-term sexual orgasm.
==>http://www.actionlove.com/cases/case11818.htm
He said ' Hello, I have been taking the fish oils and the borage oils now for 4 weeks. I am also very pleased with your products and my hair as well as my wife's hair is turning dark again. My wife has been almost white since her late 30's This is nothing short of a miracle. Thank-you.'
for more sexual orgasm! On Dr. Lin's Natural Prostaglandin E-1 therapeutic formula
==>http://www.actionlove.com/cases/case11805.htm
She has proved what Dr. Lin said - tubaligation results in the state of peri-menopause and menopause transition for PMS and no more sexual orgasm.
==> http://www.actionlove.com/cases/case11800.htm
He said 'Love the products....... my eyesight is so much improved...... I wonder why this is? ' for more sexual orgasm - the electric engineering solution for eyesight and eye floaters.
http://www.actionlove.com/cases/case11735.htm
He said ' I have been practicing your ballooning method since 1998. I went from 5inches to 7 inches. Then you told me I have probably reached my full potential, that my foreskin was limiting me, which I believe is correct.'
on the penile and hair re-growth for more sexual orgasm. On the calculation of the nervous erectile power change based upon the
penile shrinkage rate.
http://www.actionlove.com/cases/case11591.htm
How drugs take over your brain and nervous system and how to
detoxify your brain and nervous fiber/synapse for restoration of sexual orgasm.
==> http://www.actionlove.com/cases/case11500.htm
When Prostatitis can not be solved by over-ejaculation and antibiotics, you are asking for more troubles - for no more erection
(impotency and sexual
exhaustion) and sexual orgasm -Solution
==> http://www.actionlove.com/cases/case11430.htm
On seminal retention and prostate-cancer protection, and of course, on Over-masturbation and sexual orgasm
==> http://www.actionlove.com/cases/case11407.htm
He said 'when i take your detox pill i feel really relaxed and think clearly do you know why that is.'
a full detoxification of the liver and nervous system for better health and sexual orgasm
==> http://www.actionlove.com/cases/case11347.htm
He said ' By the way, about your 5-htp. ANOTHER GREAT PRODUCT.
... last week when I got the attack, I opened an additional capsule and poured the powder beneath my tongue (sublingually). It COMPLETELY stopped the migraine progressively over a one hour
period. WITH NO SIDE EFFECTS!'; more sexual orgasm without headaches and migraine or panic attack.
==> http://www.actionlove.com/cases/case11323.htm
On the role of DHT in the penile Growth, Repair (Re-Growth) and structure for more sexual orgasm.
==> http://www.actionlove.com/cases/case11311.htm
Evidences show destruction of pot (marijuana) smoking, resulting in low libido, erectile dysfunction, premature ejaculation and low
seminal production for no more sexual orgasm
==> http://www.actionlove.com/cases/case11303.htm
He said 'first of all, may i thank you for your miracle products, they have totally transformed my life.'
ViaPal-hGH-P and 5-HTP have rejuvenated his damaged penis and resumed his seminal production for ejaculation and sexual orgasm through normal
vaginal intercourse.
==> http://www.actionlove.com/cases/case11269.htm
He said ' Love+your products= AMAZING! What's going on inside my brain, chemically, since I don't feel like eating?
I'm not tired either.'; less foods and more sexual orgasm.
==> http://www.actionlove.com/cases/case11191.htm
He said 'I am nearly at the end of my course of ViaPal-HGH-P (3-010) and I have experienced excellent results. I no longer suffer from extreme fatigue, blurred vision, buzzing ears or nasal
congestion after ejaculation. Thank you very much for your help!' on retaining the brain
concentration after ejaculating or having sexual orgasm
==> http://www.actionlove.com/cases/case11147.htm
He said 'I feel like a New Man I have No Erection Problems. My erection are very firm and
long lasting. I had to take a weaker dosage because I was waking up and walking around with an erection for
long periods..' for more sexual orgasm
==> http://www.actionlove.com/cases/case11119.htm
What are the differences between the Penile Ballooning and Penile Exercises/Jelqing/Milking for penile enlargement?
==> http://www.actionlove.com/cases/case11114.htm
On the effect of the vaginal/cervical secretion on penile erection/ballooning and premature ejaculation. Why one tight vagina makes him
erect harder and last longer for sexual orgasm , but the other tight one promotes his premature ejaculation?
==> http://www.actionlove.com/cases/case11032.htm
He said 'I could say that you made me a man again.' and gets recovered from extremely sexual
exhaustion due to pre-teen over-masturbation; on buzzing ears; Why don’t write a book for parents about how to teach their sons the sexual energy control and development?
==> http://www.actionlove.com/cases/case10924.htm
A MD (a vasectomy victim too!) said 'I had 6 orgasms within a 36 hour period,.... Your products amazingly both help achieve strong erections, reduce the refractory period between intercourses, and maintain sensitivity while enhancing stamina and endurance of erections. Quite unbelievable. ' Oops!
excessive sexual orgasm!.
==> http://www.actionlove.com/cases/case10881.htm
She said 'Your products amazed me. After not being very orgasmic at all for 35 years, I began to experience wonderful orgasms often and my libido is sky high. I love it.'
What is the origin of our products?
==> http://www.actionlove.com/cases/case10632.htm
Prostate's seminal production disorder for no more ejaculation and sexual orgasm;
Under forcing with a heavy urethral stimulation, the male ejaculation is the same as the female ejaculation fluid.
==> http://www.actionlove.com/cases/case10876.htm
Non-bacterial (non-organic) testicular and penile pains due to ejaculation - why and solution.
==> http://www.actionlove.com/cases/case10853.htm
Neurophysiological approach for overcoming the masturbation addiction
==> http://www.actionlove.com/cases/case10797.htm
Why over-masturbation or excessive clitoral orgasm results in chronic clitoral pains for no more sexual orgasm
==> http://www.actionlove.com/cases/case10793.htm
Viapal-hGH-M has revived a 5-year marijuana smoker's erection for
the first times in 5 years! He needs DopaFibra too for a faster healing.
==> http://www.actionlove.com/cases/case10740.htm
Don't let Ecstacy (MDMA) fry your brain and nerves for a short-term fun, but not for a long-term sexual orgasm.
Updated - He messed up his brain in 4 months on New Year Eve of 2003!
==>http://www.actionlove.com/cases/case10350.htm
Over-masturbation causes 14-year old boy's endless (continuous) seminal leakage for no sexual orgasm;
on destruction of the prostate's
ejaculation nervous controller and modulator; The endless ejaculation can cause death during lovemaking,
but How to stop it!
==> http://www.actionlove.com/cases/case10592.htm
When 'chronic non-bacterial prostatitis' (now called 'chronic pelvic pain syndrome') is the Prostate's Seminal Blasting Syndrome,'
your prostate produces no much semen, resulting in retarded ejaculation, no sexual orgasm and vibrator-induced penile damage..
==> http://www.actionlove.com/cases/case10580.htm
Mechanism of the Penile Ballooning for a better sexual orgasm - on the
the 2-stage penile erection theory for Penile Enlargement.
http://www.actionlove.com/cases/case10565.htm
His dog makes his girl friend achieve a Level-7 orgasm,but he gives her intercourse pain for no sexual orgasm. Now, Learn the
doggy-style lovemaking.
http://www.actionlove.com/cases/case10535.htm
The final chapter of Penile Enlargement for no sexual orgasm
http://www.actionlove.com/cases/case10492.htm
Dying of Young girl's clitoris and G-spot - losing her sexual orgasm.
==> http://www.actionlove.com/cases/case10292.htm
Excessive sexual orgasm, excessive histamine release, rear-brain and neck pain, orgasmic nasal congestion, allergic responses, and dark eye circles.
==> http://www.actionlove.com/cases/case10263.htm
Cause and Solution of orgasmic convulsions upon ejaculating - the seizure response to sexual orgasm
==> http://www.actionlove.com/cases/case10241.htm
He said ' You "My Friend" are the King of Love'; ViaPal-hGH-M resolves his
Chronic penile pain;
On Dr. Lin's Bioelectric Theory of Love
Science.
==> http://www.actionlove.com/cases/case10097.htm
On the Liver P450 Detoxification and the liver protection for health and sexual orgasm
==> http://www.actionlove.com/cases/case10000.htm
General Solutions for women without experiencing sexual orgasm
==> http://www.actionlove.com/cases/case9864.htm
But, what are General causes? Here are the General problems:
How to enlarge (loosen) your vagina, shrink
(yes, kill ) your
clitoris and G-spot, and produce urinary/bowel
incontinence? (click
here for destruction of vibrator); How to become an impotent young man?
(click
here); How to shrink your penis?(click
here) or How to break a penis! (click
here with women-wild rides or penile enlargement practices); How to destroy
(castrate) your sexual functions by masturbation,
drugs
(including SSRIs
and birth
control pills/shot - one shot kills it all!), or Vasectomy(
- two cuts kill them all;) How to get a pseudo-prostatitis;
How to produce eye
floaters; Finally, you want to know how to become a
fastest semen-shooting (ejaculation) man in lovemaking or dry up your
seminal ejaculation or production.
The variation of the brain's neurotransmitters in response to ejaculation and sexual orgasm - on the Penile Ballooning
Method for penile enlargement and the destruction by over-masturbation and over-ejaculation .
==> http://www.actionlove.com/cases/case9875.htm
Destruction produced by Male or Female Over-Masturbation for no sexual orgasm.
==> http://www.actionlove.com/cases/case9848.htm
The principles of the Penile/G-spot/Clitoral enlargement and
Vaginal Narrowing (Reduction, yes!)
are the same thing! for more sexual orgasm.
==> http://www.actionlove.com/cases/case9819.htm
Brain's and nervous functions, Orgasm Headache, and nausea associated with excessive sexual orgasm (Orgasmic Stress); on anorgasm, stress effects and de-stress.
==> http://www.actionlove.com/cases/case9814.htm
When the holes down there become bigger, they will cause pain, but why? So, How to downsize the holes for men and women. Yes, his and hers!
==> http://www.actionlove.com/cases/case9767.htm
Causes and solutions for PMS, Intercourse, penetration or orgasm pains/cramps, tilted or
prolapsed uterus, and sexual orgasm; Love Positions and vaginal air trapping/pumping/escaping.
==> http://www.actionlove.com/cases/case9756.htm
He said ' I want you to KNOW that your 'pills' have done more for me..' beyond sexual orgasm.
==>http://www.actionlove.com/cases/case9689.htm
Penile Enlargement, DHT, Prostaglandins, Nitric Oxide and cGMP
==> http://www.actionlove.com/cases/case9663.htm
On Penile Enlargement and Reader's experience on Dr. Lin's Male Multiple Orgasms without ejaculation.
==> http://www.actionlove.com/cases/case9647.htm
Mechanism of sexual orgasm, damage of sexual nerves, and lesson from labor orgasm
==> http://www.actionlove.com/cases/case9589.htm
How do you know she achieve orgasm? on Penile Size and Penile enlargement, female sexual orgasm responses and dysfunction.
http://www.actionlove.com/cases/case9566.htm
Hair loss, 5-alpha reductase, prostate enlargement, erectile dysfunction, Prostaglandin,
Vaginismus, Intercourse pain, Oxytocin and powerful sexual orgasm
==> http://www.actionlove.com/cases/case9580.htm
Principles and mechanisms of the Natural Penile Enlargement - Ballooning Method
for more erection and sexual orgasm
==> http://www.actionlove.com/cases/case9499.htm
How to become a multiple Sexual-Orgasms couple.
==> http://www.actionlove.com/cases/case9303.htm
Male multiple orgasms without ejaculation by the Anal Breathing Method - The
principle, tricks and conditions.
==>http://www.actionlove.com/cases/case9422.htm
Do you want to know More Good News for Sexual Orgasm?
Click Here; Or the most self-destructive Sexual
Practice (click here)?
Interaction between the brain/nervous systems and the love-power generators (uterus, cervix and ovaries); no
hysterectomy if avoidable.
==> http://www.actionlove.com/cases/case9341.htm
She said 'following your advice my husband has a new penis' and 'I had 30% less flow - relief' from heavy menstruation with your CD-ROM and
products. For better sexual orgasm
==> http://www.actionlove.com/cases/case9275.htm
She said 'I orgasmed 3 times! AND, my husband had his first multiple orgasm.' with
Dr.Lin's Sexual ChiKong Intercourse technique
==>http://www.actionlove.com/cases/case9171.htm
Neurophysiological Explanation of Sexual ChiKong Intercourse for multiple sexual orgasms and ejaculation control
==>http://www.actionlove.com/cases/case9194.htm
She has enlarged her Clitoris and G-spot with ViaGrowth-IV and
Finger Pliers and Penile Screwing massages for more intensive sexual orgasm; but
how to continue the practice without him.
==>http://www.actionlove.com/cases/case9214.htm
Over-masturbation and over-ejaculation result in impotency, premature ejaculation, headache, memory loss, yellowish face, and
absentmindedness - the Solution.
==> http://www.actionlove.com/cases/case9263.htm
Sex is in the brain The penis, clitoris and vagina are only the
love tools, the power tools which are
actuated by the brain/parasympathetic battery - the healing power generator.
To achieve orgasm (as energy pulsing discharge driven by the brain/sympathetic
nervous function), even multiple sexual orgasms for men
and women, you have to power the
brain/nervous/liver/adrenal/cardiovascular/testicular (ovarian) functions in the first place.
Why? (click here). The brain function + sexual
technologies = multiple sexual orgasms. Caution:
Medication and/or street drugs, alcohol, cigarette, birth control pills or
injection may perform chemical castration for your
brain - disconnecting or weakening the parasympathetic nervous
communication (the acetylcholine bioelectro-chemical link)
between the brain and the love tools, leading to impotency and frigidity. The good
news is, we can help you restore and repower your brain function for relinking
your love tools with our ViaPal-hGH products.
Sex is in the brain? Yes, Please read "Dr.
Lin's formula helps a 65-year old tree grow new sprouts and tender leaves for hard erection and sexual orgasm."
==>http://www.actionlove.com/cases/case9144.htm
<< Detoxify and power your liver,
OR lose your brain/neuro-endocrine functions and shrink your love tools (the
male and female penises!)! Keep your major biochemical factory the liver alive!
>>
The role of the liver in male and female 'penile erection' and sexual orgasm. And VAGINISMUS !
==> http://www.actionlove.com/cases/case9098.htm
What's wrong when the labia minora is larger than trhe labia majora? for sexual orgasm?
==> http://www.actionlove.com/cases/case9340.htm
Get ride of SSRIs antidepressants and have Level-7 sexual orgasm back! Here is the How-to
==> http://www.actionlove.com/cases/case9117.htm
Over-Masturbation/Ejaculation has killed his liver and neuro-endocrine functions for no erection and sexual orgasm!
==> http://www.actionlove.com/cases/case9096.htm
Healing of the damaged tissues and nerves done by vibrators or vacuum pumping, for sexual orgasm .
==>http://www.actionlove.com/cases/case9087.htm
How to Reverse aging for erection and sexual orgasm - the stress-hormone busters and the parasympathetic nervous power generators!
==>http://www.actionlove.com/cases/case9068.htm
Balance the brain's parasympathetic (acetylcholine), sympathetic
(dopamine/norepinephrine/epinephrine), and Serotonin functions for prolonging intercourse and sexual orgasm; also the difference between masturbation
(self-intercourse) and lovemaking
==>http://www.actionlove.com/cases/case9032.htm
He said 'your sex chikong breathing works great' for control of ejaculation
and sexual orgasm, but how to do it right? Why it works? Turn the lungs into the air
compressing chamber and Increase the neurotransmitter CO (Carbon Monoxide) and NO
(Nitric Oxide) levels in the brain!
==>http://www.actionlove.com/cases/case9050.htm
Warning: High-level sexual orgasms can destroy pregnancy!
(click here more information on this topic)
http://www.actionlove.com/cases/case8570.htm
Better News: (the best news is that you
and your partner experience multiple orgasms again and again to supercharge both
bodies in an one or two hour love session! ) Get the most benefit from
lovemaking -
He and his girl friend get extraordinary benefits from sexual orgasm with Dr. Lin's
formulas - Sexual Orgasm recharges their bodies instantly for health!.
==>http://www.actionlove.com/cases/case8949.htm
more and more...
Customers with blood-pressure or heart conditions love ViaPal-hGH-X for better sexual orgasm
==>http://www.actionlove.com/cases/case9015.htm
ViaGrowth-II helps him release tight muscles and Dr. Lin's Sexual ChiKong makes him last for 90 minutes and gives her a lot of sexual orgasm
==>http://www.actionlove.com/cases/case8944.htm
He gains 2 inches with Dr.Lin's Natural Penile Enlargement Method for more sexual orgasm
==>http://www.actionlove.com/cases/case8902.htm
ViaPal-hGH-D powers his penis like a rock-hard rod and the 3-Point Love Position gives her eruptive orgasms.
==>http://www.actionlove.com/cases/case8938.htm
Dr. Lin's formula solved his adrenal insufficient, chronic fatigue and depression.
==>http://www.actionlove.com/cases/case8901.htm
ViaGrowth-IV strengthens her vaginal muscle, helps her achieve orgasm and rejuvenates her body (grows the G-spot and Clitoris?).
==>http://www.actionlove.com/cases/case8889.htm
He sad 'ViaPal-hGH-X is the only supplement working for me.' for heart and blood-pressure patients' Health and Sexual Orgasm
==>http://www.actionlove.com/cases/case8890.htm
He said our products have made his g/f reach very powerful multiple-cycle sexual orgasm and himself enlarge his penis to
more than 7 inches from 5.3 inches; he wants more for her!
==>http://www.actionlove.com/cases/case9046.htm
He said 'Fibra + Ginseng Power Max numb my penis' for prolonging intercourse and ViaGrowth products for more sexual orgasm
! ==>http://www.actionlove.com/cases/case9041.htm
Experience of Penile Ballooning and enlargement for sexual orgasm !
==>http://www.actionlove.com/cases/case9035.htm
More interested results in health rejuvenation ?
More interested results in Sexual Technology?
More interested results in Technical Support?
More interested results in Sexual ChiKong
Intercourse?
Please Read these articles first!
How to Emulate the Vibrator stimulation with a penis for her multiple sexual orgasm (s)
==>http://www.actionlove.com/cases/case8848.htm Dr.Lin's lovemaking methods re-ignite her fire, passion and hope for sexual orgasm
==>http:/http://www.actionlove.com/cases/case8840.htm
He said 'Your products are
certainly helping the healing process.
' - more sexual Orgasm
http://www.actionlove.com/cases/case8857.htm
Solution for venous leakage for more erection and sexual Orgasm
http://www.actionlove.com/cases/case8856.htm
He said 'Your ViaGrowth-IV works as advertised.' - more erection and sexual Orgasm
http://www.actionlove.com/cases/case8855.htm
How to increase Orgasm hormone Oxytocin and reduce orgasm inhibitor Prolactin for more sexual orgasm: Direct Stimulation of the Epicenter causes a Oxytocin burst, but her vagina must be tented up and her clitoris and G-spot must be swollen to 5-6 times in size, to prevent orgasmic pain.
==>http://www.actionlove.com/cases/case8745.htm Dr.Lin's theory of orgasmic excitation for breaking the orgasmic barrier to achieve sexual orgasm in every lovemaking. ==>http://www.actionlove.com/cases/case8601.htm
Dr. Lin helped her successfully develop her sexual orgasm. ==>http://www.actionlove.com/cases/case8693.htm
Advice to young couples on development of vaginal sexual orgasm ==>http://www.actionlove.com/cases/case8609.htm
Sexual Chikong Demonstrations help her tune her sexual muscle for multiple, sexual orgasms and female ejaculation.
==>http://www.actionlove.com/cases/case8649.htm
The Tao of Male Sexual Orgasm
==>http://www.actionlove.com/cases/case8739.htm
Glad to hear her successful story for health and sexual orgasm
==>http://www.actionlove.com/cases/case8785.htm
Update News: 3/9/2000:: We are restoring the files one by one. Please be patient! Dr. Lin has to walk through more than 10,000 web pages one by one to make sure that they are trade-marked drug names free!
The appearance of the most famous trade-marked erectile drug name in the web pages forces us to
take this action.
Now, Dr. Lin is reconstructing the Orgasm Research Center HERE. We have received thousand e-mails in last few days (3/5-3/10) concerning the shut-down of linplaza.com. Your continuous support and encouragement have been highly appreciated.
We have developed the most powerful products for rejuvenation of body
function and health, which reverse the natural aging and the side effects of
drugs on sexual functions. Our sexual technologies (lovemaking
methods, Sexual ChiKong
Intercourse, Natural Penile
and G-spot/Clitoral Enlargement)
and dietary supplements
have helped love couples regain their love and joy. The detail is in /extra/relate.htm (click here).
One reader said 'your website was the
truly genuine and useful one ...Your products are also
the only ones I had resolved to use..' We are very proud of the integrity of our services and the effectiveness of our products in help loving couples out, so Dr. Lin's orgasm legend has been continued here! Welcome back, Folk!
HERE are few examples of readers and customers' correspondences during the
shut-down of linplaza.com:
==>http://www.actionlove.com/cases/case8886.htm
==>http://www.actionlove.com/cases/case8885.htm
==>http://www.actionlove.com/cases/case8884.htm
==>http://www.actionlove.com/cases/case8883.htm
==>http://www.actionlove.com/cases/case8882.htm
==>http://www.actionlove.com/cases/case8881.htm
==>http://www.actionlove.com/cases/case8880.htm
==>http://www.actionlove.com/cases/case8879.htm
==>http://www.actionlove.com/cases/case8878.htm
==>http://www.actionlove.com/cases/case8877.htm
Please Read these articles first!
How to Emulate the Vibrator stimulation with a penis for her multiple sexual orgasm (s)
==>http://www.actionlove.com/cases/case8848.htm Dr.Lin's lovemaking methods re-ignite her fire, passion and hope for sexual orgasm
==>http:/http://www.actionlove.com/cases/case8840.htm
He said 'Your products are
certainly helping the healing process.
' - more sexual Orgasm
http://www.actionlove.com/cases/case8857.htm
Solution for venous leakage for more erection and sexual Orgasm
http://www.actionlove.com/cases/case8856.htm
He said 'Your ViaGrowth-IV works as advertised.' - more erection and sexual Orgasm
http://www.actionlove.com/cases/case8855.htm
How to increase Orgasm hormone Oxytocin and reduce orgasm inhibitor Prolactin for more sexual orgasm: Direct Stimulation of the Epicenter causes a Oxytocin burst, but her vagina must be tented up and her clitoris and G-spot must be swollen to 5-6 times in size, to prevent orgasmic pain.
==>http://www.actionlove.com/cases/case8745.htm Dr.Lin's theory of orgasmic excitation for breaking the orgasmic barrier to achieve sexual orgasm in every lovemaking. ==>http://www.actionlove.com/cases/case8601.htm
Dr. Lin helped her successfully develop her sexual orgasm. ==>http://www.actionlove.com/cases/case8693.htm
Advice to young couples on development of vaginal sexual orgasm ==>http://www.actionlove.com/cases/case8609.htm
Sexual Chikong Demonstrations help her tune her sexual muscle for multiple, sexual orgasms and female ejaculation.
==>http://www.actionlove.com/cases/case8649.htm
The Tao of Male Sexual Orgasm
==>http://www.actionlove.com/cases/case8739.htm
Glad to hear her successful story for health and sexual orgasm
==>http://www.actionlove.com/cases/case8785.htm
Warning: High-level sexual orgasms can destroy pregnancy!
http://www.actionlove.com/cases/case8570.htm
Hot Topic:
How to power up the penis, last longer and resonate her sexual orgasm!
http://www.actionlove.com/cases/case8544.htm
Dr. Lin's formulas reverse the side effects of hair-growth drugs and restore erection for sexual orgasm!
==>http://www.actionlove.com/cases/case8572.htm
The Screwing Finger Pliers for all ages. Never too old to enjoy more sexual orgasm with Dr.Lin's sexual ChiKong Practice ==>http://www.actionlove.com/cases/case8573.htm
New tricks help women develop vaginal sexual orgasm ==>http://www.actionlove.com/cases/case8575.htm
An erectile drug User confirms Dr. Lin's liver and hormonal dynamics for sexual orgasm! ==>http://www.actionlove.com/cases/case8590.htm
Feature Topics:
Vasectomy, ejaculation disorder, and sexual orgasm.
Outline of powering up the penis and clitoris/G-spot/Epicenter for prolonged intercourse and multiple sexual orgasm (s)
Dr.Lin's Sexual Chikong let him experience sexual orgasm induced by Tailbone-muscle contraction without semen ejaculation and prostate contraction!
How to Become an Impotent (Pre-aged) Young Man (click here)
Readers' experiences: How to break a penis! (click here)
Tips for her multiple orgasms (click here)
Full solutions for powerful erection, lasting longer and her sexual orgasm! (click her)
He said "Heat Tea triples her G-spot size; what should I do for her sexual orgasm?"
Cornell's Ob/Gyn professor's website is for sexual orgasm too.
Use morning intercourse (without ejaculation for growing the penis) or Screwing Finger Pliers Method to grow her G-spot and Epicenter for sexual orgasm.
He said Dr. Lin's Natural Penile Enlargement (Power-Up or Ballooning) Method works well, for sexual orgasm.
The effects of hormone change on sexual orgasm.
An erectile drug user with high-blood pressure likes the full spectrum-hormone releaser for better sexual orgasm.
How to benefit from Sexual Orgasm.
He experienced an unusual erection and sexual orgasm with ViaGrowth-III which is for the Natural Penile and G-spot Enlargement
GOOD NEWS:
Dr.Lin's philosophy of formulating full-spectrum hormone releasers for sexual orgasm, without any side
effects (why?). The Taoism approach.
==>http://www.actionlove.com/cases/case8463.htm
Since our establishment of this website in May of 1997, We have successfully served more than
20,000 couples (as of 7/19/1999, with 30-40 e-mails a day). This website contains more than 2000 COPYRIGHTED documents. It is
the most complete data base for sexual technologies and problems/solutions.
It may take you a few weeks or months to go through it.
We have highly appreciated your contributions - your important questions. Sometimes, you may get a delay or sluggish response from Dr. Lin as a result of e-mail overloading. This always happens during weekends. But, Dr. Lin will never ignore your important E-mail(s) as long as you have submitted your questions with Your Correct E-mail Address.
Note: We reserve the right to publish the original correspondences between you and Dr. Lin, but your name will be deleted under our 1000% privacy-protection guarantee.
BREAKING NEWS: Now, we are enterprising our business to serve you better.
A combination of Our 10-year R & D, the 5000-year Taoists' wisdom, and
the modern bioengineering advanced finally concludes our New Products,
ViaGrowth-I, II, and -III, helping men and women rejuvenate the natural
body functions, the aging body, and the shrinking sex organs. They are
available Now!
[TLI News Updated 9/1/1999] - Our success with ViaGrowth products, after 3-month introductory pricing and customers responses during 6/1/1999-8/31/1999, would like to continue benefitting all brothers and sisters around the world with reduced pricing.
Upon request of Mrs. Lin, we add ViaGrowth-III (60 tablets) to the Heat Tea package at no extra charge. We could not build this website to help you out and Dr. Lin could not write his book " Resonant Excitation of Sexual Orgasms," without her wisdom. We have honored her request for benefitting all the sisters around the world. ViaGrowth-III is very effective to resolve post-menopause hot flash, intercourse/post-orgasmic pain/cramp and PMS.
We also add the Fibra or Energia (for Heart/High-blood-pressure patients) to the ViaGrowth products as a package deal for Teenagers/ Young Men (ViaGrowth-I), 30-somethings (ViaGrowth-II), and middle agers (ViaGrowth-III). The most effective packages for middle agers, seniors and Erectile-drug Users are the full-spectrum hormone releasers, ViaPal-hGH-P and ViaPal-hGH-E (for heart and high-blood pressure patients.) We also include ViaGrowth-II into Androbolic for the high-performance, 20-70's men to shorten the Refraction Period or Time to re-arm their love weapon.
Our 10-year studies on pain and cramp in the muscles, ligaments and joints conclude "Blood Congestion" and "Hormone (DHEA/testosterone) Deficiency" in the local tissue are the most common causes. So, we offer our solutions with Pressure or Vacuum-cupping Massage and hormone-boosting supplements such as Heat Tea, PeniSOS, ViaGrowth-I, -II, and -III. They are the solutions for chronic pain or cramp in the back (from the shoulders to the tail bone), legs/toes, groins, thighs, hands/wrists/fingers, and intercourse and post-orgasmic pains or cramps.
ANOTHER BREAKING NEWS (updated 9/2/1999):
[TLI News Updated, 9/1/1999] - ViaGrowth-IV has passed testing. ViaGrowth-IV, a combination of Paragon, ViaGrowth-I, and ViaGrowth-III, with extra Choline (9/2/1999), is on the way, under testing for highly performing, middle-ager and senior couplers which want to retain their dynamic orgasmic life with 3-5 times a week and refuse to grow old! Our goal is to help senior couples enjoy more funs in their golden age! Life is too short to fully enjoy being together.
Your Sexual Orgasm is our business. Please Feel Free to contact Dr. Lin.
Missions:
=> Education of Love, Sex, Marriage, bioelectricity or life energy(the missing chapter in the modern medical textbooks which have been written based upon a corpse or an anatomical structure of the corpse), Naturopathy and Rejuvenation with Traditional Taoists'
Wisdom - Give the 5000-year "Tao of Love" a trial: Your Success with us is our sexual
orgasm(s) ; We can not limit our knowledge on a corpse. Instead, we have to study "life."
=> Helping Loving Couples, including the so-called Sex Experts, Therapists, Professors or
Scientists, Solve Sexual Problems. It is FREE! We can train old dogs new tricks; We look
beyond the so-called G-spot orgasm..
=> Research/Development of Naturopathic/Bio-Engineering Approaches for Solving Sexual
Dysfunctions and Health Disorder, and Rejuvenating the Natural Body Functions -by promoting
the parasympathetic function (the self healing power) and cooling down the sympathetic function for better health (of
course, including SEX!)- that is, Cultivate your Chi (Qi or Ki) and love.
==> Help people reverse the side effects produced by medication drugs, painkillers, smoking , drinking, improper diets, birth control pill and injection, surgery, over-masturbation and over-ejaculation , resulting premature ejaculation and weak erection or impotence.
=
=> Help people solve chronic pain, fatigue, cramp, spasm, arthritis and non-disease health problems with the bioelectric theory.
Safe Sex Advice for Young Women: My Finger Pliers
Method can trigger the G-spot sexual orgasm without breaking the hymen!
Dear Sex Experts, Therapists, Professors or Scientists:
Erectile dysfunction and sexual-orgasm disorder are physiological, not psychological! We can make earth move!
Do your sexual problems always bother you?
Or, You don't know where is the G-spot, or cannot distinguish the G-spot from the Epicenter which has been named as the "Center of Lotus" by the old Taoists.
Or, you got divorce.
Or, Never have vaginal orgasm, or experience Premature Ejaculation, Erectile Dysfunction, or have a Shrinking
Vagina or Penis, or a Prolapsing Uterus/Cervix causing pain/cramp in the pelvic cavity/low abdomen/low
back/legs/butts.
And, you have nowhere to ask , just because your expertise is SEX. That is unfair to your soul.
We can help you out with the 5000-year Taoists' wisdom and the bioelectric engineering of the brain, nervous and endocrine functions plus the hydraulic engineering of the blood circulation - the plumbing problem of sex organs! It is FREE! We protect Your 100% privacy.
A combination of 5000-year love experiments and SEX 101 with the Dr. Lin's bioelectric engineering theory can not be wrong.
Sincerely yours, Lovebug.
Sexual Orgasm Technologies, Methods and Treatment Programs:(WARNING: All the contents are
copyrighted - File NOs: TX 4-698-609, TXu 824-686 and current filing in the US Copyright Office. For private use
only. We reward your reporting on copyright violation. Academic/commercial uses of the contents in this website
without written agreement are absolutely prohibited.)
1. Anal Breathing Intercourse and Screwing Technique - the Penile/Vaginal Mutual Massage
(Kissing) Method, Sexual
ChiKong Intercourse, Natural Penile Enlargement (Power-up or Ballooning) Method, Vacuum-Cupping Massage,
and Herbal supplements (Natural Hormone Enhancers) for
powering the brain function, curing premature ejaculation and prostate
enlargement, penile/G-spot shrinking, weak erection/engorgement and
impotence/frigidity, and for combating the chronic health problems, such
as high-blood pressure, diabetes, pain and numbness in the neck, back, hands, fingers, waist, groins, butts, legs and
feet, depression, side effects of drugs/medication/smoking/the erectile drugs,.. and so on; and
2. Finger Plier(2-Point excitation) Method, 3_point Excitation Method,
Screwing Technique and Anal Breathing
Method, Pressure and Vacuum-Cupping Massages, and herbal supplements (Natural Hormone
Enhancers) for achieving multiple sexual orgasms, and for curing frigidity, vaginal dryness, vaginal shrinking, uterus prolapsing, thinning vaginal liner, prolapsed uterus,
hysterectomy, Intercourse Pain,
post-orgasmic cramp and pain, vaginismus,... and so on.
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