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Welcome to Orgasm Research Center

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In GOD we trust; all others provide evidences - data and cases! Yes, we got them all!  Since 1997,  we have collected human and animal sexual and drug experiences and experiments, classical, empirical and academic,  from 5000 years ago to today,  to share with you! Here, we deal with Sexual Exhaustion Symptoms, resulting from the evolution (or neuroplasticity)  of both the hypothalamus-pituitary-adrenal axis and the neuro-immune system induced by excessive sex, drug abuse, and traumatic stress.
Therefore, we have collected historical lessons and cases to support our claims as :
Suffering is Believing, Seeing is Believing, Hearing is Believing, Forgetting is Believing, Shaking is Believing; Dizzying is Believing; Head-aching is Believing; Peeing is Believing; Vibrating is BelievingTiring is Believing; Depressing is Believing; Feeling is Believing; Stressing is Believing; ReTooling is Believeing; Pleasing is Believing;
  or get Benefits from Optimal Orgasms (This is what you love to hear about. Yes, orgasm and sex can help improve your health!)

Dr. Lin uncovered the mystery of sexual orgasm!

img Warning, Warning: Finally,   some conscious researchers want to tell you that high-frequency sexual activity (intercourse, masturbation, overall) may increase risk of prostate cancer as given in http://www3.interscience.wiley.com/journal/121510647/abstractIt is not a joke! But, do you believe in them this time since the last time you were told that masturbation can reduce prostate cancer risk (yes, and you got excited by the "good" news which becomes your nightmare now!)?  Dr Lin has collected the ill effects (sexual exhaustion symptoms) from Over-masturbation/Over-ejaculation/Excessive Orgasm since 1997 to prove what the 5000-year old Chinese medical text said.  Dr. Lin has concluded sex/psychological- induced  excessive prolactin, norepinephrine, epinephrine and prostaglandin E2 can cause autoimmune disorders (more reference?), brain overheating with fever/flu-like symptoms ( http://ajpregu.physiology.org/cgi/content/full/294/4/R1294 ) vasoconstriction ( although prostaglandin E2 is an inflammator as well as a dilator),  fear, anxiety, restlessness, pounding headaches, dizziness, tremors, weakness, respiratory difficulty, palpitations, cardiac arrhythmias, skin cancers, skin disorders (including acne ), allergy, asthma, hair loss( more reference, and more; on hair cycling), neuroplasticity ( http://www.la-press.com/redirect_file.php?fileId=829&filename=GRSB-1-Akenaya&fileType=pdf  )and cancerous/tumorous cellular development and locomotion,  and ignite negative neuro-immuro-reaction, arterial constriction (via the alpha-adrenergic receptors) / inflammatory narrowness and venous constriction for blood-cutoff castration of the hypothalamus-pituitary-testicular axis and heart diseases, and inflammatory responses. Interrupting the stimulation of nuerohormones norepinephrine and epinephrine on the beta-adrenergic receptors via the sympathetic nerves (T10-L2) results in the prostate atrophy for spinal-injured men- http://www.nature.com/sc/journal/v44/n1/abs/3101804a.html while sympathetic nervous over-excitation of the neurohormones on the prostate causes prostate enlargement and pains.  For more information on Cancer, Sex and Stress, please click here - Stress Increases Prostate (and Ovarian) Cancer Risk. Yes, ovarian cancer too (yes, more reference); actually, any types of cancers or tumors, (for examples: skin cancers, colon cancer, liver cancer, et. al.) as well; and neuroplastic Post-Stress-Trauma brain/nervous damage. No doubt, current researches have tied breast and prostate cancers to excessive prolactin release and stress hormones norepinephrine (more?)and epinephrine  By the way, if you have been misled to over-masturbation, over-ejaculation (high-frequency ejaculation),  or excessive sex, our products can help you get recovery from Sexual Exhaustion Symptoms unless your testicular function was fully castrated by excessive sex. When sex stresses your Hypothalamus-Pituitary-Adrenal  (HPA) axis out, you get neuroplastic Post-Sex Stress Trauma Disorders (PSSTD), that is Dr. Lin's Sexual Exhaustion Symptoms, but no health benefit at all: you die for sex like insects! Are you on the way to selfdestruction?  By the way, you may would like to know what are effects of  semen and sperms on you can your partner (please click here)!  Maybe, you should learn about "The effects of stress hormones norepinephrine and epinephrine on cancers , the
sympathetically-driven cancers."

Why?  Consider the Sexual Arousal Neuroimmune Pathway: The dopamine nervous system stimulates the hypothalamus-pituitary axis, with orchestral effects of androgen hormones DHEA/testosterone/DHT  ( http://csbn.concordia.ca/Faculty/Pfaus/docs/Damsma,Pfaus,Wenkstern,Phillips,Fibiger%20(1992)%20Behav%20Neurosci.pdf, http://www.jneurosci.org/cgi/reprint/17/12/4849 http://synapse.koreamed.org/Synapse/Data/PDFData/0162PI/pi-6-194.pdf
http://pdf.medrang.co.kr/paper/pdf/Androl/Kjan018-02-09.pdf ,
http://pdf.medrang.co.kr/Kju/035/Kju035-05-02.pdf 
http://pdf.medrang.co.kr/Kju/039/Kju039-05-05.pdf 
http://www.nature.com/ijir/journal/v13/n3s/pdf/3900719a.pdf )
,  to activate the norepinephrine/sympathetic nervous action and the oxytocin, NOergic (NO = Nitric Oxide - released from the parasympathetic nervous endings)  and prostaglandin E2 stimulation on sex organs (prostate, seminal vesicles, penis and testicles, clitoris, uterus, vagina and ovaries), leading to the induction of swelling/congestive/inflammatory  pressure, arterial dilation and nervous sensitivity.  The swelling/congestive/inflammatory pressure won't give you pain, but nervous sensitivity if the tissues release sufficient prostaglandins E1 and E3 to relax the nerves and blood vessels and to enhance their elasticity and flexibility.  This is how sexual desire initiates and how people experience the persistent sexual arousal symptom. Noticeably, the highly stretched penile nerves may be desensitized when a penis is ballooned into the 2nd stage erection where the erecting penis becomes about 120% bigger than the initial erection. This exception can be achieved by the penile ballooning enlargement where prostaglandins E1/E2/E3,  androgen hormones, oxytocin, histamine, sympathetic and parasympathetic nervous erectile mechanism are synchronically working together.   Before sexual exhaustion, prostaglandin E2, with oxytocin and histamine,  acts as a vasodepressor/vasodilator; after sexual exhaustion, it, with a high level of prolactin and a lack of oxytocin and NO release,  becomes vasopressor/vasoconstrictor and arterial/venous narrowing  imflammator,  even with a high level of histamine. The tricky roles of prostaglandin E2 are also described in http://hyper.ahajournals.org/cgi/reprint/35/5/1129 .  Men or women can get a lot of erection, sex-organ swelling, and sexual desire from the stimulation of prostaglandin E2 (in conjunction with a high level of histamine release) with a high price - inflammatory body pains, congestive headaches, dizziness, or/and excessive, unwanted leakage/discharge out of the penis/vagina, if the cholinergic/vagal/serotonin/GABA nervous function, in conjunction with action of androgen hormones and prostaglandins E1 and E3,  are too weak to modulate the local inflammatory response induced by noradrenergic (norepinephrine)/sympathetic nervous fires (pyrogens) and prostaglandin E2 in the sympathetic adrenergic receptors.  In the brain, the hypothalamic dopamine-norepinephrine conversion during sexual arousal triggers endogenous pyrogens to act on the Organum Vasculation of the Lamina Terminalis of the third ventricle to promote prostaglandin E2 release to open the blood-brain barriers for more androgen hormones (stress hormones and toxins too!) to enter the brain and central nervous system, and to elevate the core temperature for sex heat. That is why you feel heat and warm when you become sexual arousal.  You may feel dizziness in your first encounter with a new partner. In the body, prostaglandin E2 promotes bradykinin-induced pains, spinal/back pains, the coagulation of platelets, bone resorption and formation (good!), immune disabling (for infection, but good for making babies: 1. de-activating the urethral, vaginal and uterine immune to help sperms survive through male ejaculation duct, female vagina, cervix, and uterus; 2. disabling the egg immune to help a sperm fertilize the egg; 3. disabling the uterine immune to allow the fertilized egg to be implanted or transplanted; 4. inducing labor (orgasms too)),  cancer and carcinogenesis, hypertension,  muscle protein degradation (muscular weakness and shrinkage), cardiovascular disorders, and synaptic neuroplasticity for alternation and reprogramming of brain/nervous functions (for better or worse), short-and long-term memory (including sexual pleasures!), addiction (of drug and sex!), alzheimer's disease, psychological disorders, and promotion of chronic noradrenergic/sympathetic fight or flight responses. You see, prostaglandin E2 plays the role of the good, the bad and the ugly in your life from the beginning to the end (death.)
Thus,  sex is a neuro-immune and hypothalamus-pituitary-adrenal and -testicular (-ovarian) challenge, good (constructive) or bad (destructive) depending on how you manipulate and perform it.  Sexual arousal or orgasm triggers the neuro-immuno-endocrine function for better or worse, depending on the immunoreaction of the noradrenergic (norepinephrine)/sympathetic nervous system to its resulted stress  and on the balance of its induced pro-inflammatory and anti-inflammatory responses. If you ignore the neuro-immune responses to sex-induced stressors norepinephrine and epinephrine, sex will destroy your health for no more orgasm, but pains and psychological disorders like drug abuse.  The neuro-immune-endocrine responses to sex-induced stress are driven by the sympathetic nervous alpha- and beta-adrenergic receptors of the immune cells which release immunotransitters cytockines and protein kinases for pro-inflammation or/and anti-inflammation.  The classic Taoism teaching considers sex as a powerful drug for better or worse, up to individual practices.   Don't become a LOOSER!
Over-masturbation/over-ejaculation/excessive-orgasm can castrate the hypothalamus-pituitary-testicular(ovarian) axis by arterial constriction and inflammatory narrowness in your brain and pelvic organs (testicles, prostate, seminal vesicles, penis, ovaries, uterus, vagina and clitoris) due to excessive release of prolactin, norepinephrine, and epinephrine, excessive binding of norepinephrine/epinephrine on the alpha-adrenergic receptors, the norepinephrine/epinephrine induced excessive prostaglandin E2, and the post-sex deficiency of nitric oxide and prostaglandins E1/E3 production. As a result of arterial constriction and inflammatory narrowness (leading to  arterial thrombosis and atherothrombosis! http://jem.rupress.org/cgi/content/full/204/2/311http://jpet.aspetjournals.org/cgi/content/full/300/2/393; http://jem.rupress.org/cgi/content/full/204/2/311  ),  your brain, testicles, penis, (clitoris, vulva, G-spot, vagina, uterus and ovaries for women)  feet and hands get low blood supplies and less androgen hormones and nuerochemicals, but more inflammatory hormone production and stress hormones.  And, it will take a long time for you to get recovery from sexual exhaustion and post-sex inflammation. You may also wonder why your  penis or clitoris go limps and your vagina become dry in the middle of sex.  When your adrenal and testicular (or ovarian) function are disabled, you will have to rely on the skin neruoendocrine function to elevate your androgen hormones.  Please also note that prostaglandin E2 also inflame veins too - http://atvb.ahajournals.org/cgi/content/full/18/10/1655http://ajpcell.physiology.org/cgi/content/full/281/3/C1038, http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=199422, and  http://atvb.ahajournals.org/cgi/content/full/17/9/1644 .  When you get inflamed arteries and veins, your blood circulation won't reach the inflamed areas and you will experience pain, numbness or cramp .  As for sex, you don't want inflamed arteries and veins in your penis and testicles (clitoris, labia, G-spot,  vagina. uterus (and its support ligaments and tissues) and ovaries for women), do you?

In addition, excessively accumulation of prolactin as a result of  high-frequency ejaculation or orgasm disables the activin release from the testicles, epididymis, prostate,and seminal vesicles (or ovaries for women),  leading to a low pituitary FSH release, followed by a low pituitary LH release, resulting in deficiency of androgen hormonal production from the testicles and ovaries. On the other hand, activin is a negative regulator of prolactin and cell growth ( http://mend.endojournals.org/cgi/content/full/18/6/1558 ). Without sufficient activin, the excessive release prolactin becomes persistent,  and thus the androgen hormones (testosterone and DHT) level remains too low to help the exhausted hypothalamus-pituitary-adrenal and testicular (ovarian) axis to recover from sexual exhaustion or post-sex illness or to suppress the inflammatory pains. No wonder, you will experience persistent  sexual exhaustion, fatigue, tiredness and inflammatory pains. 

Recent studies show that sexual exhaustion also reduces the androgen receptor density and expression, but upregulates estrogen receptor alpha expression,  particularly in  in the medial preoptic area (MPOA),  ventromedial hypothalamic nucleus (VMH), medial amygdala (MeA),  and lateral septum, ventral part (LSV) -  http://www.ncbi.nlm.nih.gov/pubmed/12914589 , http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000099250, http://www.ncbi.nlm.nih.gov/pubmed/17239879?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed  http://www.ncbi.nlm.nih.gov/pubmed/19073212?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed 
These researches basically re-verify the effectiveness of our products which were in the markets for solve sexual exhaustion symptoms long before these studies were done. However, the studies doesn't address catastrophic (permanent) castration of the pituitary-testicular and ovarian axis due to excessive prolactin and norepinephrine induced arterial and venous constriction and inflammatory narrowness in the brain, testicles, penis, ovaries, clitoris and other pelvic organs. We have found there are about 5-10% of sexual exhausted patients unable to get recovery.

Why are sexual exhaustion symptoms complicated by the exhaustion of the hypothalamus-pituitary-adrenal and -testicular (-ovarian) axis and the destruction of the dopamine, cholinergic/vegal/parasympathetic, serotonin and GABA nervous function with inflammatory responses?
Orgasm-stress induced inflammatory hormone prostaglandin E2  can over-excite mast cells to release histamine to activates the central histaminergic nerves and other numerous vasoactive, neurosensitizing and inflammatory molecules.  Histamine and its receptors are very dense in the hypothalamus, heart, lungs and arteries; Psychological or physiological stress, including sex-induced stress,  can induce significant alterations in both histamine synthesis and its concentration in several brain regions. During stress reactions, histamine may act as a neurotransmitter within the hypothalamus. A high density of brain mast cells in regions situated at the boundary between the central nervous system (CNS) and its surroundings such as in the circumventricular organs and median eminence can induce immediate hypersensitivity either in the CNS or in the periphery.  This gives you orgasmic headaches, allergic responses,  asthma, sneezing,  sinus,  itchiness, scalping burning sensation, hair loss and premature ejaculation.  Histamine, in turn, may also trigger the release of various stress hormones to prolong your sex-induced stress for several days.  Psychological or physiological stress, including orgasm/sex-induced stress also induces cardiac mast cell activation and histamine release into the bloodstream. Chronic excessive norepinephrine and its induced excessive histamine and prostaglandin E2 promote the development of atherosclerosis, coronary inflammation and cardiac ischemia, besides environmental toxins such as smoking (nicotine, pot, etc.).  In myocardial ischemia, excessive norepinephrine release causes severe arrhythmias and sudden cardiac death. Recent studies shows histamine H3-receptors can provide a negative feedback control for the release of norepinephrine from the sympathetic nervous endings, and for a number of other neurotransmitters such as histamine itself, dopamine, GABA, acetylcholine, and serotonin. But, this negative feed control can be easily breakdown by excessive stress. On the other hands, histamine H1 and H2 receptors promote cardiac disorders.  Reduction of endogenous histamine release or/and blockade of histamine H1 and H2 receptors can protects against ischemia. This is why there are  a lot of reports about  sudden death or cardiac arrest during intercourse or masturbation when histamine stimulates H1 and H2 receptors more than H3.  And, severe allergy can cause cardiac arrest.  However, what happens when histamine over-stimulates H3 but understimulate H1 and H2?  In this regard, you will likely experience the sexual exhaustion symptoms resulted from post-sex deficiency of dopamine, acetylcholine, norepinephrine, serotonin and GABA.  Unfortunately, in the most of sexual exhaustion symptoms we have collected, it seems H3 fails to negatively feedback control the norepinephrine and histamine release since sexual arousal, orgasm or ejaculation always triggers the hypothalamic and adrenal dopamine-norepinephrine conversion and histamine release when you are in the exhaustion state of the hypothalamus-pituitary-adrenal axis. For those with premature ejaculation, precum flooding, or premature orgasm, the sex organs start to release excessive histamine when  norepinephrine and its induced prostaglandin E2 start to heat up the brain, sex organs and noradrenergic/adrenergic/sympathetic nervous systems. Our readers' urinary analyses always showed an excess of norepinephrine and a severe deficiency of serotonin. This indicates that under the stimulation of excessive inflammatory hormone prostaglandin E2 and prolactin in sexual exhaustion conditions,  H3 fails to suppress the histamine and norepinephrine release, but  it positively and successfully block the dopamine, acetylcholine, serotonin, and GABA release in the nervous terminals. You may wonder why sexual exhaustion symptoms are complicated by the exhaustion of the hypothalamus-pituitary-adrenal and -testicular axis as well as  the destruction of the dopamine, cholinergic(acetylcholine)/vegal/parasympathetic, serotonin and GABA nervous functions, but with the excessive noradrenergic,  adrenergic, sympathetic, histaminergic or/and glutamate nervous function.
Ref:
http://www.ingentaconnect.com/content/mksg/all/2006/00000061/00000004/art00016
http://www.ingentaconnect.com/content/bsc/pse/1999/00000220/00000002/art09913
http://clincancerres.aacrjournals.org/cgi/reprint/11/19/6807
http://www.jimmunol.org/cgi/content/full/165/11/6545 
http://www.ncbi.nlm.nih.gov/pubmed/9274980?dopt=Abstract
http://ps.fass.org/cgi/reprint/86/5/843
http://www.jneurosci.org/cgi/content/abstract/23/14/5975
http://www.faqs.org/abstracts/Health/Production-of-prostaglandin-E2-induced-by-histamine-by-cloned-rheumatoid-synovial-cells.html 
http://ajpgi.physiology.org/cgi/content/abstract/242/1/G21 
http://www.jci.org/articles/view/107307/pdf 
http://www.jleukbio.org/cgi/content/abstract/74/3/420 
http://ajrccm.atsjournals.org/cgi/content/full/161/2/S1/S62 
http://ajrccm.atsjournals.org/cgi/content/full/169/1/15 
http://www.jci.org/articles/view/13930 
http://ajpheart.physiology.org/cgi/content/full/273/6/H2726
http://gut.bmj.com/cgi/content/abstract/18/6/429 
http://ard.bmj.com/cgi/content/abstract/49/7/504 
http://www.ingentaconnect.com/content/klu/428/2004/00000445/00000005/art00008 

In addition, excessive histamine stimulates excessive α-MSH release in the tissues around the eyes (dark eye circles),  scrotum, labia majors or minors, perineum, inner thighs and even nipples, leading to skin darkness known as Hyperpigmentation.  Thus, darkness of these skins indicate excessive histamine release locally. Beside excessive sex, other factors such as genetic factors, allergy, sleeping depletion (melatonin deficiency),  sickness,  and psychological stress,  can also cause excessive α-MSH release. However, high-frequency sex will darken eye circles and labia minors very fast due to its induced poor local blood circulation and overall blood color change as result of excessive norepinephrine, epinephrine, prolactin and α-MSH in the bloodstream. For more information, please go to Excessive sex for darker eye cycles, nips, labia minors, pelvic area, perineum, clitoral and penile foreskin.

By the way, excessive norepinephrine and prostaglandin E2 in the brain causes Homosynaptic and Heterosynaptic plasticity ( http://www.la-press.com/redirect_file.php?fileId=829&filename=GRSB-1-Akenaya&fileType=pdf ), that is nervous damage or alternation. Homosynaptic plasticity alternates synaptic strength that results from the history of activity at a particular synapse. For examples, norepinephrine increases the noradrenergic and sympathetic nervous fires; epinephrine increases the adrenergic and sympathetic nervous fires.  Serotonin Reuptaking Inhibitors outgrow the serotonin neurons and post-synapses and produces long-term inhibitory effects on the presynaptic terminals of the dopaminergic neurons. On the other hands, heterotropic plasticity changes synaptic strength that results for the activity of other neurons. For example, chronic norepinephrine stimulation under the noradrenergic/sympathetic nervous systems produces long-term inhibitory effects on the presynaptic terminals of neurons of the cholinergic/vegal/parasympathetic/serotonin/GABA neurons.  This is why Drug and excessive Sex are so destructive to the brain, in particular, when alcohol opens the brain-blood barriers to allow more excitatory toxins and neurohormones (such as norepinephrine, epinephrine, glutamate, histamine and prostaglandin E2) to screw up the brain and nervous systems.

Excessive sweating and Frequent Urination vs. the hypothalamic overheating and the pituitary AVP (Arginine vasopressin):
Noradrenergic, adrenergic and sympathetic nervous fires overheat the body for sweating. Sweating is to expel the internal body heat from the skin surface, and serves as a means of thermoregulation. External heat (hot weather),  muscular or joint heat, nervousness and nausea, panic responses, physical or psychological stress can cause excessive sweating. Exhaustion of the hypothalamus-pituitary-adrenal axis can cause excessive noradrenergic, adrenergic and sympathetic nervous fires and/or deficiency of AVP.   Frequent urination is a result of the excessive sympathetic nervous action on the adrenergic alpha receptors in the bladder and urethra (and prostate for men) while the vagal, serotonin and GABA nervous control are very weak.   When the AVP level is low, the fluid passes through the digestive tract, kidney and the bladder very fast by its dehydration effect. This will increase urination frequency upon fluid intake. A abrupt drop of AVP during the hypothalamic-pituitary overheating can may also trigger sudden sweating in conjunction with urinary urgency.  This is likely to occur for the drug abusers with sexual exhaustion, who serotonin and GABA nervous control on the hypothalamic dopamine-norepinephrine conversion and the core temperature regulation is out of order..

 OK,  we provide the  following topics for you, so that you can understand why sex is not for entertainment:
1. Destruction of Excessive Orgasms(for men and women) - About 5-10% of over-masturbators get permanently damaged! Over-masturbation/over-ejaculation/excessive-orgasm  can castrate your hypothalamus-pituitary-testicular(ovarian) axis by arterial constriction and inflammatory narrowness in your brain and pelvic organs (testicles, prostate, seminal vesicles, penis, ovaries, uterus, vagina and clitoris) due to excessive release of prolactin, norepinephrine, and epinephrine, excessive binding of norepinephrine/epinephrine on the alpha-adrenergic receptors, the norepinephrine/epinephrine induced excessive prostaglandin E2, and the post-sex deficiency of nitric oxide and prostaglandins E1/E3 production.  God punishes the self-destructors! Don't become one of them! Or you have to pay a high price for the consequence.
2. Male Ejaculatory Frequency and Seasonal Change vs Semen Quality
3. Male Ejaculation Frequency vs. Testosterone Level -
Psychological (Sexual) Stress locks up the hypothalamus-pituitary-adrenal and testicular axis via cortisol, prolactin and inflammatory hormone prostaglandin E2
4. Semen contains human growth hormone, Insulin-like growth factor-I,  alpha2-macroglobulin, testosterone, other therapeutic and pharmaceutical proteins and a lot of prostaglandins for better (Prostaglandin E1 and E3 for healing)  or worse (prostaglandin E2 causes cancers and tumors in the prostate and cervix)
5. Sex as an Addictive Drug
(but, can we retrain old dogs with new tricks to reverse addiction?)- the neuroplasticity of the hypothalamus by norepinephrine and its induced prostaglandin E2(for men and women) 
6. Excessive sex for darker eye cycles, nips, labia minors, pelvic area, perineum, clitoral and penile foreskin
7. Excessive sex and Light Over-Sensitivity in Retina
8 Benefits from Optimal Orgasms(
for men and women)
9. Brain-Skin/Brain-Hair connection - the effect of excessive sex-induced stress on skin (acne) and hair (hair loss)
(for men and women)
10.  Sex-stress (Norepinephrine/ Epinephrine)  induced Inflammatory Pains, Headaches and Hangover 
(for men and women)-  Norepinephrine-induced prostaglandin E2 release sets the brain and body on fire for sexual arousal/orgasm and pains
11. Persistently Sexual Arousal (breeding) or Over-ejaculation (Frequent Orgasm) Reducing/Suppressing Male Immune Function via Norepinephrine Induced Prostaglandin E2 Release
12. Liver/organs malfunction and inflammation and
Hypothalamus-Pituitary-Adrenal  impairement - ageing - induced by sex stress with chronic elevation of immunotransmitter cytokines and inflammatory hormone prostaglandin E2 (for men and women)

13. Stress hormones norepinephrine and epinephrine induced apoptosis in blood vessels.
14. Anxiety, Neuroimmune Reaction, and Premature Ejaculation
15. Orgasm-induced neuroimmune disorders, allergy and asthma.
16. Orgasm Brain Sex Pain examples
(for men and women)

Destruction of Excessive Orgasms
After you enjoyed too many sexual orgasms and/or too much pleasure, you have likely blown your brain/nervous bioelectric circuit breaker, and may have started to deal with the Sexual Exhaustion Symptoms - the exhaustion of the hypothalamus-pituitary-adrenal/-testicular (-ovarian) axis (cases are listed in Over.htm, Over2.htm, Over3.htm, and GirlOverSex.htm) very possibly or likely including the hypothalamus-pituitary-thyroid dysfunction, and deducing/downgrading or desensitization of the androgen hormonal receptors in the hypothalamus, hippocampus and pituitary, resulting from the Nervous Excitotoxicity and Inflammation induced by excessive norepinephrine, epinephrine and glutamate (& other excitory neurohormones, for a short-term pleasure reward and the long-term dopamine depletion),  long-term excessive elevation of prolactin ( to inhibit GnRH release from the hypothalamus and therefore LH and FSH secretion from the pituitary and to directly desensitize pituitary gonadotropic cells and the Leydig cells of the testes) , and Prostaglandin E2 (the brain heater for the core temperature rise!)  At the sexual exhaustion state, the constant elevation of excessive prolactin (mimics Hyperprolactinaemia) suppress sensitivity of  prolactin-negative feedback on hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons for persistently low dopamine synthesis,  blocks the beta-adrenergic receptors and nitric oxide nervous mechanisms and promotes norepinphrine and epinpehrine binding to the alpha-adrenergic receptors for vasoconstriction and restriction of blood flow to the brain and genitals, and destroys or desensitizes the hypothalamic androgen receptors, as described in
http://jp.physoc.org/cgi/content/abstract/576/2/585 
http://cancerres.aacrjournals.org/cgi/content/abstract/65/17/7984 
http://endo.endojournals.org/cgi/content/abstract/145/12/5714  
http://endo.endojournals.org/cgi/content/abstract/148/8/4080 
http://www3.interscience.wiley.com/journal/118874269/abstract?CRETRY=1&SRETRY=0 
http://www.psy.fsu.edu/faculty/hull/D&H_review.pdf  
http://ep.physoc.org/cgi/content/abstract/91/3/603 
http://jp.physoc.org/cgi/content/abstract/557/1/307  
http://endo.endojournals.org/cgi/content/full/147/3/1195
Cutting down the brain and genital blood circulation naturally alternates the neurotransmitters and hormonal syntheses, the major brain nervous function including the dopamine, acetylcholine, serotonin, GABA, noradrenergic, adrenergic, glutamate, oxytocin, nitric-oxide(NO), vagal and autonomic nerves functions,  and the hypothalamus-pituitary-adrenal and -testicular(-ovarian) function.
The Traditional Chinese Medicine has termed the hypothalamus-pituitary-adrenal (HPA) exhaustion as "Kidney Deficiency", since the classic Chinese anatomy text assumed the tiny adrenal gland, sitting on the top of  the kidney, is a part of the kidney about 2000 years ago. The HPA exhaustion results in the erratic release of CRH (corticotropin releasing hormone), POMC (proopinomelanocortin),  ACTH (adrenocorticotropc hormone),  -lipotropic hormone, -endorphin, α-melanocyte-stimulating hormone (α-MSH),  -MSH, CA (catecholamines) and TSH (thyroid stimulation hormone), in response to stress, sex and environmental/dyshomeostatic stimuli.  Since skin and hair follicles also display a functional equivalent of the HPA axis, sexual exhaustion will also extensively affect your skin (for examples: darkening skins in certain areas such as eye cycles, nips, labia minors, foreskin, perineum and groins, due to excessive release or trapping of the POMC peptide α-MSH which is also an anti-inflammatory and immunomodulating hormone - anti-tissue abrasion!) and the hair (for examples: hair loss in the scalp and gray hair, but it won't grow hair in your palms although it will destroy your HPA axis.)  The explanation of the HPA, skin and hair connection are given in the following links: http://edrv.endojournals.org/cgi/reprint/21/5/457, http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1839836&blobtype=pdf , http://www.fasebj.org/cgi/reprint/04-1968fjev1.pdf,  http://www.tufts.edu/sackler/pharmacology/faculty/theoharides/documents/TiI-brain-skin.pdf , http://physrev.physiology.org/cgi/reprint/80/3/979 , http://ard.bmj.com/cgi/content/abstract/66/suppl_3/iii52 , http://www.ncbi.nlm.nih.gov/pubmed/12576179 , http://www.fasebj.org/cgi/reprint/19/10/1332.pdf, http://www.annalsnyas.org/cgi/content/abstract/885/1/350 , and http://www.jci.org/articles/view/33508/pdf
As a result, sex is like a good investment with a bad return. When you reach the neuro-endocrine breaking point, it is like the stoke market cash leading to the great depression!! Yes,  excessive sex induces psychological and physiological disorders.

For example:
Penile sensitivity, erection, semen retention and prostate pains
http://www.actionlove.com/cases/case16702.htm
His ER (Emergence Room) doctors puzzled about his UFO sexual exhaustion symptoms: dizziness, headaches, ear buzzing (inner ear or cochlea inflammation), neck stiffness, shoulders tightness and pains, sleeping disorders, fatigue, short breathing racing heart, involuntary leg jerks and hand shaking (hyperactive sympathetic nerves L1 and L2 for Parkinson symptoms with dopamine, cholinergic serotonin and GABA nervous control disorders), and water retention (too much vasopressin), as a result of chronic over-masturbation and over-ejaculation.
==> http://www.actionlove.com/cases/case16084.htm

Destructive over-masturbation practices at 3-5 times a day resulted in brain fires and hydraulic shock waves, unconsciousness, panics, rapid heart beat, hypertension, short breathing, chest weird feeling urination difficulty, and frequent urination.
==> http://www.actionlove.com/cases/case15882.htm
After sexually exhausting his the brain's and internal Hypothalamus-Pituitary-Adrenal (HPA) axis, he has gotten headache and felt death and exhaustion from wet dream, even once a weak. Why he felt worse on the 2nd day after ejaculation? He may have to rely on  the Cutaneous Hypothalamus-Pituitary-Adrenal (CHPA) function to assist post-ejaculation or post-orgasm recovery.
http://www.actionlove.com/cases/case15761.htm
Excessive dopamine-norepinephrine/epinephrine induced excessive prostaglandin E2 production to elevate core temperature for over-heating brain, skin and hair follicles' neuro-endocrine function,  leading  to dark eyes, enlarged eye pupils, low testosterone, hot flushes, low libido,  cognitive disorders, and  speed disorders.
==> http://www.actionlove.com/cases/case15821.htm
Why psychological stress (excessive norepinephrine/epinephrine) induced excessive prostaglandin E2 production to elevate core temperature for over-heating brain, skin and hair follicles' neuro-endocrine function,leading to no erection, dark eyes, enlarged eye pupils, low testosterone, low libido, erectile dysfunction,  cognitive disorders and testicular disorders for no sexual orgasm - solution
==> http://www.actionlove.com/cases/case15822.htm
Chronic over-stress in war zone results in Posttraumatic Stress Disorder (PTSD), traumatic brain injury (TBI), depression, panic and erectile disorders due to serotonin/GABA neuroplasticity in hypothalamus, hippocampus and adrenal glands - Dr. Lin's proposed solution for neuroplasticity reversal.
http://www.actionlove.com/cases/case15877.htm

After our 10-year case collection and research, we now understand why excessive sex and drug abuses are so destructive. We are able to zoom into the main causes:
(1).  Sex-induced excessive excitory neurohormones norepinephrine/epinephrine/glutamate/histamine production for nervous toxicity: According to a American Scientists's report - http://www.americanscientist.org/template/AssetDetailNoFrame;jsessionid=aaaaBjcbX4%0D%0AuGmh?assetId=49707),   epinephrine can easily penetrate the mouse's blood-brain barrier into the limbic system, and allow lupus-like autoantibodies to reach the amygdala, where " the antibodies bind to and overactivate certain cell receptors, eventually killing the cells through excitotoxicity."  Excessive dopamine-norepinephrine-epinephrine conversion during sexual arousal/orgasm/ejaculation will drop the dopamine level (yes, for dopamine excitotoxicity prevention and rewarding pleasure if your dopamine level is too high!) , leading to excessive pituitary prolactin release to cause testicular and ovarian disorders, and keep the stress neurohormone norepinephrine or/and epinephrine in the excitotoxicity level. Our readers also reported chronic excessive orgasm/ejaculation induced seizure, headache, migraine, blackout, allergy, asthma, eye floaters and ear ringing (tinnitus), as a result of nervous excitotoxicity induced by excessive norepinephrine, epinephrine (particularly this one), glutamate or/and histamine. Prolonged and repeated assaults on the hippocampus nerve cell structure may permanently fry your brain. (Here are the other recent research examples:
http://jcem.endojournals.org/cgi/reprint/87/9/4245
http://www.biomedcentral.com/1471-2172/5/22
http://circ.ahajournals.org/cgi/content/full/102/1/96
http://www.algonot.com/pdf/mastcellsinflammation.pdf
http://www.ionchannels.org/showabstract.php?pmid=15970488
http://www.pnas.org/cgi/reprint/103/3/678
http://www.sciencemag.org/cgi/content/abstract/174/4008/512,
http://www.pnas.org/cgi/content/full/96/12/7093
http://ajpheart.physiology.org/cgi/content/full/289/4/H1577 
http://jcem.endojournals.org/cgi/content/full/89/5/2000
http://www.anesthesia-analgesia.org/cgi/content/full/100/2/520
http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=6793231, as addressed in this link-

How to kick the pornography addiction:  Reduction of the inflammatory hormone prostaglandin E2 production, Excessive epinephrine and norepinephrine induces inflammatory responses, persistent sexual arousal, and brain/nervous excitotocixity, and enhancement of the serotonin and GABA nervous modulation and control
==> http://www.actionlove.com/cases/case15570.htm
). 

Dopamine and glutamate are essential for sex. For healthy person, sexual stimulation elevates the dopamine and glutamate synthesis. Excessive dopamine triggers the stress hormone production and promotes the liver P450 enzymes and Monoamine oxidases (MAO) to  deamination of dopamine and stress hormones. In addition to elevating the stress hormones norepinephrine and epinephrine,  chronic excessive sexual stimulation, excessive orgasm, over-masturbation/over ejaculation, or drug abuse will result in excessive glutamate release or accumulation due to a shortage of the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate in efficiently converting elevating glutamate into GABA during sex, or/and due to a shortage of the enzymes gamma-glutamylcysteine synthetase and glutathione synthetase or/and a shortage of  amino acids L-cysteine and glycine, in converting elevating glutamate into the liver detoxification promoter Glutathione.   Elevation of GABA with serotonin, norepinephrine and prolactin after sex or orgasm will trigger the pineal gland to release melatonin for sleeping and restoration;  Elevating of glutathione can reduce the formation of  oxidative toxins, such as Hydrogen peroxide (H2O2),  associated with oxidative injury and cellular/nervous damage.  
Hair graying is a typical example of the hydrogen peroxide (H2O2) damage.  According to the recent study (http://www.fasebj.org/cgi/content/abstract/fj.08-125435v1 ), accumulation of  hydrogen peroxide (H2O2) bleaches human gray/white scalp hair shafts for graying when methionine sulfoxide (Met-S=O) is insufficient to repair in the entire gray hair follicle. It also indicates that  hydrogen peroxide (H2O2) damages hair follicle melanocyte apoptosis and DNA. That is, H2O2-mediated oxidative stress alternate human hair color by blunting methionine sulfoxide repair.  Excessive psychological and physiological stress can interrupt the Methionine-Glutathione Transsulfuration pathway with a lack of the choline-phosphatidylethanolamin synthesis, the phosphatidylcholine synthesis-  ( http://www.ajcn.org/content/vol85/issue3/images/large/znu0030743980001.jpeg & http://www.ajcn.org/cgi/content/full/85/3/702 ).  These research results seem to support  the folk medicine approach of using eggs to shampoo the scalp for reversing gray hairs.  Stress also attack the Hair Follicle Pigmentary unit, and disable or reduce hair pigmentation while hydrogen peroxide (H2O2)  bleaches hair shafts or damages the follicles.  Note that a  pigment  is any colored material of plant or animal cells. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1201498&blobtype=pdf and http://www3.interscience.wiley.com/cgi-bin/fulltext/120756708/PDFSTART .  In some extreme cases, chronic excessive stress or drug abuse may cause the hair pigment stem cells (melanocytes) to die prematurely.
Of course, you will benefit from optimal sex and orgasm if you get a resulted elevation of both GABA and glutathione.  However,  when the liver are stressed out by orgasm, over-ejaculation, drugs, and aged/toxified by the monoamine oxidization toxins, the liver can not efficiently provide the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate for glutamate-GABA conversion, leading to accumulation of glutamate in the brain/nervous systems and cerebrospinal fluid for ultimate nervous and brain destruction. ( Note that increasing the conversion of L-arginine to the inhibitory neurotransmitter agmatine can help block the action of glutamate on the NMDA receptor and acts as a neuromodulator. This is an important mechanism in preventing the harmful effects of excess glutamate. Agmatine is decarboxylated argenine. Studies shows agmatine can reverse pain induced by inflammation, neuropathy, and spinal cord injury - http://www.pnas.org/cgi/content/abstract/97/19/10584 ).

Furthermore, chronically excessive sexual arousal, over-ejaculation (overmaturbation), excessive orgasms or/and drug abuse can hyperativate the enzyme Monoamine oxidases (MAO) for dopamine-DOPAL conversion , where DOPAL stands for 3,4-dihydroxyphenylacetaldehyde.  DOPAL is a potent neurotoxin to cause Parkinson's-like brain lesions, and its resulted cognitive impairment is very similar to autism. In addition to DOPAL, norepinephine and epinephrine can be converted to 3,4-dihydroxyphenylglycoaldehyde (DOPEGAL) by MAO too. DOPEGAL has been found to trigger apoptosis and cause the loss of CNS neurons. Therefore, the synergic destructive effects of both DOPAL and DOPEGAL accelerates death of nerve cells, as seen in SIDS (sudden infant death syndrome), Alzheimer’s, Parkinson’s disease, and dysfunctional disorders of development and aging.

Overmasturbation resulted in Parkinson's symptom - restless or shivering legs and hands - due to abrupt drop of dopamine for excessive dopamine-neorepinephrine-epinephrine-DOPEGAL (3,4-dihydroxyphenylacetaldehyde) and dopamine-DOPAL(3,4-dihydroxyphenylacetic acid) conversion, leading to neurotoxicity and nervous death for no more sexual orgasm
==> http://www.actionlove.com/cases/case15611.htm
http://www.jneurosci.org/cgi/reprint/19/1/456 
http://www.jneurosci.org/cgi/content/full/17/12/4849 
http://psycnet.apa.org/index.cfm?fa=main.showContent&id=1992-18831-001&view=fulltext&format=pdf 

MAO, the brain/nervous and liver enzyme,  exists virtually in all mammalian cell types, with the notable exception of the erythrocyte. Excessive monoamines such as dopamine, norepinephrine and epinephrine induced by chronic stress, excessive sexual stimulation and orgasm and/or drugs will activate the liver Cytochrome P450 and MAO for oxidization (deamination) and detoxification, as described above, in order to maintain the homeostasis of the brain and nervous function. But, unfortunately, the resulting toxins destroy or damage the local neurons or synapses. In humans, there are two types of MAO: MAO-A and MAO-B. Both are found in neurons, hypothalamus, cerebral cortex (conscious control center), cerebellar cortex, pons, medulla oblongata, substantia nigra, caudate, astroglia, skins, and skeletal muscles.  Outside the brain and central nervous system, the liver, gastrointestinal tract , adrenal glands, kidnes, heart, lungs, and placenta have about 60-90% MAO-A and 10-40% MAO-B, but, MAO-B is mostly found in blood platelets. MAO's are enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. After placenta, liver contains the highest level of MAO, followed by kidneys, adrenal glands, heart, hypothalamus, substania nigra, lungs, intestine, caudate, medulla oblongata, pons, cerebral cortex and cerebellar cortex. That is, the liver, kidneys, adrenal glands, heart,  hypothalamus and substania nigra are likely aged or damaged by the  MAO-deaminated or oxidized toxins DOPAL, DOPEGAL, hydrogen peroxide (H2O2) and 5-Hydroxyindoleacetic acid (5-HIAA, as discussed below) faster than the other organs, and the liver will be damaged first. 
The main substrates of MAO-A include dopamine, serotonin, norepinephrine, epinephrine, octopamine, tyramine and tryptamine; the main subtstrates of MAO-B include dopamine, phenylethylamine, beta -phenylethylamine (PEA),  benzylamine, MPTP (1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine),  tyramine, and tryptamine. 
MAO plays the key roles in the development of neurodegenerative disease,  including not only its putative role in converting an exogenous protoxin to a toxin, as mentioned above, but also its role in the formation of peroxides generated from the oxidative metabolism of dopamine.  MAO catalyzed deamination of dopamine to DOPAL and production of hydrogen peroxide (H2O2) and ammonia NH3 depend on concentrations of dopamine within the cytoplasm. Hydrogen peroxide, if not detoxified by glutathione peroxidase, can be converted by iron-mediated Fenton reactions to toxic hydroxyl radicals ( -OH) that induce lipid peroxidation and cell death. In addition, excessive ammonia accumulation in the bloodstream, termed as hyperammonemia,  can cause the confusion and coma of hepatic encephalopathy as well as the neurologic disease.     On the other hand, MAO-A breaks down serotonin into 5-Hydroxyindoleacetic acid (5-HIAA) and steals serotonin from arylalklamine N-acetyltransferase (AANAT), resulting in depleting the melatonin synthesis. Melatonin plays the key role for the mechanisms of circadian rhythm for healing the damaged cells while 5-HIAA is responsible for the developments of certain tumors or cancers.  Graveyard workers are at risk due to hyperactivities of MAO.  Our product DeToxiA, MoodMax, ViaGrowth-IV, PinealTonin and ArgiNOx have been formulated  to help you reduce the MAO gene expression
(or weaken the MAO activities in the dopamine, serotonin, norepinephrine and epinephrine nervous terminals) and hydrogen peroxide (H2O2)  formation, and enhance the liver urea cycle to remove ammonia NH3 from the blood stream (that is, detoxification of the nervous system, liver and blood!)
Most recent studies also indicate there is significant positive correlations between platelet MAO activity and cortisol measures. In normal sexual activities, orgasm or ejaculation is supposed to drop the cortisol level and to elevate norepinephrine and epinephrine level. If MAO turns serotonin into 5-HIAA and depletes serotonin production during or after sex, the post-sex elevation of norepinephrine and epinephrine will activate the MAO action on the adrenal cortex for excessive cortisol elevation several hours after the cortisol drop induced by ejaculation or orgasm.  Cortisol overshooting suppresses the adrenal DHEA production and testicular function, resulting depletion of androgen hormones in the brain,  and then causes post-sex hangover,  memory loss and depression in the next few days.  Maintaining a high level of cortisol will suppress immune function, promote atherosclerosis, and damage and kill brain cells eventually.  Excessive sex, orgasm or ejaculation, or/and drug abuse for pleasure rewarding or/and sexual enhancements can let you experience both hypocortisolism and hypercortisolism in your daily life when the cortisol diurnal rhythm is disturbed or the cortisol level is too low in the certain time of a day, but becomes over-shooting in the other time.  The complicated symptoms induced by sexual practices was named as Sexual Exhaustion Symptoms by Dr. Lin, as given in http://www.actionlove.com/cases/case9848.htm.

With an exhausting hypothalamus-pituitary-adrenal axis, patients may experience some of hypocortisolism symptoms during sex or in couple hours after sex, followed by some of hypercortisolism symptoms  several hours or in next days after sex. This will puzzle your medical doctors.

In addition, Hydrogen peroxide (H2O2) inhibits the capacity of the circulating endothelial progenitor cells in the repair of damaged blood vessels ( http://informahealthcare.com/doi/abs/10.3109/10715760903402898  ) Endothelial progenitor cells, which are stem cells forming blood vessel during vasculogenesis, are believed to be capable of differentiating into endothelial cells, the cells that line the inner surfacer of blood vessels.  The adult endothelial progenitor cells are responsible for restoring and maintaining the lining of blood vessels. Inhibition of endothelial progenitor capacity by excessive H2O will thin the blood vessels and make the blood vessels become very fragile, resulting in breakage or bleeding under slight friction, abrasion or contraction or dilation.    The presence of blood in the semen ( hematospermia ) or the stool without organic causes is a typical example. The main non-organic cause is over-sex induced stress and its resulted excessive H2O, leading to the weakening or thinning of the veins  or capillaries. The tissue repair requires stimulation of hGH on the endothelial cells in conjunction with nutrients, vitamins ( such as B-complex, A, C, D and E), and minerals (such as Ca, Mg, K, and Zn.) 

(2). Sex-induced excessive inflammatory hormone prostaglandin E2 production, due to the excessive excitory neurohormones and the deficiency of androgen hormones (due to the disabling of the testicular and ovarian function by an excessive, persistent prolactin elevation at about 2-4 hours after orgasm/ejaculation):  In this regard, prostaglandin E2 induced body pain or inflammation originally serves as a warning sign of excessive sex.  If you ignore the warning signal, prostaglandin E2 will eventually give you more, including  inflammation responses, cellular multiplication, nervous excitation (for androgen hormone production and memory neuroplasticity (the good), inflammatory orgasm (the bad) and persistent sexual arousal and synaptic damage (the ugly)), nervous exitotoxcity and immune suppression.  Prostaglandin E2  induces enhancement of synaptic transmission is mediated via a cAMP/PKA(Protein Kinase A) pathway.  Prostaglandin E2 plays an important role in fever, pain, inflammation, sleep disorders, regulation of membrane excitability, sexual behavior, synaptic transmission, integration, neurotoxicity neuroplasticity, and neurologic disorders such as epilepsy and Alzheimer's disease. Excessive prostaglandin E2 can also degrade the short time memory and spatial navigation by enhancing membrane excitability (burning the synapse out) and then causing long-term damaged synaptic neuroplasticity in hippocampal perforant path-dentate gyrus synapses. Sexual pleasure and images will be imprinted  in your hippocampus by synaptic neuroplasticity resulted from the orgasm-induced prostaglandin E2 with a help of calcium channel of the synapse,  like remembering what you learn, hear, or see in daily life. Neuroplasticity is essential to learning and memory, like burning data into EEPROM. In eleccronic circuit, EEPROM can be eased and re-written.  I think our hippocampus can be reprogrammed by neuroplasticity (reversing sex and drug addition), with long-term potentiation (LTP) and long-term memory (LTM) formation, like training old dogs new tricks. However, if you apply a voltage to a memory cell higher than the upper limit of the EEPROM biased voltage, you will burn the memory cell out.  This condition also happens to your hippocampus.  Prostaglandin E-2 amplifies the excitatory post synaptic potentials (EPSPs) and heats the neuron and its synapse. Repeating the stimulation of the neuron and its synapse over time with accumulation of prostaglandin E2 will increase the action potential (accumulatively) in the neuron and synapse to cause the permanent deformation (forever memory) or damage (electrical overloading or thermal overheating ) of the synapse and neuron.  It can happen in the short time when prostaglandin E2 is excessive under a high-stress. extreme or/and shock condition. For this reason, you always remember your first-time masturbation and sexual intercourse.  In addition, persistent action of prostaglandin E2 on a cell will eventually alternate the cellular gene for potential cancerous or tumor development.  For examples, excessive prostaglandin E2 causes inflammation, enlargement, tumor and even cancers in the prostate, breasts, uterus and cervix.  Ref: http://jnnp.bmj.com/cgi/content/abstract/77/1/85 
http://bmc.ub.uni-potsdam.de/1471-2202-6-14/ 
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=356994 
http://ajpgi.physiology.org/cgi/content/full/274/3/G493  http://jn.physiology.org/cgi/reprint/93/2/929?ijkey=a9024b9ce74ad6d9ccd2311f9f39ee084760b417, http://jpet.aspetjournals.org/cgi/reprint/293/2/417?ijkey=3badb86cdf65c4b7c1d53623aea092cf7279b9b2 , http://jn.physiology.org/cgi/content/abstract/87/6/2851?ijkey=5cee184dd3946b4945f9cc00585dec35e2d51349&keytype2=tf_ipsecsha
http://cancerres.aacrjournals.org/cgi/content/abstract/65/12/5211 
http://www.jbc.org/cgi/content/abstract/263/11/5380 
http://www.annalssurgicaloncology.org/cgi/content/full/10/4/469 
http://cancerres.aacrjournals.org/cgi/content/abstract/63/17/5218 
http://cancerres.aacrjournals.org/cgi/content/abstract/65/2/657 
http://www.spacedu.com/ereprints/prostatecfos.pdf 
http://www.ncbi.nlm.nih.gov/pubmed/16293724 
http://www.pnas.org/cgi/content/short/101/2/415 
http://www.jneurosci.org/cgi/content/full/25/43/9858#REF41
http://pharmrev.aspetjournals.org/cgi/reprint/58/1/115.pdf
http://www.nature.com/mp/journal/v5/n6/full/4000811a.html  
http://www.cellscience.com/Reviews5/Ca2+_stimulated_Adenylyl_Cyclases_Hippocampal_Neuroplasticity.html

In addition, excessive sex or/and drug abuse also alternate the functions of the hypothalamus-pituitary-adrenal axis (HPA) and the sympathetic adrenomedullary system.  In addition to body pains and inflammation, our readers have also reported sex-or drug-induced memory loss, absent mindedness,  no concentration, less focusing,  hangover, or pseudo-Alzheimer's symptoms.  These problems can be associated with an overshooting of cortisol. In the normal condition, the sexual activities should not increase the cortisol level unless sexual arousal or orgasm induces inflammation; instead, normal sex tends to slightly reduce the cortisol level for activation of the pituitary-adrenal and -testicular function during and after sex.   In some case, the cortisol level drops too low, low enough to activate the inflammatory factors, leading to sex-induced pains , cramps or headaches while the norepinephrine and epinephrine level shoot up or remain too high. During sexual arousal, if the cortisol level shoots up (Note:  prolonged exercises overshoot cortisol, epinephrine, norepinephrine, Glucagon and growth hormones at the same time for a hyper-sympathetic nervous Fight), the prolactin level will follow; the man will go limp and the women will becomes dry; the lovemaking couples will experience sympathetic nervous Flight responses and the sexual arousal will be terminated. The release of cortisol, from the adrenal cortex,  is supposed to suppress the activities of the pro-inflammatory factors induced by an elevation of epinephrine, norepinephrine or/and histamine when the hypothalamus-pituitary-adrenal axis (HPA) responds to sexual arousal,  orgasm, masturbation, ejaculation, stress or drugs.   Under chronic loading of sexual arousal,  orgasm, masturbation, ejaculation, stress or drugs, the HPA can respond in 2 ways:  either abruptly dropping cortisol or excessively releasing cortisol.  If the adrenal cortex  released insufficient cortisol, the patients will experience immediate shape pain or mood change when the epinephrine, norepinephrine or/and histamine level overshoot out of the normal range.  

Under adrenal fatigue or deficiency conditions, the patient can experience the deficiency of both cortisol and androgen hormones (DHEA, testosterone or DHT), leading to persistent and severe body pains or inflammatory responses.

On the other hand,  if the adrenal cortex persistently shoot up the cortisol level and keep it high, the patient will experience foggy brain, memory/contraction/focusing loss, sleeping disorder,  and hangover in next few days. If either prolactin or cortisol level maintains too high, high enough to slow or shut down the adrenal and testicular function, leading to deficiency of DHEA, androstenedione, testosterone or/and DHT,  the patient will also experience post-sex inflammatory body pains, cramps or muscular rigidity due to excessive prostaglandin E2 production as a warning sign. The inflammatory responses usually occurs in few hours and the next day when the DHEA, androstenedione, testosterone or/and DHT are used up and drop down to deficient levels, too low to suppress the pro-inflammatory responses induced by excessive epinephrine and/or, norepinephrine.  
A chronic elevation of cortisol in the cerebrospinal fluid will cause depression and memory loss since cortisol can shrink or atrophy the hippocampus, associated with many kinds of memory and learning.  Unfortunately, under the conditions of chronically excessive sex/orgasm or over-masturbation/over-ejaculation, prolonged stress or drug abuse, excessive release of epinephrine, norepinephrine or/and histamine will open the brain-blood barrier (BBB) for more cortisol and other toxins to cross the BBB to pollute the cerebrospinal fluid and then to shrink the hippocampus,  like the elderly people experience.

Memory, brain and nervous functions can be also associated with Phosphorylcholine, a molecule mainly secreted by the seminal vesicle.  But, Dawson also reported that phosphorylcholine can also be found in the rat liver, testicles, spleen, intestines, kidney and brain, but there is only trace amounts in muscles, heart and blood, as given in http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1215699 and http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1215984.  More recently, it was found that the phosphorylcholine synthesis also occurs in the photoreceptors in supporting the eye visual sensing system (for example, http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=348559&blobtype=pdf ).  Phosphorylcholine combines with ceramide through a phosphodiester bond to create sphingomyelin, an important compound in the formation of the myelin sheath. Stroke victims and Alzheimer patients have shown improvement by increasing the phosphorylcholine level. In rat studies, tissue examination showed that phosphorylcholine was able to help repair damaged neurons. Phosphorylcholine was also found to help prevent a drug-induced drop in acetylcholine levels and improve memory and cognitive function ( http://www.fasebj.org/cgi/content/full/14/14/2198 ).  Over-ejaculation or excessive orgasm burns out, interrupts or discharges excessive phosphorylcholine and may let you experience poor memory or concentration and visual disorders.  I suspect that the depletion of phosphorylcholine synthesis induced by excessive ejaculation or orgasm, in conjunction with neuroexcitotocity of glutamate/norepinephrine/epinephrine and monoamine oxidization toxins (3,4-dihydroxyphenylacetaldehyde(DOPAL), 3,4-dihydroxyphenylglycoaldehyde (DOPEGAL), hydrogen peroxide (H2O2) and 5-Hydroxyindoleacetic acid (5-HIAA)), its resulted excessive release of  prolactin/cortisol and prostaglandin E2,  and its resulted deficiency of androgen hormones, leads to premature onset of Alzheimer's and Parkinson's disease, brain/nervous damage, liver/spleen/digestive/testicular disorders, cardiovascular disorders, and poor vision.  
Note:
Semen has high concentrations of potassium, zinc, calcium, magnesium, citric acid, fructose, phosphorylcholine, spermine, prostatic acid phosphatase, free amino acids, prostaglandins and enzymes, which nourish and protect the sperm.  Due to the high concentration of Phosphorylcholine in semen, the old Taoists theorized that men can return semen (actually phosphorylcholine) to revert the brain. Generally speaking, the concept is correct; however,  when the brain's dopamine or testosterone level is too high for excessive semen production, you still have to ejaculate to burn the dopamine and testosterone and to induce the prolactin release in the pituitary and retina for some protective and anti-inflammatory hormone 16K-prolactin to cool down the nervous systems, so that you can avoid the side effects of excessive dopamine or testosterone.  In this way, you can benefit from sex. Note that testosterone and acetylcholine can excite the dopamine-hypothalamus-pituitary axis and oxytocin release for sex.
Semen for testosterone replacement therapy (TRT)? Maybe, the ram seminal plasma testosterone concentration is high enough for natural TRT.
http://www.actionlove.com/cases/case16698.htm
Furthermore, Semen contains a lot of GABA ( http://www.andrologyjournal.org/cgi/content/full/25/1/140 , http://www.ncbi.nlm.nih.gov/pubmed/6237538?ordinalpos=1&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1 ) and beta-endorphin http://www.ncbi.nlm.nih.gov/pubmed/6291653?ordinalpos=1&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlusDrugs1 , http://www.ncbi.nlm.nih.gov/pubmed/2216060?ordinalpos=8&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum), both of which are the calm/inhibitory neurochemicals.  For a healthy man, ejaculation triggers glutamate-GABA conversion with the liver enzyme glutamate decarbozylase while glutamine is converted to glutamate by the liver enzymes glutamate synthase and synthelase.  In a male rates model, the cerebrospinal fluid(CSF)'s GABA and Asparagine/glutamate concentration increases 1000% and 200%, respectively, and there is a small decrements in amino accids such as serine, arginine, Alanine and leucine ( http://www.ncbi.nlm.nih.gov/pubmed/2877423?ordinalpos=4&itool=
EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum. ).  If there is a lack of  the liver enzyme glutamate decarbozylase, glutamate in CSF becomes too high and GABA becomes too low. This is why ejaculation causes deficiency of GABA and excessive glutmamte for the brain and nervous instability and sympathetic nervous Fight or Flight responses. Semen's GABA and beta-endorphin in the vaginal and cervix can block the female dopamine, oxytcoin and glutamate nervous excitation in the brain via the pituitary-uterus/cervix vagal nervous pathway, Both GABA and beta-endorphin also increase the female cerebrospinal fluid's GABA and beta-endocrine concentration right after male ejaculation, leading to calming the female central nervous system and reducing the oxytocin release. That is why premature ejaculation will disable libido immediately, unless the semen's prostaglandin E2 and glutamate can continue exciting the clitoral, G-spot, cervix and uterus vagal nerves. However, semen/CSF's GABA and beta-endorphin can help male and female post-orgasm pains in the urethra, prostate, bladder, clitoris,  vagina, uterus, and tailbone http://endo.endojournals.org/cgi/reprint/145/3/1331. Note: Beta-endorphin is mainly produced by the hypothalamus-pituitary-adrenal and -testicular/Ovarian axis in response to stress.  A sexual exhaustion person will fail to release sufficient beta-endorphin in help suppress pains.  A persistent sexual arousal person lacks of GABA and beta endorphin, but has a high level of glutamate, dopamine, norepinephrine, epinephrine and/or histamine.  Obviously, a person with a lack of serotonin, GABA and beta-endorphin will experience severe anxiety, depression, mood swing, de-realization, irrational thinking, irritation, panic responses, premature ejaculation, penile or clitoral over-sensitivity, and pains.   

Therefore, excessive sex or/and drug abuse result in multiple, sexual exhaustion symptoms which become UFO for western doctors and medical societies, although the Chinese Sex Bible and medicine documented them 5000 years ago.
==> http://www.actionlove.com/cases/case15448.htm
Why great sex life can result in divorce and end his sex life with low libido and headaches.
==> http://www.actionlove.com/cases/case15717.htm

On the effect of ejaculation on the testosterone production and aggressiveness or mode swing. Why it will take about 7 days to release the post-ejaculation or post-orgasm sexual exhaustion symptoms
http://www.actionlove.com/cases/case15719.htm

Warning: Pornography is a dirty bomb that can blast your mind, body and soul away, that is, kills your brain by excitotoxicity!  And,  SEX is a most strange, addictive drug without ingredients, in the name of love. Sex overdosing is an extremely destructive self-destruction, but unfortunately you will die for it (you become addictive to sex, due to the brain/dopamine nervous plasticity or the prostaglandin E2 induced persistent sexual arousal)!!!!!  When you have sex overdosed, your brain's acetylcholine, dopamine, serotonin and GABA nervous systems are burned out (ok, Dr. Lin called it the nervous excitotoxicity), your hypothalamus-pituitary-adrenal and testicular (ovarian) axis are partially or fully disabled,  your blood and cerebrospinal fluid chemistries are changed with a chronic elevation of epinephrine, cortisol, prolactin and prostaglandin E-2 for sexual exhaustion symptoms and sympathetic nervous fires (anxiety, stress, mood swing,  hangover, sleeping disorders, Obsessive Compulsive Disorder (OCD), inflammatory pains (in the upper back, neck, rear brain, joints, pelvis, perineum, low back, vulva, clitoris, vaginapenis, testicles, urethra, prostate and stomach), parkinsonism,  memory loss, vision disorders, ear ringing, chronic fatigue, brain disorders, headaches, dizziness, migraines, vertigoinflammatorily persistent sexual arousal symptoms, ejaculation or post-orgasm pains or cramps,  and so on) with a lack of healing and restoration forces, even if you are female,  and your excessive "love" becomes a poison to your health!  Realistically, your organs are bathed in the "bad" blood and your brain and spinal nerves work under chemically- and hormonally-unbalanced cerebrospinal fluid very day!!!  It is expected that the cellular DNA/genes in the organs will be gradually changed for worse, accordingly. Your 20-year old body then become 60 years old!!!! And your doctorS can not help you out even if prescribing drugs to shut down your sexual function won't help. Your doctors may tell you that you have psychological or psychiatric disorders. Please don't consider suicidal.  We can help you out.

Ejaculatory Frequency and Seasonal Change vs Semen Quality: according to http://www.ncbi.nlm.nih.gov/pubmed/15302284?dopt=Abstract , Increasing your ejaculatory frequency will drop your sperm concentration, but there is no seasonal variations in sperm concentration, motility, or morphology. Compared with one ejaculation per week, sperm concentration fell 29% with two ejaculations per week, and by 41% with three ejaculations per week.  Noticeable, the spring ejaculatory frequency is significantly higher in spring months than the winter's.  Note:  the pituitary-testicular axis and the skin endocrine function respond to the seasonal temperature change, and more active in warm weather.

Ejaculation Frequency vs. Testosterone Level
1. http://www.ncbi.nlm.nih.gov/pubmed/12659241?dopt=Abstract - "The purpose of this study is to gain understanding of the relationship between ejaculation and serum testosterone level in men. The serum testosterone concentrations of 28 volunteers were investigated daily during abstinence periods after ejaculation for two phases. The authors found that the fluctuations of testosterone levels from the 2nd to 5th day of abstinence were minimal. On the 7th day of abstinence, however, a clear peak of serum testosterone appeared, reaching 145.7% of the baseline ( P < 0.01). No regular fluctuation was observed following continuous abstinence after the peak. Ejaculation is the precondition and beginning of the special periodic serum testosterone level variations, which would not occur without ejaculation. The results showed that ejaculation-caused variations were characterized by a peak on the 7th day of abstinence; and that the effective time of an ejaculation is 7 days minimum. These data are the first to document the phenomenon of the periodic change in serum testosterone level; the correlation between ejaculation and periodic change in the serum testosterone level, and the pattern and characteristics of the periodic change."  also in http://www.ncbi.nlm.nih.gov/pubmed/12506329?ordinalpos=2&itool=EntrezSystem2.PEntrez
.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

or http://www.zju.edu.cn/jzus/2003/0302/030219.pdf 
Please note that average testosterone in this study is 378 nd/dl (for the ejaculation group) and 387 ng/dl (for the semen retention group), respectively. Men with a testosterone level below 500 nd/gl can not sexually perform well will likely experience post-orgasm andropause (male menopause) symptoms, such as anxiety, stress, hot flushing, cognitive disorders, exhaustion, fatigue, tremors, visual disorders, inflammatory pains, and so on.   For those with a testosterone level between 400-500 ng/dl , their erection will go limp very quickly in the middle of intercourse and likely to experience sexual exhaustion after ejaculating or sexual arousal;  for  those with a testosterone level below 400 ng/dl, they will experience impotency from the beginning of sexual encounter.  Based upon our definition of sexual age, the participating men in this study have a sexual age of  about 70 years old  with a refraction time of 6-7 days as defined below, despite of the calendar ages from 28 years old to 45 years old, where the refraction time is considered the sexual recovery time for another run of ejaculation.  They are premature-aged men!  (as a result of chronic over-masturbation??? I wonder).   Our optimal testosterone level for sexual performance is from 500 nd/dl to 1000 ng/dl.  This study also indicates that practicing sperm retention, like vasectomized men do, will gradually disable the testicular function as described and explained in the following links- 
Non-orgasmic semen retention is as bad as over-ejaculation; both are for no more sexual orgasm ,but for sympathetic nervous pains and burning. What is different between both cases in term of the dopamine-norepinephrine-epinephrine conversion?
==> http://www.actionlove.com/cases/case13176.htm

On seminal retention and prostate-cancer protection, and of course, on Over-masturbation and sexual orgasm
==> http://www.actionlove.com/cases/case11407.htm or
http://actionlove.com/extra/vascectomy.htm 
You may also wonder why Buddhism monks practice sperm retention for  disabling  their testicular function and forming semen stones from minerals collected in semen at the same time. 

2. http://www.ncbi.nlm.nih.gov/pubmed/11760788?dopt=Abstract - "This current study examined the effect of a 3-week period of sexual abstinence on the neuroendocrine response to masturbation-induced orgasm. Hormonal and cardiovascular parameters were examined in ten healthy adult men during sexual arousal and masturbation-induced orgasm. Blood was drawn continuously and cardiovascular parameters were constantly monitored. This procedure was conducted for each participant twice, both before and after a 3-week period of sexual abstinence. Plasma was subsequently analysed for concentrations of adrenaline, noradrenaline, cortisol, prolactin, luteinizing hormone and testosterone concentrations. Orgasm increased blood pressure, heart rate, plasma catecholamines and prolactin. These effects were observed both before and after sexual abstinence. In contrast, although plasma testosterone was unaltered by orgasm, higher testosterone concentrations were observed following the period of abstinence. These data demonstrate that acute abstinence does not change the neuroendocrine response to orgasm but does produce elevated levels of testosterone in males."
3. American population testosterone level dropped about 50 ng/dl for men at around age 64-65 between 2 groups of men born in 1920-1924 and 1930-1934, according to in http://jcem.endojournals.org/cgi/reprint/92/1/196. When the 1920-1924 group reached the median age 65, their mean testosterone level was 500 ng/dl; when the 1930-1934 group reached the median age 56 and 64, their mean testosterone was 529 ng/dl and 444 ng/dl, respectively. The 1930-1934 group has a testosterone drop rate at about 10.65 ng/dl per year during ages 56-64. This report also shows that the testosterone drop rate generally becomes faster for the men from 55 to 65. If we use the same annual drop rate of the 1930-1934 group, the extrapolated, averaged testosterone level of of 20 year old men born during 1930-1934 should be about 911 ng/dl.  Assuming that the mean 20-year old testosterone level for both groups are the same  is about  911 ng/dl, the overall-averaged testosterone drop for the 1920-1924 group is about 9.13 ng/dl/year, while the overall-averaged testosterone drop for the 1930-1934 group  is about 10.61 ng/dl/year  I suspect the higher masturbation/ejaculation frequency in the younger generation after the 60's sexual revolution resulted in a higher cortisol/ prolactin level (or faster ageing of the hypothalamus-pituitary-adrenal and -testicular axis) accelerates the testosterone drop, since some high-frequency over-masturbation young men experience male menopause (andropause) between ages 20-30. 
4. Our observations for healthy ejaculation frequency (or refraction times) vs age, in order to maximize the testosterone level, are:
  1. 4-7 times per week for teenagers of age 16-19.
  2. 3-6 times per week for young men of age 20-25.
  3. 3-5 times per week for young men of age 25-30.
  4. 2-4 times per week for men of age 30-45,
  5. 1-3 times per week for men of age 45-60,
  6. 1-2 times every 10 days for men of age 60-70.
  7. No more than once a week days after age 70
 Lovemaking orgasms stimulate the pituitary to release oxytocin for a faster recovery; while masturbation may not help the pituitary to release enough oxytocin. Therefore, the masturbation ejaculation frequency should be limited to the low limit as possible as you can. If your ejaculation orgasm produces sexual exhaustion symptoms,  your ejaculation frequency should be lower than the listed above.  The actual ejaculation frequency is associated the refraction (recovery time) of the hypothalamus-pituitary-adrenal, -thyroid and -testicular axis. The energetic time (full recovery with powering up) for a man having a morning (8 AM)  testosterone level at 350-400 nd/gl is about 7 days when his testosterone level reach its peak, over 500 ng/dl. If he keeps this ejaculation frequency, he will likely maintain his testosterone level around 450-550 ng/dl, thereafter. A man with a high testosterone level of 700 ng/dl or higher can re-erect  the penis in a few minutes after ejaculating if his pituitary doesn't overshoot his prolactin level, but it doesn't mean he can ejaculate again.  This is because the ability of penile re-erection can be associated with the dopamine nervous action on the pituitary oxytocin and prolactin release and the stimulation of testosterone, nitric oxide, prostaglandin E1 and  prostaglandin E2 stimulation on the prostate and penile erectile nerves.  Prostaglandin E2 can re-erect the post-ejaculating penis again when the oxytocin level is high and the prolactin level is not overshooting out of the range. The prostaglandin E2 induced erection usually accompanies a little pains in the prostate, urethra and penis. Even if you can re-erect your penis for sex again,  the post-ejaculation elevating cortisol and prolactin will start to lock up the adrenal and testicular function to drop your DHEA and testosterone production few hours after the first ejaculation. 
Like  psychological stress or exercise-induced stress, sex-induced stress induces excessive cortisol, prolactin and norepinephrine/epinpehrine release to lock up the hypothalamus-pituitary-adrenal and -testicular axis during sex or few hours later after orgasm or ejaculation. The neuro-immune-endocrine  responses to sex-induced stress can be delayed until cortisol starts to exert its effects on  the adrenal cortex, prolactin on the pituitary-testicular axis, and norepinephrine/epinephrine and its induced prolstaglandin E2 overheat the hypothalamus, pituitary, adrenal glands, testicles (ovaries), prostate, liver, lungs, heart and pancreases (for a high glucogan release) via the alpha- and beta -andrenergic receptors. For the same reason, people with chronic stress, no matter from which sources, generally have a lower testosterone level.  Over-trained athletes and soldiers and psychologically stressed-out persons are not exceptional. Testosterone and norepinephrine can positively or negatively interact each other through their receptors.  Initially,  testosterone induces norepinephrine release to give your arousal and heat, and then excessive norepinephrine with a high level of proactin and cortisol reduces testosterone release; on the other hand, without the inhibition effects of excessive prolactin and cortisol, norepinpehrine stimulates testosterone release via  action on both alpha- and beta-andrenergic receptors in the adrenal and testicles (ovaries) when the testosterone level is too low. To avoid the inhibition effects of excessive prolactin and cortisol, you need a normal dopamine-hypothlamaus-pituitary-adrenal function.  Any way, there are a lot of researches backing up the claim about the interaction among the nervous, immune and endocrine system:
Ref: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T99-42MFD98-12&_user=10&_rdoc=1&_fmt=&_orig=search

&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2ddd3a7402479afca7ce03f4b59238f9  
http://hyper.ahajournals.org/cgi/content/abstract/32/5/880  
http://cat.inist.fr/?aModele=afficheN&cpsidt=2480820 

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600009&lng=e&nrm=iso&tlng=e   
http://www.biolreprod.org/cgi/content/abstract/40/3/541 
http://www.popline.org/docs/0198/751348.html 
http://hyper.ahajournals.org/cgi/reprint/17/6/1104.pdf 
http://cat.inist.fr/?aModele=afficheN&cpsidt=15071810 
http://www.ncbi.nlm.nih.gov/pubmed/1337237 
http://endo.endojournals.org/cgi/content/full/144/11/4923  

The following research suggests the inflammatory cytokine IL-1beta and its induced prostaglandin E2 can stimulate the hypothalamus to induce release of norepinephrine, dopamine, and serotonin as a feedback control.
http://www.jneurosci.org/cgi/reprint/13/8/3574 

This article suggest norepinephrine control the feedback of  LH secretion in the hypothalamus-pituitary-testicular axis - http://www.popline.org/docs/0188/761130.html 

You will get more explanation in the following about the role of norepinephrine and epinephrine in the sexual arousal, orgasm responses, sexual exhaustion symptoms,  and neuro-immune function.


Semen contains human growth hormone, Insulin-like growth factor-I,  alpha2-macroglobulin, testosterone, other therapeutic and pharmaceutical proteins and prostaglandins for better or worse:  
Pre-puberty overmasturbation may limit the body and penile growth. Chronic over-masturbation/over-ejaculation or excessive sex exhausts the hypothalamus-pituitary axis.  don't expect the exhausted pituitary gland to properly release hGH, oxytocin, prolactin and arginine vasopressin (AVP.) Vasectomy can significantly drops hGH and testosterone at about 30-60% and 25-53%, respectively, in seminal plasma.   Also sperm retention in Seminiferous tubules causes inflammatory hormone production inside the testicles (leading to the blue ball effect at an extreme) and forces the sperm antigen to leak through the testicle-blood barriers to activate inflammatory hormone prostaglandin E2 production in the other areas, particularly in the prostate and seminal vesicles. Elavation of prostaglandin E2 will also trigger excessive adrenal and hypothalamic dopamine-norepinephrine conversion for sympathetic nervous Fight and Flight responses, where Fight = " Premature Ejaculation" and Flight = "Going Limp" during sex. A low dopamine nervous function  will also drop the hypothalamus-pituitary-testicular function, leading to Hypogandism.
http://humrep.oxfordjournals.org/cgi/reprint/11/11/2454
http://humrep.oxfordjournals.org/cgi/reprint/14/6/1534 
http://www.biolreprod.org/cgi/reprint/67/2/648 
http://ps.fass.org/cgi/content/full/86/1/112 
The serum IGF-I concentration can be correlates to the IGF-I concentration in reproductive traits.
http://jas.fass.org/cgi/reprint/82/8/2285 
It is also shown the seminal vesicles can produce HGH and other therapeutic and pharmaceutical proteins -
http://www.bioteach.ubc.ca/TeachingResources/Genetics/MouseGeneticsQsAnsB.pdf 

Semen for testosterone replacement therapy (TRT)? Maybe, the ram seminal plasma testosterone concentration is high enough for natural TRT.
http://www.actionlove.com/cases/case16698.htm

Semen contains a lot of proimflammatory factors such as cytokines, prostaglandin E2 and 19-hydroxy prostaglandin E2, polyamines, and histamine. Although it also have anti-inflammatory cytokines and prostaglandin E1/E3, the pro-inflammatory factors usually overpower the anti-inflammatory factors since the pro-inflammatory factors are essential to the immune suppression so that the sperms can safely pass the male ejaculation tract in the prostate and urethra, survive in the vagina and uterus,  fertilize eggs, swell endometrium,  and eventually implant the fertilized eggs in the endometrium. For men, chronically blasting  the tissues and nerves of the ejaculation tract with seminal fluids result in inflammation, immune suppression, and hypersensitivity.  The inflammatory mediators may also exert toxic effects on sperms, leading to infertility too. Refs: http://www.andrologyjournal.org/cgi/content/full/28/2/325
Prostaglandin E1and E3 are the good guys for healing and restoration, but prostaglandin E2 is the good , the bad and the ugly. Prostaglandin E2 also stimulates the cells to grow and perform multiplication, and induces orgasm and labors. Recent study suggest prostaglandin E2 in seminal plasma promote cervical cancers - 

http://jcem.endojournals.org/cgi/content/full/86/5/2243 
http://endo.endojournals.org/cgi/content/full/147/7/3356 
http://humrep.oxfordjournals.org/cgi/reprint/22/1/36.pdf 

In addition to induction of inflammations, pains, tumors and cancers, prostaglandin E2 causes premature ejaculation and anxiety by stimulating the sympathetic nerves in the seminal vesicles and prostate for more hypothalamic and adrenal norepinephrine and epinephrine production.  After sexual intercourse, the prostaglandin E2 release in the prostate, urethra, vagina, cervix and uterine will shot up for 24-48 hours. The elevation of prostaglandin E2 will skew the physical examination of the sex organs and their secretion. If you want to have a precious physical examination in your pelvic organs, you should avoid sex at least 48 hours before going to see your doctor.

Semen fluid disables neuroimmune responses of the female reproductive tract, essential to establish pregnancy. Semen's cytokines and prostaglandins bind into receptors on target cells in the cervix and uterus for activating changes in gene expression for pro-inflammatory response with induction of proinflammatory cytokines and COX-2 ,  and  sperms also modulate neutrophil influx into the uterine lumen to enhance the local leukocyte population and cytokines synthesis originally elicited by semen plasma.  As a result, semen fluid  signals the ovarian function to increase progesterone by stimulating the cervix and uterus. Elevation of progesterone in the cervix receptors will shrink/harden the cervical tissues and close the cervical orifice up in order to retain semen and sperms. In some animals, such as dogs and pigs, which have a long cervix to interlock the penis, semen fluid can trigger the long cervix to lock up the penis, known as  mating or copulatory tie. The mating or copulatory tie also happens to human. As a result of mating tie, some male insects die from mating due to a full drain of semen and sperms. During the ovulation or heat, the cervix is very flexible and its orifice is open to welcome the penis. After ovulating or heat, the cervix become less flexible and its office closes.  Since the human vagina is long and the cervix orifice orients to about 30-45 degrees to the vaginal axis, the chance for the penis to penetrate into the cervical office is very small, and therefore, the chance of  human copulatory tie is very small.  But,  for some women with a titled cervix/uterus and uterus prolapsed, it is possible to have copulatory tie. (examples: http://www.actionlove.com/cases/case15659.htm and  http://www.actionlove.com/cases/case16375.htm )

Semen fluid can also stimulate vaginal/cervical/uterine master cells for histamine and prostaglandin D2 release to trigger allergic and hypersensitive responses, which occurs for some women. Although semen also contains anti-inflammatory cytokines and prostaglandin E1/E3 to balance the inflammatory responses, but it produces more effective proinflammatory responses than anti-inflammatory one.  Thus, the chance of post-copulatory inflammatory reaction becomes high.   With a rough sex,  vaginal or cervical abrasion can cause vaginal, vulva and cervical inflammation, pains and even infection by mechanically stimulating enzyme COX-2 expression for extra prostaglandin E2 release. Therefore, the tissue abrasion must be avoided during sexual intercourse. 

For the sake of your girlfriends (girlfriend)  and/or wives (wife) and your prostate , you should  reduce the prostaglandin E2 level and increase hGH and other therapeutic and pharmaceutical proteins in your seminal plasma.   You can last longer during intercourse and also renourish your girlfriends and wives with your semen via the vaginal/cervical/uterine absorption. To improve your seminal quality, you should take out ViaPal-hGH formulas.  Don't let your poor semen cause the vaginal yeast infection, urethral tract infection, Vaginosis or Vulvodynia, or even allergy

By the way, don't empty your seminal vesicles by multiple ejaculation in one love session. You should leave about 1/3 of semen in seminal vesicles, so that the residual semen can help you restore your nervous functions and your brain and testicular blood circulation for recovery.

More about the seminal plasma and sperms induced anti-inflammatory and pro-inflammatory immunogenic effects on the tissues (vaginal, cervix, uterine, urethra and even male prostate), please read
http://jas.fass.org/cgi/reprint/85/13_suppl/E36  
http://molehr.oxfordjournals.org/cgi/content/full/13/7/491 
http://molehr.oxfordjournals.org/cgi/content/full/5/3/220 
http://endo.endojournals.org/cgi/content/short/en.2005-1429v1 
http://molehr.oxfordjournals.org/cgi/reprint/13/7/491 

http://molehr.oxfordjournals.org/cgi/content/full/5/3/220#THOMPSON-ETAL-1992
http://molehr.oxfordjournals.org/cgi/reprint/13/7/491 
http://humrep.oxfordjournals.org/cgi/reprint/12/3/586.pdf 
http://humupd.oxfordjournals.org/cgi/reprint/12/1/23.pdf
http://www.biolreprod.org/cgi/content/full/66/2/445 
http://www.andrologyjournal.org/cgi/content/full/24/5/704 
http://www.reproduction-online.org/cgi/reprint/131/3/613 
http://www.andrologyjournal.org/cgi/reprint/24/3/448 
http://www.jbc.org/cgi/content/full/277/36/32562 
http://www.jbc.org/cgi/reprint/275/29/21844  
http://humrep.oxfordjournals.org/cgi/reprint/22/11/2928 
http://www.andrologyjournal.org/cgi/content/full/28/2/325 
http://humupd.oxfordjournals.org/cgi/reprint/13/3/225 
http://www.ncbi.nlm.nih.gov/pubmed/16129942 
http://www.jimmunol.org/cgi/content/abstract/136/8/2862 
http://www.biolreprod.org/cgi/content/full/59/1/202 
http://www.reproduction-online.org/cgi/reprint/132/1/147 
http://www.reproduction-online.org/cgi/reprint/131/3/613 
http://www.reproduction-online.org/cgi/reprint/128/2/237 
http://www.jrijournal.org/article/S0165-0378(02)00042-6/abstract 
http://www.ncbi.nlm.nih.gov/pubmed/7932389?dopt=Abstract 
http://www.ncbi.nlm.nih.gov/pubmed/11839394?dopt=Abstract 
http://humupd.oxfordjournals.org/cgi/content/full/12/1/23 
http://www.reproduction-online.org/cgi/reprint/94/1/213?ijkey=3a5b7bcceb881f062ee51828c033c6aeaaffe200 
http://www.reproduction-online.org/cgi/reprint/107/2/265?ijkey=a0d200ea06db70a2aec626c4916b5b199b9c6615 
http://www.reproduction-online.org/cgi/reprint/66/1/157?ijkey=a9067f9685e5a013abf5cf7e4ae335d09afde778 


Semen in the seminal vesicles contains varieties of androgen hormones, neurochemicals and prostaglandins, such as hGH, DHEA, testosterone, DHT, oxytocin, prolactin, glutamate, histamine, dopamine, norepinephrine, epinephrine, serotonin, GABA, glycine, agmatine, prostaglandin E1, Prostaglandin E2, prostaglandin E3, and etc.  Diffusion of the hormones, neuronchmicals and prostaglandins into the cholinergic (vagal and parasympathetic) and sympathetic neurons will modulate the nervous function as they do in the spinal cord deep dosal hormone neurons. Seminal vesicles serves as a neuronutrient reservoir in the end of the spinal cord while the spinal cord deep dosal horn in the beginning of the spinal cord. Bathing the neurons in the reservoirs will affect the spinal sensory nervous function.  This is what fully emptying seminal vesicles by ejaculation is not recommended. http://jn.physiology.org/content/86/5/2183.full.pdf+html


Sex as an Addictive Drug (but, can we retrain old dogs with new tricks to reverse addiction?) : Stimulation of a neuron will promote release of neurotrophins from the neuron terminal. Neurotrophins, also known as the -nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), belongs to a class of secreted proteins, responsible for the growth and survival of developing neurons and the maintenance and differentiation of mature neurons.  Neurotrophic factors also are capable of regrowing damaged neurons.   BDNF can mediate neuronal plasticity (neuroplasticity) and influences learning, memory and cognitive behavior. Neuroplasticity is an alternation of a nervous system to adapt the short- or long-term biochemical, physiological and morphological changes in response to intrinsic or extrinsic inputs. Neuroplasticity in the central nervous system is essential to learning and memory.   Therfoere, chronic nervous over-stimulation induces over-release of the central BDNF, with drug or sex, can result in alternation of brain and synaptic plasticity, leading to addiction behaviors. The central neuronal plasticity promotes the noradenergic, adrenergic and sympathetic nervous function and weakens the parasympathetic, vegal, serotonin and GABA nervous synaptic modulation and control on the noradrenergic, andrenergic and sympathetic nervous function.  That is, chronic nervous over-stimulation on certain nervous systems, for examples, such as dopaminergic, glutaminergic, norandrenergic nervous systems,  can modify the brain function for psychological disorders and addiction.  In addition, hormone such as hGH, DHEA, oxytocin, prolactin, LH, FSH, testosterone, DHT, progesterone and estrogen, can modify (enhance) BDNF release and nervous growth, differentiation and maintenance.  Therefore, we should separate neuroplasticity into the  positive or negative one. Reversal of a negative (destructive) neuroplasticity into a positive one is very difficulty. You can consider the reversing process is brainwash. A positive neuroplasticity allows a person to partially or fully recover their brain function from stroke or brain injuries or illness. A negative neuroplasicity will let people experience drug addiction,  drug withdrawal symptoms, mood swing, depression, stress, anxiety or obsessive-compulsive disorder, due to synaptic rewiring ,  neuronal outgrowth or neuronal death. For example, SSRIs antidepressants can outgrow certain neurons in the brain, but drug withdrawal, without help the nervous terminals to produce sufficient serotonin, will result in brain shock,  nervous sparking,  agitation, more depression, more anxiety, akathisia, panic attacks, irritability, aggressiveness, worsening of mood, dysphoria, crying spells,  mood/emotional  lability, overactivity,  hyperactivity, depersonalization, decreased concentration, slowed thinking, confusion,  memory/concentration difficulties,  nausea, drowsiness, sleeping disorder,  headache, migraines, dizziness, mania biopolar or unipolar, premature ejaculation, persistent sexual arousal or orgasm, liver or renal impairment, high photosensitivity, digestive panic response, overactive bladder,  and even suicidal tendency 
Ref:
http://content.karger.com/produktedb/produkte.asp?doi=103570 , http://www.ncbi.nlm.nih.gov/pubmed/16824691 , http://brain.oxfordjournals.org/cgi/content/full/129/7/1659 , http://www.springerlink.com/content/h1127g504q2h1060/, http://www.pnas.org/cgi/content/abstract/80/11/3517, http://www.sciencemag.org/cgi/content/abstract/227/4694/1544?ck=nck , http://www.acnr.co.uk/JA07/ACNR_JA07_review_plasticity.pdf, http://thomasland.metapress.com/content/a422g91uq4hb86xc/http://endo.endojournals.org/cgi/content/full/145/1/161 and http://humrep.oxfordjournals.org/cgi/reprint/22/4/995 
A positive neuroplasticity should improve your life and productivity.

Neuroplasticity also occurs when changes in electrical excitability and changes in gene expression can long outlast the initial causal stimulus. For example,   airway inflammation in baby monkeys repeated ozone exposures results to persistent increase in the excitability of nucleus tractus solitarius neurons in the brain stem as described in Plasticity in Respiratory Motor Control Selected Contribution: Vagal neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates (http://jap.physiology.org/cgi/content/abstract/94/2/819?ijkey=0b358ac59f303cf9c8922f1afdf2b9d4a5889946&keytype2=tf_ipsecsha).
This is an adaptation of the respiratory motor responses, a part of biological evolution.  Vago-vagal reflex circuits controlling and modulating digestive functions from the oral cavity to the transverse colon can be activity-dependently plastic in controlling stomach behavioral and physiological homeostasis.( http://ajpgi.physiology.org/cgi/content/full/284/2/G180 ).  Nerves can regrow in a failure transplant heart. you can remodel the sympathetic nervous system with Neuroplasticity for better or worse ( http://hyper.ahajournals.org/cgi/content/full/47/2/143).  Biofeedback can train your cardiovascular function for better output. http://www.psychosomaticmedicine.org/cgi/reprint/65/5/796.pdf .  Meditation may induce short-term and long-term neural changes as described in http://www.pnas.org/cgi/content/full/101/46/16369 and http://www.pnas.org/content/101/46/16369.full#abstract-1 .  Meditation generally produces vagal or parasympathetic nervous plasticity, but can be highly dopaminergic and noradrenergic , depending on what types of parctices..  Some people who do it in a wrong way get sympathetic neuroplasticity for headaches or other  sympathetic nervous Fight and Flight responses. This also indicates the sensory and motor nerves in the central and peripheral nervous system can be plastic. ( http://www.jneurosci.org/cgi/content/full/25/44/10167  and http://www.research.va.gov/programs/JRRD/45_2/Forrester.pdf ) This also tell you that  you can reduce sexual urgency and may help you unhook yourself from sex addiction with Dr. Lin's ChiKong and anal breathing practices. You can improve your focusing and cognitive function with a focusing effect of acetylcholine (ACh)  on neuroplasticity of cortical networks. ACh not only increased selectively the efficacy of synapse-specific excitability-enhancing neuroplasticity,  but also prolonged the excitability diminution in case of asynchronous synapse-specific inputs and suppressed global excitability enhancements. ( http://www.jneurosci.org/cgi/content/full/27/52/14442  ).  That is why our pro-acetylcholine products ,such as Moodmax and ViaGrowth-IV , can improve your congestive function.

Sexual or orgasm addiction is due to the nervous plasticity of the hypothalamic paraventricular nucleus (PVN) where the dopamine, acetylcholine, oxytocinergic, noradrenergic (norepinephrine), adrenergic(epinephrine), autonomic (sympathetic and parasympathetic) vagal, glutamate, NOergic, GABAergic and serotonin  nervous system innervate. The nervous plastic remodeling occurs under a frequent oxytocin, prostaglandin E2 (http://ajpregu.physiology.org/cgi/content/full/294/4/R1294) and norepinephrine stimulation during sex when the GABAergic and serotonin nervous function are too weak to modulate the dopamine-norepinephrine conversion and the noradrenergic nervous firing. The main source of  noradrenergic innervations of higher brain sites, including the hypothalamus and PVN, is the locus ceruleus (LC) where norepinephrine activates pro-inflammatory pyrogenic cytokins and protein kinases in LC  for prostaglandin E2 which,  in conjunction with action of oxytocin, let you feel high, arousing and exciting. Sex can increase the density of PVN dopamine beta-hydroxylase immunoreactivity (DBHir), so that the enzyme dopamine beta-hydroxylase can constantly convert dopamine to norepinephrine to keep on sexual fire, leading to addiction. Prostaglandin E2 is involved in the regulation of synaptic activity, transmission and plasticity, and in brain evolution. Prostaglandin E2 accelerates neuroplasticity.  You need prostaglandin E2 for neuroplasticity - learning, memory and addiction. Thus, you have to study hard (for more norepinephrine and prostaglandin E2)  to memorize contents of the books you read  in a short time. However, you use them (norepinephrine and prostaglandin E2)  for sex addiction, you will love sex more than your life.  Prostaglandin E2 can also degrade the short time memory and spatial navigation by enhancing membrane excitability and then inducing long-term synaptic plasticity in hippocampal perforant path-dentate gyrus synapses.
Ref: http://www.jneurosci.org/cgi/content/full/25/43/9858 
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2292143&blobtype=pdf 
http://www.nature.com/nm/journal/v7/n4/full/nm0401_414.html
http://ajpgi.physiology.org/cgi/content/full/277/1/G79  
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1430829 
http://jn.physiology.org/cgi/content/full/88/1/49 
http://ajpheart.physiology.org/cgi/content/full/291/6/H2847 
http://ajpheart.physiology.org/cgi/content/full/274/4/H1284 
http://ep.physoc.org/cgi/content/full/90/2/169 
http://www.jneurosci.org/cgi/content/full/24/35/7604/ 
http://physiologyonline.physiology.org/cgi/content/full/14/3/100 
http://ajpregu.physiology.org/cgi/content/full/292/4/R1717 
http://endo.endojournals.org/cgi/content/full/145/11/4917 
http://joe.endocrinology-journals.org/cgi/content/full/190/3/593 
http://www.acnp.org/g4/GN401000155/Default.htm and http://jn.physiology.org/cgi/content/abstract/87/6/2851?ijkey=5cee184dd3946b4945f9cc00585dec35e2d51349&keytype2=tf_ipsecsha 

Excessive sex also cause memory loss and learning inhibition, as reported in http://www.actionlove.com/extra/alzheimer.htm What happens inside your brain memory center - the hippocampus when you have excessive sex?  Does it make you become stupid?  Yes, it can produce destructive neuroplasticity.  Here, neuroplasticity is referred to the brain rewiring in response to changes in environment, experience or  brain chemistry. The brain areas related to memory formation and learning, such as the hippocampus and dentate gyrus, were highly plastic.  Neurons continue to be produced, synoptically deformed, and destroyed into adulthood. You can alternate your brain function in positive or negative way. The Ying-Type stress hormone cortisol is responsible for alternating structure and function of the hippocampus. Excessive cortisol inhibits adult neurogenesis in the dentate gyrus, and impairs hippocampus-dependent learning and memory, as described in.
http://www.kzoo.edu/psych/Karten%20et%20al.2005.pdf
Note: Cortisol is one of corticosteroid hormones and biologically active while cortisone is the biologically inert one. Cortisol is metabolized by the 11-beta hydroxysteroid dehydrogenase system (11-beta HSD), which consists of two enzymes: 11-beta HSD1 and 11-beta HSD2.
11-beta HSD1 utilizes the cofactor NADPH to convert biologically inert cortisone to biologically active cortisol. 
11-beta HSD2 utilizes the cofactor NAD+ to convert cortisol to cortisone.

Case example:
Chronic over-masturbation at 3 times a day since age 6 and 1-year marijuana smoking results in memory loss, terrible eye floaters, dizziness, severe depression, frequent urination, anxiety, insomnia, neck tremors, severe leg tremors, and restless leg syndrome (Parkison's disease or symptoms) for no more sexual orgasm
http://www.actionlove.com/cases/case15916.htm
Serotonin and GABA nervous deficiency and noradrenergic/sympathetic nervous excess can be caused by pregnant mother's caffeine or drug abuse or/and by individual chronic over-masturbation and drug abuse (marijuana, methamphetamine, cocaine, heroin or other nervous toxins), leading to severe eye floaters, dizziness, memory loss, depression, anxiety, tachycardia, penile numbness,  and psychological disorders (including suicidal tendency) for no more sexual orgasm
http://www.actionlove.com/cases/case15914.htm
Chronic Over-masturbation results in premature ejaculation, erectile dysfunction (going limp),  precum leakage, urethral itching/sensation, penile/groin/leg/prostate inflammatory pains, hair loss, irritation, anxiety, mood swing, loss concentration and absent mindedness for no more sexual orgasm
http://www.actionlove.com/cases/case15904.htm
Over-Masturbation at 20-25 times a day since age 7, masturbation addiction, masturbation withdrawal symptoms, and brain damage turned a gifted kid into a stupid junkie

http://www.actionlove.com/cases/case15605.ht
Pornography triggers dopamine-norepinephrine conversion for psychological stress; then, norepinephrine induces prostaglandin E2 production in your hypothalamic preoptic area, adrenal glands, testicles, prostate, seminal vesicles,  bulbourethral glands and urethra for psychologically stress-induce fever (brain overheating), body aches and pains, precum/semen leakage and premature ejaculation/orgasm. Addiction on the norepinephrine and prostaglandin E2 stimulation from pornography will produce withdrawal symptoms.
==> http://www.actionlove.com/cases/case15815.htm
The destructive testing results of over-masturbation from a 17-yearo-old boy - sexual exhaustion symptoms for no more life and sexual orgasm, including, body pains, arthritis, testicular pain, penile pain, prostate pain, back pain, face pain, gum pain, tinnitus (excessive glutamate and inflammatory hormone prostaglandin E2), headcahes, fatigue, anxiety, nightmare, chilliness and shivering attacks, hot flashing/fever (premature male menopause), cracking joints, fibromyalgia, impotence, Restless Leg Syndromes (pre-parkinson's disease) and so on.
==> http://www.actionlove.com/cases/case15655.htm

FDA Warnings: 
News Upadated (July 8, 2005): All the erectile PDE5 inhibiting drugs can cause sudden decreases or loss of eyesight (even blindness, under a very fancy name "Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)", as warned by the US FDA in in -
http://www.fda.gov/cder/drug/InfoSheets/patient/sildenafilPIS.htm 
http://www.fda.gov/cder/drug/infopage/cialis/default.htm or http://www.fda.gov/cder/consumerinfo/viagra/default.htm
http://www.fda.gov/cder/drug/InfoSheets/HCP/sildenafilHCP.htm  or http://www.pbm.va.gov/alerts/PDE5.pdf 
News Upadated (Oct. 18, 2007): All the erectile PDE5 inhibiting drugs can cause sudden decreases or loss of hearing, tinnitus and dizziness as warned by the US FDA in http://www.fda.gov/medwatch/safety/2007/safety07.htm#PDE5.  

In fact, Dr. Lin has documented the sex-induced nervous disorders since 1997 in our websites,  although these problems were well-addressed in the Chinese Sexual Bible "Suu-Nu Ching" and Medical Textbook "Yellow Emperor's Classic of Internal Medicine" around 2600 B.C..  Realizing the sexual exhaustion systems, Dr. Lin has developed the ViaPal-hGH formulas and other products to help you rejuvenate your exhausted brain/nervous and endocrine functions for health and then sex. Dr. Lin has also addressed the optimal, safe sexual/orgasm frequency for the different age groups of people without damaging the brain and neuro-endocrine system.
Health Canada Warning - http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/2005/2005_83_e.html.
So, you should read this link about sex and vision too before taking erectile drugs -
http://www.actionlove.com/extra/eyefloater.htm,  but don't have to die for SEX! 
The Root of Over-Masturbation/Excessive Sex:
 

Male/Female Persistent Sexual Arousal Syndrome - http://www.actionlove.com/extra/psas.htm
Penile Enlargement Updated: The role of DHT, prostaglandins E-1/E-2/E-3, and Nitric Oxide in the penile enlargement for more sexual orgasm (Here is the fact: A balance action of prostaglandin E-1 and E-2 on the nerves and blood vessels allow the tissue to expand and stretch without pains. For example: pregnant women stretch and grow the uterus and abdomen without pains under a simultaneous, balanced action of prostaglandin E-1 and E-2,  but start labor contraction pains when prostaglandin E-2 overpower prostaglandin E-1, in conjunction with the action of oxytocin, cotisol and epinephrine!)
http://www.actionlove.com/cases/case13917.htm
 
Natural Vaginal Rejuvenation and Tightness Updated: ballooning of the vaginal spongy tissues, G-spot erectile tissues, corpus cavernosum clitoridis, and vestibular bulbs will tighten up you vaginal orifice and canal. For detail please go to http://www.actionlove.com/extra/vsize.htm 
The basic principle of the penile and clitoral/G-spot ballooning is to turn the local skin into an endocrine organs for more DHEA,  DHT, testosterone, and prostaglandins production to feed the erectile tissues and nerves, as described in
http://www.fasebj.org/cgi/reprint/04-1968fjev1
and
http://edrv.endojournals.org/cgi/reprint/21/5/457 


Excessive Sex for dark eye cycles, nips, labia minors, pelvic area, perineum clitoral/penile forskin:   Skin is a neuroendocrine organ. Chronic stimulation of sex organs can lead to over-production of α-MSH and Trapping excessive α-MSH in certain areas of skin results in extra skin darkness, particularly in eye cycles, nips, labia minors, penile and clitoral foreskin, and perineum if the local skin neuroendocrine function was working, but the local blood circulation becomes poor due to excessive noepinephrine or epinpehrine binding in the sympathetic andrenergic-α2 receptors of the blood vessels or a lack of nitric oxide and prostaglandins E1/E3 in the local tissues. Over-ejaculation, high-frequency sex or/and excessive orgasm causes excessive histamine release; histamine, in turn, stimulates α-MSH release from the pituitary in an attempt to counterbalance the histamine level and counteract the histamine-induced inflammatory and allergic responses.  Thus, excessive sex results in excessive histamine, prostaglandin E2 and α-MSH release.  α-MSH stimulates excessive production of melanin, a brown pigment manufactured by certain cells in the skin called melanocytes, from tyrosine. Excessive melanin is responsible for dark skin color. This is called Hyperpigmentation. The dark skin as a result of chronically excessive sex-stress norepinephrine induced inflammatory hormone prostaglandin E2 stimulation is considered as Post-inflammatory hyperpigmentation. In this regard, the excess melanin is produced in the upper layer of skin (epidermis). The cells that normally produce brown pigment evenly across your skin go into overdrive and produce too much melanin. Then,  the pigmentation color is a darker shade of brown.
http://www.fasebj.org/cgi/content/full/21/4/976 
http://physrev.physiology.org/cgi/content/full/80/3/979
http://edrv.endojournals.org/cgi/content/full/21/5/457  
The tissues also around the eyes contain a high level of COX enzyme receptors, histamine receptors,  and master cells .  You will feel itchiness and allergy-like responses in your eyes.  Due to the constriction of the arteries and veins, melanin is trapped around the eye cycles leading to darkening of eye cycles.  This also happens in your groins area too.  Generally,  the skin in a poor blood circulation area, even if there is no UV exposure,  becomes darker than the other areas.  
Although melanin is a skin and hair protector,  over-production of melanin signals sexual exhaustion and reduces dopamine and oxytocin synthesis as a self regulation of libido, thus,  to slow down libido.
However, in the brain,  overloading of neuro melanin (also known as neuromelanin) in in the substantia nigra pars compacta  is an increased contribution to oxidative stress and intraneuronal damage in patients with Parkinson's disease, resulting in degeneration of dopaminergic neurones. http://www.ingentaconnect.com/content/bsc/jnc/2003/00000086/00000005/art00009,
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1187132&blobtype=pdf 
Does this concludes that the excessive sex, besides ageing and drug uses,  leads to restless leg syndromes or parkinson's disease?
Genetic factors also play the important role in α-MSH and melanin release and the distribution of melanin in cells over the body.

The epidermis is avascular, nourished by diffusion from the dermis, and composed of four cell types: keratinocytes, melanocytes, Langerhans cells, and the Merkels cellMelanocytes  is responsible for  pigmentation.  Similar to paint or ink, skin color is a result  of mixing four biochromes: oxyhemoglobin (red), reduced hemoglobin (blue), carotenoids (yellow) and, melatonin (brown).  The amounts and types of melanins produced and their distribution vary in the skin, responding to α-MSH, blood circulation, and internal or external stimulus including VU, drugs and mechanic/abrasive stimulation. Different body parts have melanocyte density. For example, the palms and soles contain less melanocytes while nipples have higher. For some people, the eye circle tissues and groins also contain a high density of melanocyte than the other areas do.  Melanocytes are cells located in the bottom layer (the stratum basale) of the skin's epidermis, hair follicles, the middle layer of the eye (the uvea, the pigmented middle of the three concentric layers that make up an eye), the inner ear,  meninges,  bones and heart.  In the skin, melanocytes comprise from 5% to 10% of the cells in the basal layer of epidermis while keratinocytes is the major constituent of the epidermis, constituting 90% to 95% of the cells in epidermis.  Melanin is synthesized and stored in membrane-bound organelles (termed melanosomes) where melanosomes form a critical barrier, a protection layer, to shield DNA from external stimulus such as ultraviolet radiation or external drug and mechanical stimulation   As melanosome grows to neighboring keratinocytes,  the protection layer expands as proliferating keratinocytes in the suprabasal epidermal layers.  As a result, the local skin becomes darker. 
Recent studies shows glutathione, glycine, L-alanine, L-isoleucine and L-leucine can inhibit melanin synthesis in the reaction of trysinase and L-dopa.  OurViaGrowth-IV contains glutathione, glycine and L-alanine, as well as L-tyrosine
Ref: http://www.ncbi.nlm.nih.gov/pubmed/18670186
http://www.jstage.jst.go.jp/article/bpb/30/4/677/_pdf
http://www.jstage.jst.go.jp/article/bpb/30/11/2031/_pdf
http://endo.endojournals.org/cgi/reprint/146/2/532
and http://www.fasebj.org/cgi/content/full/20/7/882 
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2678743&blobtype=pdf 

Garland CF, et al. Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates. Ann Epidemiol. 2003; 13(6):395–404.
http://www.ncbi.nlm.nih.gov/pubmed/12875796
Wolf P, et al. Effect of sunscreens on UV radiation-induced enhancement of melanoma growth in mice. J. Natl Cancer Inst. 1994; 86 (2):99–105.
http://www.ncbi.nlm.nih.gov/pubmed/8271307 
Tadokoro T, et al. UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin. Faseb J. 2003;17(9):1177–1179. http://www.fasebj.org/cgi/reprint/02-0865fjev1
Yamaguchi Y, et al. Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J. Cell Biol. 2004; 165 (2):275–285.
http://jcb.rupress.org/cgi/content/full/165/2/275 
Montagna W, Carlisle K. The architecture of black and white facial skin. J Am Acad Dermatol. 1991;24(6Pt 1):929–937.
http://www.ncbi.nlm.nih.gov/pubmed/1714469
Galus R, Zandecki Ł,Sajjad E, Jźwiak J, Włodarski K. Factors affecting melanogenesis and methods used for identification of pigmentation disorders, Pol Merkur Lekarski. 2008 Aug;25(146):188-91 http://www.ncbi.nlm.nih.gov/pubmed/18942345?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedreviews&logdbfrom=pubmed 
Special Note:
from http://en.wikipedia.org/wiki/Melanin: The photochemical properties of melanin make it an excellent photoprotectant. It absorbs harmful UV-radiation and transforms the energy into harmless amounts of heat through a process called "ultrafast internal conversion". This property enables melanin to dissipate more than 99.9% of the absorbed UV radiation as heat[3] and it keeps the generation of free radicals at a minimum (see photoprotection). This prevents the indirect DNA damage which is responsible for the formation of malignant melanoma.


Excessive sex and Light Over-Sensitivity in Retina  Beside inflammation of eyeballs due to excessive prostaglandinE2 and histamine induced by excessive norepinephrine and prolactin, melatonin, melanin, dopamine and glutamate are responsible for visual perception and multilevel regulation of visual sensitivity in response to the intensity of ambient lighting, while the pupil,  a circular opening located in the center of the iris of the eye  controls the amount of light that enters the eye.  Excessive norepinephrine-induced prostaglandin E2 and histamine in the retina, with a lack of prostaglandin E1, GABA, serotonin and glycine and agmatine nervous modulation,  can over-excite the visual receiving sensors.

Melanin in the eyes, in the iris and choroid, is supposed to adjust and darken the their color to filter out ultraviolet and high-frequency visible light.  There are two layers in the iris: the front pigmented fibrovascular tissue, also known as stroma, and,  behind the stroma, pigmented epithelial cells. The stroma connects to the iris sphincter muscle responsible for adjustment of the pupil in response to light intensity.  Strong light constrict the pupil for limiting the rays.A wide pupil results in an image that is sharp around what the iris is focusing on and blurred otherwise  The back surface of the stroma is covered by a heavily pigmented epithelial layer, the iris pigment epithelium which release melanin in response to light. The higher the pigment content is, the more light from passing through the iris to the pupil is attenuated.  This light filtration mechanism relies on the release of melanin.  Since L-Ddopa  is the immediate precursor of melanin,  If there is a deficiency of L-dopa, this optical filtration will be malfunctioning. If sexual arousal or orgasm turns too much L-Dopa  into dopamine and then norepinephrine and epinephrine,   the L-Dopa will drop too low to support the iris and choroid pigmentation in response to light. As a result, your visual receiving sensors will become hypersensitive to light, in addition to experiencing  UV damage 

Melatonin is the main regulator of light sensitivity by many ways.  Melatonin is responsible for photomechanical movement, cone photoreceptor elongation and rod photoreceptor contraction,  as the adaptation to decreasing light intensity which increases melatonin release. The photosensitivity of the receiving circuits increases in the weak light to compensate the weak visibility,  so that the visual perception can become clearer.  The opposite photomechanical adjustment occurs in response to increasing light intensity and the resulted increase of dopamine in the central nervous system and retina.  The dopamine release in the retina increases after light exposure and decreases in darkness. Melatonin suppresses the light-elicited dopamine release from retina, as photoreceptor adaptation to darkness.  That is, we can say:  melatonin is the darkness hormone while dopamine is the light hormone.  The photosensitivity of the receiving circuit decreases as dopamine increases, as a feedback control of the visual circuit , so that there is no truncation of visual signals entering the visual cortex. When the dopamine level is too low, the retinal receiving circuit become too sensitive to light. In particular, the eye pupils are dilated by the norepinephrine/sympathetic nervous function.  Excessive hypothalamic and adrenal dopamine-norepinephrine conversion can cause this problem.
Melatonin, synthesized in the retina also modulates the retinal pigment epithelium (RPE) function by aggregating pigmented cells in the RPE and choroid of the eye.  Thus, the another way for melatonin to regulate the amount of light entering the photoreceptor is to control the movement of melanosome granules within the RPE where melanosome granules stores melanin. Eye pigmentation of releasing melanin in response to light attenuates the light intense before entering the retina.  Melatonin can also alter the electrical activity of the RPE of the mammalian eye.  http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=286629&blobtype=pdf
Glutamate, the darkness neurotransmitter,  in the retinal receiving circuit modulate the visual response to the light by decreasing its concentration. When the eyes abruptly expose to the light, it will take a while to turn on the color receiving circuit by removing glutamate. Unfortunately, dopamine and glutamate are essential to sexual arousal and orgasm. During orgasm and in the pos-orgasm state, excessive glutamate is supposed to turned into GABA, 5-HTP to serotonin, and dopamine to norepinephrine,  resulting in elevation of melatonin to suppress dopamine synthesis. In some cases, glutamate won't turn to GABA or/and dopamine drops too low, leading to eye floaters, light-oversensitivity in retina, and of course, depression and brain fog

MCCORMACK, C. A., AND B. BURNSIDE. A role for endogenous dopamine in circadian regulation of retinal cone movement. Exp. Eye Res. 55: 511-520, 1992, http://www.ncbi.nlm.nih.gov/pubmed/1426081?dopt=Abstract 
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KAZULA, A., J. Z. NOWAK, AND P. M. IUVONE. Regulation of melatonin and dopamine biosynthesis in chick retina: the role of GABA. Vis. Neurosci. 10: 621-629, 1993, http://www.ncbi.nlm.nih.gov/pubmed/8101728?dopt=Abstract 
BOATRIGHT, J. H., M. J. HOEL, AND P. M. IUVONE. Stimulation of endogenous dopamine release and metabolism in amphibian retina by light- and K+-evoked depolarization. Brain Res. 482: 164-168, 1989 ,http://www.ncbi.nlm.nih.gov/pubmed/2706474?dopt=Abstract


Benefits from Optimal Orgasms (the Tao of Sexual Orgasms): Orgasm triggers the pituitary to release prolactin. Although chronically excessive prolactin can disable the sexual function, induce cancerous development, screw up the reproduction system and cause depression, an optimal prolactin release from your pituitary and eyes, as a result of an orgasm, is good for hGH production, cancer and tumor prevention and for healthy eyes, brain, heart, liver, kidneys, uterus and prostate. Particularly, if chondrocytes (bone marrow stromal stem cells) can release the enzyme matrix metalloproteinases to convert prolactin into 16K-prolactin (16 kDa N-terminal fragment of the hormone prolactin), you will benefit from the antiangiogenic effects from 16K-prolactin. 16K-prolactin can block the blood vessel invasion or new blood vessel growth, associated with the endochondral bone formation (blocking mitogen-induced vascular endothelial cell proliferation, involved activation of programmed cell death) and tissue repair after injury and inflammation (by prostaglandin E2!),  which is an important mechanism underlying human diseases such as cancer, diabetic retinopathy, rheumatoid arthritis, and heart diseases. It is antiangiogenic, but excessive 16K-prolactin inhibits the penile or clitoral growth, or other normal cellular or nervous repair and regeneration/rejuvenation.  Therefore, you need an optimal orgasm frequency to prevent cancers (including prostate cancers), tumors and retinopathy (non-inflammatory damage to the retina of the eye, due to lack of of the blood supply, damaged or constricted blood vessels. However, you should not have an excessive sex or orgasm since it will produce excessive stress hormones to inhibit the release of the enzyme matrix metalloproteinases, to suppress the neuro-immune system and to activate the inflammatory factors triggering your health alarm system, as a result of the excessive prostaglandin E2 production. The inflammatory factors actually damage the bone marrow cells. Due to the fact that semen contains high concentration of Phosphorylcholine essential to the brain and nervous function and repair, the old Taoists theorized that men can return semen (actually phosphorylcholine) to revert the brain. Generally speaking, the concept is correct; however,  when the brain's dopamine or testosterone level is too high for excessive semen production, your pituitary will be over-exited, leading to excessive oxytocin release and prolactin deficiency, in addition to neuroexcitotocity from dopamine-induced excessive glutamate and histamine production, the deamination of dopamine to DOPAL and the oxidative stress from the demination byproduct Hydrogen Peroxide.  Therefore, Optimal orgasm and ejaculation can help you burn some dopamine and testosterone out,  and then induce the prolactin release from the pituitary and retina tissues for some protective and anti-inflammatory hormone 16K-prolactin in cooling down the nervous systems. In this way, you can avoid the side effects of excessive dopamine or testosterone, and benefit from sex. That is, an optimal orgasm or sex can improve your health.
Remember this:
Bone Morrow and Sperms: Reuters (April 13, 2007) said Dr. Karim Nayernia at the University of Gottingen, discovered stem cells taken from the bone marrow of men may be able to transdifferentiate to sperm cells in 3-5 years - http://search.yahoo.com/search?p=Karim+Nayernia+sperm+marrow&ei=UTF-8&fr=moz2
The Traditional Chinese Medicine considered bone marrow is Essence (Jing) for semen production. What is a coincidence! This means that over-ejaculation or excessive orgasm will cost your bone marrow and weaken your bone. Other stem cells researches have done similar work in female mice and turned bone marrow cells into egg cells. What does this mean to women's body pains or arthritis?  This means excessive orgasm/sex/ejaculation, job-related stress, substance abuse or toxins can inhibit the enzyme matrix metalloproteinases from the bone marrow stromal stem cells.  This is why our readers kept reporting inflammatory pains and arthritis induced by orgasm/ejaculation,  job-related stress, substance abuse or toxins. 

As of today,  a high level of prolactin has been realized as a promoter or co-initiator of breast and prostate cancers, in addition to disable the sexual function. It appears to play a key role in the development and progression of breast and prostate cancer and tumors.  So, keep your prolactin level in the normal range and avoid the synergistically biological effects of the prolactin on the estrogen or/and DHT receptors.

You will get another benefit from sex and orgasm if you get a resulted elevation of both GABA and glutathione which are converted from excitototoxicity glutamate. GABA is synthesized from glutamate using the enzyme L-glutamic acid decarboxylase and pyridoxal phosphate as a cofactor, and glutathione from the amino acids L-cysteine, L-glutamate and glycine in two adenosine triphosphate-dependent steps:   by combining L-glutamate and cysteine via the enzyme gamma-glutamylcysteine synthetase to form gamma-glutamylcysteine, and then adding glycine to gamma-glutamylcysteine via the enzyme glutathione synthetase to produce glutathione. Elevation of GABA with serotonin, norepinephrine and prolactin after sex or orgasm will trigger the pineal gland and retina to release melatonin for better sleeping, hGH production, nervous regrowth, neuro-endocrine restoration, cellular repair,  and shaper vision;  Elevating of glutathione can reduce the formation of  oxidative toxins, such as Hydrogen peroxide (H2O2),  associated with oxidative injury and cellular/nervous damage.  However, if you lack of these liver enzymes ( L-glutamic acid decarboxylase, pyridoxal phosphate , gamma-glutamylcysteine synthetase and glutathione synthetase)  and amino acids L-cysteine and glycine, you will get excitotoxicity and brain/nervous damage from your orgasm sponsoring neurotransmitters glutamate, dopamine, norepinephrine, epinephrine and histamine which stimulate the gene over-expression of monoamine oxidase in your brain, liver, kidneys, adrenal glands, heart and other organs for premature ageing, brain and nervous damage,  and sexual exhaustion symptoms (as listed in http://www.actionlove.com/cases/case9848.htm).

Sexual arousal, ejaculation or orgasm induces a burst of norepinephrine and epinephrine release.  For a health person, the norepinephrine and epinephrine release is supposed to stop in few minutes after sex and drops in maintaining the homeostasis. Overall, the norepinephrine and epinephrine level will stay higher for few hours.  Norepinephrine and epinephrine can trigger both proinflammatory and anti-inflammatory cytokines and kinases in the immune system via the stimulation of the alpha- and beta-adrenergic receptors.   Moderate increase in norepinephrne and epinephrine during and fater sex results in increase in the concentration of lymphocytes in the bloodstream for immune enhancemen; t and the anti-inflammatory cytokins overpowers the side effects produced by proinflammatory cyrockins.  That is why optimal sex, like moderate exercises, can improve your health and neuroimmune function. However, excessive norepinephrine induces more proinflammatory effects than anti-inflammatory ones, leading to excessive prostaglandin E2 production to set your brain and body on fire - over-heating, immune disorder and inflammatory responses. This is what you have to concern about.


Brain-Skin/Brain-Hair connection - the effect of excessive sex-induced stress on skin (acne) and hair (hair loss) !  

My case collection since 1997 is given in
http://www.actionlove.com/extra/acne.htm and
http://www.actionlove.com/extra/hailoss.htm 
My intention is to have a statistical data (cases) to support the traditional Taoism's and Chinese Medical claims about the side effects of over-sex on the acne outbreak and hair loss. In the past, there have been a lot of disputes on this issue (for example, please read http://answers.yahoo.com/search/search_result;_ylt=AlClvcr4x7agkfBvF65HS6Hpy6IX;_ylv=3?p=over+masturbation ).  Luckily, I also have found the scientific research support on these claims. Scientifically, it is called the skin's and hair-follicle's hypothalamus-pituitary-adrenal axis or the skin/hair stress response axis - the response of the body to acute and chronic stress induced by temporarily or chronic over-sex activities. Under acute or chronic stress, neurohormones, neurotransmitters, neuropeptides and neurotrophins will stimulate a series of adaptation responses, leading to behavioral, cardiovascular, metabolic, endocrine and immunological changes. The most critical one is the immunological changes ranging from immune suppression to imflammation. Acne, skin allergy,  and hair loss can be considered as a result of inflammatory diseases. In fact,  psychological stress causes more inflammatory and autoimmune diseases than what you think. I have termed the resuted diseases as the Sexual Exhaustion Symptoms  if they are directly or indirectly induced by sex-induced stress - chronic or acute! If you still don't understand why excessive stress induces acne and hair loss, you should read the following links-
http://edrv.endojournals.org/cgi/reprint/21/5/457 ,
http://www.fasebj.org/cgi/reprint/04-1968fjev1,
http://edrv.endojournals.org/cgi/reprint/21/5/457,
http://www.psychosomaticmedicine.org/cgi/reprint/63/3/412,
http://www.tufts.edu/sackler/pharmacology/faculty/theoharides/documents/TiI-brain-skin.pdf,
http://edrv.endojournals.org/cgi/reprint/22/4/502,
http://www.fasebj.org/cgi/reprint/19/10/1332,
http://ajp.amjpathol.org/cgi/reprint/165/1/259,
http://www.nature.com/jid/journal/v122/n1/pdf/5602146a.pdf,
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1868107&blobtype=pdf
and http://www.nature.com/jid/journal/v117/n2/pdf/5601158a.pdf

Excessive sex, drug/alcohol abuse, work overloads,  Over-eating (high-protein overdosing and high-tyramine foods), excessive caffeine intake, and excessive exercises can induce excessive stress hormone production for hair loss (actually, stopping hair regrowth after losing hair)  and acne outbreak - the sympathetic nervous fires in your skin and hair follicles. Sleeping disorders indicate excessive stress with insufficient serotonin and GABA nervous modulation on the pineal and retinal function.  Your acne and hair loss can also be associated with sleeping disorders.


Sex-Stress induced Inflammatory Pains (including your joints, muscles, brain,  eyes, ears and internal organs), Headaches and Hangover - Sexually norepinephrine-induced inflammatory hormone prostaglandin E2 release for brain-overheating (fever, headaches, migraine and body pains),  and sexually epinephrine-induced hyperalgesia with a lack of parasympathetic/vagal/serotonin/GABA/endorphin nervous modulation.
Sexual thought, arousal, activities or orgasm trigger the dopamine-norepinephrine/epinephrine conversion in the hypothalamus and adrenal medulla, and most of normal situations, maybe also induce the prolactin release from the pituitary. 
http://joe.endocrinology-journals.org/cgi/reprint/177/1/57.pdf
http://journals.endocrinology.org/joe/177/joe1770057.htm
http://www.ncbi.nlm.nih.gov/pubmed/11760788?dopt=Abstract
http://www.psychosomaticmedicine.org/cgi/reprint/61/3/280
http://www.uni-essen.de/forensik/assets/applets/EJN_Paper_-_Kr%FCger_Schiffer_et_al_-_2006.pdf
http://www.psychosomaticmedicine.org/cgi/reprint/61/3/280.pdf
http://www.nature.com/ijir/journal/v14/n2/pdf/3900823a.pdf
http://pharmrev.aspetjournals.org/cgi/reprint/52/4/595
Norepinephrine is the neurohormonal fuel that triggers the neuro-immune reaction for the generation of pyrogenic cytokins and protein kinase for pro-inflammation and anti-inflammatory responses, where cytokines, acting as Immunotransmitters,  are small proteins secreted in response to an immune stimulus to mediate and regulate immunity, inflammation, and hematopoiesis.  The initially acute release of norepinephrine induced by sexual arousal is pro-inflammatory to bring you in the "heat" or "sexual rush" state with a surge of prostaglandin E2 production in the brain, adrenal, testicles (or ovaries), prostate, uterus, G-spot (vagina)  penis and clitoris for sexual desire and erectile function.  This is how the sexual desire is initiated from the brain down to the sex organs.  Prostaglandin E2 elevates the temperature of these organs and dilate the arteries to pump the blood into these organs and help you get ready for mating if your cortisol and prolactin level won't rise high enough to cause the arterial constriction. At the same time, norepinephrine, in conjunction with the acetylcholine, parasympathetic, serotonin, GABA, and endorphrin nervous modulation,  also triggers the anti-inflammatory process to balance the excitatory effects induced by the inflammatory hormone prostaglandin E2.  For the normal neuro-immune and hypothalamus-pituitary-adrenal function function,  the anti-inflammatory process also promote the release of prostaglandins E1/E3, endorphrin, and alpa-MSH in the brain, heart, liver, adrenal glands, testicles, ovaries, prostate, uterus,  vagina, seminal vesicles, penis and skin to overcome the excitatory effects.  The effect of prostaglandin E2 on the brain, adrenal glands, testicles, ovaries, penis and clitoris will be mediated by the follow-up prostaglandin E1/E3, oxytocin, Nitric Oxide,  DHEA, androstenedione, testosterone and DHT  release for a healthy persons when the dopamine-hypothalamus-pituitary-adrenal and -testicular/ovarian axis is stimulated by prostaglandin E2 and when the cortisol level slightly decreases or remains constant (that is, production = consumption during sex); under this condition,  the prostaglandin E2 release doesn't trigger inflammatory pains and disorders yet, but induces sexual arousal and orgasmic responses since the anti-inflammatory process is working properly. However, in the exhausted hypothalamus-pituitary-adrenal function,  the pituitary will release prolactin and the adrenal cortex will shoot up cortisol to shut down sexual desire and erectile function immediately to protect the neuro-immune system.  If the neuro-immune system fails to exert an anti-inflammatory action, the adrenal cortisol release mechanism will go wild; then the inflammatory alarm goes off,  resulting in body pains, cramps, headaches, migraine, hangeover, premature orgasm/ejaculation, precum (or excessive wetness) in response to sexual thought, sexual stimulation, arousal, and orgasm, or in the post-orgasm state for several hours or days.   
Ok. let's consider how sexual thought/fantasy, romantic novels and movies, pornography, and visual, auditory or physical stimulation heat up our brain and sexual organs and shorten our orgasm responses (premature ejaculation for men too!).  Sexual stimulation, arousal or orgasm ignites the dopamine-norepinephrine conversion in the hypothalamus and adrenal medulla, and, then, activates the norepinephrine (NE) neurons of the locus coeruleus (LC); the neural signals are relayed to the preoptic area (POA) of the hypothalamus via the ventral norepinephrine noradrenergic bundle, where noepinephrine is released; then, norepinephrine stimulates the synthesis of prostaglandin E2 in local neurons and/or astrocytes, by activating  a group of proinflammatory cytokines such as IL-1{alpha}, IL-1, IL-6, TNF-{alpha}, IFN-{alpha}, and MIP-1 in the the immune system. These cytokines, acting as the endogenous pyrogen of desire fires,  turn on the brain by the following steps:
(1) performing active transport of cytokines into the brain,
(2) generating a blood cytokines-to-brain signal transduction at the circumventricular organs which have an incomplete blood-brain barrier and where neurons can directly sense and utilize various compounds such as neurohormones, hormones, neuropetides, cytokines and protein kinase
(3) producing the brain-permeable paracrine substance prostaglandin E2  at endothelial cells in the cerebral microvessels and 
(4) stimulating somatic and visceral (including vagal) afferent nerves. 
Ref:  http://www.jbc.org/cgi/reprint/272/41/25693 
http://jp.physoc.org/cgi/content/abstract/443/1/421?ck=nck 
http://www.psychosomaticmedicine.org/cgi/content/abstract/63/3/476 
http://jn.physiology.org/cgi/reprint/93/2/929?ijkey=a9024b9ce74ad6d9ccd2311f9f39ee084760b417 
http://www.csbmb.princeton.edu/ncc/PDFs/Locus%20Coeruleus/Aston-Jones%20&%20Cohen%20(ARN%2005).pdf 
and http://physrev.physiology.org/cgi/reprint/63/3/844?ijkey=f678964b1c98ed1891648bba0c8432d5f2385bc3&keytype2=tf_ipsecsha 
That is, the cytokine-to-brain communication can result in alterations of brain function and behavior. Finally, a combining action of prostaglandin E2 and dopamine-induced oxytocin release turns on sexual arousal/heat and orgasmic responses.  In fact, prostaglandin E2 amplifies or enhance the excitatory postsynaptic potentials (EPSPs) of  neurons and synapses in all the nervous systems. It can be considered as an initiator of sexual responses, which neurochemically initiates the nervous transduction and communication between the brain and sex organs.  However, when excessive prostaglandin E2 over-stimulates the hypothalamus, it produces centrally-mediated "illness" responses such as headaches, migraine, brain overheating, fever, hot flushes, sweating,  brain-stem inflammatory pains, eye inflammatory pain, blurry vision, eye over-light sensitivity to light,  sinus, flu-like symptoms, ear ringing and inflammatory pressure, regardless of the dopamine level.  
Example: Excessive norepinephrine and its induced prostaglandin E2 production in the hypothalamic locus coeruleus (LC) and preoptic area (POA) elevate the core temperature for excessive sweating during sex.
http://www.actionlove.com/cases/case15878.htm

At the same time, the adrenal medulla also release norepinephrine and epinephrine into the bloodstream  in response to sexual stimulation and orgasm.  Norepinephrine reach all the alpha and beta adrenergic receptors everywhere in the body, where the local tissues, under the norepinephrine stimulation, release postaglandin E2 into the bloodstream or for exciting the local sensory nerves. When a local tissue won't produce enough prostaglandin E1 and endorphin or have a weak serotonin and GABA nervous modulation and control on the nervous stimulation by prostaglandin E2, the local nerves will be inflammatory with tingling, pains,  cramps, allergy, or other nervous reaction symptoms, such as frequent urination, incontinence, peeing urgency without a full bladder, and premature ejaculation.  Similarly, sex organ under the norepinephrine action on sympathetic nervous beta-and alpha-andrenergic receptors can release excessive prostaglandin E2 release too.   Please note: the binding of norepinephrine in the alpha-adrenergic receptors will give your erectile dysfunction or let your penis or clitoris and G-spot go limp while the excessive norepinephrine-induced prostaglandin E2 produces premature orgasm, premature ejaculation, precum  or semen leakage, excessive vaginal wetness, inflammatory headaches or migraines, inflammation-induced vision and hearing disorders (inflammatory eyeballs and inner ears), and pains in your sex organs, stomach, neck,  joints or/and muscles.  (special ref:  http://www.iovs.org/cgi/reprint/22/6/757 for the inflammatory iris-ciliary body of eyes, and http://www.iovs.org/cgi/reprint/15/2/102 )

Mechanical stimulation on sex organs (actually, any skin tissues) can also trigger the cutaneous neuro-immino-endocrine function and induce norpeinephrine and prostaglandin E2 release from the local cells without the central hypothalamus-adrenal action, so that the stimulation signal can be amplified as EPSPs and then coupled into the postsynaptic neurons for the sensory relay to the brain and central nervous system. Once stimulation signal reaches the brain, it can turn on the central neuro-immno-endocrine action from the hypothalamus-pituitary-adrenal and -testicular axis.

It should be noted that sexual arousal and orgasm requires testosterone and dopamine to sensitize the LC and POA nervous sensitivity, to promote the dopamine-norepinephrine conversion for induction of the sympathetic nervous fires and prostaglandin E2 release, and to stimulate the oxytocin release from the pituitary.  Testosterone is the fuel of sex, dopamine is the lighter, and norepinephrine is the fire. However, we can not ignore the effect of the 5-alpha testosterone metabolite, DHT, on sexual function.  Blocking testosterone-DHT conversion will also reduce courtiship, sex organ erectile function and size, and male semen production and quality. DHT acts to increase survival of penile musculature followed by survival of spinal nucleus of the bulbocavernosus (SNB), whose motoneurons innervate perineal muscles involved in copulatory reflexes.  In the adult, DHT also affects the morphology of SNB neurons, the growth of cell bodies and dendrities, and the penile/clitoral/G-spot size during erection when binding of DHT into its receptors. The motoneurons innervate the bulbocavernosus (BC) and levator ani (LA), in striated skeletal muscles that attach to the base of the penis (and maybe, clitoris too.)  The motoneurons also innervate the external anal sphincter for both sexes. Deficiency of DHT will induce inflammatory pains, with prostaglamndin E2 release,  in the pelvic floor (perineum), penis, testicles, vagina, vulva, and anus,  and cause Interstitial Cystitis (IC). Excessive DHT will over-expand the local tissues for pains too.
Ref:  https://www.msu.edu/~breedsm/pdf/JCN2004ARinMuscle.pdf,
http://www.ingentaconnect.com/content/bsc/jneur/2007/00000019/00000010/art00010,
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=91005
http://content.karger.com/ProdukteDB/produkte.asp?Doi=48115  
http://jcem.endojournals.org/cgi/content/abstract/79/2/409
http://endo.endojournals.org/cgi/reprint/136/4/1495 
http://cat.inist.fr/?aModele=afficheN&cpsidt=14669477 
http://www.andrologyjournal.org/cgi/reprint/26/2/242.pdf 
http://www.mindfully.org/Pesticide/Alligator-Penis-Apopka-Guillette.htm 
http://www.reproduction-online.org/cgi/content/full/133/2/331 
http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1008-862X.2005.00003.x 
http://www.ncbi.nlm.nih.gov/pubmed/11845321?dopt=Abstract 
http://humupd.oxfordjournals.org/cgi/content/abstract/7/3/314?ijkey=99f7484e2eaccb186ea17615366f70e2a7798679&keytype2=tf_ipsecsha 
http://www.ncbi.nlm.nih.gov/pubmed/2177574?dopt=Abstract 
http://www.bch.msu.edu/~zacharet/publications/pdf/Rosen-JNeuroEndo14(1)19-28,2002.pdf, http://www.medscape.com/medline/abstract/9212065  and http://endo.endojournals.org/cgi/content/full/147/5/2392 

Excessive Prostaglandin E2 also suppresses the the neuroimmune and inflame your internal organs and joints for functional disorders, and let you get infection, allergy and sinus,  and catch cold easily, and experience arthritis and Chronic Fatigue Immune Deficiency Syndrome (CFIDS.) When your core temperature rises due to the action of prostaglandin E2 on the brain, you only feel over-heating and sweating for unknown reasons (even in a cool or cold condition), but also are very easy to get sick or catch cold. Particularly, you may become very hot and sweating due to the brain overheating, and then if you feel chilly after sex, you can be in trouble.
Note that rheumatoid arthritis (RA) is an inflammatory disorder with characterization of systemic and local inflammation resulting in cartilage and bone destruction.  Prostaglandin E2 can be linked to the edema and the erosion of cartilage and juxta-articular bone.  Reducing the stress-induced  prostaglandin E2 production and increasing the prostaglandin E1 and endorphin production by improving the hypothalamus-pituitary-adrenal and -testicular/ovarian function can resolve both the signs and levels of inflammation.  Therefore, reduction excessively sex-induced and other psychological stress is the way to prevent the decay of the joints.  Ref: http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=151107&blobtype=pdf 

The other problems associated with excessively norepinephrine-induced prostaglandin E2 are ejaculation/orgasm induced sleeping disorder and persistent sexual arousal.  It is like your body on fire. The persistent sexual arousal and orgasm/ejaculation urgency are due to excessive prostaglandin E2 stimulation on the seminal vesicles, prostate, bulbourethral glands, penis, kidneys and bladder for men,  and the uterus, G-spot, vagina and clitoris for women. This means the norepinephrine-induced prostaglandin E2 over-excited your pineal gland and retinal and cut down your melatonin production, inflamed your eye balls and sex organs,  and over-dilated your eye pupils, prostate, penis, G-spot and clitoris.

It is also found out-of-bounded hormones, such as DHEA (that may produce a high level of testosterone, although an extremely high DHEA won't directly cause inflammatory responses, according to this report- http://jcem.endojournals.org/cgi/reprint/83/6/2012.pdf ), testosterone, DHT, LH, FSH, estrogen, and progesterone  will also induce prostaglandin E2 production.  The menopause symptoms, hot flushes, overheated brain and spine,  body pains, sweating, insomnia, are the typical examples. This is a result of excessive LH-induced prostaglandin E2 release. It can happen to young men and women who have excessive sex or the exhausted hypothalamus-pituitary-adrenal/-testicular(-ovarian) function although it is common for middle-age men and women, even without having sex.  The overshooting of the pituitary LH hormone responds to deficiency of testosterone (and DHT) and estrogen/progesterone, for  men and women, respectively, several hours or days after sex, when the serotonin and GABA nervous modulation are too weak.  After ejaculation or orgasm, norepinephrine and its induced prostaglandin E2 remain very high in keeping your brain and sex organs in heat, while the orgasm-induced cortisol and  prolactin release will continue for several hours or days and will become high enough to block the testosterone or estrogen/progesterone production from the testicles and ovaries, respectively. In this case, the pituitary gland will continue to fire up LH in an attempt to increase testosterone and estrogen production to cool down the negative dopamine-hypothalamus-pituitary-testicular/ovarian hormonal control loop.  Excessive LH release, in turn,  elevates the prostaglandin E2 in the brain and spinal fluid for hot flashes and core temperature rise- the menopause symptoms for men and women.  This results in sleep disorders, sweating, pains, losing memory or concentration, even headaches or hangover. In this regard, you will need ViaPal-hGH-M or ViaPa-hGH-E to turn off  the negative dopamine-hypothalamus-pituitary-testicular/ovarian hormonal control loop for a good sleep.

Although norepinephrine is the main contributor to both inflammatory and neuropathic pains. These pain states can be sensitized with increase in  the norepinephrine-epinephrine conversion in the adrenal medulla and the sympathetic nervous neuromuscular endings via the stimulation of epinephrine on the adrenergic beta receptors.  Sexual arousal and orgasm/ejaculation ultimately elevate the plasma concentrations of epinephrine as a final stage of the catecholamines metabolism from dopamine.  With  oxytocin  and prostaglandin E2 stimulation,  epinephrine produces a beta -adrenergic receptor-mediated mechanical  hyperalgesia for a swelling, hypersensitive penis, clitoris and G-spot upon orgasm or ejaculation. The sex organs can become too sensitive to touch or couple minutes after orgasm or ejaculation. At some extreme swellings cases,  orgasm-induce excessive norepinephrine-epinephrine conversion result in shooting pain in the brain, stomach, low back, low abdomen, tailbone, testicles, prostate, uterus, penis, and vagina.  In some cases, the brain arteries are inflamed and  restricted so much that the brain blood flow is nearly cut off, resulting in  blackout or seizure orgasm responses or little death.  

Researches have found that epinephrine induces cutaneous mechanical hyperalgesia and sensitizes the dorsal root ganglion neurons via its action at a beta -adrenergic receptor and the effects of epinephrine are enhanced by both the inflammatory protein kinases A and  C second-messenger pathways.  Ref:  http://jn.physiology.org/cgi/content/full/81/3/1104 

Researches also found that epinephrine contributes to the mechanism of the sensitizing effect of ethanol on the liver and the initiation and progression of alcoholic liver disease. http://intl-ajpgi.physiology.org/cgi/content/abstract/00050.2008v1 . Actually, alcohol can promote norepinephrine and epinephrine synthesis. Prostaglandin E2 plays a key role in mediating liver inflammation and damage - http://ajpgi.physiology.org/cgi/content/full/275/4/G605 
Therefore, drunk sex is very destructive to the liver and brain.

People with a sexually exhausted or genetically weak  hypothalamus-pituitary-adrenal axis,  the hypothalamus and adrenal glands constantly produces excessive dopamine-norepinephrine-epinephrine conversion and keep a high prostaglandin E2 level in the local tissues and bloodstream. With a high level of prostaglandin E2 in the brain and pelvic and sex organs, the person, man or woman, will experience persistent sexual arousal,  swelling sex organs, and male pre-ejaculation fluid leakage or vaginal excessive wetness. Besides psychological stresses, mechanical or heat stimulation on the skin can activate the skin's neuroimmunoendocrine circuitry for release of prostaglandin E2 and histamine. Prostaglandin E2 sensitizes local nerves, stimulates the hypothalamus-pituitary-adrenal and -testicular (ovarian) axis, induces more norepinephrine and epinephrine release,  and alternates behaviors and brain chemistry. Excessive dopamine-norepinephrine-epinephrine conversion can result in deficiency of dopamine and oxytocin, but excess of  cortisol and prolactin in the bloodstream, leading to sexual exhaustion systems or delay of post-ejaculation or post-orgasm recovery. However, for whose dopamine level remains sufficient,  they are likely to experience persistently sexual arousal with sexual exhaustion symptoms.  If there is a high level of androgen hormones, histamine and oxytocin to orchestrate the stimulation of prostaglandin E2 on the brain and sympathetic nervous system, the patient will suffer from constant orgasm or ejaculation urgency or persistent sexual orgasm syndromes.  Mechanical stimulation of sex organs by excessive over-masturbation or rough sex (including vibrator abuse) results in the skin's neuroimmunoendocrine responses, promotes the hypothalamus-pituitary-adrenal's norepinephrine and epinpehrine release,  and ignites the release proinflammatory cytokines and other mediators (enzymes and kinases) to signal the brain,  and alternates behavior and body reactions and responses.

Finally, Prostaglandin E2 is important in maintaining tumor and cancer integrity and growth, it prevent the timorous or cancerous cells from committing suicide,  and  Its mediated modulation of [Ca2+] and the proliferative effects may be involved in tumorigenesis. http://cancerres.aacrjournals.org/cgi/content/full/62/2/403


Persistently Sexual Arousal (breeding) or Over-ejaculation (Frequent Orgasm)  Reducing/Suppressing Male Immune Function via Norepinephrine Induced Prostaglandin E2 Release: Ref - http://www.actionlove.com/extra/psas.htm and http://www.actionlove.com/extra/over.htm 
The effect of sex hormones on neuro-immune function is a very controversial topics.  First, in the last few decades, epicdemiological, clinical and laboratory data have suggested women generally have a higher serum immunoglobulin level and stronger antibody response to infection or vaccination than do males. This misleads a conclusion that testosterone is the main cause of male immune disorders and an increase in testosterone will decrease male neuro-immune function. In castrated animal models, it is shown the sex steroid hormones enhance immunity in both male and female animals by rebalancing sex hormones with injection. In fact, studies on hypertension show that testosterone enhance renal norepinephrine release in animals with the  chromosome raising renal norepinephrine and release. This can explain what men hace a greater incidence of hypertension than women, as given in
http://hyper.ahajournals.org/cgi/reprint/32/5/880 .
Thus, a high dose of testosterone replacement therapy  or testosterone injection can result in anxiety, stress and shot temper, or even irregular cardiovascular output. The research result can also explain why testosterone is the fuel of sex heat and norepinephrine is the fire for everything.  Testosterone tends to elevate the dopamine level and promote dopamine-norepinephrine conversion for excessive norepinephrine to activate the pro-inflammatory cytokines for COX-2 expression and prostaglandin E2 production during breeding or reproductive state where the oxytocin level is high. This makes testosterone become a bad boy as a strong immunosuppressant. However, bird breeding studies show that in the breeding state males have a lower immune responses than both molting and nonbreeding birds, after a immune challenger mitogen phystohmagglutinin(PHA) is injected into the patagium for swelling the wing web. Testosterone implant with PHA injection for nonbreading birds shows there is a slight higher swelling (about 2% higher) in 24 hours, but after 30 hours, testosterone-implanted birds have much less swelling responses (about 30% less) as shown in http://www.princeton.edu/~hau/ReprintLinks/Greenman%20et%20al%202005.pdf
(A medical castration study about the effect of testosterone in
http://ajpendo.physiology.org/cgi/reprint/290/5/E856
shows the similar result. Personally, I consider the testosterone replacement is likely to increase DHEA and DHT in the immune cells due to the fact that the brain, adrenal glands and other tissues (including skin) metabolize DHEA to testosterone and then DHT.  Testosterone replacement is likely to reduce DHEA-testosterone conversion and to increase testosterone-DHT conversion, leading to elevation of DHEA and DHT as well.  Both DHEA and DHT are anti-inflammatory in nature as given in the following discussion if they are within their normal ranges. Chemically or mechanically castrated animals or men likely have a lower DHEA level  and out-of-bounded low testosterone and DHT due to the null testicular function. )

The bird study also suggests the transient testosterone burst will induce some degrees of proinflammatory responses to immune challenger, but the immune adaptive responses and anti-inflammatory cytokines release seems to in favor of testosterone increase if there is no sexual arousal or excessive norepinephrine release. Please note that the testosterone implant in that study is to bring the male testosterone level back to the normal level after castrating. This may imply testosterone can be proinflammatory and anti-inflammatory, depending on the stress hormone level. A high level of norepinephrine and testosterone makes people become very aggressive and anxious (Ref: http://cat.inist.fr/?aModele=afficheN&cpsidt=2480820).
Another study on castrated rats shows castration significantly drop blood pressures but testosterone replacement restore the blood pressure back - http://www.informaworld.com/smpp/content?content=10.3109/10641969409067965
Castration can increase norepinephrine release via stimulation of excessive pituitary LH release induced testosterone (or estrogen) deficiency , similar to the responses of hypothalamus and adrenal function to andropause or menopause.  However, testosterone replacement on castrated rats do increase the norepinephrine release by increase in dopamine-beta-hydroxylase activity for dopamine-norepinephrine conversion.  It also happens in rat vas deferens under androgenic control, as shown in http://www.biolreprod.org/cgi/content/abstract/40/3/541
Endocrine feedback of testosterone in regulation of the hypothalamus-pituitary-testicular axis is via the effects of testosterone on the noradrenergic (norepinephrine) system where the dopamine-norepinephrine conversion occurs in the brain. 

One cellular culture study suggests that "DHT acts as an antiinflammatory agent and depresses both nitric oxide and TNF-alpha production in a dose-dependent fashion, but testosterone treatment of microglia and peritoneal macrophages increased supernatant nitrite levels, indicative of a proinflammatory effect, as given in
http://endo.endojournals.org/cgi/content/short/148/7/3383 
The similar arguments are given in
http://ajpcell.physiology.org/cgi/reprint/277/1/C35  ,  http://ajpcell.physiology.org/cgi/content/abstract/274/6/C1530  
http://archsurg.ama-assn.org/cgi/reprint/139/2/157.pdf  , and http://jap.physiology.org/cgi/content/full/95/1/104 
DHT therapy has been patented for treating prostate cancer in http://www.freepatentsonline.com/5648350.html.
Therefore, DHT is not a bad guy at all in term of immune responses, unless you have too much DHT and too stress hormone norepinephrine together.  Please also note that in the Trauma or Hemorrhage state, the stress hormones norepinephrine and epinephrine level are very high. It is the stress hormones or testosterone, or both weakening the immune. Based upon the bird study, it seems testosterone enhanced stress-induced immune disorders.
Another study suggest that only constantly elevated DHT could decrease the cell immune response but not at significantly. But, in realty, the androgenic metabolism remains altered in the presence of exogenous androgens unless your tissues trap a high level of DHT due to blood vessel constriction (poor blood circulation) induced by the binding of stress hormones norepinephrine and epinephrine in the alpha-adrenergic receptors. Therefore, we can not fully blame DHT for prostate cancers and hair loss at all. In fact, "ecrease in DHT can cause autoimmune disorder while "a DHT increase could protect the gland from immune aggression and/or its consequences in regard to prostatic androgenic metabolism, as described in
Ref: http://linkinghub.elsevier.com/retrieve/pii/S0022534705628923
As for autoimmune, DHT seems a good guy -
http://www.jem.org/cgi/reprint/175/5/1409.pdf 
These results suggest testosterone is a double-edge sword. You need it for DHT production but can not store too much.

On the other hand, DHEA always seems a good guy for the immune function. DHEA significantly inhibits IL-6 secretion at serum concentrations of 5x10-9mol/L (or 1.4 ng/ml) to 5x10-8 (or 14 ng/ml), as described in
http://jcem.endojournals.org/cgi/reprint/83/6/2012.pdf, which also shows a higher DHEA is harmless,   and
http://biomed.gerontologyjournals.org/cgi/content/abstract/52/1/M1  
Castrated men or animals have fully relied on DHEA for their immune function. It can even help HIV patients to improve immunity.
http://gateway.nlm.nih.gov/MeetingAbstracts/ma?f=102192754.html 
DHEA can help overcame the age-related defect in the immunity of old mice against influenza.
http://cat.inist.fr/?aModele=afficheN&cpsidt=3022765 
In following article, DHEA is portraited as pro-immune and antiageing, but cortisol is negatively (we know cortisol can increase the stress hormones norepinephrine and epinephrine release!)
http://www.ingentaconnect.com/content/nrc/apnm/2008/00000033/00000003/art00001 
and http://jp.physoc.org/cgi/content/abstract/557/1/307 
For immune enhancement use, please this patent - http://www.freepatentsonline.com/5407684.html

In conclusion, you need an optimal range of androgen hormones to balance your pro-inflammatory and anti-inflammatory immune function responses. In particular, the pro-inflammatory effects of testosterone (during sexual arousal or breeding) should be balanced by the anti-inflammatory effects of DHEA and testosterone, while the dopamine-norepinephrine conversion in the hypothalamus and adrenal medulla should be properly modulated by the serotonin and GABA nervous function and the liver enzyme dopamine beta-hydroxylase with Vitamin C in order to avoid excessively- norepinephrine-induced persistent sexual arousal and inflammatory responses.


Liver/organs malfunction and inflammation and Hypothalamus-Pituitary-Adrenal  impairement induced by sex stress with chronic elevation of immunotransmitter cytokines and inflammatory hormone prostaglandin E2:
Prostaglandin E2 promotes inflammation and scarring (organ fibrogenesis, or tissue reconnection/growth (good for bad/ injured tissues) or inflammatory enlargement (bad for good tissues)!).
http://pharmrev.aspetjournals.org/cgi/content/full/56/3/387#E._Immune_System
Cytokines are the immunotransmitters that regulates homeostatic nueroimmune responses among multiple tissues. One role of cytokines is to modulate inflammatory responses to anti-inflammatory healing cascades for the first line of body defense.  For people with a history of sexual exhaustion and drug abuse, they seems to lose their healing power and  have a weak nueorimmune function with persistent inflammatory responses. The natural neuroimmune generators from the acetylcholine/parasympathetic (vagal) nervous system and the liver system can no longer support anti-inflammatory efforts, the vagal, serotonin, and GABA nervous system  and the liver system are too weak to control the adrenal norepinephrine and epinephrine release. Instead, the liver system dumps excessive dopamine beta-hydroxyalse to fuel the dopamine-norepeinphrine conversion, but fails to supply the enzymes that help the synthesis of androgen hormones and neurotransmitters,  such  as DHEA, DHT, serotonin, GABA, endorphrin, alpha-MSH, glycine and agmatine, and optimization of testosterone, to mediate proinflammatory responses. Therefore, we have to specially consider the effects of prostaglandin E2 on the liver, visceral organs and brain. 

Studies have demonstrated that norepinephrine induces calcium spikes for portal hypertension, promotes liver stress, and activate its contraction proinflammatory effects in the human hepatic stellate cells via the action of immflammatory cytokines RANETes and Interleukin-8 on the alpha1-andrenergic receptors, as described in
http://ajpgi.physiology.org/cgi/reprint/00537.2005v1.pdf
http://gut.bmj.com/cgi/content/abstract/50/4/571
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=546435&blobtype=pdf
http://jpet.aspetjournals.org/cgi/content/abstract/244/1/283
http://archsurg.ama-assn.org/cgi/content/full/140/8/801
http://ajpgi.physiology.org/cgi/content/full/290/1/G66
http://jpet.aspetjournals.org/cgi/reprint/jpet.107.121277v1.pdf
http://ajpregu.physiology.org/cgi/content/full/290/5/R1262
http://www.ncbi.nlm.nih.gov/pubmed/12901866?dopt=Abstract
In the liver, both norepinephrine and its induced prostaglandin E2 work together to heighten the effects of calcium on the body bioelectric wave functions such as nerve stimulation, hormonal regulation of liver metabolism, or bile secretion, in both normal and pathogenic conditions. The proimflammatory effect also induces proliferation and collagen gene expression for liver hardening - hepatic fibrogensis. Actually, norepinephrine promote inflammation in any tissues, and then, inflammation induces collagen release to harden the local tissues. This is a bad news for the heart and arteries, in addition to the direct induction of hypertension by the norepinephrine-driven sympathetic nervous action on the cardiosvacular function. The arteries inflammation and hardening can result in clogging the coronary artery even if you have a good cholesterol makeup. It is medically termed as coronary atherosclerosis. It is the major cause of heart attack. That is, excessive sex-induced stress can cause heart attack. Scarring or hardening of heart smooth muscles will let you heart over-work, but still cannot pump enough blood flow to your brain and penis (or clitoris and G-spot). More references? please read
http://hyper.ahajournals.org/cgi/content/abstract/40/2/148
http://cardiovascres.oxfordjournals.org/cgi/content/full/55/2/329 and
http://ajpheart.physiology.org/cgi/content/full/279/3/H1147
No wonder, it can give you poor blood circulation, dizziness, vertigo, headache, heart attack, and strokes too.
When any tissues release excessive Inflammatory hormone prostaglandin E2 into the bloodstream due to psychological or physical stresses, internal organs will be on fire and damaged. The liver is not exceptional. Here is one of examples, for the side effect of urinary retention on the liver -
http://ajprenal.physiology.org/cgi/content/full/288/5/F1005 .
Similar to urinary retention,  semen retention,  sperm retention (due to vasectomy), or egg retention (tubaligation) can induce excessive prostaglandin E2 production in the sex organs and elevate prostaglandin E2 into the bloodstream for liver damage, sex organ pains, abdominal/pelvic pains, muscular and joints pains, headaches and  other psychological and physical disorders -
http://www.actionlove.com/extra/vascectomy.htm  
http://www.actionlove.com/extra/tubaligation.htm 
http://www.actionlove.com/cases/case13176.htm

Sex can induce prostaglandin E2 in two ways - by the internal neuro-immune-endocrine stress responses and by the mechanical sex-organ stimulation, erection, and contraction stress ( the engineering material stress). Masturbation or foreplay (vibrator, dildo, hand or oral stimulation) can directly induced the local skin or tissue to release prostaglandin E2 to heat up the brain, nervous systems, internal organs and local tissues/nerves and to induce sexual arousal and orgasm. Prostaglandin E2, in turn, stimulate the hypothalamus and adrenal glands for the norepinephrine release. On the other hand, as we discussed before, sex-or drug- induced stressors norepinephrine and epinephrine release, mediated by the hypothalamus-pituitary-adrenal axis, triggers the neuro-immune reaction for the generation of pyrogenic cytokins and protein kinase for pro-inflammation and anti-inflammatory response for excessive prostaglandin E2 release.  That is, excessive sexual practice (over-masturbation, over-ejaculation or/and excessive orgasm) keeps the stressors level in the bloodstream and brain constantly high , leading to persistent sympathetic nervous Fight and Flight responses with inflammation in the brain, organs and tissues.  The excessive norpeinephrine-induced  prostaglandin E2, resulting from excessive dopamine-norepinephrine conversion at the depletion of dopamine, also stimulates the hypothalamus-pituitary-adrenal axis to release excessive cortisol and prolactin which, in turn,  block the adrenal DHEA,  pituitary oxytocin and testicular testosterone release, leading to few-days post-orgasm physical illness and psychological disorders.   
Excessive norepinephrine or/and epinephrine also kills cells and neurons, as mentioned before, and their induced persistent inflammation stimulates collagen release in the damaged tissues for scarring and hardening the internal organs such as the liver, heart, lungs, pancreases, blood vessels, adrenal glands, kidneys, and sex organs (of course, you worry about the ovaries, testicles, prostate, penis, G-spot and clitoris). This is what persistent inflammation is so destructive. For example, inflammation and scarring of blood vessels causes poor blood circulation (arterial and venous blockage)  and reduces the blood flow to the brain, any organs, joints, muscles, feet and toes. Inflammation of the hypothalamus-pituitary-adrenal/-testicular axis or the liver results in deficiency of androgen hormones ( DHEA, testosterone, DHT) and oxytocin. Cool feet or toes, even if your brain is overheating),  are the sign of poor blood circulation or androgen deficiency. 

The other liver inflammation factors beside psychological stress are given in 
http://gut.bmj.com/cgi/content/full/54/2/303
http://content.nejm.org/cgi/content/extract/343/20/1467
http://jgld.ro/42006/42006_6.pdf
http://care.diabetesjournals.org/cgi/content/full/27/8/2057
http://pubs.niaaa.nih.gov/publications/arh27-4/307-316.pdf
http://www.hepatitis-central.com/hcv/info/2003/aug/hepcinfo413.pdf
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9122234
http://www2.niddk.nih.gov/NR/rdonlyres/7DDAC2D5-9096-4EAF-AC19-DCF781CFE390/0/ldrb_chapter7.pdf 
Noticeably, over-eating/over-drinking and alcohol abuse can be avoided by change of your life style.

Studies show that persistent stimulation of cytokine Interleukin 1beta (IL 1beta) on the hypothalamus-pituitary-adrenal axis results in an overall inhibitory effect. Ref:
http://www.ncbi.nlm.nih.gov/pubmed/9050749?ordinalpos=40&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_
RVDocSum 
http://endo.endojournals.org/cgi/reprint/145/1/104 http://www.ncbi.nlm.nih.gov/pubmed/8903845?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_
DiscoveryPanel.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed 
http://www.ncbi.nlm.nih.gov/pubmed/11155801?ordinalpos=25&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 

An acute over-sex (multiple session of sexual activities,  multiple ejaculation,  or multiple orgasms) even in one day, like over-eating,  can be very destructive. It stresses our the hypothalamus-pituitary-adrenal axis,  internal organs and sex organs for a global release of  cytokines.  The resulted acute increases in serum cytokines can induce long lasting increases in brain proinflammatory cytokines, result in persistent alterations of cytokines,  and significantly amplify the magnitude and duration of central and peripheral proinflammatory cytokines and microglial activation.  This implies that one excessive sex session with over-ejaculation or multiple orgasms, which causes an acute elevation of norepinephrine from the adrenal medulla for  an acute increase in serum cytokines, will produce catastrophic damage. of the hypothalamus-pituitary-adrenal and testicular/ovarian axis, as  described in 
http://www.actionlove.com/cases/case15800.htm
http://www.actionlove.com/cases/case15750.htm,  and more in
http://www.actionlove.com/extra/over.htm    
http://www.actionlove.com/extra/over2.htm  and
http://actionlove.com/extra/girloversex.htm.
   
Also, the inflammation induced differential anti-inflammatory cytokine IL-10 responses in liver and brain could cause long lasting disruption of cytokine cascades for autoimmune disorders.
Ref:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18348728
http://www.ncbi.nlm.nih.gov/pubmed/12946286?ordinalpos=10&itool=EntrezSystem2.
PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum 
http://www.actabiomedica.it/data/2007/supp_1_2007/hopkins.pdf 
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=333413&blobtype=pdf 

In summary, norepinephrine and prostaglandin E2 causes nervous plasticity and remodeling of your hypothalamus and internal organs (particularly, GABA nervous control on PVN and LC,  the liver, heart, lungs, adrenal glands, kidneys and so on)  for chronic physiological and psychological disorders. Even if you don't have over-sex or other psychological stress , your brain and organ will be deteriorated with natural ageing. The liver and heart  always goes before any organs or brain in the natural ageing process.
http://ajpregu.physiology.org/cgi/reprint/282/3/R909
http://ajpheart.physiology.org/cgi/content/full/287/5/H1895
http://www.brain.psu.edu/pdf/2006lullen_genes_brain_behav.pdf
A study shows "healthy, natural ageing" significantly increases the sympathetic nervous system and brain norepinephrine turnover.  In a group of healthy men aged 60-75 years, the  norepinephrine turnover in suprabulbar subcortical brain regions is about 317 ng/min in average, while it is about 107 ng/min in average for young men aged 20-30 years.
http://ajpregu.physiology.org/cgi/content/full/282/3/R909
http://diabetes.diabetesjournals.org/cgi/content/full/53/2/276
Reducing the norepinpehrine turnover can prevent age-related disease.
http://circ.ahajournals.org/cgi/content/full/circulationaha;91/2/351
http://ajpheart.physiology.org/cgi/content/full/287/5/H1895
http://www.brain.psu.edu/pdf/2006lullen_genes_brain_behav.pdf
For some ideas about "Neuroendocrinology of ageing" - http://ageing.oxfordjournals.org/cgi/reprint/30/4/279.pdf


Serotonin and GABA nervous modulation on the stress response axis - the hypothalamus-pituitary-adrenal axis for better sex.
1. Serotonin regulates upstream corticotropin-releasing hormone (CRH) signaling systems via activation of serotonin 2C receptors (5-HT2CRs)in the hypothalamic paraventricular nucleus (PVN).
http://www.jneurosci.org/cgi/content/full/27/26/6956
2. In the hypothalamus, here is a convergence of critical synaptic input including GABA and serotonin on proopiomelanocortin (POMC)neurons to regulate the output of hypothalamic neurons.
http://molpharm.aspetjournals.org/cgi/content/abstract/72/4/885
Hypoththalamic proopiomelanocortin (POMC) neurons release GABA and respond to opioids
http://www.jneurosci.org/cgi/content/full/24/7/1578 
3. Serotonergic nerve fibers and receptors have been found in both the hypothalamic supraoptic nucleus (SON) and the paraventricular nucleus (PVN), where they play key role in regulating the release of adrenal and neurohypophysical hormones  (Sawchenko et al. 1983, Chaouloff 2000, Kang et al. 2004). Accordingly,  serotonin may play as a mediator/control of hormone secretion.
http://joe.endocrinology-journals.org/cgi/content/full/190/3/581
4. GABAergic and serotoninergic systems regulate gonadotrophin secretion and modify hypothalamic concentration of dopamine, norpeinpehrine and epinpehrine.
5. Serotonin is very concentarted in hypothalamus and the raphe nuclei in the mid-brain,  and its neurons project in a diffuse way form raphe nuclei to the cerebral cortex, hippocampus, limbic system, and hypothalamus as well as down the spinal cord. But,  the cortex and cerebellum contain low concentrations.  Serotoninergic nervous systems reduces the release of norepinephrine from sympathetic nerves, by acting on 5HT1 receptors on the nerve terminals in the adrenal medulla.
6. Serotonin inhibits offensive aggression facilitated by the arginine vasopressin (AVP) system in the anterior hypothalamic region. http://www.jneurosci.org/cgi/content/full/17/11/4331 . Chronic inhibition of GABA synthesis and consequently enhanced glutamatergic excitation in the dorsomedial hypothalamus(DMH) produce panic attack -
http://www.jneurosci.org/cgi/content/full/26/26/7093 .
7. Serotonin and GABA, in conjunction with dopamine, acetylcholine, norepinephrine, melatonin and insulin,  regulates the pituitary LH, FSH, prolactin, oxytocin , hGH,  adrenocorticotropin (ACTH) and alpha-melanotropin. http://www.ihop-net.org/UniPub/iHOP/pm/541411.html?pmid=8625616
8. GABA acts as a paracrine or autocrine signaling molecule in endocrine tissues such as the pancreatic islets, adrenal glands, vas deferens, prostate, epididymis, seminal vesicle, ovaries (with activation of Calcium channel)s, 
and testis (yes, sperm cells contain GABA receptors, important to male fertility). GABA is locally synthesized and stored by steroid-producing cells of the adrenal cortex, possibly forming an auto- or paracrine GABAergic system,  and may influence these cells in cortisol and DHEA synthesis. In addition to hormonal control by the circulating hormones ACTH and angiotensin II, a wide variety of other hormones, neuropeptides, neurotransmitters, and cytokines participate in the control of adrenal function. These substances originate from the adrenal medulla, neurons, vascular cells, and immune cells. GABA and functional GABAB receptors have been detected in peripheral tissues such as adrenal medulla, islets of Langerhans, placenta, and smooth muscle cells of the airway, urinary bladder and uterus, responsible for control of norepinephrine and epinpephrine release from adrenal medulla, relaxation of smooth muscles, and mitigation of blood vessel constrictive and inflammatory effects via the alpha-adrenergic receptors.
http://www.ncbi.nlm.nih.gov/pubmed/6237538?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_RVAbstractPlusDrugs1 
http://ajplung.physiology.org/cgi/content/abstract/291/5/L923 
http://ajplung.physiology.org/cgi/content/abstract/294/6/L1206 
http://pats.atsjournals.org/cgi/content/abstract/5/1/47 
http://ajplung.physiology.org/cgi/content/full/291/5/L923
http://www.ncbi.nlm.nih.gov/pubmed/16343781?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_
ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=5&log$=relatedarticles&logdbfrom=pubmed and
http://endo.endojournals.org/cgi/content/abstract/145/5/2402 

9. Both GABAergic and Serotoninergic neurons modulate the cleavage of Pro-OpioMelanoCortin (POMC) into ACTH  and β-lipotropin (β-LPH) in the anterior pituitary gland; Corticotropin-like intermediate peptide (CLIP), γ-LPH, α-MSH , γ-MSH, β-MSH and β-endorphin in the intermediate lobe; MSH, by POMC neurons in the arcuate nucleus of the hypothalamus.  α-MSH released into the brain by these neurons has effects on feeding behavior, energy expenditure, and sexual arousal; α-MSH released into the blood stream or synthesized by skin cells or hair folliclesm, under action of UV or genes, will darken the skin and hair color respectively.  α-MSH stimulates oxytocin (OT) release from dendrites of the magnocellular neurons in conjunction with action of dopaminergic neurons on D2 receptors while blocking "normal" OT release at the axonal release sites. This helps the brain turn on the sexual libido and erectile circuits. Serotoninergic and GABAnergic( with Chloride-dependent Calcium Channel Activation) nervous system modulate the entire hypothalamus-pituitary-adrenal axis and reduce the ACTH release or action while increasing endorphin,  MSH and lipotropin.
http://www.uco.es/investiga/grupos/endocelular/papers-pdf/Peptides-Regulation%20of%20alpha-MSH%20release%20by%
20GABA%20via%20a%20Cl-dependent%20Ca2+%20increase%20in%20frog%20melanotropes.pdf 
http://ajpregu.physiology.org/cgi/content/full/290/3/R577 
http://www.jneurosci.org/cgi/content/full/23/32/10351 
http://content.karger.com/ProdukteDB/produkte.asp?Doi=126582 
http://jeb.biologists.org/cgi/content/abstract/203/11/1711 
http://www.annalsnyas.org/cgi/content/abstract/994/1/90 
http://jpet.aspetjournals.org/cgi/content/abstract/271/2/1000 
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.7108414
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.17003261
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.466509
http://www.ncbi.nlm.nih.gov/pubmed/1003058?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.
Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed 
http://sciencelinks.jp/j-east/article/200001/000020000199A0753468.php 
http://joe.endocrinology-journals.org/cgi/content/abstract/90/1/53
http://www.ncbi.nlm.nih.gov/pubmed/7291039
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=237945
http://ajpendo.physiology.org/cgi/content/full/284/6/E1181
http://edrv.endojournals.org/cgi/content/full/27/7/736 http://www.jneurosci.org/cgi/content/abstract/12/3/864
http://www.patentstorm.us/patents/6051555/fulltext.html

10. GABAergic neurons in the peri-LC dendritic zone may provide interneuronal integration for hypothalamic locus ceruleus (LC) noradrenergic neurons, where GABA controls the dopamine-norepinpehrine conversion and adrenergic/sympathetic nervous function.    http://www.jneurosci.org/cgi/content/full/24/9/2313 
http://www.jneurosci.org/cgi/content/abstract/28/22/5806 


Stress hormones norepinephrine and epinephrine induced apoptosis in blood vessels.
Norepinephrine and epinephrine induce apoptosis of endothelial cells (Ref: Fu YC, Yin SC, Chi CS, Hwang B, Hsu SL, Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway. Apoptosis, 2006 Nov;11(11):2053-63;  Yun-Ching Fu, Ching-Shiang Chi, Sui-Chu Yin, Betau Hwang, Yung-Tsung Chiu and Shih-Lan Hsu, Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of β-adrenergic and caspase-2 pathways, Cardiovascular Research 2004 61(1):143-151 - http://cardiovascres.oxfordjournals.org/cgi/content/full/61/1/143; Romeo F., Li D., Shi M., Mehta J.L. Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc. Res. (2000) 45:788–794, http://cardiovascres.oxfordjournals.org/cgi/reprint/45/3/788?ijkey=
bca9f5122205d5f9dd39125a4ede820f97d2e833; Stefanec T. Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease? Chest (2000) 117:841–854, http://www.chestjournal.org/content/117/3/841.full.pdf+html , Communal C., Singh K., Pimentel D.R., Colucci W.S. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation (1998) 98:1329–1334, http://circ.ahajournals.org/cgi/reprint/98/13/1329?ijkey=f6a585d88fef2136ced80d0d9be63425f1870dd1 ).  Thus, chronic elevation of norepinephrine and epinephrine by excessive sex can result in thinning blood vessels and ultimate breakage for bleeding in the brain, prostate, urethra, colon and rectum too. Our empirical data shows the excessive stress hormones elicit the prostate, stomach, colon and rectum bleeding. 

Generally, sex-induced excessive stress hormones, inflammatory hormone Prostaglandin E2,  and over-excitation of histamine H1 receptors cause the stomach problems too. It is one of the sympathetic nervous Fight and Flight responses.


Anxiety, Neuroimmune Reaction,  and Premature Ejaculation Anxiety indicates the serotonin and GABA nervous modulation/control disorders on the autonomic nervous system, leading to the norandrenergic/sympathetic nervous function overpowering the parasympathetic nervous function. This leads to severe premature ejaculation, termed as performance anxiety.
The serotonin and GABA nervous function modulate the norandrenergic/sympathetic nervous function in two ways: the autonomic nervous system (ANS) via direct the norepinephrine (NE) neurons of the hypothalamic locus coeruleus (LC), and the neuroendocrine humoral outflow via the hypothalamus (paraventricular nucleus (PVN))-pituitary-adrenal axis.
The GABAerginic nerves control on the norandrenergic (norpeinephrine) firing in the LC while the sertoninergic nerves reduce the noradrenergic/sympathetic nervous function  by affecting the reflex mechanism via the vagus nerves. The serotoninergic and GABA nerves can also modulate and reduce the somatic and sympathetic nervous sensing and response via the beta-endorphin release.  That is, the GABA, serotonin and endorphin nervous control  can also reduce the seminal vesicles, prostate, bulbourethral and penile nervous sensitivity.
Sexual stimulation, arousal or orgasm ignites the dopamine-norepinephrine conversion in the hypothalamus and adrenal medulla, and, then, activates the norepinephrine (NE) neurons of the locus coeruleus (LC); the neural signals are relayed to the preoptic area of the hypothalamus via the ventral norepinephrine noradrenergic bundle, where noepinephrine is released; then, norepinephrine stimulates the synthesis of prostaglandin E2 in local neurons and/or astrocytes, by activating  a group of proinflammatorycytokines such as IL-1{alpha}, IL-1, IL-6, TNF-{alpha}, IFN-{alpha}, and MIP-1in the the immune system. These cytokines, acting as the endogenous pyrogen of desire fires. Prostaglandin E2 sensitizes the sympathetic nerves in the adrenal glands, prostate, seminal vesicles, testicles and penis for norepinephrine release in the nervous endings in preparing for sexual activity. The release of norepinephrine in the local tissues, in turn, triggers the neuroimmunotransmitters cytokins, proinflammatory prostaglandin E2 or antiinflammatory prostaglandin E1 release.  Both prostaglandins initiate erection, followed by the parasympathetic nervous erectile mechanism via the Nitric Oxide and cGMP action, and the binding of norepinephrine in the sympathetic nervous beta-adrenergic receptors.
The inflammatory hormone prostaglandin E2 can sensitize the sympathetic and somatic nerves in the seminal vesicles, prostate, bulbourethral glands and penis and inflame the orgasm to induce precum leakage, followed by ejaculation in few seconds or minutes, depending on the concentration of prostaglandin E1 and endorpin in the precum. 

Orgasm induced neuroimmune disorders, allergy and asthma
Our reader has reported overshooting of norepinephrine (8.6 nmol/L while the normal is supposed to be less than 4 nmol/L at that time, about 2 hours after ejaculating), IgM (250%), IgE (200%) and C3 (125%) results in brain fog, fatigue, tiredness, muscle and joint stiffness and pain, Heart palpitations (rapid heartbeat), and digestive panic attack
Orgasm induces immune challenge in 2 ways: direct and indirect. The direct one is to respond to the foreign substances bringing to the contact organs including the mouth and sex organs. The indirect one is a neuro-immune response to the orgasm induced norepinephrine release from the hypothalamus and adrenal glands, leading to the elevation of Immunoglobulin (antibodies ). Chronic over-masturbation, over-ejaculation or excessive orgasm generally exhausts dopamine, cholinergic/vagal(acetylcholine), serotonin and GABA nervous control with excessive hypothalamic and adrenal dopamine-norepinephrine conversion for constant sympathetic nervous fight or/and flight, excessive norepinephrine-induced informatory hormone prostaglandin E2 production over your body cells from the head down to the  toes, excessive norepinephrine-induced Immunoglobulin (antibodies such as IgA, IgD, IgE, IgG and IgM) elevation for neuroimmune weakness and disorders, constant elevation of the pituitary prolactin release for autoimmune disorders, and constant constriction and inflammation of your arterial and heart smooth muscles. The problem is: Chronic elevation of the stress hormone norepinephrine and its induced immune suppression will collapse the immune system. There are several symptoms associated with excessive norepinephrine-induced Immunoglobulin elevation and excessive immune-suppression prostaglandin E2 for neuroimmune weakness and disorders.
For sexual induced asthma, sneezing, allergy and sinus, we will have to deal with the excessive norepinephrine induced IgE which triggers excessive release of both histamine and prostaglandin E2.
The antibody IgE, which is found in the lungs, skin, and mucous membranes, is responsible for activation of mast cells to release histamine,  and  for triggering cytokines like interleukin-4 (IL-4) and interleukin-13 (IL-13) and other inflammatory mediators to release inflammatory hormone and immune-suppressor prostaglandin E2.  Thus, overshooting of IgE causes allergy, sneezing and hypersensitivity.  Elevation of the stress neurohomrone norepinephrine will generally trigger the elevation of IgE for allergy, sneezing and hypersensitivity,  and activates enzyme Cyclooxygenase-2 (also known as COX-2) to oxidize arachidonic acid into prostaglandin E2.  Excessive psychological or physical stress, excessive sex, over-exposure to sunlight or intensive heat, air pollution, or pollen can overshoot IgE for allergy, sinus, headaches and other inflammatory diseases.
IgM is found in blood and lymp fluid in response to an infection. It promotes other immune system cells to destroy intruders. However,  Excessive elevation of IgM indicates ectodermal dysplasia and immunodeficiency, or humoral immune defect. 
IgG is found in the body fluid, very important in fighting against bacterial and viral infections. Norepinephrine is not supposed to increase IgG antibodies.
IgA is found in the areas of the body, that exposed to foreign substances. Those areas include the nose, breathing passages, digestive tract, ears, eyes, and vagina. IgA antibodies protect the body surfaces  against outside foreign substances. Sexual intimacy may elevate IgA  in response to the secretion from the mouth, vagina, uterus and  cervix and other sexual aid substances for men, and to the secretion of mouth, the ejaculation fluid and sexual aid substances for women. It is supposed to be an immune challenge.
Chronic over-stimulation of the immune system with excessive stress neurohormone norepinephrine and its induced immune suppressor prostaglandin E2 will breakdown the immune adaptive ability  and collapse the the adaptive immune system, leading to immune disorders. Thus, if your norepinephrine and prostaglandin E2 are not overshooting, immune stimulation with norepinephrine will improve the adaptive immune system to combat pathogens, the alternative term "infectious agents" or the common name "germs."
The other immune complements of the innate immune system,  known as the complement system which is not adaptable and won't change overtime in an individual's lifetime, can be recruited and brought into action by the adaptive immune system. The complement system is a biochemical cascade that clears pathogens by attacking the surface of foreign cells. It contains over 20 different proteins, circulating in the blood and bathing the tissues in an inactive form.  In response to the recognition of  foreign cells, the proteins become sequentially activated, working in a cascade  in which the binding of one protein will promote the binding of the next protein in the cascade. It is the major humoral component of the innate immune response.
The complement cascade is a double-edged sword.  While protecting against the invasion of foreign cells, the complement system has the potential to be extremely damaging to host tissues via its induced inflammation and phagocytosis. A long-term stimulation of the complement system may lead to many diseases associated with an immune component, such as Barraquer-Simons Syndrome, asthma, lupus erythematosus, glomerulonephritis, vasculitis (inflammatory destruction of blood vessels including both arteries and veins)), kidney basement membrane diseases, nephritis (kidney inflammation), hemolysis (rupture of red blood cells), arthritis, autoimmune heart disease, multiple sclerosis, inflammatory bowel disease,  ischemia-reperfusion injuries, and autoimmune disorders,   and to the diseases of the central nervous system such as Alzheimer's disease, Parkinson's diseases,  parkinsonism,  and other neurodegenerative conditions. 

Ref: 
Arachidonic Acid Oxygenation by COX-1 and COX-2 MECHANISMS OF CATALYSIS AND INHIBITION
http://www.jbc.org/content/274/33/22903.full.pdf+html
Complement determinations in human disease
http://www.questdiagnostics.com/hcp/intguide/Immuno/Complement%20on%20IG_Glovsky%20et%20al.pdf 
Neural Adrenergic/Cyclic AMP Regulation of the Immunoglobulin E Receptor α-Subunit Expression in the Mammalian Pinealocyte A NEUROENDOCRINE/IMMUNE RESPONSE LINK?*
http://www.jbc.org/content/282/45/32758.full.pdf+html 


Orgasm Brain Sex Pain?!! - Oops! Click the links in the left-handed side if you need our case collection since 1997.  Or read some interested cases below:

What is POIS ( Post Orgasmic Illness Syndrome)? Traditional Chinese Medicine (TCM) terms POIS as Qi (Chi)-Blood Stagnation or Blockage, as parts of Sexual Exhaustion Symptoms
==> http://www.actionlove.com/cases/case16665.htm
On Taoist's ejaculation frequency vs testosterone level and sperm concentration.; 5000-years Sexual exhaustion symptoms were also mentioned by the Seventh-day Adventist church; what is a consistence of old culture wisdoms!
==> http://www.actionlove.com/cases/case15675.htm
causes and solutions for sexual exhaustion symptoms - body pains, eye floaters, blurry vision, ear buzzing, headaches, chronic non-bacterial prostatitis and poor semen quality and quantity for no sexual orgasm. Why his doctors could not found his UFO symptoms induced by sexual exhaustion!? And Antibiotics won't work but can cause excessive histamine release in certain cells for allergic responses
==> http://www.actionlove.com/cases/case16082.htm

Why sexual arousal gives him tiredness, and sexual orgasm worsens his tiredness?
http://www.actionlove.com/cases/case15955.htm
Excessive dopamine-norepinephrine/epinephrine conversion, resulting from parasympathetic/vagal, GABA and serotonin nervous control disorder, induces organ inflammation, brain fog, depression, autoimmune disorder, chronic infection,  inflammatory pain, digestive disorder and panic responses, low libido, premature ejaculation, adrenal fatigue and lyme disease.
==> http://www.actionlove.com/cases/case15858.htm
On Sexual Energy Exchange during intercourse for the Tao of Love -
He said 'I will continue to use your products for time to time and hang on to your words of wisdom.' on sexual energy exchange during intercourse for more sexual orgasm
==> http://www.actionlove.com/cases/case15578.htm
why ejaculation or sexual orgasm induced awful depression, anxiety, body pains (dull throbbing gallbladder and liver pain) for a few day - Solution
==> http://www.actionlove.com/cases/case15444.htm
Pot smoking and alcohol result in memory loss, eye floaters, upper abdominal/stomach pains (went to ER twice for MRI, scans, colonoscopy..), vaginal dryness, uterine cramp and pain, post-sex low abdominal (uterine) pain, allergies. sinus, puffy eyes, headaches, forehead tenderness and no more sexual orgasm
==> http://www.actionlove.com/cases/case15747.htm
What cause the post-ejaculation and post-orgasm pains, cramps, tightness, joint rigidity and muscle weakness for no more sexual orgasm
==> http://www.actionlove.com/cases/case15079.htm 
Sexual Hangover - Sex or orgasm induced headache, poor mentality, mood swings, dizziness and vertigo - solution for the severe side effects of sexual orgasm
==> http://www.actionlove.com/cases/case15010.htm
The similarity of between the penile jelq-induced damage and heart failure as a result of increased collagen synthesis for no more sexual orgasm - A special Penile Enlargement advice
http://www.actionlove.com/cases/case14906.htm
He said ' I am so incredibly grateful for everything you have done for me so far! My erection is back for good now, and what your miracle products did for my health remains truly without precedence. ViaPal-HgH-J helped me to rejuvenate my penile erectile nerves and revive my dead penis after a very severe penile injury, after I ruptured both of my spongy tissues with one of the jelqing/stretching exercises I had found on the internet.'  Re-grow Corpora Cavernosa and penile nerves, heal penile varicose veins, improve penile curvature, solve penile pains, stop precum, and restore libido and sexual orgasm.
==> http://www.actionlove.com/cases/case14677.htm
2-week Finasteride (5-alpha reductase inhibitor for Hair ReGrowth and shrinking the enlarged prostate ) disabled his liver 5-alpha reducatse release in blocking the testosterone-DHT conversion for a high testosterone level, but administration of aromatase inhibitor supplements, in conjunction with the side effect of Finasteride, further kept his testosterone level too high, high enough to stimulate the excessive liver SHBG protein release in binding testosterone in the bloodstream for penile shrinkage, no more libido and sexual orgasm
==> http://www.actionlove.com/cases/case14664.htm
Why drug abuse and antidepression drugs result in excessive prostaglandin E-2 and epinephrine release to induce psychological disorders ( mood swing, anger, and aggression), extremely headaches, shooting pains low stomach swelling, body pains, body heat, light headedness confusion, uncontrollable over-masturbation (persistent sexual arousal), particularly during ovulation, for no more sexual orgasm
==>http://www.actionlove.com/cases/case14644.htm
Chronically over-masturbating for 2.5 years  resulted in low back pain, testicular pains, groins pains, urethral/penile pains, erectile dysfunction, painful erection, chronic constipation and elevation of the liver enzymes LST and AST (liver damaged index enzymes) for no more sexual orgasm, but pains.
==> http://www.actionlove.com/cases/case14451.htm
Why a hard core body builder or athletic person experiences penile and testicular shrinkage even if he is taking a lot of Nitric Oxide enhancements; on the role of the sympathetic nervous beta receptors in the penile erection, testicular function and sexual orgasm (the same conditions apply to women's clitoral/G-spot erectile dysfunction, vaginal looseness, and ovarian functional disorder too)
==> http://www.actionlove.com/cases/case14402.htm
His and her post-orgasm sexual exhaustion symptoms - sympathetic nervous panic and inflammatory responses, low back pains, low abdomen pains/cramps, perineum inflammatory pains, and so on, for no sexual orgasm - solution
http://www.actionlove.com/cases/case13819.htm
Why ejaculation/orgasm causes his mood swing, anger, aggression, anxiety, stress, fatigue, tiredness.... for no more sexual orgasm -  On the brain and body chemistry change in response to ejaculation or orgasm.
==> http://www.actionlove.com/cases/case13755.htm
He said ' I want to thank you because your products worked as you say they will and the value I got from them went beyond what I expected.' with ViaPal-hGH-J, DeToxiA and PinealTonin in detoxification of anti-psychotic and bipolar medication drugs for restoration of normal erection and sexual orgasm.
http://www.actionlove.com/cases/case13900.htm
She said ' a couple months ago I wrote to you about my problem with vestibulitis. your prescribed that i take vial pal hgh j along with borage oil, fish oil, and 5-htp. ... my doctor, who is one of the few vulvodynia and vestibulitis specialists in the country, is amazed by my rapid progress.' for solving vestibulitis, quitting pot smoking and restoring sexual orgasm.
==> http://www.actionlove.com/cases/case13584.htm
Solution for Persistent Sexual Arousal Syndrome and interstitial cystitis induced by COX-2 over-expression and inflammatory hormone prostaglandin E-2 in the pelvic cavity tissue and for control of unwanted, spontaneous sexual orgasm
http://www.actionlove.com/cases/case13532.htm
Non-orgasmic semen retention is as bad as over-ejaculation; both are for no more sexual orgasm ,but for sympathetic nervous pains and burning. What is different between both cases in term of the dopamine-norepinephrine-epinephrine conversion?
==> http://www.actionlove.com/cases/case13176.htm
He said 'I want to thank you for your products. I cannot begin to tell you how great it was for us to be able to have her squirt, and boy did she. I had no idea of the quantity of fluid that would come out or how forceful the ejaculation would be, I know for a fact that the movies that I have seen are indeed real!!!' with Heat Tea and L-Arginine! A realistic experiment for a healthy female ejaculation pumped out by an extremely powerful sexual orgasm!
http://www.actionlove.com/cases/case13138.htm
Why his doctors and drugs can not solve his non-organic prostate and testicle pains as a result of sexual exhaustion and prostate abrasion for no more sexual orgasm
http://www.actionlove.com/cases/case13121.htm
He said 'The chikong breathing worked! I thought your site was just after my money, but when I tried your advice my control over ejaculation was exactly like you said. The ballooning trick also worked and I was able to control (for the first time in my life) as long as I wanted' for  more sexual orgasm
http://www.actionlove.com/cases/case13080.htm
He said 'Your medium dosage of (MoodMax, 5HTP + Dopa Fibra, Dopa Fibra, MoodMax) has been great.'  for more sexual orgasm. How to shut down and boost your oxytocinergic nervous action for control of libido, erection and  sexual orgasm.
http://www.actionlove.com/cases/case13040.htm
Chronic over-masturbating from age 14-31 results in all of the sexual exhaustion symptoms, some fatigue, graying of hair, hair thinning, eye floaters, sinus, ear aches, and sleeping disorder for no more sexual orgasm. On the arylalklamine N-acetyltransferase gene expression disorder in the pineal gland and retina for circadian rhythm and visual nervous disorders. Why can a good sex improve your health?
http://www.actionlove.com/cases/case12909.htm
She said ' i am glad to notify you that it's unbeleavable how i have managed to get almost all my problems eliminated.as of now',  no more depression, hypertension, painful periods due to fibroids, migraine headache, vaginal muscle weakness, urinary sensation reaction, nausea, chronic sinuses, painful nipples, and low libido, but for sexual orgasm; on the pineal gland gene expression disorder.
==> http://www.actionlove.com/cases/case12813.htm
Over-ejaculating several times in 20-50 minutes have abraded his prostate and elevated a high PSA release for many days - for self destruction and no more sexual orgasm!
http://www.actionlove.com/cases/case12785.htm
ViaPal-hGH-M and DeToxiA have helped her resolve her chronic bladder disorder/ incontinence, vulva pain (Vulvodynia & vestibulitis ) & throat infection (tonsils), restore her menstrual cycle, and smooth out her PMS Pains/Cramps, for restoration of sexual orgasm
==> http://www.actionlove.com/cases/case12703.htm
Chronic over-masturbation/over-ejaculation or excessive orgasm alternates the Dopamine D1 and D2 gene expression for sympathetic nervous fires - no sexual orgasm - the brainwash solution..
http://www.actionlove.com/cases/case12612.htm
The cellular biochemistry of premature ejaculation for no more sexual orgasm.
==> http://www.actionlove.com/cases/case12610.htm
How to treat pot smokers' common problems for restoration of sexual orgasm
==>http://www.actionlove.com/cases/case12583.htm
Why his penile stretching enlargement exercise for 2 days results in youth (teenager's) impotence, glans shrinkage, premature ejaculation and low libido for no sexual orgasm
==> http://www.actionlove.com/cases/case12560.htm
A senior medical student said ' I have already been taking ViaPal-M for around 2 1/2 weeks and I must say that the results have been significant improving my symptoms of anxiety, poor memorization, acne, depression, etc. ' for sexual orgasm, and questioned on medication drugs for psychological and physiological disorders.
http://www.actionlove.com/cases/case12529.htm
Why this 20-year old man experiences orgasmic dysfunction and  withdrawal  for no sexual orgasm. On the role of prolactin and oxytocin in the sexual and orgasmic functions and in the switching of sympathetic nervous beta and alpha receptors for orgasmic contraction for men and women.
==> http://www.actionlove.com/cases/case12488.htm
Chronically masturbating twice a day lets her feel sexually unfulfilled, crave for more sex, and experience cramps in the low abdomen and back for sexual exhaustion symptoms, but no sexual orgasm. On the physiology and psychology of orgasm
==> http://www.actionlove.com/cases/case12487.htm
Dr. Lin's advices to a porn actor: Avoid multiple ejaculation in one day; Knock out all your partners with one and only one ejaculation for the most violent sexual orgasm by rhythmically stimulating the clitoris and blending the G-spot and Epicenter/cervix at the same time; Drink your own first morning pee - the Natural Spectrum Hormone Therapy.
==> http://www.actionlove.com/cases/case12460.htm
Chronic Over-masturbation causes a chronic elevation of prolactin for seminal / sperm production disorder, low libido, orgasmic disorder for infertility and no more sexual orgasm!  Why?
http://www.actionlove.com/cases/case12388.htm
Over-masturbation/over-ejaculation and drugs abuse killed his brain and nervous functions for chronic headaches, blurred vision, ear ringing and no more sexual orgasm. Here is Dr. Lin's Brainwash Engineering treatment.
http://www.actionlove.com/cases/case12366.htm
Over-masturbation has alternated and exhausted this 19-years old boy's brain/nervous functions for pains in the testicles/penile/groins/low abdomen/low back/everywhere, eye floaters and  suicidal thought for no more sexual orgasm, beyond ability of his psychologist and urologist and SSRIs antidepression drugs. The brain/nervous function destructed by over-masturbation or over-ejaculation can not be healed naturally! Here is Dr.Lin's cheap 'Brainwash' solution.
http://www.actionlove.com/cases/case12364.htm
After he spent all his money, why all his doctorS and all the prescription drugS can have never solved his non-bacterial prostatitis and prostate swelling with frequent urination, perineum heat/pains, and hair loss, leading to no more sexual orgasm - Here is Dr. Lin's cheap solution - The Natural Prostaglandin E-1 therapy.
==> http://www.actionlove.com/cases/case12346.htm
He said ' I have purchased your ViaPal-hGH-J pack and have been very happy with the results with an improvement after only 2 weeks.' how to balloon your penis and her clitoris/G-spot/vaginal/urethral erectile tissues for more sexual orgasm!
==> http://www.actionlove.com/cases/case12339.htm
Why his optometrist can not see his eye floaters resulting from over-masturbation/over-ejaculation or excessive sexual orgasm
==> http://www.actionlove.com/cases/case12334.htm
He said ' I have sexual functioning again.' with ViaPal-hGH-P; Re-Grow his circumcised foreskin, enlarge his penis, restore his orgasm and penis sensitivity after jelqing damage,  and shrink his enlarged prostate back to normal for peeing, and solve his urinary tract infection (UTI) for  more erection and sexual orgasm.
==> http://www.actionlove.com/cases/case12265.htm
Finally, a 21-year old  heavy-duty pot-smoking, post-hernia-operation over-masturbator said ' my urinary incontinence is absolutely GONE AWAY...  Thanks for your great product Dr.Lin !!'  Restoring his sexual orgasm in only 1 month!
http://www.actionlove.com/cases/case12201.htm
[Warning: This article may be very offensive to you, but you can learn about the relationship between the penile/vaginal temperature and orgasmic response, and the relationship among the urogenital blood circulation, urinary continence, androgen hormones and prostaglandin E-1. For a better sex, keep your penis/clitoris/vagina hot, but your brain cool; that is, pump your blood down to your sex organs, but not to your brain during lovemaking!  Their sexual adventures in helping us cross-verify our long-term hypotheses should be highly appreciated! OK, Here we go for it:
After her husband failed to maintain his erection for her, she is interested in dog sex for sexual orgasm. Can she have a dog tie? Dr. Lin's saddest advice! Updated (3/17/2004): She had experienced powerful multiple orgasms with the high-temperature dog penis and semen (3 degrees F higher than the human's). The result of the Dog Sex experiments can lead to a new powerful therapeutic concept for urinary incontinence! Why?
==> http://www.actionlove.com/cases/case12137.htm]
Dr. Lin's penile growth theory and permanently penile enlargement for you to go all the way to heaven and to have more sexual orgasm after you die.
http://www.actionlove.com/cases/case12121.htm
How urethral female ejaculation occurs and produces pelvic/bladder/urethral/vagina/uterus spasms and legs shaking (a temporary Parkison's phenomenon by sexual stimulation) , but no sexual orgasm; on the formation of  the sensory-sympathetic L1/L2 nervous reflex arc.
==>http://www.actionlove.com/cases/case12082.htm
He said ' i have been purchasing your products for about 4 months now for my wife. and they have helped a great deal!' for her Interstitial Cystitis (IC), fibromyalgia, migraine headaches, sleeping disorder, vaginismus (penetration/intercourse pains) and restoration of sexual orgasm - This serious case has been abandoned by the medical societies.
==> http://www.actionlove.com/cases/case12046.htm
Ear ringing (Tinitus) - the ear stresses out for no sexual orgasm
==> http://www.actionlove.com/cases/case12026.htm
He said 'we all should recommend you for a noble prize in your field of study.' after experiencing the powerful Dr. Lin's Natural  Prostaglandin E-1 therapy for prolonging his erection and sexual orgasm, increasing his semen production, darkening his hair, dropping his bad cholesterol level and blood pressure (with a high dose of Yohimbe in DopaFibra!?), eliminating his body pains ...
==> http://www.actionlove.com/cases/case11983.htm
Solution for the post-ejaculation or post-orgasmic brain/nervous disorder, trauma and fatigue - for sexual orgasm
==> http://www.actionlove.com/cases/case11980.htm
She said ' I ordered your products Moodmax, Viagrowth-IV and 5htp for vaginal looseness right before Christmas.... I can say Your products really work. Thank! You have a customer' for Vaginal Tightness and more sexual orgasm! Again, the Dr. Lin's Natural Prostaglandin E-1 Therapy
==>http://www.actionlove.com/cases/case11964.htm
Dr. Lin's Prostatitis solutions - the restoration of sexual orgasm with Natural Prostaglandin E-1 therapy.
==> http://www.actionlove.com/cases/case11924.htm
An endocrinology doctor's experience with over-masturbation or over-ejaculation, resulting in prostatitis, urethritis, erectile dysfunction, low libido, and pains in penis, low back, perineum and anus for no more sexual orgasm -Solution
==> http://www.actionlove.com/cases/case11918.htm
He said ' dear dr lin WOW it worked!!!! i took borage oil 1 capsule a day,3 capsules fish oil and 6 capsules of flaxseed per day.....RESULT- longer sexual intercourse didnt cum as quick and a much harder penis that increased in length by 1 inch and a fatter girth my girl loved my 8inch cannon. i notice also after doing your breathing method i can shoot my big cannon for another round i also take your moodmax and viagrowth4 great stuff' for more sexual orgasm and having Merrier X'mas and happier holidays!
==> http://www.actionlove.com/cases/case11904.htm
He said ' Thank you for a wonderful set of products and information! I have enjoyed them and I believe they have assisted me and my wife to enjoy sex more and conceive a child on our first try!' for a life-term sexual orgasm.
==>http://www.actionlove.com/cases/case11818.htm
He said ' Hello, I have been taking the fish oils and the borage oils now for 4 weeks. I am also very pleased with your products and my hair as well as my wife's hair is turning dark again. My wife has been almost white since her late 30's This is nothing short of a miracle. Thank-you.'  for more sexual orgasm! On Dr. Lin's Natural Prostaglandin E-1 therapeutic formula ==>http://www.actionlove.com/cases/case11805.htm
She has proved what Dr. Lin said - tubaligation results in the state of peri-menopause and menopause transition for PMS and no more sexual orgasm.
==> http://www.actionlove.com/cases/case11800.htm
He said 'Love the products....... my eyesight is so much improved...... I wonder why this is? ' for more sexual orgasm - the electric engineering solution for eyesight and eye floaters.
http://www.actionlove.com/cases/case11735.htm  
He said ' I have been practicing your ballooning method since 1998. I went from 5inches to 7 inches. Then you told me I have probably reached my full potential, that my foreskin was limiting me, which I believe is correct.' on the penile and hair re-growth for more sexual orgasm. On the calculation of the nervous erectile power change based upon the penile shrinkage rate.
http://www.actionlove.com/cases/case11591.htm
How drugs take over your brain and nervous system and how to detoxify your brain and nervous fiber/synapse for restoration of sexual orgasm.
==> http://www.actionlove.com/cases/case11500.htm
When Prostatitis can not be solved by over-ejaculation and antibiotics, you are asking for more troubles - for no more erection (impotency and sexual exhaustion) and sexual orgasm -Solution
==> http://www.actionlove.com/cases/case11430.htm
On seminal retention and prostate-cancer protection, and of course, on Over-masturbation and sexual orgasm
==> http://www.actionlove.com/cases/case11407.htm
He said 'when i take your detox pill i feel really relaxed and think clearly do you know why that is.' a full detoxification of the liver and nervous system for better health and sexual orgasm
==> http://www.actionlove.com/cases/case11347.htm
He said ' By the way, about your 5-htp. ANOTHER GREAT PRODUCT. ... last week when I got the attack, I opened an additional capsule and poured the powder beneath my tongue (sublingually). It COMPLETELY stopped the migraine progressively over a one hour period. WITH NO SIDE EFFECTS!'; more sexual orgasm without headaches and migraine or panic attack.
==> http://www.actionlove.com/cases/case11323.htm
On the role of DHT in the penile Growth, Repair (Re-Growth) and structure for more sexual orgasm.
==> http://www.actionlove.com/cases/case11311.htm
Evidences show destruction of pot (marijuana) smoking, resulting in low libido, erectile dysfunction, premature ejaculation and low seminal production for no more sexual orgasm
==> http://www.actionlove.com/cases/case11303.htm
He said 'first of all, may i thank you for your miracle products, they have totally transformed my life.' ViaPal-hGH-P and 5-HTP have rejuvenated his damaged penis and resumed his seminal production for ejaculation and sexual orgasm through normal vaginal intercourse.
==> http://www.actionlove.com/cases/case11269.htm
He said ' Love+your products= AMAZING! What's going on inside my brain, chemically, since I don't feel like eating? I'm not tired either.'; less foods and more sexual orgasm.
==> http://www.actionlove.com/cases/case11191.htm
He said 'I am nearly at the end of my course of ViaPal-HGH-P (3-010) and I have experienced excellent results. I no longer suffer from extreme fatigue, blurred vision, buzzing ears or nasal congestion after ejaculation. Thank you very much for your help!' on retaining the brain concentration after ejaculating or having sexual orgasm
==> http://www.actionlove.com/cases/case11147.htm
He said 'I feel like a New Man I have No Erection Problems. My erection are very firm and long lasting. I had to take a weaker dosage because I was waking up and walking around with an erection for long periods..' for more sexual orgasm
==> http://www.actionlove.com/cases/case11119.htm
What are the differences between the Penile Ballooning and Penile Exercises/Jelqing/Milking for penile enlargement?
==> http://www.actionlove.com/cases/case11114.htm
On the effect of the vaginal/cervical secretion on penile erection/ballooning and premature ejaculation. Why one tight vagina makes him erect harder and last longer for sexual orgasm , but the other tight one promotes his premature ejaculation?
==> http://www.actionlove.com/cases/case11032.htm
He said 'I could say that you made me a man again.' and gets recovered from extremely sexual exhaustion due to pre-teen over-masturbation; on buzzing ears; Why don’t write a book for parents about how to teach their sons the sexual energy control and development?
==> http://www.actionlove.com/cases/case10924.htm
A MD (a vasectomy victim too!) said 'I had 6 orgasms within a 36 hour period,.... Your products amazingly both help achieve strong erections, reduce the refractory period between intercourses, and maintain sensitivity while enhancing stamina and endurance of erections. Quite unbelievable. ' Oops! excessive sexual orgasm!.
==> http://www.actionlove.com/cases/case10881.htm
She said 'Your products amazed me. After not being very orgasmic at all for 35 years, I began to experience wonderful orgasms often and my libido is sky high. I love it.'  What is the origin of our products?
==> http://www.actionlove.com/cases/case10632.htm
Prostate's seminal production disorder for no more ejaculation and sexual orgasm; Under forcing with a heavy urethral stimulation, the male ejaculation is the same as the female ejaculation fluid.
==> http://www.actionlove.com/cases/case10876.htm
Non-bacterial (non-organic) testicular and penile pains due to ejaculation - why and solution.
==> http://www.actionlove.com/cases/case10853.htm
Neurophysiological approach for overcoming the masturbation addiction
==> http://www.actionlove.com/cases/case10797.htm
Why over-masturbation or excessive clitoral orgasm results in chronic clitoral pains for no more sexual orgasm
==> http://www.actionlove.com/cases/case10793.htm
Viapal-hGH-M has revived a 5-year marijuana smoker's erection for the first times in 5 years! He needs DopaFibra too for a faster healing.
==> http://www.actionlove.com/cases/case10740.htm
Don't let Ecstacy (MDMA) fry your brain and nerves for a short-term fun, but not for a long-term sexual orgasm. Updated - He messed up his brain in 4 months on New Year Eve of 2003!
==>http://www.actionlove.com/cases/case10350.htm
Over-masturbation causes 14-year old boy's endless (continuous) seminal leakage for no sexual orgasm; on destruction of the prostate's ejaculation nervous controller and modulator; The endless ejaculation can cause death during lovemaking, but How to stop it!
==> http://www.actionlove.com/cases/case10592.htm
When 'chronic non-bacterial prostatitis' (now called 'chronic pelvic pain syndrome') is the Prostate's Seminal Blasting Syndrome,' your prostate produces no much semen, resulting in retarded ejaculation, no sexual orgasm and vibrator-induced penile damage..
==> http://www.actionlove.com/cases/case10580.htm
Mechanism of the Penile Ballooning for a better sexual orgasm - on the the 2-stage penile erection theory for Penile Enlargement.
http://www.actionlove.com/cases/case10565.htm
His dog makes his girl friend achieve a Level-7 orgasm,but he gives her intercourse pain for no sexual orgasm. Now, Learn the doggy-style lovemaking.
http://www.actionlove.com/cases/case10535.htm
The final chapter of Penile Enlargement for no sexual orgasm
http://www.actionlove.com/cases/case10492.htm
Dying of Young girl's clitoris and G-spot - losing her sexual orgasm.
==> http://www.actionlove.com/cases/case10292.htm
Excessive sexual orgasm, excessive histamine release, rear-brain and neck pain, orgasmic nasal congestion, allergic responses, and dark eye circles.
==> http://www.actionlove.com/cases/case10263.htm
Cause and Solution of orgasmic convulsions upon ejaculating - the seizure response to sexual orgasm
==> http://www.actionlove.com/cases/case10241.htm
He said ' You "My Friend" are the King of Love'; ViaPal-hGH-M resolves his Chronic penile pain; On Dr. Lin's Bioelectric Theory of Love Science.
==> http://www.actionlove.com/cases/case10097.htm
On the Liver P450 Detoxification and the liver protection for health and sexual orgasm
==> http://www.actionlove.com/cases/case10000.htm

General Solutions for women without experiencing sexual orgasm
==> http://www.actionlove.com/cases/case9864.htm
But, what are General causes? Here are the General problems:

How to enlarge (loosen)  your vagina, shrink (yes, kill ) your clitoris and G-spot, and produce urinary/bowel incontinence? (click here for destruction of vibrator); How to become an impotent young man? (click here); How to shrink your penis?(click here) or How to break a penis! (click here with women-wild rides or penile enlargement practices); How to destroy (castrate) your sexual functions by masturbation, drugs (including SSRIs and birth control pills/shot - one shot kills it all!), or Vasectomy( - two cuts kill them all;) How to get a pseudo-prostatitis; How to produce eye floaters;  Finally, you want to know how to become a fastest semen-shooting (ejaculation)  man in lovemaking or dry up your seminal ejaculation or production.  
The variation of the brain's neurotransmitters in response to ejaculation and sexual orgasm - on the Penile Ballooning Method for penile enlargement and the destruction by over-masturbation and over-ejaculation .
==> http://www.actionlove.com/cases/case9875.htm
Destruction produced by Male or Female Over-Masturbation for no sexual orgasm.
==> http://www.actionlove.com/cases/case9848.htm
The principles of the Penile/G-spot/Clitoral enlargement and
Vaginal Narrowing (Reduction, yes!) are the same thing! for more sexual orgasm.
==> http://www.actionlove.com/cases/case9819.htm
Brain's and nervous functions, Orgasm Headache, and nausea associated with excessive sexual orgasm (Orgasmic Stress); on anorgasm, stress effects and de-stress.
==> http://www.actionlove.com/cases/case9814.htm
When the holes down there become bigger, they will cause pain, but why? So, How to downsize the holes for men and women. Yes, his and hers!
==> http://www.actionlove.com/cases/case9767.htm
Causes and solutions for PMS, Intercourse, penetration or orgasm pains/cramps, tilted or prolapsed uterus, and sexual orgasm; Love Positions and vaginal air trapping/pumping/escaping.
==> http://www.actionlove.com/cases/case9756.htm 
He said ' I want you to KNOW that your 'pills' have done more for me..' beyond sexual orgasm.
==>http://www.actionlove.com/cases/case9689.htm
Penile Enlargement, DHT, Prostaglandins, Nitric Oxide and cGMP
==> http://www.actionlove.com/cases/case9663.htm
On Penile Enlargement and  Reader's experience on Dr. Lin's Male Multiple Orgasms without ejaculation.
==> http://www.actionlove.com/cases/case9647.htm
Mechanism of sexual orgasm, damage of sexual nerves, and lesson from labor orgasm
==> http://www.actionlove.com/cases/case9589.htm
How do you know she achieve orgasm? on Penile Size and Penile enlargement, female sexual orgasm responses and dysfunction.
http://www.actionlove.com/cases/case9566.htm
Hair loss, 5-alpha reductase, prostate enlargement, erectile dysfunction, Prostaglandin, Vaginismus, Intercourse pain, Oxytocin and powerful sexual orgasm
==> http://www.actionlove.com/cases/case9580.htm
Principles and mechanisms of the Natural Penile Enlargement - Ballooning Method for more erection and sexual orgasm
==> http://www.actionlove.com/cases/case9499.htm
How to become a multiple Sexual-Orgasms couple.
==> http://www.actionlove.com/cases/case9303.htm
Male multiple orgasms without ejaculation by the Anal Breathing Method - The principle, tricks and conditions.
==>http://www.actionlove.com/cases/case9422.htm

Do you want to know More Good News for Sexual Orgasm? Click Here; Or the most self-destructive Sexual Practice (click here)?

Interaction between the brain/nervous systems and the love-power generators (uterus, cervix and ovaries); no hysterectomy if avoidable.
==> http://www.actionlove.com/cases/case9341.htm 
She said 'following your advice my husband has a new penis' and 'I had 30% less flow - relief' from heavy menstruation with your CD-ROM and products. For better sexual orgasm
==> http://www.actionlove.com/cases/case9275.htm
She said 'I orgasmed 3 times! AND, my husband had his first multiple orgasm.' with Dr.Lin's Sexual ChiKong Intercourse technique
==>http://www.actionlove.com/cases/case9171.htm
Neurophysiological Explanation of Sexual ChiKong Intercourse for multiple sexual orgasms and ejaculation control
==>http://www.actionlove.com/cases/case9194.htm
She has enlarged her Clitoris and G-spot with ViaGrowth-IV and Finger Pliers and Penile Screwing massages for more intensive sexual orgasm; but how to continue the practice without him.
==>http://www.actionlove.com/cases/case9214.htm
Over-masturbation and over-ejaculation result in impotency, premature ejaculation, headache, memory loss, yellowish face, and absentmindedness - the Solution.
==> http://www.actionlove.com/cases/case9263.htm


Sex is in the brain

The penis, clitoris and vagina are only the love tools, the power tools which are actuated by the brain/parasympathetic battery - the healing power generator.
To achieve orgasm (as energy pulsing discharge driven by the brain/sympathetic nervous function), even multiple sexual orgasms for men and women, you have to power the brain/nervous/liver/adrenal/cardiovascular/testicular (ovarian) functions in the first place. Why? (click here). The brain function + sexual technologies = multiple sexual orgasms. Caution: Medication and/or street drugs, alcohol, cigarette,  birth control pills or injection may perform chemical castration for your brain - disconnecting  or weakening the parasympathetic nervous communication (the acetylcholine bioelectro-chemical link) between the brain and the love tools, leading to impotency and frigidity. The good news is, we can help you restore and repower your brain function for relinking your love tools with our ViaPal-hGH products.
Sex is in the brain?  Yes,  Please read "Dr. Lin's formula helps a 65-year old tree grow new sprouts and tender leaves for hard erection and sexual orgasm."
==>http://www.actionlove.com/cases/case9144.htm
<< Detoxify and power your liver,  OR lose your brain/neuro-endocrine functions and shrink your love tools (the male and female penises!)! Keep your major biochemical factory the liver alive! >>
The role of the liver in male and female 'penile erection' and sexual orgasm. And VAGINISMUS !
==> http://www.actionlove.com/cases/case9098.htm 
What's wrong when the labia minora is larger than trhe labia majora? for sexual orgasm?
==> http://www.actionlove.com/cases/case9340.htm 

Get ride of SSRIs antidepressants and have Level-7 sexual orgasm back! Here is the How-to
==> http://www.actionlove.com/cases/case9117.htm
Over-Masturbation/Ejaculation has killed his liver and neuro-endocrine functions for no erection and sexual orgasm!
==> http://www.actionlove.com/cases/case9096.htm 
Healing of the damaged tissues and nerves done by vibrators or vacuum pumping, for sexual orgasm .
==>http://www.actionlove.com/cases/case9087.htm

How to Reverse aging for erection and sexual orgasm - the stress-hormone busters and the parasympathetic nervous power generators!
==>http://www.actionlove.com/cases/case9068.htm
Balance the brain's parasympathetic (acetylcholine), sympathetic (dopamine/norepinephrine/epinephrine), and Serotonin functions for prolonging intercourse and sexual orgasm; also the difference between masturbation (self-intercourse) and lovemaking
==>http://www.actionlove.com/cases/case9032.htm
He said 'your sex chikong breathing works great' for control of ejaculation
and sexual orgasm, but how to do it right? Why it works? Turn the lungs into the air
compressing chamber and Increase the neurotransmitter CO (Carbon Monoxide) and NO
(Nitric Oxide) levels in the brain! 
==>http://www.actionlove.com/cases/case9050.htm

Warning: High-level sexual orgasms can destroy pregnancy! (click here more information on this topic)
http://www.actionlove.com/cases/case8570.htm

Better News: (the best news is that you and your partner experience multiple orgasms again and again to supercharge both bodies in an one or two hour love session! ) Get the most benefit from lovemaking -
He and his girl friend get extraordinary benefits from sexual orgasm with Dr. Lin's formulas - Sexual Orgasm recharges their bodies instantly for health!.
==>http://www.actionlove.com/cases/case8949.htm
more and more...
Customers with blood-pressure or heart conditions love ViaPal-hGH-X for better sexual orgasm
==>http://www.actionlove.com/cases/case9015.htm
ViaGrowth-II helps him release tight muscles and Dr. Lin's Sexual ChiKong makes him last for 90 minutes and gives her a lot of sexual orgasm
==>http://www.actionlove.com/cases/case8944.htm
He gains 2 inches with Dr.Lin's Natural Penile Enlargement Method for more sexual orgasm
==>http://www.actionlove.com/cases/case8902.htm
ViaPal-hGH-D powers his penis like a rock-hard rod and the 3-Point Love Position gives her eruptive orgasms.
==>http://www.actionlove.com/cases/case8938.htm  
Dr. Lin's formula solved his adrenal insufficient, chronic fatigue and depression.
==>http://www.actionlove.com/cases/case8901.htm
ViaGrowth-IV strengthens her vaginal muscle, helps her achieve orgasm and rejuvenates her body (grows the G-spot and Clitoris?).
==>http://www.actionlove.com/cases/case8889.htm
He sad 'ViaPal-hGH-X is the only supplement working for me.' for heart and blood-pressure patients' Health and Sexual Orgasm
==>http://www.actionlove.com/cases/case8890.htm
He said our products have made his g/f reach very powerful multiple-cycle sexual orgasm and himself enlarge his penis to more than 7 inches from 5.3 inches; he wants more for her!
==>http://www.actionlove.com/cases/case9046.htm
He said 'Fibra + Ginseng Power Max numb my penis' for prolonging intercourse and ViaGrowth products for more sexual orgasm !
==>http://www.actionlove.com/cases/case9041.htm
Experience of Penile Ballooning and enlargement for sexual orgasm !
==>http://www.actionlove.com/cases/case9035.htm

More interested results in health rejuvenation  ? 
More interested results in Sexual Technology?
More interested results in Technical Support?
More interested results in Sexual ChiKong Intercourse?


Please Read these articles first!
How to Emulate the Vibrator stimulation with a penis for her multiple sexual orgasm (s)
==>http://www.actionlove.com/cases/case8848.htm
Dr.Lin's lovemaking methods re-ignite her fire, passion and hope for sexual orgasm
==>http:/http://www.actionlove.com/cases/case8840.htm
He said 'Your products are certainly helping the healing process. ' - more sexual Orgasm
http://www.actionlove.com/cases/case8857.htm
Solution for venous leakage for more erection and sexual Orgasm
http://www.actionlove.com/cases/case8856.htm
He said 'Your ViaGrowth-IV works as advertised.' - more erection and sexual Orgasm
http://www.actionlove.com/cases/case8855.htm
How to increase Orgasm hormone Oxytocin and reduce orgasm inhibitor Prolactin for more sexual orgasm: Direct Stimulation of the Epicenter causes a Oxytocin burst, but her vagina must be tented up and her clitoris and G-spot must be swollen to 5-6 times in size, to prevent orgasmic pain.
==>http://www.actionlove.com/cases/case8745.htm
Dr.Lin's theory of orgasmic excitation for breaking the orgasmic barrier to achieve sexual orgasm in every lovemaking.
==>http://www.actionlove.com/cases/case8601.htm
Dr. Lin helped her successfully develop her sexual orgasm.
==>http://www.actionlove.com/cases/case8693.htm
Advice to young couples on development of vaginal sexual orgasm

==>http://www.actionlove.com/cases/case8609.htm
Sexual Chikong Demonstrations help her tune her sexual muscle for multiple, sexual orgasms and female ejaculation.
==>http://www.actionlove.com/cases/case8649.htm
The Tao of Male Sexual Orgasm
==>http://www.actionlove.com/cases/case8739.htm
Glad to hear her successful story for health and sexual orgasm
==>http://www.actionlove.com/cases/case8785.htm

Update News: 3/9/2000::
We are restoring the files one by one. Please be patient! Dr. Lin has to walk through more than 10,000 web pages one by one to make sure that they are trade-marked drug names free!
The appearance of the most famous trade-marked erectile drug name in the web pages forces us to take this action. Now, Dr. Lin is reconstructing the Orgasm Research Center HERE. We have received thousand e-mails in last few days (3/5-3/10) concerning the shut-down of linplaza.com. Your continuous support and encouragement have been highly appreciated.

We have developed the most powerful products for rejuvenation of body function and health, which reverse the natural aging and the side effects of drugs on sexual functions.  Our sexual technologies (lovemaking methods, Sexual ChiKong Intercourse, Natural Penile and G-spot/Clitoral Enlargement)  and dietary supplements have helped love couples regain their love and joy. The detail is in /extra/relate.htm (click here).

One reader said 'your website was the truly genuine and useful one ...Your products are also the only ones I had resolved to use..' 
We are very proud of the integrity of our services and the effectiveness of our products in help loving couples out, so Dr. Lin's orgasm legend has been continued here! Welcome back, Folk!
HERE are few examples of readers and customers' correspondences during the shut-down of linplaza.com:
==>http://www.actionlove.com/cases/case8886.htm
==>http://www.actionlove.com/cases/case8885.htm
==>http://www.actionlove.com/cases/case8884.htm
==>http://www.actionlove.com/cases/case8883.htm
==>http://www.actionlove.com/cases/case8882.htm
==>http://www.actionlove.com/cases/case8881.htm
==>http://www.actionlove.com/cases/case8880.htm
==>http://www.actionlove.com/cases/case8879.htm
==>http://www.actionlove.com/cases/case8878.htm
==>http://www.actionlove.com/cases/case8877.htm


Please Read these articles first!
How to Emulate the Vibrator stimulation with a penis for her multiple sexual orgasm (s)
==>http://www.actionlove.com/cases/case8848.htm
Dr.Lin's lovemaking methods re-ignite her fire, passion and hope for sexual orgasm
==>http:/http://www.actionlove.com/cases/case8840.htm
He said 'Your products are certainly helping the healing process. ' - more sexual Orgasm
http://www.actionlove.com/cases/case8857.htm
Solution for venous leakage for more erection and sexual Orgasm
http://www.actionlove.com/cases/case8856.htm
He said 'Your ViaGrowth-IV works as advertised.' - more erection and sexual Orgasm
http://www.actionlove.com/cases/case8855.htm
How to increase Orgasm hormone Oxytocin and reduce orgasm inhibitor Prolactin for more sexual orgasm: Direct Stimulation of the Epicenter causes a Oxytocin burst, but her vagina must be tented up and her clitoris and G-spot must be swollen to 5-6 times in size, to prevent orgasmic pain.
==>http://www.actionlove.com/cases/case8745.htm
Dr.Lin's theory of orgasmic excitation for breaking the orgasmic barrier to achieve sexual orgasm in every lovemaking.
==>http://www.actionlove.com/cases/case8601.htm
Dr. Lin helped her successfully develop her sexual orgasm.
==>http://www.actionlove.com/cases/case8693.htm
Advice to young couples on development of vaginal sexual orgasm

==>http://www.actionlove.com/cases/case8609.htm
Sexual Chikong Demonstrations help her tune her sexual muscle for multiple, sexual orgasms and female ejaculation.
==>http://www.actionlove.com/cases/case8649.htm
The Tao of Male Sexual Orgasm
==>http://www.actionlove.com/cases/case8739.htm
Glad to hear her successful story for health and sexual orgasm
==>http://www.actionlove.com/cases/case8785.htm

Warning: High-level sexual orgasms can destroy pregnancy!
http://www.actionlove.com/cases/case8570.htm
Hot Topic:
How to power up the penis, last longer and resonate her sexual orgasm!
http://www.actionlove.com/cases/case8544.htm
Dr. Lin's formulas reverse the side effects of hair-growth drugs and restore erection for sexual orgasm!
==>http://www.actionlove.com/cases/case8572.htm
The Screwing Finger Pliers for all ages. Never too old to enjoy more sexual orgasm with Dr.Lin's sexual ChiKong Practice
==>http://www.actionlove.com/cases/case8573.htm
New tricks help women develop vaginal sexual orgasm
==>http://www.actionlove.com/cases/case8575.htm
An erectile drug User confirms Dr. Lin's liver and hormonal dynamics for sexual orgasm!
==>http://www.actionlove.com/cases/case8590.htm

Feature Topics:
Vasectomy, ejaculation disorder, and sexual orgasm.
Outline of powering up the penis and clitoris/G-spot/Epicenter for prolonged intercourse and multiple sexual orgasm (s)
Dr.Lin's Sexual Chikong let him experience sexual orgasm induced by Tailbone-muscle contraction without semen ejaculation and prostate contraction!
How to Become an Impotent (Pre-aged) Young Man (click here)

Readers' experiences: How to break a penis! (click here)
Tips for her multiple orgasms (click here)
Full solutions for powerful erection, lasting longer and her sexual orgasm! (click her)
He said "Heat Tea triples her G-spot size; what should I do for her sexual orgasm?"
Cornell's Ob/Gyn professor's website is for sexual orgasm too.
Use morning intercourse (without ejaculation for growing the penis) or Screwing Finger Pliers Method to grow her G-spot and Epicenter for sexual orgasm.
He said Dr. Lin's Natural Penile Enlargement (Power-Up or Ballooning) Method works well, for sexual orgasm.
The effects of hormone change on sexual orgasm.
An erectile drug user with high-blood pressure likes the full spectrum-hormone releaser for better sexual orgasm.
How to benefit from Sexual Orgasm.
He experienced an unusual erection and sexual orgasm with ViaGrowth-III which is for the Natural Penile and G-spot Enlargement
GOOD NEWS:
Dr.Lin's philosophy of formulating full-spectrum hormone releasers for sexual orgasm, without any side effects (why?). The Taoism approach.
==>http://www.actionlove.com/cases/case8463.htm

Since our establishment of this website in May of 1997, We have successfully served more than 20,000 couples (as of 7/19/1999, with 30-40 e-mails a day). This website contains more than 2000 COPYRIGHTED documents. It is the most complete data base for sexual technologies and problems/solutions. It may take you a few weeks or months to go through it.
We have highly appreciated your contributions - your important questions. Sometimes, you may get a delay or sluggish response from Dr. Lin as a result of e-mail overloading. This always happens during weekends. But, Dr. Lin will never ignore your important E-mail(s) as long as you have submitted your questions with Your Correct E-mail Address. Note: We reserve the right to publish the original correspondences between you and Dr. Lin, but your name will be deleted under our 1000% privacy-protection guarantee.
BREAKING NEWS:
Now, we are enterprising our business to serve you better.
A combination of Our 10-year R & D, the 5000-year Taoists' wisdom, and the modern bioengineering advanced finally concludes our New Products, ViaGrowth-I, II, and -III, helping men and women rejuvenate the natural body functions, the aging body, and the shrinking sex organs. They are available Now!
[TLI News Updated 9/1/1999] - Our success with ViaGrowth products, after 3-month introductory pricing and customers responses during 6/1/1999-8/31/1999, would like to continue benefitting all brothers and sisters around the world with reduced pricing.
Upon request of Mrs. Lin, we add ViaGrowth-III (60 tablets) to the Heat Tea package at no extra charge. We could not build this website to help you out and Dr. Lin could not write his book " Resonant Excitation of Sexual Orgasms," without her wisdom. We have honored her request for benefitting all the sisters around the world. ViaGrowth-III is very effective to resolve post-menopause hot flash, intercourse/post-orgasmic pain/cramp and PMS.
We also add the Fibra or Energia (for Heart/High-blood-pressure patients) to the ViaGrowth products as a package deal for Teenagers/ Young Men (ViaGrowth-I), 30-somethings (ViaGrowth-II), and middle agers (ViaGrowth-III). The most effective packages for middle agers, seniors and Erectile-drug Users are the full-spectrum hormone releasers, ViaPal-hGH-P and ViaPal-hGH-E (for heart and high-blood pressure patients.) We also include ViaGrowth-II into Androbolic for the high-performance, 20-70's men to shorten the Refraction Period or Time to re-arm their love weapon.

Our 10-year studies on pain and cramp in the muscles, ligaments and joints conclude "Blood Congestion" and "Hormone (DHEA/testosterone) Deficiency" in the local tissue are the most common causes. So, we offer our solutions with Pressure or Vacuum-cupping Massage and hormone-boosting supplements such as Heat Tea, PeniSOS, ViaGrowth-I, -II, and -III. They are the solutions for chronic pain or cramp in the back (from the shoulders to the tail bone), legs/toes, groins, thighs, hands/wrists/fingers, and intercourse and post-orgasmic pains or cramps.
ANOTHER BREAKING NEWS (updated 9/2/1999):
[TLI News Updated, 9/1/1999] - ViaGrowth-IV has passed testing.

ViaGrowth-IV, a combination of Paragon, ViaGrowth-I, and ViaGrowth-III, with extra Choline (9/2/1999), is on the way, under testing for highly performing, middle-ager and senior couplers which want to retain their dynamic orgasmic life with 3-5 times a week and refuse to grow old! Our goal is to help senior couples enjoy more funs in their golden age! Life is too short to fully enjoy being together.
Your Sexual Orgasm is our business. Please Feel Free to contact Dr. Lin.
Missions:
=> Education of Love, Sex, Marriage, bioelectricity or life energy(the missing chapter in the modern medical textbooks which have been written based upon a corpse or an anatomical structure of the corpse), Naturopathy and Rejuvenation with Traditional Taoists' Wisdom - Give the 5000-year "Tao of Love" a trial: Your Success with us is our sexual orgasm(s) ; We can not limit our knowledge on a corpse. Instead, we have to study "life."
=> Helping Loving Couples, including the so-called Sex Experts, Therapists, Professors or Scientists, Solve Sexual Problems. It is FREE! We can train old dogs new tricks; We look beyond the so-called G-spot orgasm..
=> Research/Development of Naturopathic/Bio-Engineering Approaches for Solving Sexual Dysfunctions and Health Disorder, and Rejuvenating the Natural Body Functions -by promoting the parasympathetic function (the self healing power) and cooling down the sympathetic function for better health (of course, including SEX!)
- that is, Cultivate your Chi (Qi or Ki) and love.
==> Help people reverse the side effects produced by medication drugs, painkillers, smoking , drinking, improper diets, birth control pill and injection, surgery, over-masturbation and over-ejaculation , resulting premature ejaculation and weak erection or impotence.
= => Help people solve chronic pain, fatigue, cramp, spasm, arthritis and non-disease health problems with the bioelectric theory.
Safe Sex Advice for Young Women: My Finger Pliers Method can trigger the G-spot sexual orgasm without breaking the hymen!
Dear Sex Experts, Therapists, Professors or Scientists:
Erectile dysfunction and sexual-orgasm disorder are physiological, not psychological!
We can make earth move!
Do your sexual problems always bother you?
Or, You don't know where is the G-spot, or cannot distinguish the G-spot from the Epicenter which has been named as the "Center of Lotus" by the old Taoists.
Or, you got divorce.
Or, Never have vaginal orgasm, or experience Premature Ejaculation, Erectile Dysfunction, or have a Shrinking Vagina or Penis, or a Prolapsing Uterus/Cervix causing pain/cramp in the pelvic cavity/low abdomen/low back/legs/butts.
And, you have nowhere to ask , just because your expertise is SEX. That is unfair to your soul.
We can help you out with the 5000-year Taoists' wisdom and the bioelectric engineering of the brain, nervous and endocrine functions plus the hydraulic engineering of the blood circulation - the plumbing problem of sex organs! It is FREE! We protect Your 100% privacy.
A combination of 5000-year love experiments and SEX 101 with the Dr. Lin's bioelectric engineering theory can not be wrong.
Sincerely yours, Lovebug.
Sexual Orgasm Technologies, Methods and Treatment Programs:(WARNING: All the contents are copyrighted - File NOs: TX 4-698-609, TXu 824-686 and current filing in the US Copyright Office. For private use only. We reward your reporting on copyright violation. Academic/commercial uses of the contents in this website without written agreement are absolutely prohibited.)

1. Anal Breathing Intercourse and Screwing Technique - the Penile/Vaginal Mutual Massage (Kissing) Method, Sexual ChiKong Intercourse, Natural Penile Enlargement (Power-up or Ballooning) Method, Vacuum-Cupping Massage, and Herbal supplements (Natural Hormone Enhancers) for powering the brain function, curing premature ejaculation and prostate enlargement, penile/G-spot shrinking, weak erection/engorgement and impotence/frigidity, and for combating the chronic health problems, such as high-blood pressure, diabetes, pain and numbness in the neck, back, hands, fingers, waist, groins, butts, legs and feet, depression, side effects of drugs/medication/smoking/the erectile drugs,.. and so on; and

2. Finger Plier(2-Point excitation) Method, 3_point Excitation Method, Screwing Technique and Anal Breathing Method, Pressure and Vacuum-Cupping Massages, and herbal supplements (Natural Hormone Enhancers) for achieving multiple sexual orgasms, and for curing frigidity, vaginal dryness, vaginal shrinking, uterus prolapsing, thinning vaginal liner, prolapsed uterus, hysterectomy, Intercourse Pain, post-orgasmic cramp and pain, vaginismus,... and so on.

Any love problems, Ask the black-belt Sexual ChiKong(KungFu) Master, Dr. Lin. FREE! 
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